144 research outputs found
3D Printed Polycaprolactone/Gelatin/Bacterial Cellulose/Hydroxyapatite Composite Scaffold for Bone Tissue Engineering
Three-dimensional (3D) printing application is a promising method for bone tissue engineering. For enhanced bone tissue regeneration, it is essential to have printable composite materials with appealing properties such as construct porous, mechanical strength, thermal properties, controlled degradation rates, and the presence of bioactive materials. In this study, polycaprolactone (PCL), gelatin (GEL), bacterial cellulose (BC), and different hydroxyapatite (HA) concentrations were used to fabricate a novel PCL/GEL/BC/HA composite scaffold using 3D printing method for bone tissue engineering applications. Pore structure, mechanical, thermal, and chemical analyses were evaluated. 3D scaffolds with an ideal pore size (~300 ”m) for use in bone tissue engineering were generated. The addition of both bacterial cellulose (BC) and hydroxyapatite (HA) into PCL/GEL scaffold increased cell proliferation and attachment. PCL/GEL/BC/HA composite scaffolds provide a potential for bone tissue engineering applications
A novel approach to treat the Thiel-Behnke corneal dystrophy using 3D printed honeycomb-shaped polymethylmethacrylate (PMMA)/Vancomycin (VAN) scaffolds
Thiel-Behnke corneal dystrophy, or honeycomb corneal dystrophy, is an autosomal dominant corneal disorder. Tissue engineering can be a novel approach to regenerate this dystrophy. In this study, the honeycomb geometry of the dystrophy mimicked with a 3D printing technology, and 40% PMMA, 40% PMMA/(0.1, 0.5, 2, and 10)% VAN scaffolds were fabricated with honeycomb geometry. As a result of the biocompatibility test with mesenchymal stem cells (MSCs), it can be said that cells on the scaffolds showed high viability and proliferation for all incubation periods. According to the antibacterial activity results, the 40% PMMA/10% VAN showed antibacterial activity against S. aureous. Mechanical results reported that with the addition of VAN into the 40% PMMA, the tensile strength value increased up to 2% VAN amount. The swelling behaviours of the scaffolds were examined in vitro, and found that the swelling rate increased with a high VAN amount. The release of VAN from the scaffolds showed sustained release behaviour, and it took 13 days to be released entirely from the scaffolds
Gas and seismicity within the Istanbul seismic gap
Understanding micro-seismicity is a critical question for earthquake hazard
assessment. Since the devastating earthquakes of Izmit and Duzce in 1999, the
seismicity along the submerged section of North Anatolian Fault within the Sea
of Marmara (comprising the âIstanbul seismic gapâ) has been extensively
studied in order to infer its mechanical behaviour (creeping vs locked). So
far, the seismicity has been interpreted only in terms of being tectonic-
driven, although the Main Marmara Fault (MMF) is known to strike across
multiple hydrocarbon gas sources. Here, we show that a large number of the
aftershocks that followed the M 5.1 earthquake of July, 25th 2011 in the
western Sea of Marmara, occurred within a zone of gas overpressuring in the
1.5â5âkm depth range, from where pressurized gas is expected to migrate along
the MMF, up to the surface sediment layers. Hence, gas-related processes
should also be considered for a complete interpretation of the micro-
seismicity (~Mâ<â3) within the Istanbul offshore domain
Tajik Basin: A composite record of sedimentary basin evolution in response to tectonics in the Pamir
Investigation of a >6âkmâthick succession of Cretaceous to Cenozoic sedimentary rocks in the Tajik Basin reveals that this depocentre consists of three stacked basin systems that are interpreted to reflect different mechanisms of subsidence associated with tectonics in the Pamir Mountains: a Lower to midâCretaceous succession, an Upper CretaceousâLower Eocene succession and an EoceneâNeogene succession. The Lower to midâCretaceous succession consists of fluvial deposits that were primarily derived from the Triassic KarakulâMazar subductionâaccretion complex in the northern Pamir. This succession is characterized by a convexâup (accelerating) subsidence curve, thickens towards the Pamir and is interpreted as a retroarc foreland basin system associated with northward subduction of Tethyan oceanic lithosphere. The Upper Cretaceous to early Eocene succession consists of fineâgrained, marginal marine and sabkha deposits. The succession is characterized by a concaveâup subsidence curve. Regionally extensive limestone beds in the succession are consistent with late stage thermal relaxation and relative seaâlevel rise following lithospheric extension, potentially in response to Tethyan slab rollback/foundering. The Upper Cretaceousâearly Eocene succession is capped by a middle Eocene to early Oligocene (ca. 50â30 Ma) disconformity, which is interpreted to record the passage of a flexural forebulge. The disconformity is represented by a depositional hiatus, which is 10â30 Myr younger than estimates for the initiation of IndiaâAsia collision and overlaps in age with the start of prograde metamorphism recorded in the Pamir gneiss domes. Overlying the disconformity, a >4âkmâthick upper EoceneâNeogene succession displays a classic, coarsening upward unroofing sequence characterized by accelerating subsidence, which is interpreted as a retroâforeland basin associated with crustal thickening of the Pamir during IndiaâAsia collision. Thus, the Tajik Basin provides an example of a longâlived composite basin in a retrowedge position that displays a sensitivity to plate margin processes. Subsidence, sediment accumulation and basinâforming mechanisms are influenced by subduction dynamics, including periods of slabâshallowing and retreat
26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 - Meeting Abstracts - Antwerp, Belgium. 15â20 July 2017
This work was produced as part of the activities of FAPESP Research,\ud
Disseminations and Innovation Center for Neuromathematics (grant\ud
2013/07699-0, S. Paulo Research Foundation). NLK is supported by a\ud
FAPESP postdoctoral fellowship (grant 2016/03855-5). ACR is partially\ud
supported by a CNPq fellowship (grant 306251/2014-0)
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