919 research outputs found

    Complete suppression of in vivo growth of human leukemia cells by specific immunotoxins: nude mouse models.

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    SPEAR Far Ultraviolet Spectral Images of the Cygnus Loop

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    We present far-ultraviolet (FUV) spectral images, measured at C IV 1550, He II 1640, Si IV+O IV] 1400, and O III] 1664, of the entire Cygnus Loop, observed with the Spectroscopy of Plasma Evolution from Astrophysical Radiation (SPEAR) instrument, also known as FIMS. The spatial distribution of FUV emission generally corresponds with a limb-brightened shell, and is similar to optical, radio and X-ray images. The features found in the present work include a ``carrot'', diffuse interior, and breakout features, which have not been seen in previous FUV studies. Shock velocities of 140-160 km/s is found from a line ratio of O IV] to O III], which is insensitive not only to resonance scattering but also to elemental abundance. The estimated velocity indicates that the fast shocks are widespread across the remnant. By comparing various line ratios with steady-state shock models, it is also shown that the resonance scattering is widespread.Comment: 13 pages, 3 figures, 1 table, accepted for publication in ApJ

    Consistency test of general relativity from large scale structure of the Universe

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    We construct a consistency test of General Relativity (GR) on cosmological scales. This test enables us to distinguish between the two alternatives to explain the late-time accelerated expansion of the universe, that is, dark energy models based on GR and modified gravity models without dark energy. We derive the consistency relation in GR which is written only in terms of observables - the Hubble parameter, the density perturbations, the peculiar velocities and the lensing potential. The breakdown of this consistency relation implies that the Newton constant which governs large-scale structure is different from that in the background cosmology, which is a typical feature in modified gravity models. We propose a method to perform this test by reconstructing the weak lensing spectrum from measured density perturbations and peculiar velocities. This reconstruction relies on Poisson's equation in GR to convert the density perturbations to the lensing potential. Hence any inconsistency between the reconstructed lensing spectrum and the measured lensing spectrum indicates the failure of GR on cosmological scales. The difficulties in performing this test using actual observations are discussed.Comment: 7 pages, 1 figur

    Symptom Clusters in Acute Myocardial Infarction: A Secondary Data Analysis

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    Background: Early recognition of acute myocardial infarction (AMI) symptoms and reduced time to treatment may reduce morbidity and mortality. People having AMI experience a constellation of symptoms, but the common constellations or clusters of symptoms have yet to be identified. Objectives: To identify clusters of symptoms that represent AMI. Methods: This was a secondary data analysis of nine descriptive, cross-sectional studies that included data from 1,073 people having AMI in the United States and England. Data were analyzed using latent class cluster analysis, an atheoretical method that uses only information contained in the data. Results: Five distinct clusters of symptoms were identified. Age, race, and sex were statistically significant in predicting cluster membership. None of the symptom clusters described in this analysis included all of the symptoms that are considered typical. In one cluster, subjects had only a moderate to low probability of experiencing any of the symptoms analyzed. Discussion: Symptoms of AMI occur in clusters, and these clusters vary among persons. None of the clusters identified in this study included all of the symptoms that are included typically as symptoms of AMI (chest discomfort, diaphoresis, shortness of breath, nausea, and lightheadedness). These AMI symptom clusters must be communicated clearly to the public in a way that will assist them in assessing their symptoms more efficiently and will guide their treatment-seeking behavior. Symptom clusters for AMI must also be communicated to the professional community in a way that will facilitate assessment and rapid intervention for AMI

    Search for CP Violation in D Meson Decays to phi pi+

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    We search for CP violation in Cabibbo-suppressed charged D meson decays by measuring the difference between the CP violating asymmetries for the Cabibbo-suppressed decays D+ -> K+K-pi+ and the Cabibbo-favored decays Ds -> K+K-pi+ in the K+K- mass region of the phi resonance. Using 955/fb of data collected with the Belle detector we obtain A_CP(D+ -> phi pi+) = (+0.51 +- 0.28 +- 0.05)%. The measurement improves the sensitivity of previous searches by more than a factor of five. We find no evidence for direct CP violation.Comment: submitted to PR

    The Cell Agglutination Agent, Phytohemagglutinin-L, Improves the Efficiency of Somatic Nuclear Transfer Cloning in Cattle (Bos taurus)

