A periodic elastic medium in which periodicity is relevant

We analyze, in both (1+1)- and (2+1)- dimensions, a periodic elastic medium in which the periodicity is such that at long distances the behavior is always in the random-substrate universality class. This contrasts with the models with an additive periodic potential in which, according to the field theoretic analysis of Bouchaud and Georges and more recently of Emig and Nattermann, the random manifold class dominates at long distances in (1+1)- and (2+1)-dimensions. The models we use are random-bond Ising interfaces in hypercubic lattices. The exchange constants are random in a slab of size $L^{d-1} \times \lambda$ and these coupling constants are periodically repeated along either {10} or {11} (in (1+1)-dimensions) and {100} or {111} (in (2+1)-dimensions). Exact ground-state calculations confirm scaling arguments which predict that the surface roughness $w$ behaves as: $w \sim L^{2/3}, L \ll L_c$ and $w \sim L^{1/2}, L \gg L_c$, with $L_c \sim \lambda^{3/2}$ in $(1+1)$-dimensions and; $w \sim L^{0.42}, L \ll L_c$ and $w \sim \ln(L), L \gg L_c$, with $L_c \sim \lambda^{2.38}$ in $(2+1)$-dimensions.Comment: Submitted to Phys. Rev.

Magnetic nanocomposites at microwave frequencies

Most conventional magnetic materials used in the electronic devices are ferrites, which are composed of micrometer-size grains. But ferrites have small saturation magnetization, therefore the performance at GHz frequencies is rather poor. That is why functionalized nanocomposites comprising magnetic nanoparticles (e.g. Fe, Co) with dimensions ranging from a few nm to 100 nm, and embedded in dielectric matrices (e.g. silicon oxide, aluminium oxide) have a significant potential for the electronics industry. When the size of the nanoparticles is smaller than the critical size for multidomain formation, these nanocomposites can be regarded as an ensemble of particles in single-domain states and the losses (due for example to eddy currents) are expected to be relatively small. Here we review the theory of magnetism in such materials, and we present a novel measurement method used for the characterization of the electromagnetic properties of composites with nanomagnetic insertions. We also present a few experimental results obtained on composites consisting of iron nanoparticles in a dielectric matrix.Comment: 20 pages, 10 figures, 5 table

Aeolian sans ripples: experimental study of saturated states

We report an experimental investigation of aeolian sand ripples, performed both in a wind tunnel and on stoss slopes of dunes. Starting from a flat bed, we can identify three regimes: appearance of an initial wavelength, coarsening of the pattern and finally saturation of the ripples. We show that both initial and final wavelengths, as well as the propagative speed of the ripples, are linear functions of the wind velocity. Investigating the evolution of an initially corrugated bed, we exhibit non-linear stable solutions for a finite range of wavelengths, which demonstrates the existence of a saturation in amplitude. These results contradict most of the models.Comment: 4 pages, 5 figures, submitted to Phys. Rev. Lett. Title changed, figures corrected and simplified, more field data included, text clarifie

Response to antipsychotic drugs in treatment-resistant schizophrenia : Conclusions based on systematic review

Peer reviewe

The prognostic value of extramural venous invasion in preoperative MRI of rectal cancer patients

Aim This study aimed to examine the prognostic value of extramural venous invasion observed in preoperative MRI on survival and recurrences. Method In total, 778 rectal cancer patients were evaluated in multidisciplinary meetings in Helsinki University Hospital during the years 2016-2018. 635 patients met the inclusion criteria of stage I-III disease and were intended for curative treatment at the time of diagnosis. 128 had extramural venous invasion in preoperative MRI. Results The median follow-up time was 2.5 years. In a univariate analysis extramural venous invasion was associated with poorer disease-specific survival (hazard ratio [HR] 2.174, 95% CI 1.118-4.224, P = 0.022), whereas circumferential margin = T3c or nodal positivity were not. Disease recurrence occurred in 17.3% of the patients: 13.4% had metastatic recurrence only, 1.7% mere local recurrence and 2.2% both metastatic and local recurrence. In multivariate analysis, extramural venous invasion (HR 1.734, 95% CI 1.127-2.667, P = 0.012) and nodal positivity (HR 1.627, 95% CI 1.071-2.472, P = 0.023) were risk factors for poorer disease-free survival (DFS). Circumferential marginPeer reviewe

