919 research outputs found
Complete suppression of in vivo growth of human leukemia cells by specific immunotoxins: nude mouse models.
SPEAR Far Ultraviolet Spectral Images of the Cygnus Loop
We present far-ultraviolet (FUV) spectral images, measured at C IV 1550, He
II 1640, Si IV+O IV] 1400, and O III] 1664, of the entire Cygnus Loop, observed
with the Spectroscopy of Plasma Evolution from Astrophysical Radiation (SPEAR)
instrument, also known as FIMS. The spatial distribution of FUV emission
generally corresponds with a limb-brightened shell, and is similar to optical,
radio and X-ray images. The features found in the present work include a
``carrot'', diffuse interior, and breakout features, which have not been seen
in previous FUV studies. Shock velocities of 140-160 km/s is found from a line
ratio of O IV] to O III], which is insensitive not only to resonance scattering
but also to elemental abundance. The estimated velocity indicates that the fast
shocks are widespread across the remnant. By comparing various line ratios with
steady-state shock models, it is also shown that the resonance scattering is
widespread.Comment: 13 pages, 3 figures, 1 table, accepted for publication in ApJ
Consistency test of general relativity from large scale structure of the Universe
We construct a consistency test of General Relativity (GR) on cosmological
scales. This test enables us to distinguish between the two alternatives to
explain the late-time accelerated expansion of the universe, that is, dark
energy models based on GR and modified gravity models without dark energy. We
derive the consistency relation in GR which is written only in terms of
observables - the Hubble parameter, the density perturbations, the peculiar
velocities and the lensing potential. The breakdown of this consistency
relation implies that the Newton constant which governs large-scale structure
is different from that in the background cosmology, which is a typical feature
in modified gravity models. We propose a method to perform this test by
reconstructing the weak lensing spectrum from measured density perturbations
and peculiar velocities. This reconstruction relies on Poisson's equation in GR
to convert the density perturbations to the lensing potential. Hence any
inconsistency between the reconstructed lensing spectrum and the measured
lensing spectrum indicates the failure of GR on cosmological scales. The
difficulties in performing this test using actual observations are discussed.Comment: 7 pages, 1 figur
Symptom Clusters in Acute Myocardial Infarction: A Secondary Data Analysis
Background: Early recognition of acute myocardial infarction (AMI) symptoms and reduced time to treatment may reduce morbidity and mortality. People having AMI experience a constellation of symptoms, but the common constellations or clusters of symptoms have yet to be identified. Objectives: To identify clusters of symptoms that represent AMI. Methods: This was a secondary data analysis of nine descriptive, cross-sectional studies that included data from 1,073 people having AMI in the United States and England. Data were analyzed using latent class cluster analysis, an atheoretical method that uses only information contained in the data. Results: Five distinct clusters of symptoms were identified. Age, race, and sex were statistically significant in predicting cluster membership. None of the symptom clusters described in this analysis included all of the symptoms that are considered typical. In one cluster, subjects had only a moderate to low probability of experiencing any of the symptoms analyzed. Discussion: Symptoms of AMI occur in clusters, and these clusters vary among persons. None of the clusters identified in this study included all of the symptoms that are included typically as symptoms of AMI (chest discomfort, diaphoresis, shortness of breath, nausea, and lightheadedness). These AMI symptom clusters must be communicated clearly to the public in a way that will assist them in assessing their symptoms more efficiently and will guide their treatment-seeking behavior. Symptom clusters for AMI must also be communicated to the professional community in a way that will facilitate assessment and rapid intervention for AMI
Search for CP Violation in D Meson Decays to phi pi+
We search for CP violation in Cabibbo-suppressed charged D meson decays by
measuring the difference between the CP violating asymmetries for the
Cabibbo-suppressed decays D+ -> K+K-pi+ and the Cabibbo-favored decays Ds ->
K+K-pi+ in the K+K- mass region of the phi resonance. Using 955/fb of data
collected with the Belle detector we obtain A_CP(D+ -> phi pi+) = (+0.51 +-
0.28 +- 0.05)%. The measurement improves the sensitivity of previous searches
by more than a factor of five. We find no evidence for direct CP violation.Comment: submitted to PR
The Cell Agglutination Agent, Phytohemagglutinin-L, Improves the Efficiency of Somatic Nuclear Transfer Cloning in Cattle (Bos taurus)
