The hidden burden of influenza: A review of the extra-pulmonary complications of influenza infection

Severe influenza infection represents a leading cause of global morbidity and mortality. Although influenza is primarily considered a viral infection that results in pathology limited to the respiratory system, clinical reports suggest that influenza infection is frequently associated with a number of clinical syndromes that involve organ systems outside the respiratory tract. A comprehensive MEDLINE literature review of articles pertaining to extra-pulmonary complications of influenza infection, using organ-specific search terms, yielded 218 articles including case reports, epidemiologic investigations, and autopsy studies that were reviewed to determine the clinical involvement of other organs. The most frequently described clinical entities were viral myocarditis and viral encephalitis. Recognition of these extra-pulmonary complications is critical to determining the true burden of influenza infection and initiating organ-specific supportive care

Strong light-matter coupling in bulk GaN-microcavities with double dielectric mirrors fabricated by two different methods

Two routes for the fabrication of bulk GaN microcavities embedded between two dielectric mirrors are described, and the optical properties of the microcavities thus obtained are compared. In both cases, the GaN active layer is grown by molecular beam epitaxy on (111) Si, allowing use of selective etching to remove the substrate. In the first case, a three period Al0.2Ga0.8N / AlN Bragg mirror followed by a lambda/2 GaN cavity are grown directly on the Si. In the second case, a crack-free 2,mu m thick GaN layer is grown, and progressively thinned to a final thickness of lambda. Both devices work in the strong coupling regime at low temperature, as evidenced by angle-dependent reflectivity or transmission experiments. However, strong light-matter coupling in emission at room temperature is observed only for the second one. This is related to the poor optoelectronic quality of the active layer of the first device, due to its growth only 250 nm above the Si substrate and its related high defect density. The reflectivity spectra of the microcavities are well accounted for by using transfer matrix calculations. (C) 2010 American Institute of Physics. [doi:10.1063/1.3477450

How to Change Behavior in the Context of an FBA-Based Intervention

Teachers implementing behavior interventions are often more effective in eliminating problem behavior and building new skills if they start with functional behavior assessment (FBA). Using FBA, the teacher identifies the purpose, or function, of a problem behavior, then teaches a “replacement skill” that serves the same function. For example, rather than throw a tantrum to avoid a high demand assignment, a teacher teaches a seventh grader to approach an adult in the room to ask for help on particularly difficult problems. Or, instead of making noises to get attention, a teacher teaches a first grader to submit a card with a picture of himself helping the teacher as if to ask “can I be your helper this morning?

Ancestry of the AUTS2 family–a novel group of polycomb-complex proteins involved in human neurological disease

Autism susceptibility candidate 2 (AUTS2) is a neurodevelopmental regulator associated with an autosomal dominant intellectual disability syndrome, AUTS2 syndrome, and is implicated as an important gene in human-specific evolution. AUTS2 exists as part of a tripartite gene family, the AUTS2 family, which includes two relatively undefined proteins, Fibrosin (FBRS) and Fibrosin-like protein 1 (FBRSL1). Evolutionary ancestors of AUTS2 have not been formally identified outside of the Animalia clade. A Drosophila melanogaster protein, Tay bridge, with a role in neurodevelopment, has been shown to display limited similarity to the C-terminal of AUTS2, suggesting that evolutionary ancestors of the AUTS2 family may exist within other Protostome lineages. Here we present an evolutionary analysis of the AUTS2 family, which highlights ancestral homologs of AUTS2 in multiple Protostome species, implicates AUTS2 as the closest human relative to the progenitor of the AUTS2 family, and demonstrates that Tay bridge is a divergent ortholog of the ancestral AUTS2 progenitor gene. We also define regions of high relative sequence identity, with potential functional significance, shared by the extended AUTS2 protein family. Using structural predictions coupled with sequence conservation and human variant data from 15,708 individuals, a putative domain structure for AUTS2 was produced that can be used to aid interpretation of the consequences of nucleotide variation on protein structure and function in human disease. To assess the role of AUTS2 in human-specific evolution, we recalculated allele frequencies at previously identified human derived sites using large population genome data, and show a high prevalence of ancestral alleles, suggesting that AUTS2 may not be a rapidly evolving gene, as previously thought

