Línea eléctrica aérea de alta tensión para el suministro de energía eléctrica a una nave industrial situada en polígono industrial de Villadangos

En el siguiente proyecto se exponen todos los documentos necesarios para la colocación de una línea subterránea de 20 kV que realiza la conexión entre la infraestructura existente en el polígono industrial y un centro de seccionamiento de 250 kVA. También se presentan los datos necesarios para la construcción de una línea subterránea de características similares a la primera para realizar la conexión entre el centro de seccionamiento y el centro de transformación. El último componente de este proyecto es una instalación de baja tensión que cubre las necesidades de una nave industrial situada en la provincia de Leó

Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Data on convalescent plasma (CP) treatment in COVID-19 outpatients are scarce. We aimed to assess whether CP administered during the first week of symptoms reduced the disease progression or risk of hospitalization of outpatients. Two multicenter, double-blind randomized trials (NCT04621123, NCT04589949) were merged with data pooling starting when = 50 years and symptomatic for <= 7days were included. The intervention consisted of 200-300mL of CP with a predefined minimum level of antibodies. Primary endpoints were a 5-point disease severity scale and a composite of hospitalization or death by 28 days. Amongst the 797 patients included, 390 received CP and 392 placebo; they had a median age of 58 years, 1 comorbidity, 5 days symptoms and 93% had negative IgG antibody-test. Seventy-four patients were hospitalized, 6 required mechanical ventilation and 3 died. The odds ratio (OR) of CP for improved disease severity scale was 0.936 (credible interval (CI) 0.667-1.311); OR for hospitalization or death was 0.919 (CI 0.592-1.416). CP effect on hospital admission or death was largest in patients with <= 5 days of symptoms (OR 0.658, 95%CI 0.394-1.085). CP did not decrease the time to full symptom resolution

Late cardiovascular and neurological complications in Hodgkin lymphoma survivors

This thesis focuses on the early detection of cardiovascular and neurological abnormalities in Hodgkin Lymphoma Survivors (HLS) in a population of 82 patients and 40 controls and in a cross-sectional setting. Several screening test were performed for the assessment of these late effects of treatment. Arterial stiffness has been previously shown to be an early marker of cardiovascular disease (CVD) and a surrogate marker for cardiovascular mortality in several high risk populations. In the studied population two different parameters of arterial stiffness were measured: the carotid-femoral pulse wave velocity (PWVcf) and the common carotid artery (CCA) distensibility coefficient (DC). It is shown for the first time that arterial stiffness is associated with radiotherapy in HLS. Arterial stiffness was most increased in HLS irradiated at older age (above 35-40 years). We hypothesise that the pathophysiology of arterial stiffening after radiotherapy is multifactorial. First, arterial stiffening can be a consequence of nitric oxide (NO)- and prostacyclin-mediated endothelial dysfunction which was shown to occur early and probably still is present years after radiotherapy. Furthermore, atherosclerotic lesions of the arterial wall can contribute to the stiffening of arteries. Preclinical atherosclerotic disease was evaluated by evaluating Intima media thickness (IMT) and the occurrence of plaque at the CCA and Coronary artery calcium (CAC)-score. All these three indicators demonstrate an association between radiotherapy and atherosclerotic disease. Atherosclerosis was most prevalent when HLS were followed for 10-15 years or more form radiotherapy. This is consistent with findings from studies describing symptomatic CVD, suggesting that radiotherapy has a prolonged effect on atherosclerosis. When screening for valvular disease, we found that nearly half of all patients had mild, moderate or severe valve abnormalities. Valvular disease was more prevalent in HLS treated with mediastinal radiotherapy (61.2 %) when compared to HLS treated without mediastinal radiotherapy (31%). Furthermore, the prevalence of valvular disease increased with time after radiotherapy. For the first time a study was performed that systematically looked into the burden and pathophysiological mechanism of radiation-induced muscular damage. Based on clinical findings, results of muscle ultrasound and needle electromyography of muscles situated within and outside the radiation field, we conclude that damage is most likely caused by an extrinsic factor such as progressive microvascular fibrosis. When considering a vascular injury as the primary cause of myogenic damage, we suggest training of the affected muscles, starting soon after radiotherapy to promote increased vascularisation of the muscles by forming collateral vessels. After considering the results of these screening tests, we recommend a comprehensive screening programme of HLS for the timely detection of cardiovascular damage

