Enhanced product functionality with life cycle units

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.Cycle economy is not only ecologically reasonable but also a chance for new business. Selling utilization instead of selling products is advantageous once additional costs for information processing and logistics are less than costs for underutilized capacity. A competitive provider offers product functionality in quality, time and location as required by the user. Lifetime component monitoring is conditional for this performance. Modern microelectronic technology enables the acquisition of component deterioration with sensorial devices, information processing and storing with microcontrollers and initiating appropriate actions such as maintenance. The architecture of a microsystem called the life cycle unit (LCU) for product and component monitoring is introduced and specified. Product examples illustrate some application areas.DFG, SFB 281, Demontagefabriken zur Rückgewinnung von Ressourcen in Produkt- und Materialkreisläufe

'Will the Paris Agreement protect us from hydro-meteorological extremes?'

Multi-hazard assessment is needed to understand compound risk. Yet, modelling of multiple climate hazards has been limitedly applied at the global scale to date. Here we provide a first comprehensive assessment of global population exposure to hydro-meteorological extremes—floods, drought and heatwaves—under different temperature increase targets. This study shows how limiting temperature increase to 1.5 and 2 °C, as for the goals of the Paris Agreement, could substantially decrease the share of global population exposed compared to a 3 °C scenario. In a 2 °C world, population exposure would drop by more than 50%, in Africa, Asia and the Americas, and by about 40% in Europe and Oceania. A 1.5 °C stabilization would further reduce exposure of about an additional 10% to 30% across the globe. As the Parties of the Paris Agreement are expected to communicate new or updated nationally determined contributions by 2020, our results powerfully indicate the benefits of ratcheting up both mitigation and adaptation ambition

Continuous and discrete Clebsch variational principles

The Clebsch method provides a unifying approach for deriving variational principles for continuous and discrete dynamical systems where elements of a vector space are used to control dynamics on the cotangent bundle of a Lie group \emph{via} a velocity map. This paper proves a reduction theorem which states that the canonical variables on the Lie group can be eliminated, if and only if the velocity map is a Lie algebra action, thereby producing the Euler-Poincar\'e (EP) equation for the vector space variables. In this case, the map from the canonical variables on the Lie group to the vector space is the standard momentum map defined using the diamond operator. We apply the Clebsch method in examples of the rotating rigid body and the incompressible Euler equations. Along the way, we explain how singular solutions of the EP equation for the diffeomorphism group (EPDiff) arise as momentum maps in the Clebsch approach. In the case of finite dimensional Lie groups, the Clebsch variational principle is discretised to produce a variational integrator for the dynamical system. We obtain a discrete map from which the variables on the cotangent bundle of a Lie group may be eliminated to produce a discrete EP equation for elements of the vector space. We give an integrator for the rotating rigid body as an example. We also briefly discuss how to discretise infinite-dimensional Clebsch systems, so as to produce conservative numerical methods for fluid dynamics

Long-lifetime, reliable liquid metal ion sources for boron, arsenic, and phosphorus

Operation of liquid–metalion sources based on palladium alloys that contain boron, arsenic, and phosphorus (singly or in combination) was studied. These sources, when run on refractory metal needles and heater ribbons, have exhibited high angular intensity (1.5–5 μA/sr), long lifetime (\u3e150 h), low energy spread (eV), and stable operation with extracted currents down to 2 μA

Dynamical model of sequential spatial memory: winnerless competition of patterns

We introduce a new biologically-motivated model of sequential spatial memory which is based on the principle of winnerless competition (WLC). We implement this mechanism in a two-layer neural network structure and present the learning dynamics which leads to the formation of a WLC network. After learning, the system is capable of associative retrieval of pre-recorded sequences of spatial patterns.Comment: 4 pages, submitted to PR

Strongly Non-Equilibrium Bose-Einstein Condensation in a Trapped Gas

We present a qualitative (and quantitative, at the level of estimates) analysis of the ordering kinetics in a strongly non-equilibrium state of a weakly interacting Bose gas, trapped with an external potential. At certain conditions, the ordering process is predicted to be even more rich than in the homogeneous case. Like in the homogeneous case, the most characteristic feature of the full-scale non-equilibrium process is the formation of superfluid turbulence.Comment: 4 pages, revtex, no figures. Submitted to PR

Supernatants from lymphocytes stimulated with Bacillus Calmette-Guerin can modify the antigenicity of tumours and stimulate allogeneic T-cell responses

BACKGROUND: Reduced expression of class 1 human leucocyte antigens (HLA1) is often a mechanism by which tumours evade surveillance by the host immune system. This is often associated with an immune function that is unable to mount appropriate responses against disease, which can result in a state that favours carcinogenesis. METHODS: In the current study, we have explored the effects of Bacillus Calmette-Guerin (BCG) on the cytokine output of leucocytes, which is a key determinant in generating antitumour action, and have also assessed the effect of these cytokine cocktails on HLA1 expression in solid tumour cell lines. RESULTS: BCG potently activated a broad range of leucocytes, and also enhanced the production of cytokines that were Th(1)-predominant. Supernatants from BCG-treated leucocytes significantly increased the expression of HLA1 on the surface of cancer cell lines, which correlated with increased cytolytic T-cell activity. We also showed that the increased HLA1 expression was associated with activation of intracellular signalling pathways, which was triggered by the increases in the Th(1)-cytokines interferon-γ and tumour necrosis factor-α, as counteracting their effects negated the enhancement. CONCLUSION: These studies reaffirm the role of BCG as a putative immunotherapy through their cytokine-modifying effects on leucocytes and their capacity to enhance tumour visibility

Differential down-modulation of HLA class I and II molecule expression on human tumor cell lines upon in vivo transfer

Previous evidence from our laboratory showed that Epstein–Barr virus–immortalized lymphoblastoid B cells undergo a prominent down-modulation of HLA-II molecule expression when injected intraperitoneally in SCID mice, while HLA-I remains almost unaffected. Since this phenomenon can alter the experimental outcome of therapeutic protocols of adoptive cell therapy, we decided to evaluate the behavior of MHC antigens in a panel of cell lines belonging to the B- and T-cell lineages, as well as in epithelial tumor cell lines. Cells were administered in mice either intraperitoneally or subcutaneously and recovered 4 days later for HLA molecule expression analysis. Collected data showed a highly heterogeneous in vivo behavior of the various cell lines, which could alternatively down-modulate, completely abrogate or maintain unchanged the expression of either MHC-I or MHC-II molecules. Moreover, the site of injection impacted differentially on these aspects. Although such phenomena still lack a comprehensive clarification, epigenetic mechanisms are likely to be involved as epigenetic drugs could partially counteract MHC down-modulation in vivo. Nonetheless, it has to be pointed out that careful attention must be paid to the assessment of therapeutic efficacy of translational protocols of adoptive immunotherapy, as modulation of MHC molecules on human target cells when transferred in a mouse environment could readily interfere with the desired and expected therapeutic effects