On Typical Materials Acting as the Dividing Standard of the Development Stages of Human Substance Civilization

During more than three million years, the substance civilization of human society went through the Stone Age, the Bronze Age, the Iron Age, the Steel and Cement Age, and the Silicon Age. At the beginning of the new century, the human society has entered into the Nanomaterials Age, which indicates that a completely new substance civilization of human society has started. This paper analyses and discusses why the typical materials serve as the only standard for dividing the eras of the substance civilization of human society. The author argues about the subject of dividing the substance civilization of human society. The goal is to initiate broad and thorough discussion of that subject so as to get a rather thorough understanding about it

The burden of HIV/AIDS in Ethiopia from 1990 to 2016: evidence from the Global Burden of Diseases 2016 Study

BACKGROUND: The burden of HIV/AIDS in Ethiopia has not been comprehensively assessed over the last two decades. In this study, we used the 2016 Global Burden of Diseases, Injuries and Risk factors (GBD) data to analyze the incidence, prevalence, mortality and Disability-adjusted Life Years Lost (DALY) rates of Human Immunodeficiency Virus / Acquired Immune Deficiency Syndrome (HIV/AIDS) in Ethiopia over the last 26 years. METHODS: The GBD 2016 used a wide range of data source for Ethiopia such as verbal autopsy (VA), surveys, reports of the Federal Ministry of Health and the United Nations (UN) and published scientific articles. The modified United Nations Programme on HIV/AIDS (UNAIDS) Spectrum model was used to estimate the incidence and mortality rates for HIV/AIDS. RESULTS: In 2016, an estimated 36,990 new HIV infections (95% uncertainty interval [UI]: 8775-80262), 670,906 prevalent HIV cases (95% UI: 568,268-798,970) and 19,999 HIV deaths (95% UI: 16426-24412) occurred in Ethiopia. The HIV/AIDS incidence rate peaked in 1995 and declined by 6.3% annually for both sexes with a total reduction of 77% between 1990 and 2016. The annualized HIV/AIDS mortality rate reduction during 1990 to 2016 for both sexes was 0.4%

Surface Energy Balance Algorithm for Land (SEBAL) based Evapotranspiration Estimation in Lower Gilgel Abay Catchment Lake Tana Sub-Basin, Ethiopia

On land, Evapotranspiration (ET) plays an important role in the water cycle and is an important parameter in water resources management. Remote sensing is one of the important sources of data and techniques to estimate many climate elements including evapotranspiration. The estimation based on remote sensing is vital for the management of water resources in the catchment. This study estimated the spatio-temporal variation of evapotranspiration in the lower Gilgel Abay catchment, Lake Tana sub-basin from January to March 2016. The evapotranspiration was quantified using the Surface Energy Balance (SEBAL) algorithm and Landsat 8 imagery with climate data. For this analysis, ASTER GDEM, GRASS-python & reference weather parameters from Bahir Dar weather station were used. Parameters including surface radiance, surface reflectance, surface albedo, NDVI, LAI, surface emissivity, surface temperature, net radiation, soil heat flux, sensible heat flux, and latent heat flux were computed. Consequently, the hourly, daily, monthly and seasonal evapotranspiration in the study area were calculated with SEBAL python. The pixel wise calculation shows that the values of the spatial variation of mean ET varied from 0 mm/day to 7.39 mm/day with a mean value of 4.78 mm/day for 23 December 2016. The computed ET values for the months December to March, the maximum estimated ET over the whole catchment ranged from 6.51 mm/day to 7.82 mm/day. The mean ET ranged from 4.37 mm/day to 4.78 mm/day while the seasonal ET was 539.92 mm for 2016. ET values were computed for different conventional methods using REF-ET software. The value of Standard P-M for the weather station was used as a reference to compare the values obtained from other conventional methods as well as SEBAL method. The mean value of the study area from SEBAL calculation approached the point values of CIMIS penman, standard P-M and Priestly Taylor methods. The analyses are vital from the perspective of water resources management on various surfaces of the earth that need to be understood to achieve sustainable development of water resources in the basin and recommended to apply in the remaining sub-basins in the region.Keywords: Evapotranspiration, Gilgel Abay, GRASS-GIS, Landsat-8, RS, SEBAL

