Infusion of aerial parts of Salvia chudaei Batt. & Trab. from Algeria: chemical, toxicological and bioactivities characterization

Ethnopharmacological relevance: Salvia chudaei Batt. & Trab. from Algeria is traditionally used to relieve several dysfunctions, including inflammatory and pain-related situations. Aim of the study: This work aimed to confirm scientifically the referred properties. For that, the phenolic composition and antioxidant activity were evaluated as well as acute toxicity, anti-inflammatory and analgesic effects of different doses of the infusion of S. chudaei aerial parts. Materials and methods: Infusion of aerial parts of S. chudaei was prepared and screened for phenolic composition by generalized methods TPC and TFC then by LCDAD- ESI/MSn. DPPH and FRAP were used to evaluate antioxidant activity. Using mice, acute toxicity, anti-inflammatory by carrageenan-induced paw edema, and analgesic by acetic acid-induced writhing and formalin-induced pain activities were tested. Results: The infusion showed 2018 mg GAE/100g DW of phenolics and 1956 mg ECE/100g DW of flavonoids. Phenolic profile by LC-DAD-ESI/MSn revealed the presence of ten compounds: syringic acid hexoside derivative, kaempferol-O-diglucuronide, kaempferol-O-deoxyhexoside-hexoside, kaempferol-O-glucuronide, apigenin-O-diglucuronide, caffeic acid, 4-O-caffeoylquinic acid, eriodictyol-O-glucuronide, rosmarinic acid hexoside, and rosmarinic acid. This acid was the major compound representing 54% of the total content of the identified compounds and an absolute content of 18 mg/g of extract. Additionally, the infusion exhibited a good antioxidant activity (DPPH: 81 μmol TE/g DW, FRAP: 438 μmol FSE/g DW). By oral administration to mice, the infusion showed a significant (p<0.05) dose-dependent reduction of carrageenan-induced inflammation and inhibition of formalin-induced pain (late and early phase) and acetic acid-induced writhing compared with the control. On the other hand, infusion up to 8 g/kg b.w. showed no signs of toxicity or mortality. Conclusion: This study reveals, for the first time, that the infusion of the aerial parts of S. chudaei is not toxic in a single dose and has remarkable antioxidant, antiinflammatory, and analgesic activities, supporting the use of this species in folk medicine.We thank the University of Porto for receiving R.S. and the MARE NOSTRUM 2017–2019 project allowing this mobility. This work was supported by AgriFood XXI I&D&I project (NORTE-01-0145-FEDER- 000041) co-financed by ERDF through NORTE 2020 (Programa Operacional Regional do Norte 2014/2020), by the UIDB/50006/2020 project with funding from FCT/MCTES through Portuguese funds, by the Foundation for Science and Technology (FCT, Portugal) through national funds FCT/MCTES to CIMO (UIDB/00690/2020), and by the Ministry of Higher Education and Scientific Research (MESRS) (Algeria).info:eu-repo/semantics/publishedVersio

Extraction et caractérisation des constituants contenus dans les extraits de Scolymus grandiflorus, Carduncellus pinnatus et Salvia argentea : évaluation de leurs activités biologiques

The main objective of this work falls within the broad field of the chemistry of natural substances. The assigned objective is to contribute to the knowledge of the chemical composition of essential oils of two plants of the asteraceae family: Scolymus grandiflorus and Carduncellus pinnatus; and a plant of the Lamiaceae family: Salvia argentea by implementing modern and complementary analysis techniques (CPG, CPG-MS and NMR). This thesis work is also an in-depth study of the biological properties of these different essential oils, by carrying out tests for antimicrobial and antioxidant activities and an initiatory work on the inhibition of VEGF receptors by two methods of computational chemistry. The chemical compositions of the oils found in these plants and the results of the biological activities are promising and open up interesting perspectives. The chemical compositions of the root parts of these plants present original constituents such as Davanones, Ferruginol, the derivative of Phenaleno [1,9-bc] furan, Aethiopinone, saprothoquinone, Salvipisone, and 12- hydroxysapriparaquinone. The study of the biological properties of the essential oils obtained from the three plants has been shown to be very conclusive.L’objectif principal de ce travail s’inscrit dans le domaine large de la chimie des substances naturelles. L’objectif assigné est une contribution à la connaissance de la composition chimique des huiles essentielles de de deux plantes de la famille des astéracées : Scolymus grandiflorus et Carduncellus pinnatus ; et une plante de la famille des Lamiacées : Salvia argentea par la mise en oeuvre de techniques d’analyses modernes et complémentaires (CPG, CPG-SM et RMN). Ce travail de thèse est aussi une étude approfondie des propriétés biologiques de ces différentes huiles essentielles, en réalisant des tests d'activités antimicrobiennes, antioxydante et un travail initiatique sur l’inhibition des récepteurs du VEGF par deux méthodes de chimie computationnelle. Les compositions chimiques des huiles trouvées dans ces plantes et les résultats des activités biologiques sont prometteurs et ouvrent des perspectives intéressantes. Les compositions chimiques des parties souterraines de ces plantes présentent des constituants originaux tels que les Davanones, le Ferruginol, le dérivé de Phenaleno[1,9-bc]furane, l’Aethiopinone, la saprothoquinone, la Salvipisone, et de la 12- hydroxysapriparaquinone. L’étude des propriétés biologiques des huiles essentielles obtenues à partir des trois plantes s’est révélée très concluante

