Government General Hospital

Abstract Introduction: Various components of metabolic syndrome have an important role in the pathogenesis of both non-alcoholic fatty liver disease (NAFLD) and psoriasis, suggesting an association between these diseases. However, at present very few studies have reported on the systematic evaluations of the prevalence of NAFLD in patients with psoriasis disorder. Aim: To investigate the prevalence of NAFLD in patients with psoriasis vulgaris. The study also evaluated the parallel relationship between both of the diseases. Material and methods: Patients over18 years old and with a diagnosis of psoriasis vulgaris at the outpatient unit of Department of Dermatology were considered for enrolment and were followed up by the Department of Hepatology, Madras Medical College. Each and every patient completed a questionnaire, underwent a thorough skin evaluation, and had a right upper quadrant ultrasound and fasting blood workup. Results: Two hundred and fifty patients were enrolled in the study. The participants were predominantly middle aged (mean: 44.74 ±11.989 years), overweight (average body mass index (BMI): 24.772 ±3.611 kg/

Continuous Shape Measure of electronic effect free steric distortions in tris(dithiocarbamato)indium(III): Synthesis, spectral, electrochemical, single crystal X-ray structural investigations and BVS calculations on tris(dithiocarbamato)indium(III) complexes

Geometrical distortions from an ideal octahedral geometry (iOh) towards an ideal trigonal prism (itp) in tris(dithiocarbamato)indium(III) complexes have been quantified by Continuous Shape Measure (CShM) analysis. Three tris(disubstituted dithiocarbamato)indium(III) complexes, cyclohexylmethyldithiocarbamate (chmdtc) (1), cyclohexylethyldithiocarbamate (chedtc) (2) and dicyclohexyldithiocarbamate (dchdtc) (3), have been prepared and characterized by spectral, cyclic voltammetric and single crystal X-ray structural techniques. The electronic effects are at a minimum for trivalent indium and the distortions follow the order: (3) > (1) > (2), as per the CShM values. The IR spectra indicate a contribution of the thioureide form of the dithiocarbamates to the stabilization of the compounds, with a characteristic C–N stretch in the range 1446–1475 cm?1.1H NMR spectra indicate that the protons in the vicinity of the thioureide nitrogen are the most affected on complexation.13C NMR spectra showed the characteristic thioureide carbon signals at 201.18, 200.98 and 200.94 ppm for complexes (1), (2) and (3) respectively. Cyclic voltammetric investigations revealed three single electron additions to the trivalent indium. The single crystal X-ray structures showed little change in the In–S and thioureide C–N bond distances or the S–In–S bite angles with changes in the steric demands, in the absence of any significant electronic effects. Bond Valence Sums (BVS) of the complexes identified the formal oxidation of indium to be +3 and the observed deviations show the increased covalent bonding. Nano indium sulfides have been prepared from the dithiocarbamates through a non-conventional solvothermal process. The nanosulfides have been characterized by SEM and EDX techniques. The ease and yield of formation follow the order: (3) > (1) > (2)

Mono and trivalent thallium-sulfur interactions and their influence on the formation of nano thallium sulphide: Single crystal X-ray structural and spectral studies on thallium(I)/(III)-cyclohexylpiperazine dithiocarbamates

Thallium(i) and thallium(iii)-cyclohexylpiperazine dithiocarbamates have been prepared with the same donor environment for the first time and analyzed by electronic, IR, 1H, 13C NMR spectral, CV and single crystal X-ray structural analyses. Solvothermal decomposition of the dithiocarbamates yielded nano Tl4S3 and were characterized. Bond parameters from single crystal X-ray structures have been used in continuous symmetry measure and bond valence sum analysis of the compounds to establish the octahedral geometry and formal oxidation numbers of thallium. [Tl(chpzdtc)]2 (1) shows extensive non covalent interactions and the hemidirected TlS2CSTl core is of distorted square pyramidal geometry with the stereo chemically active lone pair of thallium(I) occupying a vertex of the square pyramid. This is the first report which identifies the 4f7/2 and 4f5/2 electron binding energies of Tl(i) and Tl(III) dithiocarbamates unambiguously and the effect of Tl⋯action on XPS binding energies. [Tl(chpzdtc)3] (2), the trivalent analogue as a contrast is a typical holodirected TlS6 distorted octahedral core with no significant supramolecular interactions. Mean Tl-S bond distances in 1 and 2 are 2.985(7) and 2.6789(19) Å, respectively, which clearly support the higher ease of solvothermal decomposition of 1 to nano Tl4S3 than 2. A strong correlation exists between the bond strengths of Tl-S, the thioureide C-N and the ease of formation of Tl4S3 from the two dithiocarbamates 1 and 2