Suboptimal use of hormonal therapy among German men with localized high-risk prostate cancer during 2005 to 2015 : analysis of registry data

Background: This study assesses the use of hormonal therapy to treat high-risk localized prostate cancer (HRLPCa) cases diagnosed between 2005 and 2015. Methods: All N0-XM0 with ≥T3a, or PCa cases with poorly differentiated feature (equivalent to Gleason score ≥ 8), diagnosed between 2005 and 2015 were extracted from German population-based cancer registries. Cases treated by surgery or chemotherapy were excluded. Description of hormonal therapy use by HRLPCa cases’ profile was presented. Relative risk (RR) was computed with a log-link function to identify factors associated with hormonal therapy use among radiotherapy-treated HRLPCa cases. Results: A total of 5361 HRLPCa cases were analyzed. Only 27.6% (95% confidence interval [CI]: 26.4–28.8%) of the HRLPCa cases received hormonal therapy in combination with radiotherapy. The use of combined hormonal therapy and radiotherapy varied from 19.8% in Saxony to 47.8% in Schleswig-Holstein. Application of hormonal therapy was higher for the locally advanced cases compared to the poorly differentiated cases (relative risk [RR] = 1.28; 95%CI: 1.19, 1.37). Older patients showed a slightly increased use of hormonal therapy (RR for a 10-year age increase = 1.09; 95%CI: 1.02, 1.16). Compared to PCa cases from the most affluent residential areas, cases from the least affluent (RR = 0.71; 95%CI: 0.55, 0.92) and medium (RR = 0.75; 95%CI: 0.58, 0.96) areas had decreased use of hormonal therapy. The introduction of the German S3-guideline did not make a marked difference in the uptake of both hormonal therapy and radiotherapy (RR = 1.02; 95%CI: 0.95, 1.09). Conclusion: This study found a low use of hormonal therapy among HRLPCa patients treated without surgery. The introduction of the German S3-guideline for prostate cancer treatment does not seem to have impacted hormonal therapy use

National mortality burden due to communicable, non-communicable, and other diseases in Ethiopia, 1990–2015: findings from the Global Burden of Disease Study 2015

Background: Ethiopia lacks a complete vital registration system that would assist in measuring disease burden and risk factors. We used the Global Burden of Diseases, Injuries, and Risk factors 2015 (GBD 2015) estimates to describe the mortality burden from communicable, non-communicable, and other diseases in Ethiopia over the last 25 years. Methods: GBD 2015 mainly used cause of death ensemble modeling to measure causes of death by age, sex, and year for 195 countries. We report numbers of deaths and rates of years of life lost (YLL) for communicable, maternal, neonatal, and nutritional (CMNN) disorders, non-communicable diseases (NCDs), and injuries with 95% uncertainty intervals (UI) for Ethiopia from 1990 to 2015. Results: CMNN causes of death have declined by 65% in the last two-and-a-half decades. Injury-related causes of death have also decreased by 70%. Deaths due to NCDs declined by 37% during the same period. Ethiopia showed a faster decline in the burden of four out of the five leading causes of age-standardized premature mortality rates when compared to the overall sub-Saharan African region and the Eastern sub-Saharan African region: lower respiratory infections, tuberculosis, HIV/AIDS, and diarrheal diseases; however, the same could not be said for ischemic heart disease and other NCDs. Non-communicable diseases, together, were the leading causes of age-standardized mortality rates, whereas CMNN diseases were leading causes of premature mortality in 2015. Although lower respiratory infections, tuberculosis, and diarrheal disease were the leading causes of age-standardized death rates, they showed major declines from 1990 to 2015. Neonatal encephalopathy, iron-deficiency anemia, protein-energy malnutrition, and preterm birth complications also showed more than a 50% reduction in burden. HIV/AIDS-related deaths have also decreased by 70% since 2005. Ischemic heart disease, hemorrhagic stroke, and ischemic stroke were among the top causes of premature mortality and age-standardized death rates in Ethiopia in 2015. Conclusions: Ethiopia has been successful in reducing deaths related to communicable, maternal, neonatal, and nutritional deficiency diseases and injuries by 65%, despite unacceptably high maternal and neonatal mortality rates. However, the country’s performance regarding non-communicable diseases, including cardiovascular disease, diabetes, cancer, and chronic respiratory disease, was minimal, causing these diseases to join the leading causes of premature mortality and death rates in 2015. While the country is progressing toward universal health coverage, prevention and control strategies in Ethiopia should consider the double burden of common infectious diseases and non-communicable diseases: lower respiratory infections, diarrhea, tuberculosis, HIV/AIDS, cardiovascular disease, cancer, and diabetes. Prevention and control strategies should also pay special attention to the leading causes of premature mortality and death rates caused by non-communicable diseases: cardiovascular disease, cancer, and diabetes. Measuring further progress requires a data revolution in generating, managing, analyzing, and using data for decision-making and the creation of a full vital registration system in the country