Increases in body weight and nutritional status of transplanted Alaskan caribou

Body weight and natality rate in ungulates can be useful indices to nutririon, bur they may also be influenced by genetic and climatic factors. Because caribou {Rangifer tarandus granti) are distributed as discrete populations of metapopulations (i.e., herds) that are usually reproductively isolated from each other for unknown periods, it is difficult to separate the influence of genetics and nutrition on body weight, especially where historical data are lacking. To help elucidate the influence of nutrition on potential variation in body weight and natality of caribou in Alaska, we reviewed data for body weight and natality in 5 populations which resulted from Transplants to previously ungrazed ranges, or to areas where reindeer and caribou had been absent for many decades. In 2 of 5 populations body weight increased significantly, and likely increased in the other 3 populations, but data were insufficient. Natality rate increased in all 5 populations, proportion of fecund yearlings was high and 3 of the 5 newly established herds increased at about the maximum biological potential for the species (lambda=1.35). In the Adak transplant, a lactating yearling was documented. These 5 transplanted populations provide additional evidence that body weight and natality rate in Alaskan caribou are sensitive to changes in population density and relatively short-term (i.e., 10 years) increases in grazing pressure independenr of climate and genetics

The Role of Racial Identity and Implicit Racial Bias in Self-Reported Racial Discrimination: Implications for Depression Among African American Men

Racial discrimination is conceptualized as a psychosocial stressor that has negative implications for mental health. However, factors related to racial identity may influence whether negative experiences are interpreted as instances of racial discrimination and subsequently reported as such in survey instruments, particularly given the ambiguous nature of contemporary racism. Along these lines, dimensions of racial identity may moderate associations between racial discrimination and mental health outcomes. This study examined relationships between racial discrimination, racial identity, implicit racial bias, and depressive symptoms among African American men between 30 and 50 years of age (n = 95). Higher racial centrality was associated with greater reports of racial discrimination, while greater implicit anti-Black bias was associated with lower reports of racial discrimination. In models predicting elevated depressive symptoms, holding greater implicit anti-Black bias in tandem with reporting lower racial discrimination was associated with the highest risk. Results suggest that unconscious as well as conscious processes related to racial identity are important to consider in measuring racial discrimination, and should be integrated in studies of racial discrimination and mental health

Active Amplification of the Terrestrial Albedo to Mitigate Climate Change: An Exploratory Study

This study explores the potential to enhance the reflectance of solar insolation by the human settlement and grassland components of the Earth's terrestrial surface as a climate change mitigation measure. Preliminary estimates derived using a static radiative transfer model indicate that such efforts could amplify the planetary albedo enough to offset the current global annual average level of radiative forcing caused by anthropogenic greenhouse gases by as much as 30 percent or 0.76 W/m2. Terrestrial albedo amplification may thus extend, by about 25 years, the time available to advance the development and use of low-emission energy conversion technologies which ultimately remain essential to mitigate long-term climate change. However, additional study is needed to confirm the estimates reported here and to assess the economic and environmental impacts of active land-surface albedo amplification as a climate change mitigation measure.Comment: 21 pages, 3 figures. In press with Mitigation and Adaptation Strategies for Global Change, Springer, N

A review of the US Global Change Research Program and NASA's Mission to Planet Earth/Earth Observing System

This report reflects the results of a ten-day workshop convened at the Scripps Institution of Oceanography July 19-28, 1995. The workshop was convened as the first phase of a two part review of the U.S. Global Change Research Program (USGCRP). The workshop was organized to provide a review of the scientific foundations and progress to date in the USGCRP and an assessment of the implications of new scientific insights for future USGCRP and Mission to Planet Earth/Earth Observing System (MTPE/EOS) activities; a review of the role of NASA's MTPE/EOS program in the USGCRP observational strategy; a review of the EOS Data and Information System (EOSDIS) as a component of USGCRP data management activities; and an assessment of whether recent developments in the following areas lead to a need to readjust MTPE/EOS plans. Specific consideration was given to: proposed convergence of U.S. environmental satellite systems and programs, evolving international plans for Earth observation systems, advances in technology, and potential expansion of the role of the private sector. The present report summarizes the findings and recommendations developed by the Committee on Global Change Research on the basis of the presentations, background materials, working group deliberations, and plenary discussions of the workshop. In addition, the appendices include summaries prepared by the six working groups convened in the course of the workshop