4 research outputs found

    Decolonising Archives

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    "The e-publication Decolonising Archives aims to show how archives bear testimony to what was, even more so than collections. Archives present documents that allow one to understand what happened and in which order. Today Internet technology, combined with rapid moves made on the geopolitical chessboard, make archives a contested site of affirmation, recognition and denial. As such, it is of great importance to be aware of processes of colonialisation and decolonisation taking place as new technology can both be used to affirm existing hegemonic colonial relationships or break them open." -- Publisher's website

    Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice

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    <div><p>Objective</p><p>Most anti-angiogenic preeclampsia models in rodents utilized the overexpression of a truncated soluble fms-like tyrosine kinase-1 (sFlt-1) not expressed in any species. Other limitations of mouse preeclampsia models included stressful blood pressure measurements and the lack of postpartum monitoring. We aimed to 1) develop a mouse model of preeclampsia by administering the most abundant human placental sFlt-1 isoform (hsFlt-1-e15a) in preeclampsia; 2) determine blood pressures in non-stressed conditions; and 3) develop a survival surgery that enables the collection of fetuses and placentas and postpartum (PP) monitoring.</p><p>Methods</p><p>Pregnancy status of CD-1 mice was evaluated with high-frequency ultrasound on gestational days (GD) 6 and 7. Telemetry catheters were implanted in the carotid artery on GD7, and their positions were verified by ultrasound on GD13. Mice were injected through tail-vein with adenoviruses expressing hsFlt-1-e15a (n = 11) or green fluorescent protein (GFP; n = 9) on GD8/GD11. Placentas and pups were delivered by cesarean section on GD18 allowing PP monitoring. Urine samples were collected with cystocentesis on GD6/GD7, GD13, GD18, and PPD8, and albumin/creatinine ratios were determined. GFP and hsFlt-1-e15a expression profiles were determined by qRT-PCR. Aortic ring assays were performed to assess the effect of hsFlt-1-e15a on endothelia.</p><p>Results</p><p>Ultrasound predicted pregnancy on GD7 in 97% of cases. Cesarean section survival rate was 100%. Mean arterial blood pressure was higher in hsFlt-1-e15a-treated than in GFP-treated mice (∆MAP = 13.2 mmHg, p = 0.00107; GD18). Focal glomerular changes were found in hsFlt-1-e15a -treated mice, which had higher urine albumin/creatinine ratios than controls (109.3±51.7ÎŒg/mg vs. 19.3±5.6ÎŒg/mg, p = 4.4x10<sup>-2</sup>; GD18). Aortic ring assays showed a 46% lesser microvessel outgrowth in hsFlt-1-e15a-treated than in GFP-treated mice (p = 1.2x10<sup>-2</sup>). Placental and fetal weights did not differ between the groups. One mouse with liver disease developed early-onset preeclampsia-like symptoms with intrauterine growth restriction (IUGR).</p><p>Conclusions</p><p>A mouse model of late-onset preeclampsia was developed with the overexpression of hsFlt-1-e15a, verifying the <i>in vivo</i> pathologic effects of this primate-specific, predominant placental sFlt-1 isoform. HsFlt-1-e15a induced early-onset preeclampsia-like symptoms associated with IUGR in a mouse with a liver disease. Our findings support that hsFlt-1-e15a is central to the terminal pathway of preeclampsia, and it can induce the full spectrum of symptoms in this obstetrical syndrome.</p></div

    “Imprisoned Photographs”: The Looted Archive of Photo Rissas (Rassas)—Ibrahim and Chalil (Khalil) Rissas

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    This essay is the first dedicated solely to the work and archive of Ibrahim and Chalil (Khalil) Rissas (Rassas). Ibrahim was one of the pioneers of Palestinian photography in Jerusalem in the early twentieth century and Chalil, his son, was one of the first Palestinian photojournalists in the 1940s. Rissas’ images were looted and seized by Israeli officer from the photographers’ studio, from the body of a soldier or “slain Arab,” or “rescued” from a burning shop. Those photographs that had been looted from the studio, were the first collection I found in the Israeli military archives. In this essay I chart and analyze the way Rissas’ images were looted on several occasions and the moral, sociological, and political consequences of these acts—for instance how the looted object becomes a symbol of triumph or acts as a vehicle to dehumanize the enemy. The essay is also the first to focus on the phenomenon of pillage by individuals who transfer the looted cultural assets to colonial official archives where they are ruled by the colonial administration. It thus reflects not only the responsibility of states in the process of “knowledge production” and on their role in distorting the past and rewriting history by various bureaucratic, linguistic, and legal means, but also on the role of citizens in these destructive processes.Cet essai est le premier Ă  se pencher exclusivement sur le travail et les archives d’Ibrahim et Chalil (Khalil) Rissas (Rassas). Ibrahim fut un des pionniers de la photographie palestinienne Ă  JĂ©rusalem au dĂ©but du 20e siĂšcle. Son fils Chalil fut l’un des premiers photojournalistes palestiniens dans les annĂ©es 1940. Leurs archives ont Ă©tĂ© pillĂ©es et saisies, dans leur studio photo de mĂȘme que sur la dĂ©pouille d’un Arabe, par des soldats israĂ©liens. C’est la premiĂšre collection que j’ai trouvĂ©e dans les archives militaires israĂ©liennes. Tout au long de cet article, je retrace et analyse la façon dont elle a Ă©tĂ© pillĂ©e, et les consĂ©quences morales, sociologiques et politiques de ce pillage; comme la transformation de ces objets volĂ©s en symboles de triomphe, ou en vecteurs de dĂ©shumanisation de l’ennemi. Il s’agit Ă©galement du premier essai s’intĂ©ressant aux phĂ©nomĂšnes de pillages dont les auteurs transfĂšrent les biens culturels saisis aux archives coloniales officielles, oĂč ils tombent sous la responsabilitĂ© de l’administration coloniale. La rĂ©flexion ne porte donc pas uniquement sur la responsabilitĂ© des États dans le processus de « production de savoir » ou leur rĂŽle dans la dĂ©formation du passĂ© et la rĂ©Ă©criture de l’histoire par divers biais bureaucratiques, linguistiques et lĂ©gaux. Elle porte Ă©galement sur le rĂŽle des citoyens dans ce genre de processus de destruction
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