Incidence, prevalence and mortality rates of malaria in Ethiopia from 1990 to 2015: analysis of the global burden of diseases 2015

Background: In Ethiopia there is no complete registration system to measure disease burden and risk factors accurately. In this study, the 2015 Global Burden of Diseases, Injuries and Risk factors (GBD) data were used to analyse the incidence, prevalence and mortality rates of malaria in Ethiopia over the last 25 years. Methods: GBD 2015 used verbal autopsy (VA) surveys, reports, and published scientific articles to estimate the burden of malaria in Ethiopia. Age and gender-specific causes of death for malaria were estimated using Cause of Death Ensemble Modelling (CODEm). Results: The number of new cases of malaria declined from 2.8 million (95% uncertainty interval (UI): 1.4-4.5million) in 1990 to 621,345 (95% UI: 462,230-797,442) in 2015. Malaria caused an estimated 30,323.9 deaths (95% UI: 11,533.3-61,215.3) in 1990 and 1,561.7 deaths (95% UI: 752.8-2,660.5) in 2015, a 94.8% reduction over the 25 years. Age-standardized mortality rate of malaria has declined by 96.5% between 1990 and 2015 with an annual rate of change (ARC) of 13.4%. Age-standardized malaria incidence rate among all ages and gender declined by 88.7% between 1990 and 2015. The number of disability-adjusted life years lost (DALY) due to malaria decreased from 2.2 million (95% UI: 0.76-4.7 million) in 1990 to 0.18 million (95% UI: 0.12-0.26 million) in 2015, with a total reduction 91.7%. Similarly, age-standardized DALY rate declined by 94.8% during the same period. Conclusions: Ethiopia has achieved a 50% reduction target of malaria of the Millennium Development Goals (MDGs). The country should strengthen its malaria control and treatment strategies to achieve the Sustainable Development Goals (SDG)

Life without the Movius Line: The structure of the East and Southeast Asian Early Palaeolithic

© 2015 Elsevier Ltd and INQUA.The starting point of this paper is that the Movius Line is no longer an appropriate way of studying the Early Palaeolithic of East and Southeast Asia, and should be disregarded. Instead, it is argued that the Early Palaeolithic of East and Southeast Asia needs to be seen as comparable to that in the rest of Eurasia, rather than the product of an isolated backwater. Contra Movius, East Asia was not isolated throughout the entire Early and Middle Pleistocene, but open to immigration during interglacials, as is indicated by its fossil hominin record. As in Europe and Southwest Asia, both bifacial and non-biface assemblages are present in China and Korea, thus indicating the presence of an Acheulean component, although the lack of agreement over how the Acheulean should be defined creates difficulties in establishing its extent in Southeast Asia. Regarding non-biface assemblages, Zhoukoudian was an unfortunate choice of an East Asian site that lacked bifaces, as bifaces are also rare or absent in a number of caves in Southwest Asia and Europe. Additionally, the absence of bifaces in some sites is not convincingly demonstrated because of the small size of the lithic assemblage. Finally, the simple flake industries in Southeast Asia are likely contemporary with Upper Pleistocene, Middle Palaeolithic and microlithic assemblages in India rather than with Middle Pleistocene, Acheulean assemblages, as proposed by Movius