More individual differences in language attainment: How much do adult native speakers of English know about passives and quantifiers?

This paper provides experimental evidence suggesting that there are considerable differences in native language attainment, and that these are at least partially attributable to individual speakers’ experience. Experiment 1 tested high academic attainment (hereafter, HAA) and low academic attainment (LAA) participants’ comprehension using a picture selection task. Test sentences comprised passives and two variants of the universal quantification construction. Active constructions were used as a control condition. HAA participants performed at ceiling in all conditions; LAA participants performed at ceiling only on actives. As predicted by usage-based accounts, the order of difficulty of the four sentence types mirrored their frequency. Experiment 2 tested whether the less-educated participants’ difficulties with these constructions are attributable to insufficient experience. After a screening test, low scoring participants were randomly assigned to two training groups. The passive training group were given a short training session on the passive construction; and the quantifier training group were trained on sentences with quantifiers. A series of post-training tests show that performance on the trained construction improved dramatically, and that the effect was long-lasting

Effect of training traditional birth attendants on neonatal mortality (Lufwanyama Neonatal Survival Project): randomised controlled study

Objective To determine whether training traditional birth attendants to manage several common perinatal conditions could reduce neonatal mortality in the setting of a resource poor country with limited access to healthcare

Optoelectronic device technology policy in the US and Japan

M.S.John J. Havic

Epidemiology of injuries, outcomes, and hospital resource utilisation at a tertiary teaching hospital in Lusaka, Zambia

Injuries represent a global public health threat and that threat is disproportionally felt especially in low and middle income countries (LMICs) that experience 90% of global mortality from injury. Few LMICs have robust datasets describing patient injuries and injury care. Objective: To develop a hospital-based trauma registry in an urban hospital in Lusaka, Zambia to assess patterns of injury, transport methods and duration, injury severity, outcomes and hospital resource utilisation. Methods: From September 2011 to February 2012, all injured patients presenting to the Surgical Emergency Centre at University Teaching Hospital (UTH) were prospectively enrolled in an observational study to describe the epidemiology and the circumstances of injury of patients presenting to UTH, a 1400 bed urban hospital which is the primary trauma centre for Lusaka. Data on injured patients were collected by trained staff 24 h/day including: circumstances of trauma, transport method and time, injury type and location, vital signs on arrival, and disposition. Additional data regarding length of stay, HIV testing, operative procedures, use of blood products, and 30-day vital status were recorded for admitted patients. Results: A total of 3498 patients were enrolled in the trauma registry. Patients were primarily male (71.8%), young (median age 24 years), and the majority arrived by private vehicle (51.8%) or public transport (37.1%). The most common reported mechanisms of injury were falls (26.3%), road traffic accidents (25.6%) and assault (20.0%). Hospital resource utilisation data were available for 863 of the 1769 (48.7%) admitted patients. Of these, 661 (76.6%) had X-rays, 468 (57.5%) had a surgical procedure performed, 390 (45.2%) underwent HIV testing, and 50 (5.8%) received blood products. The case fatality rate was 3%. Conclusion: Limited dataset trauma registries can capture important epidemiologic data that can characterise injury care, identify patterns of injury, and inform hospital-based intervention strategies in Zambia

Entire expressed peripheral blood transcriptome in pediatric severe malarial anemia

Abstract This study on severe malarial anemia (SMA: Hb < 6.0 g/dL), a leading global cause of childhood morbidity and mortality, compares the entire expressed whole blood host transcriptome between Kenyan children (3-48 mos.) with non-SMA (Hb ≥ 6.0 g/dL, n = 39) and SMA (n = 18). Differential expression analyses reveal 1403 up-regulated and 279 down-regulated transcripts in SMA, signifying impairments in host inflammasome activation, cell death, and innate immune and cellular stress responses. Immune cell profiling shows decreased memory responses, antigen presentation, and immediate pathogen clearance, suggesting an immature/improperly regulated immune response in SMA. Module repertoire analysis of blood-specific gene signatures identifies up-regulation of erythroid genes, enhanced neutrophil activation, and impaired inflammatory responses in SMA. Enrichment analyses converge on disruptions in cellular homeostasis and regulatory pathways for the ubiquitin-proteasome system, autophagy, and heme metabolism. Pathway analyses highlight activation in response to hypoxic conditions [Hypoxia Inducible Factor (HIF)−1 target and Reactive Oxygen Species (ROS) signaling] as a central theme in SMA. These signaling pathways are also top-ranking in protein abundance measures and a Ugandan SMA cohort with available transcriptomic data. Targeted RNA-Seq validation shows strong concordance with our entire expressed transcriptome data. These findings identify key molecular themes in SMA pathogenesis, offering potential targets for new malaria therapies

A connectionist model of visual-word recognition that accounts for interactions between mask size and word length

A connectionist model is described, which accounts for data showing a “mask appropriateness” effect in word and letter recognition. In a backward-masking paradigm, if the letter fragment masks that are used are of a similar size to the word or word fragment they are masking, performance is better than if the masks are longer or discontinuous (Jordan, 1990). The model simulates these effects by adding to the familiar architecture of the interactive activation model “length” units, which are stimulated whenever word units of a particular letter length are active, and “mask” units, which are stimulated by masks of particular sizes and in turn stimulate length units. Detailed predictions of the model are examined for both forward and backward masking, and are found to be in good accord with the data