Performance Evaluation of Caching Policies in NDN - an ICN Architecture

Information Centric Networking (ICN) advocates the philosophy of accessing the content independent of its location. Owing to this location independence in ICN, the routers en-route can be enabled to cache the content to serve the future requests for the same content locally. Several ICN architectures have been proposed in the literature along with various caching algorithms for caching and cache replacement at the routers en-route. The aim of this paper is to critically evaluate various caching policies using Named Data Networking (NDN), an ICN architecture proposed in literature. We have presented the performance comparison of different caching policies naming First In First Out (FIFO), Least Recently Used (LRU), and Universal Caching (UC) in two network models; Watts-Strogatz (WS) model (suitable for dense short link networks such as sensor networks) and Sprint topology (better suited for large Internet Service Provider (ISP) networks) using ndnSIM, an ns3 based discrete event simulator for NDN architecture. Our results indicate that UC outperforms other caching policies such as LRU and FIFO and makes UC a better alternative for both sensor networks and ISP networks

Development of Benzimidazole Compounds for Cancer Therapy

A fact that is largely unknown in the lay press and even the scientific community is that today cancer kills more people worldwide than tuberculosis (TB), malaria, and human immunodeficiency virus (HIV) combined. Benzimidazole is a heterocyclic aromatic organic compound considered to be a useful pharmacophore in a variety of impactful drugs. The purpose of this review is to highlight the benzimidazole-containing agents that are currently in clinical use or in clinical development as anticancer drugs. It is hoped that this review would function as comprehensive working reference of research accomplishment in the field of discovery and development of benzimidazole-based anticancer drugs

Enhancement Security in Smart TV Web Application

During the course of its research, the security firmware of the TV's Internet interface failed to confirm script integrity before scripts were run. The attacker could intercept transmissions from the television to the network using common DNS, DHCP server, and TCP session hijacking techniques. The code could then be injected into the normal DataStream, allowing attackers to obtain total control over the device's Internet functionality. This attack could render the product unusable at important times and extend or limit its functionality without the manufacturer's permission. More importantly, however, this same mechanism could be used to extract sensitive credentials from the TV's memory, or prompt the user to fill out fake online forms to capture credit card information. Additionally, Hackers were able to recover the manufacturer's private third-party developer keys†from the television, because in many cases, these keys were transmitted unencrypted and in the clear. Many third-party searches, music, video and photo-sharing services delivered over the Internet require such keys, and a big TV Manufacturer often purchases high-volume special access privileges to these service provider's networks. A hacker could potentially employ these keys, for example, to access these high-volume services at no charge. This paper describes the new Authentication mechanism for online transaction payment for more secured service and, analyzing network managed challenge to avoid the vulnerabilities

Molecular docking studies of natural compounds of naringin on enzymes involved in the urea cycle pathway in hyperammonemia

Purpose: To investigate the anti-hyperammonemic activity of naringin by molecular docking via in silico studies.Methods: Urea cycle proteins were docked to the natural compound naringin as well as a standard drug, sodium benzoate. Hydrogen bonds and binding energy were obtained using Catalytic Site Atlas and Cast P Finder Software Tool.Results: There were six urea cycle enzymes, including N-acetyl glutamate synthase, carbamoyl phosphate synthase I, ornithine transcarbamylase, argininosuccinate synthase, argininosuccinate lyase and arginase I. On evaluating protein interactions with naringin, which is dynamically  connected to the urea cycle pathway with hyperammonemia, naringin showed more hydrogen bonds and also produced higher binding energy when compared to the standard drug, sodium benzoate.Conclusion: The results of the molecular docking study show that naringin interacts with urea cycle enzymes with more hydrogen bonds and higher bonding energy than the standard drug, sodium benzoate. This supports the hypothesis that naringin can prevent experimental hyperammonemia. Keywords: Naringin, Sodium benzoate, Hyperammonemia, Urea cycle enzymes, In silico studies &nbsp

Removal of phenol from wastewater using spiral-wound reverse osmosis process: model development based on experiment and simulation

YesThe removal of the ubiquitous phenol and phenolic compounds in industrial wastes is a critical environmental issue due to their harmful threats to wildlife and potential adverse human health effects. The removal of such compounds is therefore of significant importance in water treatment and reuse. In recent years, reverse osmosis (RO) has been successfully utilised in several industrial processes and wastewater treatment including phenol removal. In this paper, a new model based on a spiral-wound RO process is developed for the removal of phenol from wastewater. A simplified mathematical algorithm using an irreversible thermodynamic approach is developed. This results in a set of non-linear Differential and Algebraic Equations (DAEs), which are solved based on a number of optimised model parameters using a combined methodology of parameter estimation and experimental phenol-water data derived from the literature. The effects of several operational parameters on the performance (in terms of removal of phenol) of the process are explored using the model