506 research outputs found
CaractĂ©risation des sols de la vallĂ©e rizicole de Tamra dans lâĂźle de Mar, Centre-Ouest du SĂ©nĂ©gal
Tamra est une vallĂ©e trĂšs sollicitĂ©e pour la culture du riz par les populations des quatre villages implantĂ©s dans lâĂźle de Mar. LâĂ©tude pĂ©dologique a Ă©tĂ© menĂ©e suivant trois toposĂ©quences transversales le long de la vallĂ©e. Les diffĂ©rents types de sols rencontrĂ©s dans ce milieu fluvio-marin sont disposĂ©s dâune maniĂšre quasi-concentrique autour de la vallĂ©e. Les sols sont affectĂ©s par le processus de salinisation et dâacidification. Les causes principales de lâavancĂ©e de ce biseau salĂ© le long de la vallĂ©e seraient liĂ©es Ă lâenvironnement climatique peu favorable qui sĂ©vit depuis plusieurs annĂ©es et qui sâexprime par des sĂ©cheresses rĂ©currentes. La texture sableuse de ces sols, Ă dominance de sables fins, et leur niveau topographique font que certains dâentre eux sont exceptionnellement inondĂ©s. Ainsi, la rĂ©alisation dâune carte dâaptitude culturale des sols sâimpose pour une meilleure utilisation des terres de la vallĂ©e de Tamra.Mots clĂ©s : Tamra, sols, fertilitĂ©, salinisation, acidification
Molecular characterization of SSS139, a new satellite DNA family in sibling species of the Drosophila buzzatii cluster
We characterized sequences of a novel SSS139 RsaI satellite DNA family in Drosophila gouveai and Drosophila seriema, two members of the Drosophila buzzatii cluster (D. repleta group). The sequences were AT-rich (69%) with a monomer unit length of about 139 bp and contained two direct subrepeats of 14 bp and 16 bp, suggesting that it might have originated by the duplication of smaller sequences. Southern and dot-blot hybridization analyses also detected SSS139 in other Drosophila buzzatii cluster species (D. koepferae, D. antonietae, D. borborema and D. serido) but not in D. buzzatii. These results agree with the marginal phylogenetic position of D. buzzatii within the D. buzzatii cluster.Coordenação de Aperfeiçoamento de Pessoal de NĂvel Superior (CAPES)Conselho Nacional de Desenvolvimento CientĂfico e TecnolĂłgico (CNPq)Fundação de Amparo Ă Pesquisa do Estado de SĂŁo Paulo (FAPESP)FINEP - Financiadora de Estudos e Projeto
Preliminary data on the geographical distribution of Drosophila Species within Morphoclimatic Domains of Brazil
Differences in and correlates of sexual function in infertile women with and without polycystic ovary syndrome
Background: The aim of this study was to examine sexual function and its correlates among infertile women with polycystic ovary syndrome (PCOS) in comparison with their non-PCOS counterparts. Materials and Methods: In this case-control study, 209 infertile women (116 PCOS and 93 non-PCOS) from Tehran, Iran, were evaluated in February and March 2018. Female sexual function index (FSFI), hormonal status, and documented reports of hyperandrogenic manifestations of the patients were investigated. Results: The mean age of the patients was 32.00 ñ 5.00 years old. Eighty-four (40.2) patients including 42.2 of the PCOS patients and 37.6 of the non-PCOS cases (P>0.05), were suspected of female sexual dysfunction (FSD). The most impaired functions in both groups were desire and arousal. Sexual function was not significantly different between the groups. However, PCOS women had more orgasm problems and acne worsened their sexual function. Total FSFI was positively associated with prolactin level but negatively associated with central obesity in the non-PCOS group; it was negatively correlated with marital duration in the PCOS group. Luteinizing hormone (LH) and pain, prolactin level and lubrication, and central obesity and arousal were correlated in the non-PCOS women. Prolactin level and orgasm, marital duration and arousal, and marital duration and the total FSFI were correlated in the PCOS women. Conclusion: Sexual function was similarly low in infertile PCOS and non-PCOS women. However, orgasm problems and the negative effect of acne varied between the two groups. Further investigations may target how hormonal profile may affect sexual function. Practitioners should scrutinize the specific impaired sexual domains and their correlated conditions in PCOS women, notably orgasm, acne, and prolactin level. Interventions should be well tailored based on particular needs of infertile PCOS women. é 2021, Royan Institute (ACECR). All rights reserved
Facteurs de risque de démence dans une population de personnes ùgées sénégalaises
Description La dĂ©mence est devenue un problĂšme de santĂ© publique. Dans le but dâune prĂ©vention, il est important de connaitre son Ă©pidĂ©miologie au SĂ©nĂ©gal. Lâobjectif de cette Ă©tude Ă©tait dâidentifier les facteurs de risque de dĂ©mence dans une population de personnes ĂągĂ©es sĂ©nĂ©galaises. MĂ©thodesUne Ă©tude transversale a Ă©tĂ© rĂ©alisĂ©e du 01 Mars 2004 au 31 DĂ©cembre 2005 auprĂšs dâune population de 872 personnes ĂągĂ©es de 55ans et plus utilisant le Centre MĂ©dicosocial et Universitaire de lâInstitut de PrĂ©voyance Retraite du SĂ©nĂ©gal pour des soins. Par une Ă©tude en deux phases, des donnĂ©es sociodĂ©mographiques, sur le mode de vie, le rĂ©seau social, les antĂ©cĂ©dents ont Ă©tĂ© collectĂ©es Ă lâaide dâun questionnaire structurĂ© complĂ©tĂ© par un examen clinique et une Ă©valuation neuropsychologique. Le diagnostic de dĂ©mence reposait sur des critĂšres DSM IV-R
