Evaluation of the efficacy, safety, and side effects of secukinumab in patients with moderate-to-severe psoriasis: Real-world data from a retrospective multicenter study

Background: Clinical studies have demonstrated that IL-17A inhibition with secukinumab is effective for clearing the skin of patients with psoriasis and has a favorable safety profile. Objective: The authors aim to determine whether secukinumab is effective and safe for the treatment of moderate-to-severe chronic psoriasis based on clinical experience with this drug. Method: The authors conducted a multicenter retrospective study in nine referral centers and included patients with psoriasis who had received secukinumab between March 2018 to November 2020. Data on demographic characteristics, Psoriasis Area and Severity Index (PASI) scores, and previous treatments were collected from medical records. Patients were evaluated at 12, 24, and 52 weeks with respect to response to treatment and side effects. Results: In total, 229 patients were recruited for the study. A PASI score improvement of ≥90 points over the baseline was achieved by 79%, 69.8%, and 49.3% of patients at weeks 12, 24, and 52, respectively. The most common adverse events wereCandida infections and fatigue. In total, 74 (32%) patients discontinued treatment by week 52, including due to adverse events, or secondary ineffectiveness. Study limitations: Retrospective design. Conclusions: These findings suggest that secukinumab therapy is reasonably effective in patients with moderate-to-severe psoriasis. Comorbidities and time length of the disease can affect the response to treatment. The rates of adverse events were high in this patient population

Dobrava Hantavirus Infection Complicated by Panhypopituitarism, Istanbul, Turkey, 2010

We identified Dobrava-Belgrade virus infection in Turkey (from a strain related to hantavirus strains from nearby countries) in a patient who had severe symptoms leading to panhypopituitarism, but no known risk for hantavirus. Our findings emphasize the need for increased awareness of hantaviruses in the region and assessment of symptomatic persons without known risk factors for infection

Integration of structural, hydrogeological and thermal remote sensing data for the determination of geothermal capacity A case study of the Edremit (Balıkesir) Basin

Basins formed on active strike-slip faults are important prospect areas for geothermal energy exploration since the crust gets thinner in these areas and tectonic structures provide favorable conditions for heat-fluid circulation and transport. The Edremit (Balıkesir) Basin holds a great promise for the discovery of new geothermal energy sources. The objective of the recent study is to evaluate the geothermal capacity of the Edremit Basin utilizing tectonic, geological, and hydrogeological studies, combining remote sensing (land surface temperature-LST, hydrothermal alteration, and multi-temporal InSAR (MT-InSAR) assessments). We present structural literature data and the results of field mapping, which revealed the geometry, kinematics, and dynamics of structural features, geological units as geothermal system components, thermal and cold water chemistry, and thermal infrared remote sensing analysis. For the purpose of assessing new targets and recent geothermal capacity, these data are combined and evaluated. According to the outcomes of the study, the fault pattern in the Edremit Basin is generated by N-S extension, which produced E-W dominant striking normal faults with a heritage of paleostructures oriented in various directions. According to remote sensing analyses, the primary LST regions in the basin are defined by the active faults. Therefore, a high sodium sulfate ratio recorded in the chemical analyses of the water samples indicates a deep circulation and high possibility for the presence of thermal water. Consequently, our findings are consistent with the work to include thorough field geology surveys, structural patterns, LST, and water chemistry to refined exploration process