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    One of the several factors that contribute to the low efficiency of mammalian somatic cloning is poor fusion between the small somatic donor cell and the large recipient oocyte. This study was designed to test phytohemagglutinin (PHA) agglutination activity on fusion rate, and subsequent developmental potential of cloned bovine embryos. The toxicity of PHA was established by examining its effects on the development of parthenogenetic bovine oocytes treated with different doses (Experiment 1), and for different durations (Experiment 2). The effective dose and duration of PHA treatment (150 microg/mL, 20 min incubation) was selected and used to compare membrane fusion efficiency and embryo development following somatic cell nuclear transfer (Experiment 3). Cloning with somatic donor fibroblasts versus cumulus cells was also compared, both with and without PHA treatment (150 microg/mL, 20 min). Fusion rate of nuclear donor fibroblasts, after phytohemagglutinin treatment, was increased from 33 to 61% (P \u3c 0.05), and from 59 to 88% (P \u3c 0.05) with cumulus cell nuclear donors. The nuclear transfer (NT) efficiency per oocyte used was improved following PHA treatment, for both fibroblast (13% versus 22%) as well as cumulus cells (17% versus 34%; P \u3c 0.05). The cloned embryos, both with and without PHA treatment, were subjected to vitrification and embryo transfer testing, and resulted in similar survival (approximately 90% hatching) and pregnancy rates (17-25%). Three calves were born following vitrification and embryo transfer of these embryos; two from the PHA-treated group, and one from non-PHA control group. We concluded that PHA treatment significantly improved the fusion efficiency of somatic NT in cattle, and therefore, increased the development of cloned blastocysts. Furthermore, within a determined range of dose and duration, PHA had no detrimental effect on embryo survival post-vitrification, nor on pregnancy or calving rates following embryo transfer

    Observation of X(3872)J/ψγX(3872)\to J/\psi \gamma and search for X(3872)ψγX(3872)\to\psi'\gamma in B decays

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    We report a study of B(J/ψγ)KB\to (J/\psi \gamma) K and B(ψγ)KB\to (\psi' \gamma)K decay modes using 772×106772\times 10^{6} BBˉB\bar{B} events collected at the \Upsilon(4S)resonancewiththeBelledetectorattheKEKBenergyasymmetric resonance with the Belle detector at the KEKB energy-asymmetric e^+ e^-collider.Weobserve collider. We observe X(3872) \to J/\psi \gammaandreportthefirstevidencefor and report the first evidence for \chi_{c2} \to J/\psi \gammain in B\to (X_{c\bar{c}}\gamma) Kdecays,whileinasearchfor decays, while in a search for X(3872) \to \psi' \gammanosignificantsignalisfound.Wemeasurethebranchingfractions, no significant signal is found. We measure the branching fractions, \mathcal{B}(B^{\pm} \to X(3872) K^{\pm}) \mathcal{B}(X(3872) \to J/\psi\gamma) = (1.78^{+0.48}_{-0.44}\pm 0.12)\times 10^{-6},, \mathcal{B} (B^{\pm} \to\chi_{c2} K^{\pm})= (1.11^{+0.36}_{-0.34} \pm 0.09) \times 10^{-5},, \mathcal{B}(B^{\pm} \to X(3872) K^{\pm}) \mathcal{B}(X(3872) \to \psi'\gamma) < 3.45\times 10^{-6}$ (upper limit at 90% C.L.) and also provide upper limits for other searches.Comment: 6 pages, 3 figure

    Measurement of the CKM Matrix Element Vcb|V_{cb}| from B0D+νB^{0} \to D^{*-} \ell^+ \nu_\ell at Belle

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    We present a new measurement of the CKM matrix element Vcb|V_{cb}| from B0D+νB^{0} \to D^{*-} \ell^+ \nu_\ell decays, reconstructed with the full Belle data set of 711fb1711 \, \rm fb^{-1} integrated luminosity. Two form factor parameterizations, originally conceived by the Caprini-Lellouch-Neubert (CLN) and the Boyd, Grinstein and Lebed (BGL) groups, are used to extract the product F(1)ηEWVcb\mathcal{F}(1)\eta_{\rm EW}|V_{cb}| and the decay form factors, where F(1)\mathcal{F}(1) is the normalization factor and ηEW\eta_{\rm EW} is a small electroweak correction. In the CLN parameterization we find F(1)ηEWVcb=(35.06±0.15±0.56)×103\mathcal{F}(1)\eta_{\rm EW}|V_{cb}| = (35.06 \pm 0.15 \pm 0.56) \times 10^{-3}, ρ2=1.106±0.031±0.007\rho^{2}=1.106 \pm 0.031 \pm 0.007, R1(1)=1.229±0.028±0.009R_{1}(1)=1.229 \pm 0.028 \pm 0.009, R2(1)=0.852±0.021±0.006R_{2}(1)=0.852 \pm 0.021 \pm 0.006. For the BGL parameterization we obtain F(1)ηEWVcb=(34.93±0.23±0.59)×103\mathcal{F}(1)\eta_{\rm EW}|V_{cb}|= (34.93 \pm 0.23 \pm 0.59)\times 10^{-3}, which is consistent with the World Average when correcting for F(1)ηEW\mathcal{F}(1)\eta_{\rm EW}. The branching fraction of B0D+νB^{0} \to D^{*-} \ell^+ \nu_\ell is measured to be B(B0D+ν)=(4.90±0.02±0.16)%\mathcal{B}(B^{0}\rightarrow D^{*-}\ell^{+}\nu_{\ell}) = (4.90 \pm 0.02 \pm 0.16)\%. We also present a new test of lepton flavor universality violation in semileptonic BB decays, B(B0De+ν)B(B0Dμ+ν)=1.01±0.01±0.03 \frac{{\cal B }(B^0 \to D^{*-} e^+ \nu)}{{\cal B }(B^0 \to D^{*-} \mu^+ \nu)} = 1.01 \pm 0.01 \pm 0.03~. The errors correspond to the statistical and systematic uncertainties respectively. This is the most precise measurement of F(1)ηEWVcb\mathcal{F}(1)\eta_{\rm EW}|V_{cb}| and form factors to date and the first experimental study of the BGL form factor parameterization in an experimental measurement

