1,879 research outputs found
Development of Large area Gamma-ray Camera with GSO(Ce) Scintillator Arrays and PSPMTs
We have developed a position-sensitive scintillation camera with a large area
absorber for use as an advanced Compton gamma-ray camera. At first we tested
GSO(Ce) crystals. We compared light output from the GSO(Ce) crystals under
various conditions: the method of surface polishing, the concentration of Ce,
and co-doping Zr. As a result, we chose the GSO(Ce) crystals doped with only
0.5 mol% Ce, and its surface polished by chemical etching as the scintillator
of our camera. We also made a 1616 cm scintillation camera which
consisted of 9 position-sensitive PMTs (PSPMTs Hamamatsu flat-panel H8500), the
each of which had 88 anodes with a pitch of 6 mm and coupled to
88 arrays of pixelated 613 mm GSO(Ce) scintillators.
For the readout system of the 576 anodes of the PMTs, we used chained resistors
to reduce the number of readout channels down to 48 to reduce power
consumption. The camera has a position resolution of less than 6mm and a
typical energy resolution of 10.5% (FWHM) at 662 keV at each pixel in a large
area of 1616 cm. %to choose the best scintillator for our project.
Furthermore we constructed a 1616 array of 313 mm
pixelated GSO(Ce) scintillators, and glued it to a PMT H8500. This camera had
the position resolution of less than 3mm, over an area of 55 cm,
except for some of the edge pixels; the energy resolution was typically 13%
(FWHM) at 662 keV.Comment: Proceedings of PSD7 appear in NIM
Development of an advanced Compton camera with gaseous TPC and scintillator
A prototype of the MeV gamma-ray imaging camera based on the full
reconstruction of the Compton process has been developed. This camera consists
of a micro-TPC that is a gaseous Time Projection Chamber (TPC) and
scintillation cameras. With the information of the recoil electrons and the
scattered gamma-rays, this camera detects the energy and incident direction of
each incident gamma-ray. We developed a prototype of the MeV gamma-ray camera
with a micro-TPC and a NaI(Tl) scintillator, and succeeded in reconstructing
the gamma-rays from 0.3 MeV to 1.3 MeV. Measured angular resolutions of ARM
(Angular Resolution Measure) and SPD (Scatter Plane Deviation) for 356 keV
gamma-rays were and , respectively.Comment: 4 pages, 5 figures. Proceedings of the 6th International Workshop On
Radiation Imaging Detector
Studies of the performance of different front-end systems for flat-panel multi-anode PMTs with CsI(Tl) scintillator arrays
We have studied the performance of two different types of front-end systems
for our gamma camera based on Hamamatsu H8500 (flat-panel 64 channels
multi-anode PSPMT) with a CsI(Tl) scintillator array. The array consists of 64
pixels of which corresponds to the anode pixels of
H8500. One of the system is based on commercial ASIC chips in order to readout
every anode. The others are based on resistive charge divider network between
anodes to reduce readout channels. In both systems, each pixel (6mm) was
clearly resolved by flood field irradiation of Cs. We also investigated
the energy resolution of these systems and showed the performance of the
cascade connection of resistive network between some PMTs for large area
detectors.Comment: 9 pages, 6 figures, proceedings of the 7th International Workshop on
Radiation Imaging Detectors (IWORID7), submitted to NIM
Dextran and its potential use as tablet excipient
Dextrans are a class of carbohydrate polymers extensively applied in pharmaceutical applications, particularly as drug conjugate macromolecular carriers or drug delivery systems. These polysaccharides improve the stability of the therapeutics enabling also the control of their release, via either the parenteral and or oral routes. In the latter case, due to their gel forming ability they may have potential as hydrophilic matrix tablets for sustained drug release.