Void Coalescence Processes Quantified through Atomistic and Multiscale Simulation

Simulation of ductile fracture at the atomic scale reveals many aspects of the fracture process including specific mechanisms associated with void nucleation and growth as a precursor to fracture and the plastic deformation of the material surrounding the voids and cracks. Recently we have studied void coalescence in ductile metals using large-scale atomistic and continuum simulations. Here we review that work and present some related investigations. The atomistic simulations involve three-dimensional strain-controlled multi-million atom molecular dynamics simulations of copper. The correlated growth of two voids during the coalescence process leading to fracture is investigated, both in terms of its onset and the ensuing dynamical interactions. Void interactions are quantified through the rate of reduction of the distance between the voids, through the correlated directional growth of the voids, and through correlated shape evolution of the voids. The critical inter-void ligament distance marking the onset of coalescence is shown to be approximately one void radius based on the quantification measurements used, independent of the initial separation distance between the voids and the strain-rate of the expansion of the system. No pronounced shear flow is found in the coalescence process

Void Coalescence Processes Quantified Through Atomistic and Multiscale Simulation

Simulation of ductile fracture at the atomic scale reveals many aspects of the fracture process including specific mechanisms associated with void nucleation and growth as a precursor to fracture and the plastic deformation of the material surrounding the voids and cracks. Recently we have studied void coalescence in ductile metals using large-scale atomistic and continuum simulations. Here we review that work and present some related investigations. The atomistic simulations involve three-dimensional strain-controlled multi-million atom molecular dynamics simulations of copper. The correlated growth of two voids during the coalescence process leading to fracture is investigated, both in terms of its onset and the ensuing dynamical interactions. Void interactions are quantified through the rate of reduction of the distance between the voids, through the correlated directional growth of the voids, and through correlated shape evolution of the voids. The critical inter-void ligament distance marking the onset of coalescence is shown to be approximately one void radius based on the quantification measurements used, independent of the initial separation distance between the voids and the strain-rate of the expansion of the system. No pronounced shear flow is found in the coalescence process. We also discuss a technique for optimizing the calculation of fine-scale information on the fly for use in a coarse-scale simulation, and discuss the specific case of a fine-scale model that calculates void growth explicitly feeding into a coarse-scale mechanics model to study damage localization

Quasi-static cracks and minimal energy surfaces

We compare the roughness of minimal energy(ME) surfaces and scalar ``quasi-static'' fracture surfaces(SQF). Two dimensional ME and SQF surfaces have the same roughness scaling, w sim L^zeta (L is system size) with zeta = 2/3. The 3-d ME and SQF results at strong disorder are consistent with the random-bond Ising exponent zeta (d >= 3) approx 0.21(5-d) (d is bulk dimension). However 3-d SQF surfaces are rougher than ME ones due to a larger prefactor. ME surfaces undergo a ``weakly rough'' to ``algebraically rough'' transition in 3-d, suggesting a similar behavior in fracture.Comment: 7 pages, aps.sty-latex, 7 figure

The use of an intermediate wavelength laser for alignment to inertial confinement fusion targets

The conceptual design of the National Ignition Facility (NIF) 192 beam laser incorporates a low-power alignment beam injected in the pinhole plane of the final spatial filter with a wave length intermediate between the 1053 mn laser output and the 351 mn frequency-converted beam that illuminates the target Choosing the specific wavelength for which the spatial filter plane is reimaged in the same target chamber plane as the frequency-converted main laser pulse, achieves optimum accuracy without the need for additional means to insure precise overlap between the two beams. Insertion of the alignment beam after the last laser amplifier also allows alignment to the target while the amplifiers are still cooling from a previous shot