Studies of Novel Sulfapyridine Derivatives Containing Schiff Bases and Co(II), Ni(II) and Zn(II) Complexes: Synthesis, Experimental and Theoretical (DFT) Approach for Characterization and Biological Efficacy

Two new ligands were synthesized from sulfapyridine with 5-bromosalicylaldehyde (for (LH)-H-1) and 5-nitrosalicylaldehyde (for (LH)-H-2). Mononuclear complexes with metal ligand ratio 1:1 were prepared with Co(II), Ni(II) and Zn(II) salts. Their structures were elucidated on the basis of elemental analyses, IR, H-1-NMR and C-13-NMR spectra, electronic spectra, magnetic susceptibility measurements and thermogravimetric analyses (TGA). The synthesized compounds were tested for antimicrobial activity against bacterial and fungi in vitro by the minimum inhibitory concentration (MIC) method. All of the selected compounds showed strong antimicrobial activities against test microorganisms (32-256 mu g/mL). Furthermore, the antioxidant activities of the ligands and their complexes were determined by DPPH, metal chelating activity methods in vitro. The obtained IC50 value of the DPPH activity for the L-1-Ni complex (1.155 perpendicular to 0.054 mu M) and that of the metal chelating activity for the (LH)-H-2 ligand (% = 75 +/- 5.624) were higher than the values obtained for the other compounds. The computed stretching frequencies, UV spectral data and NMR spectra values were found to be in good agreement with experimental data

In vitro Antiradical, Antimicrobial and Antiproliferative Activities and Phytochemical Compositions of Endemic Alcea calvertii (Boiss) Boiss. Flowers

Alcea calvertii (Boiss) Boiss. is belonged to Malvaceae family, and it is a perennial herbaceous endemic plant. Alcea genus plants are grown as ornamental plants in the gardens. In the present study, the antiproliferative, antimicrobial, antiradical activities and phytochemical compositions of ethanol, water, methanol and acetone extracts of A. calvertii flowers were examined. A. calvertii flowers water, ethanol, methanol and acetone extracts are lower scavenged DPPH, ABTS and OH radicals than standard antioxidant trolox. A. calvertii flowers contain vitamins, sterols, flavonoids and phenolic acids, dominated by vanillic acid, gallic acid, catechin, δ-tocopherol, ergosterol and vitamin D. A. calvertii flowers water extract showed better antiproliferative activities than other extracts against to MCF-7 and HCT-116 cell lines. A. calvertii flowers methanol extract showed higher antiproliferative effect against to LNCaP cell lines

A THERMO-STABLE DEHALOGENASE IN THE EXTRACTS FROM PSEUDOMONAS SP (STRAIN-19S)

A thermo-stable dehalogenase was demonstrated in the crude extracts from Pseudomonas sp (19S). The ability of the enzyme to catalyze the dehalogenation of various halogen-substituted organic acids was investigated and the highest activity was found with monochloroacetate. The enzyme followed Michael is-Menten kinetics, and the Km for monochloroacetate was O.2mM. Maximum activity was found at pH 10.5 and 60~ The enzyme activity in the cell-free extract was unaffected by EDTA or by Mn, Zn, or Cu ions, but was dramatically reduced by HgClz (70 %) and Pb (N03)~ (80 %)

Determination of Antioxidant Capacities of Phlomis pungens Wild. var. hispida Hub.-Mor.

WOS: 000305033900091The genus Phlomis L. belongs to the Lamiaceae family and encompasses 100 species native to Turkey, North Africa, Europe and Asia. It is a popular herbal tea enjoyed for its taste and aroma. Phlomis species are used to treat various conditions such as diabetes, gastric ulcer, hemorrhoids, inflammation and wounds. In this study, ethanol and water extracts were prepared from powdered P pungens flowers and leaves. Antioxidant activities were measured by 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS(center dot+)) radical scavenging, 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH center dot) scavenging, superoxide anion (02) radical scavenging, reducing activity and ferrous metal chelating activity assays. In conclusion, P. pungens flowers and leaves had effective ABTS(center dot+) and DPPH center dot radical scavenging, superoxide anion radical scavenging, reducing power and metal chelating activities when compared with BHA, BHT and alpha-tocopherol as reference antioxidants

Effects of Diet with High Polyphenol and Protein Content and Diet with High Boron Content on Microbiota in Obesity

It is now a known fact that microbiota needs to be regulated in order to prevent obesity, which has become a global public health problem around the world. It is very important to acquire sustainable and easy-to-apply eating habits for microbiota health. Studies show that the type and amount of dietary protein, dietary polyphenol, and boron content can have positive effects on the microbiota. In the light of the research studies examined as a result of this review, it is thought that the microbiota health will improve with the acquisition of a diet with high protein, polyphenol, and boron content, and thus, many chronic health problems related to nutrition, including obesity, can be solved.Declared none.Declared none

ANTIOXIDANT ACTIVITY, TOTAL PHENOLIC AND FLAVONOID CONTENT OF WATER AND ETHANOL EXTRACTS FROM ACHILLEA MILLEFOLIUM L

Achillea millefolium (Asteraceae, civanperçemi) deri iltihaplanmaları, spazmodik ve gastrointestinal bozukluklar gibi çeşitli rahatsızlıklara karşı halk ilacı olarak kullanılmıştır. Bu çalışmada, etanol ve su ekstreleri A. millefolium çiçek, yaprak ve tohumlarından hazırlandı. Antioksidan aktivite, ferik tiyosiyanat metodu ve H2O2 radikal temizleme testleriyle ölçüldü ve A. millefolium ekstrelerinin fenolik bileşikleri ve flavonoit içerikleri saptandı. Sonuç olarak, A. millefolium çiçek, yaprak ve tohumları etkili H2O2 radikal temizleme aktivitesi ve lipid peroksidasyon inhibisyonu aktivitesi gösterdi ve bu antioksidan aktiviteler referans antioksidanlar BHA ve ?-tokoferol ile karşılaştırıldı.Achillea millefolium (Asteraceae, yarrow) has been used in folk medicine against several disturbances including skin inflammations, spasmodic and gastrointestinal disorders. In this study, ethanol and water extracts were prepared from A. millefolium flowers, leaves and seeds. Antioxidant activities were measured by ferric thiocyanate method, and H2O2radical scavenging activity assays and phenolic compounds and flavonoid contents of A. millefolium extracts were also determined. In conclusion, extracts of A. millefolium flowers, leaves and seeds had effective H2O2radical scavenging activity, total antioxidant activity, and these antioxidant activities were compared with BHA and ?tocopherol as reference antioxidant