Computer simulation of a pilot in V/STOL aircraft control loops

The objective was to develop a computerized adaptive pilot model for the computer model of the research aircraft, the Harrier II AV-8B V/STOL with special emphasis on propulsion control. In fact, two versions of the adaptive pilot are given. The first, simply called the Adaptive Control Model (ACM) of a pilot includes a parameter estimation algorithm for the parameters of the aircraft and an adaption scheme based on the root locus of the poles of the pilot controlled aircraft. The second, called the Optimal Control Model of the pilot (OCM), includes an adaption algorithm and an optimal control algorithm. These computer simulations were developed as a part of the ongoing research program in pilot model simulation supported by NASA Lewis from April 1, 1985 to August 30, 1986 under NASA Grant NAG 3-606 and from September 1, 1986 through November 30, 1988 under NASA Grant NAG 3-729. Once installed, these pilot models permitted the computer simulation of the pilot model to close all of the control loops normally closed by a pilot actually manipulating the control variables. The current version of this has permitted a baseline comparison of various qualitative and quantitative performance indices for propulsion control, the control loops and the work load on the pilot. Actual data for an aircraft flown by a human pilot furnished by NASA was compared to the outputs furnished by the computerized pilot and found to be favorable

Magnetic equivalent circuit model of surface type fractional-slot permanent magnet synchronous generator

Design of permanent magnet synchronous machines becomes more of an issue for all systems lately. There are many parameters that have influence for machine design. Each parameter should have optimized and their effects on the system should be determined. Any desired pre-design have been done for machine design except a few paper and it only showed by of Finite element analysis (FEA). In this article, analytical method is used in permanent magnet synchronous machine design and the effects of geometric on the performance of machine are presented. Magnetic equivalent circuit (MEC) model is used as numeric method. It is observed that the proposed MEC model is pertinent to Speed PC-BDC model and FEA. Besides proposed MEC model provides to calculate performances of the machines which have the desirable slot/pole combinations correctly. Proposed model is applied on the recently increased fractional slot direct drive synchronous generators

Dynamics and torque analysis of permanent magnet synchronous generator with soft magnetic composite material

Usage of permanent magnet synchronous machines (PMSM) in wind turbines recently became more of an issue. The development in permanent magnet synchronous machines through the latest technologies, especially about machine design, increases the importance of those machines. Developments in materials technology implement the development of cost effective and profitable products on electric machines and bring simplicity in design. Especially Soft Magnetic Composite (SMC) materials became to be used recently in machine designs due to its advantages such as low costs and providing 3D flux paths. In this work the 2D magnetic equivalent circuit (MEC) of PMSM machine, which includes SMC in its stator part, was composed and stated magnetic equivalent circuit was verified by finite element method. Also torque and radial forces of PMSM were calculated as well. When SMC materials are used in electric machines, flux flows in 3D. 3D finite element method takes quite long time. Due to 2D MEC analysis that was used in our work, the analysis periods become remarkably shorter. Besides the proposed MEC model enables to calculate performances of the machines, which have the desirable slot/pole combinations, correctly. Proposed model is applied on the recently improved fractional slot direct drive synchronous generators

Single Top Production at HERA and THERA

We study the single top production mediated by flavor changing neutral current via both of the $t-q-\gamma$ and $t-q-Z$ vertices (here q represents c and u quarks) in ep collisions at two colliders HERA and THERA. Contribution of the second vertex becomes even more important as the couplings take more improved values provided by the higher luminosities of colliders. In addition to these improvements if the CM energy of the collider is increased, the production will be dominated by the anomalous $t-q-Z$ vertex.Comment: 8 pages, 3 figures, RevTeX4, references adde

Magnetic equivalent circuit model of surface type fractional-slot permanent magnet synchronous generator

Design of permanent magnet synchronous machines becomes more of an issue for all systems lately. There are many parameters that have influence for machine design. Each parameter should have optimized and their effects on the system should be determined. Any desired pre-design have been done for machine design except a few paper and it only showed by of Finite element analysis (FEA). In this article, analytical method is used in permanent magnet synchronous machine design and the effects of geometric on the performance of machine are presented. Magnetic equivalent circuit (MEC) model is used as numeric method. It is observed that the proposed MEC model is pertinent to Speed PC-BDC model and FEA. Besides proposed MEC model provides to calculate performances of the machines which have the desirable slot/pole combinations correctly. Proposed model is applied on the recently increased fractional slot direct drive synchronous generators