    Bounds on the width, mass difference and other properties of X(3872) --> pi+pi-J/psi decays

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    We present results from a study of X(3872) --> pi+pi- J/psi decays produced via exclusive B--> K X(3872) decays. We determine the mass to be M_X(3872)= (3871.84\pm 0.27 (stat)\pm 0.19 (syst)) MeV, a 90% CL upper limit on the natural width of Gamma_X(3872) K+X(3872))xBf(X(3872)-->pi+pi-J/psi)=(8.61 \pm 0.82(stat) \pm 0.52 (syst)) x10^{-6}, and a ratio of branching fractions Bf(B0--> K0 X(3872))/BF(B+--> K+ X(3872))=0.50\pm 0.14(stat)\pm0.04(syst). The difference in mass between the X(3872)-->pi+pi-J/psi signals in B+ and B0 decays is Delta M_{X(3872)= (-0.69 \pm 0.97 (stat)} \pm 0.19 (syst)) MeV. A search for a charged partner of the X(3872) in the decays Bbar0-->K- X+ or B+-->K0X+, X+-->pi+pi0 J/psi resulted in upper limits on the product branching fractions for these processes that are well below expectations for the case that the X(3872) is the neutral member of an isospin triplet. In addition, we examine possible J^{PC} quantum number assignments for the X(3872) based on comparisons of angular correlations between final state particles in X(3872)-->pi+pi-J/psi decays with simulated data for J^{PC} values of 1^{++} and 2^{-+}. We examine the influence of rho-omega interference in the M(pi+pi-) spectrum. The analysis is based on a 711fb^{-1} data sample that contains 772 million BBbar meson pairs collected at the Upsilon(4S) resonance in the Belle detector at the KEKB e+e- collider.Comment: 15 pages, 10 figures and 6 tables. Submitted to Physical Review

    Observation of D0ρ0γD^0\to \rho^0\gamma and search for CPCP violation in radiative charm decays

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    We report the first observation of the radiative charm decay D0ρ0γD^0 \to \rho^0 \gamma and the first search for CPCP violation in decays D0ρ0γD^0 \to \rho^0 \gamma, ϕγ\phi\gamma, and K0γ\overline{K}{}^{*0} \gamma, using a data sample of 943 fb1^{-1} collected with the Belle detector at the KEKB asymmetric-energy e+ee^+e^- collider. The branching fraction is measured to be B(D0ρ0γ)=(1.77±0.30±0.07)×105\mathcal{B}(D^0 \to \rho^0 \gamma)=(1.77 \pm 0.30 \pm 0.07) \times 10^{-5}, where the first uncertainty is statistical and the second is systematic. The obtained CPCP asymmetries, ACP(D0ρ0γ)=+0.056±0.152±0.006\mathcal{A}_{CP}(D^0 \to \rho^0 \gamma)=+0.056 \pm 0.152 \pm 0.006, ACP(D0ϕγ)=0.094±0.066±0.001\mathcal{A}_{CP}(D^0 \to \phi \gamma)=-0.094 \pm 0.066 \pm 0.001, and ACP(D0K0γ)=0.003±0.020±0.000\mathcal{A}_{CP}(D^0 \to \overline{K}{}^{*0} \gamma)=-0.003 \pm 0.020 \pm 0.000, are consistent with no CPCP violation. We also present an improved measurement of the branching fractions B(D0ϕγ)=(2.76±0.19±0.10)×105\mathcal{B}(D^0 \to \phi \gamma)=(2.76 \pm 0.19 \pm 0.10) \times 10^{-5} and B(D0K0γ)=(4.66±0.21±0.21)×104\mathcal{B}(D^0 \to \overline{K}{}^{*0} \gamma)=(4.66 \pm 0.21 \pm 0.21) \times 10^{-4}
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