Traumatic arteriovenous fistula of the upper lip: A case report

WOS: 000282904500002PubMed ID: 20303280Traumatic arteriovenous fistula (AVF) is often challenging to diagnose and manage. Those involving the external carotid artery or its branches occur relatively rarely. We present a case of a vascular mass of the upper lip at the right side with a previous history of blunt trauma. AVF of the upper lip can be successfully managed with the preservation of lip function and the cosmetic appearance through surgical excision without embolisation if there is good local access to the lesion. (C) 2010 European Association for Cranio-Maxillo-Facial Surger

What is the effect of the early follicular phase FSH/LH ratio on the number of mature oocytes and embryo development?

WOS: 000525954500019PubMed: 32093445Background/aim: Basal level of follicle stimulating hormone (FSH), luteinizing le (LH), estradiol (E2), and antral follicle count are used as predictors of ovarian reserve before starting ovulation induction. e aimed to investigate the predictor potential of early fbllictilar phase FSH/LH ratio on controlled ovarian hyperstimulation-intrac Aasmic sperm injection (COH-ICSI) cycle outcomes. Materials and methods: This retrospective cohort study was conducted with 648 COH-ICSI cycles pertbrmed between 2012 and 2014. Cycles were classified according to their basal FSH/LH ratio, group 1(01) = FSH/LH ratio < 2, N = 473 and group 2(G2) = FSH/LH ratio 2, N = 175. Demographic characteristics and stimulation parameters were evaluated. Retrieved total oocyte count (TO C), mature oocyte count (MOO, transferred embryo number, and pregnancy results were obtained and transferred to computer by SPSS 21.0 programme. Results: TOC and \1O( of G1 were signilieantly higher than those of '2 "l he total gonadotrophin doses of 02 were significantly higher than 0l. "I here was no significant difference between groups for transferred embryo number. Pregnancy and live birth rates were similar in both groups. Conclusion. In our population, increased FSH/LH ratio did not affect he rates of pregnancy and live birth negatively

The impact of plasma SOCS3 levels and endometrial leukocytes on unexplained infertility

Ozkan, Zehra Sema/0000-0001-9185-3663; deveci, sukriye derya/0000-0002-9867-0867; Ilhan, Fulya/0000-0001-7790-1358WOS: 000435653900009PubMed: 29914245Background/aim: To investigate the possible differences in endometrial leukocyte subtype distribution between women with unexplained infertility and normal fertile women and to determine whether there is a correlation between endometrial leukocyte counts and plasma cytokine levels in unexplained infertility. Materials and methods: This case-control study involved 79 infertile and 40 fertile women. Peripheral venous blood samples and endometrial samples were obtained on day 21 of the menstrual cycle. Plasma interleukin-4 (IL4), IL6, IL10, IL17, IL35, interferongamma (IFN-g), tumor necrosis factor-alpha (TNF-a), transforming growth factor-beta (TGF-b), and suppressor of cytokine signaling-3 (SOCS3) levels were determined by enzyme-linked immunosorbent assay. Endometrial CD8, CD56, and CD163 counts were detected by immunohistochemistry. Results: CD8 and CD56 counts were significantly higher, while CD163 count was significantly lower in infertile women than in fertile women. Plasma SOCS3, IL35, and IL4 levels of the infertile group were significantly lower than those of the fertile group (P < 0.01); the remaining cytokine levels were significantly higher in the infertile group than in the fertile group (P < 0.01). Conclusion: We observed aberrant cytotoxic immune activity in infertile women. The interaction between plasma SOCS3 levels and staining degree of endometrial leukocytes may be either the reason for or result of infertility leading to unavailability of the environment for implantation.Firat University Scientific Research Foundation (FUBAP)This study was financially supported by Firat University Scientific Research Foundation (FUBAP)

What is the impact of Th1/Th2 ratio, SOCS3, IL17, and IL35 levels in unexplained infertility?

