Die technische Infrastruktur zur Teilnahme von Unternehmen an Gemeinschaften in Neuen Medien

Ein Internet-Auftritt eines Unternehmens setzt voraus, daß bezüglich der internen Informations-Infrastruktur bestimmte organisatorische und technische Voraussetzungen erfüllt sind. In diesem Beitrag soll dargelegt werden, daß eine komponentenbasierte Anwendungsarchitektur wegen ihrer leichten Erweiterbarkeit und wegen ihrer Übersichtlichkeit den Internet-Auftritt und damit die Beteiligung an Medien-Gemeinschaften erheblich erleichtern kann. Dies wird anhand einer Prototypentwicklung dargestellt und um Sicherheitsbetrachtungen, die für einen professionellen Einsatz der entwickelten Konzepte unabdingbar sind, ergänzt

AC Driven Jumps Distribution on a Periodic Substrate

A driven Brownian particle (e.g. an adatom on a surface) diffusing on a low-viscosity, periodic substrate may execute multiple jumps. In the presence of an additional periodic drive, the jump lengths and time durations become statistically modulated according to a syncronyzation mechanism reminiscent of asymmetric stochastic resonance. Here, too, bistability plays a key role, but in a dynamical sense, inasmuch as a particle switches between locked and running states.Comment: 4 pages, 4 figures, RevTeX, to be published in Surface Science Letter

Adopting basic principles of the United Nations Academic Impact initiative (UNAI): Can cultural differences be predicted from value orientations and globalization?

© 2017 Nechtelberger, Renner, Nechtelberger, Supeková, Hadjimarkou, Offurum, Ramalingam, Senft and Redfern. The United Nations Academic Impact (UNAI) Initiative has set forth 10 Basic Principles for higher education. In the present study, a 10 item self-report questionnaire measuring personal endorsement of these principles has been tested by self-report questionnaires with university and post-graduate students from Austria, China, Cyprus, India, Nigeria, and Slovakia (total N = 976, N = 627 female, mean age 24.7 years, s = 5.7). Starting from the assumptions of Moral Foundations Theory (MFT), we expected that personal attitudes toward the UNAI Basic Principles would be predicted by endorsement of various moral foundations as suggested by MFT and by the individual's degree of globalization. Whereas for the Austrian, Cypriot, and Nigerian sub- samples this assumption was largely confirmed, for the Chinese, Indian, and Slovak sub- samples only small amounts of the variance could be explained by regression models. All six sub-samples differed substantially with regard to their overall questionnaire responses: by five discriminant functions 83.6% of participants were classified correctly. We conclude that implementation of UNAI principles should adhere closely to the cultural requirements of the respective society and, where necessary should be accompanied by thorough informational campaigns about UN educational goals

The dick pic : harassment, curation, and desire

The combined rise of digital photography and social media has expanded what might be considered photo worthy. Among the pouting selfies and food stuffs of the day exists the ubiquitous dick pic. The mainstream media generally focuses on dick pics of the unsolicited kind, which, negatively positioned, are commonly associated with heterosexual harassment. Considering the ubiquity of dick pics across apps and platforms, research on the topic nevertheless remains scarce. In this article, we examine the dick pic as an online communicative form, first considering how it manifests the ability to harass and then moving beyond this dominant framing to analysis of contexts where such images are collated, expected, and sought after. Through this analysis of dick pics as figures and actors of harassment, curation, and desire, we demonstrate the simultaneous tenacity and flexibility of their meanings in connection with the dynamics of consent and non-consent, intimacy and distance, and complex circuits of desire. We further address the role of platforms, apps, and app stores, via their community standards and terms of use, in shaping the nature, and presence, of dick pics, and discuss the affective and communicative functions that these affordances serve (or fail to serve). Our analysis of three key modes of engagement with dick pics demonstrates the ambiguity and multiple valences of the phenomenon addressed

Subbarrel patterns in somatosensory cortical barrels can emerge from local dynamic instabilities

Complex spatial patterning, common in the brain as well as in other biological systems, can emerge as a result of dynamic interactions that occur locally within developing structures. In the rodent somatosensory cortex, groups of neurons called "barrels" correspond to individual whiskers on the contralateral face. Barrels themselves often contain subbarrels organized into one of a few characteristic patterns. Here we demonstrate that similar patterns can be simulated by means of local growth-promoting and growth-retarding interactions within the circular domains of single barrels. The model correctly predicts that larger barrels contain more spatially complex subbarrel patterns, suggesting that the development of barrels and of the patterns within them may be understood in terms of some relatively simple dynamic processes. We also simulate the full nonlinear equations to demonstrate the predictive value of our linear analysis. Finally, we show that the pattern formation is robust with respect to the geometry of the barrel by simulating patterns on a realistically shaped barrel domain. This work shows how simple pattern forming mechanisms can explain neural wiring both qualitatively and quantitatively even in complex and irregular domains. © 2009 Ermentrout et al

In non-transformed cells Bak activates upon loss of anti-apoptotic Bcl-X-L and Mcl-1 but in the absence of active BH3-only proteins

Mitochondrial apoptosis is controlled by proteins of the B-cell lymphoma 2 (Bcl-2) family. Pro-apoptotic members of this family, known as BH3-only proteins, initiate activation of the effectors Bcl-2-associated X protein (Bax) and Bcl-2 homologous antagonist/killer (Bak),which is counteracted by anti-apoptotic family members. How the interactions of Bcl-2 proteins regulate cell death is still not entirely clear. Here, we show that in the absence of extrinsic apoptotic stimuli Bak activates without detectable contribution from BH3-only proteins, and cell survival depends on anti-apoptotic Bcl-2 molecules. All anti-apoptotic Bcl-2 proteins were targeted via RNA interference alone or in combinations of two in primary human fibroblasts. Simultaneous targeting of B-cell lymphoma-extra large and myeloid cell leukemia sequence 1 led to apoptosis in several cell types. Apoptosis depended on Bak whereas Bax was dispensable. Activator BH3-only proteins were not required for apoptosis induction as apoptosis was unaltered in the absence of all BH3-only proteins known to activate Bax or Bak directly, Bcl-2-interacting mediator of cell death, BH3-interacting domain death agonist and p53-upregulated modulator of apoptosis. These findings argue for auto-activation of Bak in the absence of anti-apoptotic Bcl-2 proteins and provide evidence of profound differences in the activation of Bax and Bak

Medical Selfies: Emotional Impacts and Practical Challenges

Medical images taken with mobile phones by patients, i.e. medical selfies, allow screening, monitoring and diagnosis of skin lesions. While mobile teledermatology can provide good diagnostic accuracy for skin tumours, there is little research about emotional and physical aspects when taking medical selfies of body parts. We conducted a survey with 100 participants and a qualitative study with twelve participants, in which they took images of eight body parts including intimate areas. Participants had difficulties taking medical selfies of their shoulder blades and buttocks. For the genitals, they prefer to visit a doctor rather than sending images. Taking the images triggered privacy concerns, memories of past experiences with body parts and raised awareness of the bodily medical state. We present recommendations for the design of mobile apps to address the usability and emotional impacts of taking medical selfies