Progressive Muscle Atrophy and Weakness After Treatment by Mantle Field Radiotherapy in Patients with Hodgkin'S Lymphoma

Contains fulltext : 81858.pdf (publisher's version ) (Open Access

Évaluation du potentiel électrique à la surface des dispositifs enrobés

We present an iterative method for the determination of the potential map of the conducting skin coating on the surface of cast resin electrical devices. The efficiency of the procedure is shown on an exactly solvable case (bus bar). For complex devices, it is shown that the original 3D problem often degenerates into two standard 2D resolutions and one iteration. This point is illustrated with a one-phase Cast Resin Transformer

Progressive muscle atrophy and weakness after treatment by mantle field radiotherapy in Hodgkin lymphoma survivors.

Item does not contain fulltextPURPOSE: To describe the damage to the muscles and propose a pathophysiologic mechanism for muscle atrophy and weakness after mantle field radiotherapy in Hodgkin lymphoma (HL) survivors. METHODS AND MATERIALS: We examined 12 patients treated by mantle field radiotherapy between 1969 and 1998. Besides evaluation of their symptoms, the following tests were performed: dynamometry; ultrasound of the sternocleidomastoid, biceps, and antebrachial flexor muscles; and needle electromyography of the neck, deltoid, and ultrasonographically affected arm muscles. RESULTS: Ten patients (83%) experienced neck complaints, mostly pain and muscle weakness. On clinical examination, neck flexors were more often affected than neck extensors. On ultrasound, the sternocleidomastoid was severely atrophic in 8 patients, but abnormal echo intensity was seen in only 3 patients. Electromyography of the neck muscles showed mostly myogenic changes, whereas the deltoid, biceps, and antebrachial flexor muscles seemed to have mostly neurogenic damage. CONCLUSIONS: Many patients previously treated by mantle field radiotherapy develop severe atrophy and weakness of the neck muscles. Neck muscles within the radiation field show mostly myogenic damage, and muscles outside the mantle field show mostly neurogenic damage. The discrepancy between echo intensity and atrophy suggests that muscle damage is most likely caused by an extrinsic factor such as progressive microvascular fibrosis. This is also presumed to cause damage to nerves within the radiated field, resulting in neurogenic damage of the deltoid and arm muscles

Comparison of hyperspectral classification methods for the analysis of cerium oxide nanoparticles in histological and aqueous samples

Hyperspectral imaging (HSI) and classification are established methods that are being applied in new ways to the analysis of nanoscale materials in a variety of matrices. Typically, enhanced darkfield microscopy (EDFM)-based HSI data (also known as image datacubes) are collected in the wavelength range of 400-1000 nm for each pixel in a datacube. Utilising different spectral library (SL) creation methods, spectra from pixels in the datacube corresponding to known materials can be collected into reference spectral libraries (RSLs), which can be used to classify materials in datacubes of experimental samples using existing classification algorithms. In this study, EDFM-HSI was used to visualise and analyse industrial cerium oxide (CeO2; ceria) nanoparticles (NPs) in rat lung tissues and in aqueous suspension. Rats were exposed to ceria NPs via inhalation, mimicking potential real-world occupational exposures. The lung tissues were histologically prepared: some tissues were stained with hematoxylin and eosin (H&E) and some were left unstained. The goal of this study was to determine how HSI and classification results for ceria NPs were influenced by (1) the use of different RSL creation and classification methods and (2) the application of those methods to samples in different matrices (stained tissue, unstained tissue, or aqueous solution). Three different RSL creation methods - particle filtering (PF), manual selection, and spectral hourglass wizard (SHW) - were utilised to create the RSLs of known materials in unstained and stained tissue, and aqueous suspensions, which were then used to classify the NPs in the different matrices. Two classification algorithms - spectral angle mapper (SAM) and spectral feature fitting (SFF) - were utilised to determine the presence or absence of ceria NPs in each sample. The results from the classification algorithms were compared to determine how each influenced the classification results for samples in different matrices. The results showed that sample matrix and sample preparation significantly influenced the NP classification thresholds in the complex matrices. Moreover, considerable differences were observed in the classification results when utilising each RSL creation and classification method for each type of sample. Results from this study illustrate the importance of appropriately selecting HSI algorithms based on specific material and matrix characteristics in order to obtain optimal classification results. As HSI is increasingly utilised for NP characterisation for clinical, environmental and health and safety applications, this investigation is important for further refining HSI protocols while ensuring appropriate data collection and analysis