WOS: 000336873600008PubMed ID: 24368037Implantation necessitates complex interactions among the developing embryo, decidualizing endometrium, and developing maternal immune tolerance and/or alterations in cellular and humoral immune responses. Overstimulation of T helper 1 (Th1) or Th2 cytokines in systemic and local environments, alterations of the prevalence of IL17 and regulatory T cell (Treg) cytokines have also been suggested to contribute to the pathogenesis of implantation failure. We aimed to investigate the plasma levels of IL4, IL6, IL10, TNF alpha, IFN gamma, TGF beta, IL17, IL35, and SOCS3 in infertile and fertile women. This case-control study was conducted with 80 women suffering from unexplained infertility and 40 fertile women. Peripheral venous blood samples were drawn on day 21 of the menstrual cycle. The extracted plasma samples were assayed by an enzyme linked immunosorbent assay. Statistical analysis was performed using SPSS version 16.0. Our main findings were as follows: despite the significantly high IL17 and IL35 plasma levels of infertile women, IL35/IL17 ratio was significantly lower in the infertile group compared with that in the fertile group; SOCS3 plasma levels showed an inverse relation with plasma levels of all cytokines except IL35; increased plasma IL17 levels (>3.42 pg/mL) have a negative impact on fertility; TNF alpha/IL10, IFN gamma/IL10, IFN-gamma/16, and IFN gamma/IL4 ratios were significantly higher in infertile group compared with those in the fertile group. It is not possible to show the major immunological factor(s) of unexplained infertility, but our findings point out that the decreased suppressor activity of the immune system may play a role in implantation failure. (C) 2013 Elsevier Ireland Ltd. All rights reserved.Firat University Scientific Research FoundationThis study was supported by the Firat University Scientific Research Foundation. We thank Prof. Dr. Ali Risvanli for his support during this study

Is There Increased Risk of Childhood Cancers after Assisted Reproductive Techniques?

Background and Aims: Assisted reproductive techniques (ART) havebeen determined to be a risk factors for multiple pregnancy, perinatalcomplications and congenital malformations in children. In this study,we aimed to determine the role of possible risk factors for assistedreproductive techniques in childhood malignancies.Methods: 300 patients between the ages of 0-18 years who wereadmitted to Istanbul Medical Faculty, Department of Pediatric Hema-tology and Oncology, between 2000-2019 and 300 healthy childrenbetween 0-14 years of age who were admitted to Departmens of SocialPediatrics, period of May-June 2018 are included. SPSS 22.0 program was used in statistical analysis. The study was approved by the ClinicalResearch Ethics Committee (17.05.2018 / 181360).Results: The mean age of the case group was 8.3±2.1, control groupwas 6.1±1.2 years. The case group consisted of 131 solid tumors and169 leukemia-lymphoma. 17 of 300 patients in the case group wereborn ART, 21 of 300 patients in the control group were born after ART,there was no statistically significant difference (p = 0.12). Five (6.8%)of the 73 ALL patients in the case group, two of the 38 NBL patients(5.2%), one of 10 germ cell tumors (10%), one of 26 NHL (3.8%), oneof 50 HL (2%), one of 15 RMS (6.6%), two of 17 LCH (11.7%), one of 19wilms tumors (5.2%), one of 8 hepatoblastomas (12,5%) were born withART. The patient who was diagnosed with infantile hemangioendothe-lioma and congenital mesoblastic nephroma in the study were born asaresultofART.Conclusions: Our results did not support retrospectively as a possi-ble risk factor of birth as a result of fertility treatment in children withcancer. The rates of developing tumors in children with healthy donorsused in infertile families will also contribute to the questions betweenART and childhood tumors in the futur

Management of Brucella endocarditis: results of the Gulhane study

Brucella endocarditis (BE) is a rare but life-threatening complication of human brucellosis. The aim of this study was to investigate the course of BE along with the therapeutic interrelations. A total of 53 patients with BE hospitalised in 19 health institutions between 2006 and 2011 were included in the Gulhane study. Diagnosis of brucellosis was established by either isolation of Brucella sp. or the presence of antibodies, and the definition of endocarditis was made according to Duke's criteria. There were four treatment groups: ceftriaxone combined with oral antibiotics (Group 1); aminoglycosides combined with oral antibiotics (Group 2); oral antibiotic combinations (Group 3); and aminoglycoside plus ceftriaxone combined with an oral antibiotic (Group 4). Involvement rates of the aortic, mitral and tricuspid valves were 49.1%, 43.4% and 5.7%, respectively. Thirty-two patients (60.4%) had an underlying cardiac valvular problem, including previous prosthetic valve replacement (n = 18). Medical treatment was provided to 32 patients (60.4%), whilst concordant medical and surgical approaches were provided to 21 patients (39.6%). Mortality in Group 1 was 15% (3/20), whilst in Group 2 it was 5.3% (1/19). In Group 3, 25.0% (3/12) of the cases died, whereas none of the cases in Group 4 died. In conclusion, mortality increased 47-fold with pericardial effusion and 25-fold due to congestive heart failure that developed after BE. Although mortality was lower in the aminoglycoside-containing arm (Groups 2 and 4), statistical analysis could not be performed owing to the small number of patients. (C) 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved