Therapeutic efficacy of different brands of albendazole against soil transmitted helminths among students of Mendera Elementary School, Jimma, Southwest Ethiopia

Introduction: Different brands Albendazole are commercially available and the efficacious brand/s is/are required for effective control of STHs infection. Thus, this study is aimed at determining the therapeutic efficacy of different brands of albendazole against soil transmitted helminths among school children of Jimma town. Methods: A cross sectional survey for prevalence of geohelminths and a randomized trial for efficacy study of different brands of albendazole was conducted among students Mendera Elementary School from March 29 to April 29, 2010. Positive subjects were randomized into three treatment arms using lottery method. The collected stool samples were examined by the McMaster method. CRs were calculated using SPSS windows version 16 and ERRs were calculated using appropriate formula. Results: Of the 715 school children who had their stools examined, 326 were positive for STHs with a prevalence rate of 45.6%. The cure rates (CR) for A. lumbricoides, T. trichiura and Hookworm were 99.4, 59.9 and 93.7%, respectively. Similarly, the egg reduction rates (ERR) were 97, 99.9 and 99.9% respectively. A statistical significant mean STH egg count difference were observed between pre and post-intervention study (p <0.001). But no statistical significant curing effect difference were observed among the three brands used against the three STHs (p >0.05). Conclusion: All the three brands of Albendazole tested regardless of the brand type were therapeutically efficacious for Ascariasis, Trichuriasis and Hookworm infections irrespective of the infection status whether it was single or multiple.Pan African Medical Journal 2015; 2

Androgenic steroid composition of the hexane/ methanol whole plant extract of Solanecio tuberosus (Selbilla) around Lake Tana Northwest Ethiopia

The plant kingdom is a treasure house of potential drugs. Steroids are very important molecules that mediate awide range of biological functions in the human body. Today, there is no study reporting the androgenic steroidcontent of Solanecio tuberosus extract. In this study, the androgenic steroid content of hexane/methanol extractof S. tuberosus was analyzed by Fourier transform (FT)-infrared spectroscopy, ultraviolet-visible spectroscopy,FT-magnetic resonance spectroscopy, and thin layer chromatography. Androgenic steroid derivatives such aspredinsolone, testosterone cypionate, and methyltestostrone were identified. The present study showed thatS. tuberosus can be considered as a potential remedy to improve the sexual and physical health of men as theygo aged and in testosterone deficient condition if further studies are conducted on safety and efficacy of theplant material

Return of chloroquine-sensitive Plasmodium falciparum parasites and emergence of chloroquine-resistant Plasmodium vivax in Ethiopia

BACKGROUND: Increased resistance by Plasmodium falciparum parasites led to the withdrawal of the antimalarial drugs chloroquine and sulphadoxine-pyrimethamine in Ethiopia. Since 2004 artemether-lumefantrine has served to treat uncomplicated P. falciparum malaria. However, increasing reports on delayed parasite clearance to artemisinin opens up a new challenge in anti-malarial therapy. With the complete withdrawal of CQ for the treatment of Plasmodium falciparum malaria, this study assessed the evolution of CQ resistance by investigating the prevalence of mutant alleles in the pfmdr1 and pfcrt genes in P. falciparum and pvmdr1 gene in Plasmodium vivax in Southern and Eastern Ethiopia. METHODS: Of the 1,416 febrile patients attending primary health facilities in Southern Ethiopia, 329 febrile patients positive for P. falciparum or P. vivax were recruited. Similarly of the 1,304 febrile patients from Eastern Ethiopia, 81 febrile patients positive for P. falciparum or P. vivax were included in the study. Of the 410 finger prick blood samples collected from malaria patients, we used direct sequencing to investigate the prevalence of mutations in pfcrt and pfmdr1. This included determining the gene copy number in pfmdr1 in 195 P. falciparum clinical isolates, and mutations in the pvmdr1 locus in 215 P. vivax clinical isolates. RESULTS: The pfcrt K76 CQ-sensitive allele was observed in 84.1% of the investigated P.falciparum clinical isolates. The pfcrt double mutations (K76T and C72S) were observed less than 3%. The pfcrt SVMNT haplotype was also found to be present in clinical isolates from Ethiopia. The pfcrt CVMNK-sensitive haplotypes were frequently observed (95.9%). The pfmdr1 mutation N86Y was observed only in 14.9% compared to 85.1% of the clinical isolates that carried sensitive alleles. Also, the sensitive pfmdr1 Y184 allele was more common, in 94.9% of clinical isolates. None of the investigated P. falciparum clinical isolates carried S1034C, N1042D and D1246Y pfmdr1 polymorphisms. All investigated P. falciparum clinical isolates from Southern and Eastern Ethiopia carried only a single copy of the mutant pfmdr1 gene. CONCLUSION: The study reports for the first time the return of chloroquine sensitive P. falciparum in Ethiopia. These findings support the rationale for the use of CQ-based combination drugs as a possible future alternative

Spatiotemporal climate and vegetation greenness changes and their nexus for Dhidhessa River Basin, Ethiopia

Background Understanding spatiotemporal climate and vegetation changes and their nexus is key for designing climate change adaptation strategies at a local scale. However, such a study is lacking in many basins of Ethiopia. The objectives of this study were (i) to analyze temperature, rainfall and vegetation greenness trends and (ii) determine the spatial relationship of climate variables and vegetation greenness, characterized using Normalized Difference in Vegetation Index (NDVI), for the Dhidhessa River Basin (DRB). Quality checked high spatial resolution satellite datasets were used for the study. Mann–Kendall test and Sen’s slope method were used for the trend analysis. The spatial relationship between climate change and NDVI was analyzed using geographically weighted regression (GWR) technique. Results According to the study, past and future climate trend analysis generally showed wetting and warming for the DRB where the degree of trends varies for the different time and spatial scales. A seasonal shift in rainfall was also observed for the basin. These findings informed that there will be a negative impact on rain-fed agriculture and water availability in the basin. Besides, NDVI trends analysis generally showed greening for most climatic zones for the annual and main rainy season timescales. However, no NDVI trends were observed in all timescales for cool sub-humid, tepid humid and warm humid climatic zones. The increasing NDVI trends could be attributed to agroforestry practices but do not necessarily indicate improved forest coverage for the basin. The change in NDVI was positively correlated to rainfall (r2 = 0.62) and negatively correlated to the minimum (r2 = 0.58) and maximum (r2 = 0.45) temperature. The study revealed a strong interaction between the climate variables and vegetation greenness for the basin that further influences the biophysical processes of the land surface like the hydrologic responses of a basin. Conclusion The study concluded that the trend in climate and vegetation greenness varies spatiotemporally for the DRB. Besides, the climate change and its strong relationship with vegetation greenness observed in this study will further affect the biophysical and environmental processes in the study area; mostly negatively on agricultural and water resource sectors. Thus, this study provides helpful information to device climate change adaptation strategies at a local scale

An analysis of the productivity and technical efficiency of smallholder irrigation in Ethiopia

Agriculture is the mainstay of Ethiopia’s economy, contributing more than 40% to GDP and providing a livelihood to about 80% of the population. Agriculture is dominated by smallholders growing predominantly rainfed cereals, making economic performance dependent on rainfall availability. This study used the stochastic frontier production function to analyse the productivity and technical efficiency of 4 different agricultural production systems in Ethiopia; namely, irrigated seasonal farms on traditional irrigation systems, irrigated seasonal farms on modern communal irrigation systems, rainfed seasonal farms for farmers who have access to irrigation and rainfed seasonal farms for farmers who do not have access to irrigation. Simple random samples of farmers were selected from lists of farmers. The sample of farmers constituted 122 from the traditional irrigated sites, 281 from the modern communal irrigated sites and 350 from the control rainfed sites of farmers without access to irrigation. For those farmers, from both traditional and modern communal irrigation, who also had access to rainfed farms, their rainfed farms were included in the sample of rainfed with access to irrigation. This sample constituted 434 farmers. The marginal productivity of land on modern communal irrigation systems shows that this is the smallholder irrigation option that should be developed by the Government of Ethiopia. However, the marginal productivity of land in the ‘rainfed without access to irrigation’ category is higher than that of the traditional irrigated system. Thus additional developed land should be put under ‘rainfed without access to irrigation’ before it is put under traditional irrigation; otherwise it should be developed into modern communal irrigation. The average technical efficiency for the modern irrigated system was estimated to be about 71%, whereas this was estimated to be 78% for the ‘rainfed without access to irrigation’ system. There are potential gains to be realised in improving efficiency in these two systems

A comparative analysis of the technical efficiency of rain-fed and smallholder irrigation in Ethiopia

Agriculture is the most significant contributor to Ethiopia’s economy. Most of the agricultural production is under rainfed conditions and thus extremely sensitive to rainfall variability. Irrigation development, including smallholder irrigation, is used by the Ethiopian Government to attempt to mitigate the effects of rainfall variability. In this study, we look at smallholder irrigation - modern and traditional irrigation systems. A detailed description of the cropping patterns is given. The stochastic frontier production function approach is used to estimate technical inefficiency, and constraints to production are analyzed. Since the traditional system is found to be efficient but on a lower production frontier, the study shows that significant gains can be made by raising the frontier of the traditional systems and increasing the efficiency of the modern systems. Among the production constraints studied were land preparation, soil fertility, weed control, pests and diseases, soil erosion, input access and moisture deficiency. The most significant constraints on the irrigated systems were input access and moisture deficiency

A comparative analysis of the technical efficiency of rain-fed and smallholder irrigation in Ethiopia

Agriculture is the most significant contributor to Ethiopia’s economy. Most of the agricultural production is under rainfed conditions and thus extremely sensitive to rainfall variability. Irrigation development, including smallholder irrigation, is used by the Ethiopian Government to attempt to mitigate the effects of rainfall variability. In this study, we look at smallholder irrigation - modern and traditional irrigation systems. A detailed description of the cropping patterns is given. The stochastic frontier production function approach is used to estimate technical inefficiency, and constraints to production are analyzed. Since the traditional system is found to be efficient but on a lower production frontier, the study shows that significant gains can be made by raising the frontier of the traditional systems and increasing the efficiency of the modern systems. Among the production constraints studied were land preparation, soil fertility, weed control, pests and diseases, soil erosion, input access and moisture deficiency. The most significant constraints on the irrigated systems were input access and moisture deficiency