Prévalence de la démence dans une population de personnes ùgées sénégalaises
Description Avec le vieillissement de la population, survient la dĂ©mence dans la population de personnes ĂągĂ©es. Objectif. Lâobjectif de cette Ă©tude Ă©tait dâestimer la prĂ©valence de cette affection dans une population de personnes ĂągĂ©es sĂ©nĂ©galaises. MĂ©thodes Par une Ă©tude transversale qui sâest dĂ©roulĂ©e du 01 mars 2004 au 31 dĂ©cembre 2005, des personnes ĂągĂ©es de 55 ans et plus venant consulter pour un problĂšme de santĂ© au Centre MĂ©dico-Social et Universitaire de lâIPRES (SĂ©nĂ©gal) ont Ă©tĂ© Ă©valuĂ©es sur le plan clinique et neuropsychologique. Des donnĂ©es sur les caractĂ©ristiques sociodĂ©mographiques, les antĂ©cĂ©dents mĂ©dico-chirurgicaux et familiaux, le mode de vie, le rĂ©seau social ont Ă©tĂ© collectĂ©es Ă lâaide dâun questionnaire structurĂ© avec des rĂ©ponses fermĂ©es. RĂ©sultat La population Ă lâĂ©tude Ă©tait composĂ©e de 872 personnes. Elles avaient un Ăąge moyen de 67,2 ans ± 7,5.Elles Ă©taient de sexe masculin (62,6%), mariĂ©es (79%), non instruites (50,7%). Dans les antĂ©cĂ©dents, lâHTA, le diabĂšte, les affections respiratoires, les affections rhumatismales, la cataracte et les troublesdigestifs Ă©taient les plus frĂ©quents. Le tabagisme et lâalcoolisme Ă©tait faible alors que la marche constituait la principale activitĂ© physique. Les personnes ĂągĂ©es vivaient en famille avec un bon rĂ©seau social.Cinquante huit (58) personnes ont prĂ©sentĂ© une dĂ©mence (6,6%). La prĂ©valence de la maladie variait de maniĂšre significative avec lâĂąge et lâinstruction. Conclusion Ce rĂ©sultat confirme que la prĂ©valence de la dĂ©mence varie en fonction de lâĂąge et de lâinstruction de la personne ĂągĂ©e
Safety and immunogenicity of a synthetic nanoparticle-based, T cell priming peptide vaccine against dengue in healthy adults in Switzerland: a double-blind, randomized, vehicle-controlled, phase 1 study.
Vaccines that minimize the risk of vaccine-induced antibody-dependent enhancement and severe dengue are needed to address the global health threat posed by dengue. This study assessed the safety and immunogenicity of a gold nanoparticle (GNP)-based, multi-valent, synthetic peptide dengue vaccine candidate (PepGNP-Dengue), designed to provide protective CD8+ T cell immunity, without inducing antibodies.
In this randomized, double-blind, vehicle-controlled, phase 1 trial (NCT04935801), healthy naĂŻve individuals aged 18-45 years recruited at the Centre for primary care and public health, Lausanne, Switzerland, were randomly assigned to receive PepGNP-Dengue or comparator (GNP without peptides [vehicle-GNP]). Randomization was stratified into four groups (low dose [LD] and high dose [HD]), allocation was double-blind from participants and investigators. Two doses were administered by intradermal microneedle injection 21 days apart. Primary outcome was safety, secondary outcome immunogenicity. Analysis was by intention-to-treat for safety, intention-to-treat and per protocol for immunogenicity.
26 participants were enrolled (August-September 2021) to receive PepGNP-Dengue (LD or HD, n = 10 each) or vehicle-GNP (LD or HD, n = 3 each). No vaccine-related serious adverse events occurred. Most (90%) related adverse events were mild; injection site pain and transient discoloration were most frequently reported. Injection site erythema occurred in 58% of participants. As expected, PepGNP-Dengue did not elicit anti-DENV antibodies of significance. Significant increases were observed in specific CD8+ T cells and dengue dextramer+ memory cell subsets in the LD PepGNP-Dengue but not in the HD PepGNP-Dengue or vehicle-GNP groups, specifically PepGNP-activated CD137+CD69+CD8+ T cells (day 90, +0.0318%, 95% CI: 0.0088-0.1723, p = 0.046), differentiated effector memory (TemRA) and central memory (Tcm) CD8+ T cells (day 35, +0.8/10 <sup>5</sup> CD8+, 95% CI: 0.19-5.13, p = 0.014 and +1.34/10 <sup>5</sup> CD8+, 95% CI: 0.1-7.34, p = 0.024, respectively).
Results provide proof of concept that a synthetic nanoparticle-based peptide vaccine can successfully induce virus-specific CD8+ T cells. The favourable safety profile and cellular responses observed support further development of PepGNP-Dengue.
Emergex Vaccines Holding Limited
Results on hyperon production from the NA57 experiment
Recent results on hyperon production in Pb--Pb collisions from the NA57
experiment are reported. Strangeness enhancement and the transverse mass
spectra properties at 158 GeV per nucleon are described.Comment: submitted to Acta Phys. Hung. A (Heavy Ion Physics
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