One of the several factors that contribute to the low efficiency of mammalian somatic cloning is poor fusion between the small somatic donor cell and the large recipient oocyte. This study was designed to test phytohemagglutinin (PHA) agglutination activity on fusion rate, and subsequent developmental potential of cloned bovine embryos. The toxicity of PHA was established by examining its effects on the development of parthenogenetic bovine oocytes treated with different doses (Experiment 1), and for different durations (Experiment 2). The effective dose and duration of PHA treatment (150 microg/mL, 20 min incubation) was selected and used to compare membrane fusion efficiency and embryo development following somatic cell nuclear transfer (Experiment 3). Cloning with somatic donor fibroblasts versus cumulus cells was also compared, both with and without PHA treatment (150 microg/mL, 20 min). Fusion rate of nuclear donor fibroblasts, after phytohemagglutinin treatment, was increased from 33 to 61% (P \u3c 0.05), and from 59 to 88% (P \u3c 0.05) with cumulus cell nuclear donors. The nuclear transfer (NT) efficiency per oocyte used was improved following PHA treatment, for both fibroblast (13% versus 22%) as well as cumulus cells (17% versus 34%; P \u3c 0.05). The cloned embryos, both with and without PHA treatment, were subjected to vitrification and embryo transfer testing, and resulted in similar survival (approximately 90% hatching) and pregnancy rates (17-25%). Three calves were born following vitrification and embryo transfer of these embryos; two from the PHA-treated group, and one from non-PHA control group. We concluded that PHA treatment significantly improved the fusion efficiency of somatic NT in cattle, and therefore, increased the development of cloned blastocysts. Furthermore, within a determined range of dose and duration, PHA had no detrimental effect on embryo survival post-vitrification, nor on pregnancy or calving rates following embryo transfer
Observation of and search for in B decays
We report a study of and
decay modes using events collected at the
\Upsilon(4S)e^+ e^-X(3872) \to J/\psi \gamma\chi_{c2} \to J/\psi \gammaB\to (X_{c\bar{c}}\gamma) KX(3872) \to \psi' \gamma\mathcal{B}(B^{\pm} \to X(3872)
K^{\pm}) \mathcal{B}(X(3872) \to J/\psi\gamma)=(1.78^{+0.48}_{-0.44}\pm
0.12)\times 10^{-6}\mathcal{B} (B^{\pm} \to\chi_{c2} K^{\pm})=(1.11^{+0.36}_{-0.34} \pm 0.09) \times 10^{-5}\mathcal{B}(B^{\pm} \to
X(3872) K^{\pm}) \mathcal{B}(X(3872) \to \psi'\gamma)<3.45\times 10^{-6}$
(upper limit at 90% C.L.) and also provide upper limits for other searches.Comment: 6 pages, 3 figure
Measurement of the CKM Matrix Element from at Belle
We present a new measurement of the CKM matrix element from decays, reconstructed with the full Belle data set
of integrated luminosity. Two form factor
parameterizations, originally conceived by the Caprini-Lellouch-Neubert (CLN)
and the Boyd, Grinstein and Lebed (BGL) groups, are used to extract the product
and the decay form factors, where
is the normalization factor and is a small
electroweak correction. In the CLN parameterization we find
, , , . For the BGL parameterization we
obtain , which is consistent with the World Average when correcting for
. The branching fraction of is measured to be . We also present a new
test of lepton flavor universality violation in semileptonic decays,
. The errors correspond to the statistical and
systematic uncertainties respectively. This is the most precise measurement of
and form factors to date and the first
experimental study of the BGL form factor parameterization in an experimental
measurement
Bounds on the width, mass difference and other properties of X(3872) --> pi+pi-J/psi decays
We present results from a study of X(3872) --> pi+pi- J/psi decays produced
via exclusive B--> K X(3872) decays. We determine the mass to be M_X(3872)=
(3871.84\pm 0.27 (stat)\pm 0.19 (syst)) MeV, a 90% CL upper limit on the
natural width of Gamma_X(3872)
K+X(3872))xBf(X(3872)-->pi+pi-J/psi)=(8.61 \pm 0.82(stat) \pm 0.52 (syst))
x10^{-6}, and a ratio of branching fractions Bf(B0--> K0 X(3872))/BF(B+--> K+
X(3872))=0.50\pm 0.14(stat)\pm0.04(syst). The difference in mass between the
X(3872)-->pi+pi-J/psi signals in B+ and B0 decays is Delta M_{X(3872)= (-0.69
\pm 0.97 (stat)} \pm 0.19 (syst)) MeV. A search for a charged partner of the
X(3872) in the decays Bbar0-->K- X+ or B+-->K0X+, X+-->pi+pi0 J/psi resulted in
upper limits on the product branching fractions for these processes that are
well below expectations for the case that the X(3872) is the neutral member of
an isospin triplet. In addition, we examine possible J^{PC} quantum number
assignments for the X(3872) based on comparisons of angular correlations
between final state particles in X(3872)-->pi+pi-J/psi decays with simulated
data for J^{PC} values of 1^{++} and 2^{-+}. We examine the influence of
rho-omega interference in the M(pi+pi-) spectrum. The analysis is based on a
711fb^{-1} data sample that contains 772 million BBbar meson pairs collected at
the Upsilon(4S) resonance in the Belle detector at the KEKB e+e- collider.Comment: 15 pages, 10 figures and 6 tables. Submitted to Physical Review
Observation of and search for violation in radiative charm decays
We report the first observation of the radiative charm decay and the first search for violation in decays , , and , using a data sample of
943 fb collected with the Belle detector at the KEKB asymmetric-energy
collider. The branching fraction is measured to be , where the first
uncertainty is statistical and the second is systematic. The obtained
asymmetries, , , and
, are consistent with no violation. We also present an improved
measurement of the branching fractions and
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