Extraction and characterization of the constituents contained in the extracts of Scolymus grandiflorus, Carduncellus pinnatus and Salvia argentea : evaluation of their biological activities

L’objectif principal de ce travail s’inscrit dans le domaine large de la chimie des substances naturelles. L’objectif assigné est une contribution à la connaissance de la composition chimique des huiles essentielles de de deux plantes de la famille des astéracées : Scolymus grandiflorus et Carduncellus pinnatus ; et une plante de la famille des Lamiacées : Salvia argentea par la mise en oeuvre de techniques d’analyses modernes et complémentaires (CPG, CPG-SM et RMN). Ce travail de thèse est aussi une étude approfondie des propriétés biologiques de ces différentes huiles essentielles, en réalisant des tests d'activités antimicrobiennes, antioxydante et un travail initiatique sur l’inhibition des récepteurs du VEGF par deux méthodes de chimie computationnelle. Les compositions chimiques des huiles trouvées dans ces plantes et les résultats des activités biologiques sont prometteurs et ouvrent des perspectives intéressantes. Les compositions chimiques des parties souterraines de ces plantes présentent des constituants originaux tels que les Davanones, le Ferruginol, le dérivé de Phenaleno[1,9-bc]furane, l’Aethiopinone, la saprothoquinone, la Salvipisone, et de la 12- hydroxysapriparaquinone. L’étude des propriétés biologiques des huiles essentielles obtenues à partir des trois plantes s’est révélée très concluante.The main objective of this work falls within the broad field of the chemistry of natural substances. The assigned objective is to contribute to the knowledge of the chemical composition of essential oils of two plants of the asteraceae family: Scolymus grandiflorus and Carduncellus pinnatus; and a plant of the Lamiaceae family: Salvia argentea by implementing modern and complementary analysis techniques (CPG, CPG-MS and NMR). This thesis work is also an in-depth study of the biological properties of these different essential oils, by carrying out tests for antimicrobial and antioxidant activities and an initiatory work on the inhibition of VEGF receptors by two methods of computational chemistry. The chemical compositions of the oils found in these plants and the results of the biological activities are promising and open up interesting perspectives. The chemical compositions of the root parts of these plants present original constituents such as Davanones, Ferruginol, the derivative of Phenaleno [1,9-bc] furan, Aethiopinone, saprothoquinone, Salvipisone, and 12- hydroxysapriparaquinone. The study of the biological properties of the essential oils obtained from the three plants has been shown to be very conclusive

Application des modèles mathématiques pour l’optimisation de l’énergie dans un système PV

International audienceThis paper proposes an approach used to optimize the energy for a stand-alone photovoltaic (PV) system in isolated regions. The intended objective is house energy comfort. The aim is to present the impact of flow energy of housing on the system reliability. The operation of stand-alone PV system is represented by a simulation program. This later describes the principle of energy equilibrium among diverse sub-systems, using different mathematical models of different parts of renewable energy system. The recommended models were implemented via Matlab-Simulink software with real input data. The reliability is achieved by reducing the loss power supply probability criteria, with improvement of the battery life cycle during the operating years of the PV system.Cet article propose une approche basée sur des modèles mathématiques validés, pour l’optimisation de l’énergie dans un système photovoltaïque (PV) autonome destiné à l’électrification d’un habitat dans une région isolée. L’objectif attendu est le confort énergétique de l’habitat. Le but du travail est de montrer à travers la modélisation mathématique l’impact du profil dynamique de la consommation énergétique sur la fiabilité du système PV. Le fonctionnement de ce dernier est représenté par un programme de simulation sous Simulink, qui décrit le principe de l'équilibre énergétique entre les sous-systèmes, en utilisant des modèles mathématiques validés avec des données d’entrées réelles. Les résultats obtenus ont montrés une bonne fiabilité des modèles utilisés, pour prévoir le fonctionnement optimal du système photovoltaïque

Optimal sizing of a stand-alone photovoltaic system with energy management in isolated areas

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Performance evaluation of a photovoltaic system with battery storage in Ghardaïa site (South Algeria)

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The new strategy of energy management for a photovoltaic system without extra intended for remote-housing

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Sand effect on photovoltaic array efficiency in Algerian desert

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