In this paper, we investigated the behaviour of different molecular weight (1, 40, 500 and 2300 kDa) dextrans as tabletting excipients. Powder particle size and hygroscopic studies have been reported, together with tabletability, tablet stability and tablet swelling. Moreover we use tramadol as model compound to evaluate the ability of dextrans to control drug dissolution. The results suggest that dextrans with lower molecular weights may be a promising excipient to be used as filler for immediate release tablets, due to their good tabletability and fast dissolution rate, while dextrans with higher molecular weights could be an efficient disintegrant due to their swelling ability
Optical band edge shift of anatase cobalt-doped titanium dioxide
We report on the optical properties of magnetic cobalt-doped anatase phase
titanium dioxide Ti_{1-x}Co_{x}O_{2-d} films for low doping concentrations, 0
<= x <= 0.02, in the spectral range 0.2 to 5 eV. For well oxygenated films (d
<< 1) the optical conductivity is characterized by an absence of optical
absorption below an onset of interband transitions at 3.6 eV and a blue shift
of the optical band edge with increasing Co concentration. The absence of below
band gap absorption is inconsistent with theoretical models which contain
midgap magnetic impurity bands and suggests that strong on-site Coulomb
interactions shift the O-band to Co-level optical transitions to energies above
the gap.Comment: 5 pages, 4 figures, 1 table; Version 2 - major content revisio
What can(not) be measured with ton-scale dark matter direct detection experiments
Direct searches for dark matter have prompted in recent years a great deal of
excitement within the astroparticle physics community, but the compatibility
between signal claims and null results of different experiments is far from
being a settled issue. In this context, we study here the prospects for
constraining the dark matter parameter space with the next generation of
ton-scale detectors. Using realistic experimental capabilities for a wide range
of targets (including fluorine, sodium, argon, germanium, iodine and xenon),
the role of target complementarity is analysed in detail while including the
impact of astrophysical uncertainties in a self-consistent manner. We show
explicitly that a multi-target signal in future direct detection facilities can
determine the sign of the ratio of scalar couplings , but not its
scale. This implies that the scalar-proton cross-section is left essentially
unconstrained if the assumption is relaxed. Instead, we find that
both the axial-proton cross-section and the ratio of axial couplings
can be measured with fair accuracy if multi-ton instruments using sodium and
iodine will eventually come online. Moreover, it turns out that future direct
detection data can easily discriminate between elastic and inelastic
scatterings. Finally, we argue that, with weak assumptions regarding the WIMP
couplings and the astrophysics, only the dark matter mass and the inelastic
parameter (i.e. mass splitting) may be inferred from the recoil spectra --
specifically, we anticipate an accuracy of tens of GeV (tens of keV) in the
measurement of the dark matter mass (inelastic parameter).Comment: 31 pages, 7 figures, 7 table
Monoiodoacetic acid induces arthritis and synovitis in rats in a dose- and time-dependent manner: proposed model-specific scoring systems
SummaryObjectiveIn a rat monoiodoacetic acid (MIA)-induced arthritis model, the amount of MIA commonly used was too high, resulting in rapid bone destruction. We examined the effect of MIA concentrations on articular cartilage and infrapatellar fat pad (IFP). We also established an original system for “macroscopic cartilage and bone score” and “IFP inflammation score” specific to the rat MIA-induced arthritis model.DesignMale Wistar rats received a single intra-articular injection of MIA in the knee. The amount of MIA was 0.1, 0.2, 0.5, and 1 mg respectively. Articular cartilage was evaluated at 2–12 weeks. IFP was also observed at 3–14 days.ResultsMacroscopically, low MIA doses induced punctate depressions on the cartilage surface, and cartilage erosion proceeded slowly over 12 weeks, while higher MIA doses already induced cartilage erosion at 2 weeks, followed by bone destruction. MIA macroscopic cartilage and bone score, OARSI histological score, and Mankin score increased in a dose- and time-dependent manner. The IFP inflammation score peaked at 5 days in low dose groups, then decreased, while in high dose groups, the IFP score continued to increase over 14 days due to IFP fibrosis.ConclusionsPunctate depressions, cartilage erosion, and bone destruction were observed in the MIA-induced arthritis model. The macroscopic cartilage and bone scoring enabled the quantification of cartilage degeneration and demonstrated that MIA-induced arthritis progressed in a dose- and time-dependent manner. IFP inflammation scores revealed that 0.2 mg MIA induced reversible synovitis, while 1 mg MIA induced fibrosis of the IFP body
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