Norditerpenoids with selective anti-cholinesterase activity from the roots of Perovskia atriplicifolia Benth

Inhibition of cholinesterases remains one of a few available treatment strategies for neurodegenerative dementias such as Alzheimer's disease and related conditions. The current study was inspired by previous data on anticholinesterase properties of diterpenoids from Perovskia atriplicifolia and other Lamiaceae species. The acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition by the three new natural compounds-(1R,15R)-1-acetoxycryptotanshinone (1), (1R)-1-acetoxytanshinone IIA (2), and (15R)-1-oxoaegyptinone A (3)-as well as, new for this genus, isograndifoliol (4) were assessed. Three of these compounds exhibited profound inhibition of butyrylcholinesterase (BChE) and much weaker inhibition of acetylcholinesterase (AChE). All compounds (1-4) selectively inhibited BChE (IC(50) = 2.4, 7.9, 50.8, and 0.9 µM, respectively), whereas only compounds 3 and 4 moderately inhibited AChE (IC(50) 329.8 µM and 342.9 µM). Molecular docking and in silico toxicology prediction studies were also performed on the active compounds. Natural oxygenated norditerpenoids from the traditional Central Asian medicinal plant P. atriplicifolia are selective BChE inhibitors. Their high potential makes them useful candidate molecules for further investigation as lead compounds in the development of a natural drug against dementia caused by neurodegenerative diseases

Stenotrophomonas maltophilia prosthetic valve endocarditis: a case report

<p>Abstract</p> <p>Introduction</p> <p><it>Stenotrophomonas maltophilia </it>is an environmental bacterium increasingly involved in nosocomial infections and resistant to most antibiotics. It is important to recognize and efficiently treat infections with this bacterium as soon as possible.</p> <p>Case presentation</p> <p>We present a case of <it>Stenotrophomonas maltophilia </it>prosthetic valve endocarditis secondary to an indwelling catheter infection. The patient was cured without surgery. We review other cases of <it>S. maltophilia </it>endocarditis from the literature and describe the peculiarities of this case.</p> <p>Conclusion</p> <p><it>S. maltophilia </it>endocarditis is a rare disease that is often hospital-acquired and related to an indwelling catheter infection. The high lethality is likely related to the intrinsic resistance of nosocomial bloodstream infections to commonly prescribed antibiotics.</p

Paving Plant-Food-Derived Bioactives as Effective Therapeutic Agents in Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental disorder, where social and communication deficits and repetitive behaviors are present. Plant-derived bioactives have shown promising results in the treatment of autism. In this sense, this review is aimed at providing a careful view on the use of plant-derived bioactive molecules for the treatment of autism. Among the plethora of bioactives, curcumin, luteolin, and resveratrol have revealed excellent neuroprotective effects and can be effectively used in the treatment of neuropsychological disorders. However, the number of clinical trials is limited, and none of them have been approved for the treatment of autism or autism-related disorder. Further clinical studies are needed to effectively assess the real potential of such bioactive molecules.N.C.-M. acknowledges the Portuguese Foundation for Science and Technology under the Horizon 2020 Program (PTDC/PSI-GER/28076/2017)

Arterial pulse wave modelling and analysis for vascular age studies: a review from VascAgeNet

Arterial pulse waves (PWs) such as blood pressure and photoplethysmogram (PPG) signals contain a wealth of information on the cardiovascular (CV) system that can be exploited to assess vascular age and identify individuals at elevated CV risk. We review the possibilities, limitations, complementarity, and differences of reduced-order, biophysical models of arterial PW propagation, as well as theoretical and empirical methods for analyzing PW signals and extracting clinically relevant information for vascular age assessment. We provide detailed mathematical derivations of these models and theoretical methods, showing how they are related to each other. Finally, we outline directions for future research to realize the potential of modeling and analysis of PW signals for accurate assessment of vascular age in both the clinic and in daily life