Thermodynamic analysis of a single effect lithium bromide water absorption system using waste heat in sugar industry

Energy analysis plays a vital role in the industry due to the use of electrical energy, global warming, and economy crises. This paper describes the waste heat available in the exhaust of the steam turbine and beneficial use of the waste heat. The sugar industry steam turbine exhaust carries enthalpy of steam at 2500 kJ/kg, this thermal energy can be put into beneficial use as the heat source to the vapor absorption refrigeration system to compensate energy required for DC thyrist motor, and this can also be used for cold storage. Energy savings in terms of cost and fuels are calculated. Investigation on the heat and mass transfer in evaporator has been carried out in vapor absorption system by varying the operating parameter. Less circulation ratio is required to increase the coefficient of performance. The inlet temperature of the coolant should be less for achieving higher coefficient of performance

Systematic reinstatement of highly sacred Ficus krishnae based on differences in morphology and DNA barcoding from Ficus benghalensis (Moraceae)

Ficus krishnae is considered as native to India and is well-known for the peculiarity in nature of its cup-shaped leaves where both the vernacular name (Krishna Fig) and specific epithet were derived. The taxonomic status of Ficus krishnae is still unclear and currently treated as a subspecies or variety under Ficus benghalensis. In the present study, morphological characters and molecular analysis were employed to address their species delimitation. The spacer markers ITS2 and trnH-psbA were used for constructing phylogenetic trees along with morphometric analysis. Ficus krishnae distinctly differs from Ficus benghalensis by having cup-forming leaves and the nature of the aerial roots, stipules, petioles, ostiolar bracts of the receptacle, DNA content, chromosome differences and nodal anatomy. The results showed that the highest divergence is observed in trnH-psbA (20.8 ± 12.2), followed by ITS2 (5.7 ± 3.2). The phylogenetic tree construction using Bayesian analysis showed a divergent boundary between the two species suggesting that F. krishnae could be an independent species, not a variety of F. benghalensis. The present study’s findings support the view that these two floras can be treated as different species

Research Journal of Pharmaceutical, Biological and Chemical Sciences Trends in Seroprevalence of Hepatitis B Virus Infection among General Population: A Study from Chennai, Tamil Nadu, India

ABSTRACT Hepatitis B virus (HBV) infection remains a major global public health problem, despite the availability of effective vaccine and improvements in antiviral therapy. About 350 million people become chronic carriers of the virus and over 1 million die annually from HBV associated liver disease and a significant number of the chronic carriers may develop liver cirrhosis or hepatocellular carcinoma. A total of 951 participants (568 males and 383 females) from areas around our hospital were included in the study. Blood was collected from participants and sera were separated. Samples which showed positive for HBsAg by rapid test were tested for HBsAg by ELISA technique. Of the 951 samples, 40 (4.2%) were positive for HBsAg. High prevalence was recorded in males 25/951 (2.6%) than females 15/951 (1.6%). More number of positive cases (11/951 (1.2%)) were fall in the age group of 30-39. Data on HBV prevalence at country level are needed to estimate disease burden and to formulate health and vaccine policy

Phytochemical Profile of Erythrina variegata by Using High-Performance Liquid Chromatography and Gas Chromatography-Mass Spectroscopy Analyses

Natural products derived from plant sources have been utilized to treat patients with numerous diseases. The phytochemical constituents present in ethanolic leaf extract of Erythrina variegata (ELEV) were identified by using high-performance liquid chromatography (HPLC) and gas chromatography-mass spectroscopy (GC-MS) analyses. Shade dried leaves were powdered and extracted with ethanol for analyses through HPLC to identify selected flavonoids and through GC-MS to identify other molecules. The HPLC analysis of ELEV showed the presence of gallic and caffeic acids as the major components at concentrations of 2.0 ppm and 0.1 ppm, respectively, as well as other components. GC-MS analysis revealed the presence of 3-eicosyne; 3,7,11,15-tetramethyl-2-hexadecen-1-ol; butanoic acid, 3-methyl-3,7-dimethyl-6-octenyl ester; phytol; 1,2-benzenedicarboxylic acid, diundecyl ester; 1-octanol, 2-butyl-; squalene; and 2H-pyran, 2-(7-heptadecynyloxy) tetrahydro-derivative. Because pharmacopuncture is a new evolving natural mode that uses herbal extracts for treating patients with various ailments with minimum pain and maximum effect, the results of this study are particularly important and show that ELEV possesses a wide range of phytochemical constituents, as indicated above, as effective active principle molecules that can be used individually or in combination to treat patients with various diseases