Bullous hemorrhagic lichen sclerosus of the breast: a report of two cases and review of the literature

Lichen sclerosus (LS) is a chronic dermatologic condition characterized by atrophic porcelain-appearing plaques that can cause intense discomfort and eventually lead to destruction of local architecture. Lichen sclerosus most commonly arises in the anogenital area, but up to 20% of cases can present on extragenital skin. Rarely, LS can also present with hemorrhage and bullae; the mechanism by which this occurs is unknown. We report two cases of bullous hemorrhagic LS of the breast arising in 66-year-old and 77-year-old women. Bullous hemorrhagic LS of the breast is exceedingly rare, with few reported cases, and presents a diagnostic challenge to clinicians

Library Professionals’ Adoption of Cloud Computing Technologies: A Case Study on Kerala University Library, India

The purpose of this paper is to ascertain the awareness and use of cloud computing technologies among the library professionals in the Kerala University Library system, India. A survey was conducted using questionnaire among the 102 library professionals employed in the central and departmental libraries of the University of Kerala. The study revealed that 42.16% of the library professionals did not have much idea about cloud computing technology. Analysis showed that Facebook and Google Apps like Gmail, Google Doc etc are the cloud computing technologies used by majority of the respondents. It is also worth to note that the library professionals in Kerala University Library are using cloud computing technologies without being aware of doing so. Library professionals’ awareness of cloud service models is relatively very low. Web OPAC and Journal Discovery Service are the areas known to the respondents in applying cloud computing technologies in libraries. Out of 102 respondents, 14.71% of the library professionals in the University of Kerala have average skill in using these technologies. The findings of the study throw lights into the need of providing training for the library professionals in handling technology enriched library services to the users

A CLINICAL STUDY TO EVALUATE THE EFFECT OF KARPASASTHYADI TAILA NASYA, PHYSIOTHERAPY AND A COMBINATION OF BOTH IN CERVICAL SPONDYLOSIS

Present era is a period of modernization and fast life. Due to the advancement in life style people undergo many unwanted practices like faulty dietetic habits, improper sitting posture, continuous work in one posture and overexertion, load bearing movements during travelling and sports all these factors create undue pressure and compressive injury to the spine and also responsible for early degenerative changes in bodily tissue which play an important role in producing disease like cervical spondylosis. In this way, this disease is now becoming a significant threat to the working population due to its progressive nature. The Nasya Karma is considered as the best procedure for diseases of head and neck. Physiotherapy provides several benefits in relieving pain and spasm. It can help to maintain the strength of the neck muscles and improve the flexibility of the neck through therapeutic neck exercises and other form of treatment such as manipulation, US, SWD, IFT etc. These two different modes of treatment having its own importance in the management of cervical spondylosis so the present study has been conducted to evaluate the combined effects of these therapies. Results & Conclusion: All the three groups have given a highly significant improvement in reducing the signs and symptoms of cervical spondylosis. While comparing, it was also statistically proved that Nasya along with Physiotherapy is more effective than either Nasya or Physiotherapy alone in reducing the signs and symptoms of cervical spondylosis

Epidemiology of Different Types of Cancers Reported in Basra, Iraq

Objectives: This study aimed to report the incidence and pattern of various types of cancers and their distribution across various demographic groups in Basra, Iraq. Methods: Cancer cases recorded during 2017 at the Basra Cancer Control Centre, the Department of Pathology and Forensic Medicine, the Basra Oncology and Hematology Centre, the Basra Children’s Hospital and at private laboratories were included in the study. Patients’ records were analysed for information related to age, gender, residence and type of cancer. Incidences for different geographical regions and distribution of incidences across age groups were recorded as percentages. The mean age was recorded for patients of different genders and age groups. Incidence rates per 100,000 were calculated for different types of cancer. Results: A total of 2,163 cancer cases were identified of which 2,020 were in adults (93.4%) and 143 were in children (6.6%). Among adults, most cancers were found in females (59%). Patients’ mean age at diagnosis was 51.4 ± 19.6 years for adults and 6.4 ± 4.23 years for children. Cancer incidence rates per 100,000 people increased with age. Breast cancer was the most frequent cancer type found in adult females, with an incidence rate of 60.64 per 100,000 people. The most common types of cancer found in adult males were urinary bladder and lung and bronchus cancers; leukaemia was the most common cancer in children. Conclusion: The findings from this study can be used for predicting cancer epidemiology in Basra, Iraq, and to identify subsets of the population at high risk of cancer incidence. This information will help healthcare providers to adequately respond to the demands of diagnosis, treatment and palliative care for such patients.Keywords: Neoplasms; Incidence; Epidemiology; Demography; Iraq

Surgical anatomy of cervical sympathetic trunk: a cadaveric study

Background: Cervical sympathetic trunk (CST) is at risk of injury during surgical procedures of cervical spine and may result in Horner’s syndrome. The purpose of present study was to clearly describe the surgical anatomy of CST with respect to the surrounding structures and to analyse the anatomical variations.Methods: In this cross-sectional study, 50 cervical sympathetic chains were studied by bilateral neck dissections of 25 formalin fixed human cadavers from the Department of Anatomy, Government medical college Thrissur.Results: Cervical sympathetic chain was found inside the carotid sheath in 1 (2%) side of neck. Superior cervical ganglion (SCG) was consistently seen in all sympathetic chains. Middle cervical ganglion (MCG) was present in 27 (54%) chains studied; vertebral ganglion (VG) was present in 33 (66%) chains. Inferior cervical ganglion (ICG) was present in 38 (76%) CSTs. In case of stellate ganglion (SG), it was present in 12 (24%) chains. The most common type of CST was type 1 consisting of SCG, VG and ICG (17, 34%). Out of 25 cadavers studied, sympathetic chain appeared similar on right and left sides in 14 cadavers.Conclusions: This study concludes that variations occur in cervical sympathetic chain with regard to occurrence and measurements of its ganglia. Our study also emphasizes the need for awareness of the CST’s anatomy during cervical surgical procedures to prevent inadvertent injury to it

A CLINICAL STUDY TO STANDARDIZE THE PROCEDURE OF DHANYAMLA DHARA AND TO ASSESS ITS EFFICACY IN RHEUMATOID ARTHRITIS

In this era of globalization and standardization there is a dire need to arrive at a consensus in the approach to the treatment of the diseases in Ayurveda. It is an essential tool not only for proper understanding of the pathology, appropriate diagnosis, and treatment, but also for scientific documentation and generation evidence for global acceptance and appreciation among the scientific community. Classics clearly demarcate the effects of Sweda as an operative and as a pre-operative/post-operative (or both procedures). Considering the therapeutic importance of one such Swedana modality, study was attempted on standardization of the procedure of Dhanyamla dhara, a form of Parisheka sweda. Based on the references in the classics, the data collected through questionnaires and personal interviews a protocol was developed and it was clinically tested in the disease, Rheumatoid Arthritis. The study was carried out in the Department of Panchakarma, Government Ayurveda College, Tripunithura. Patients diagnosed of Rheumatoid Arthritis (As per American College of Rheumatology revised criteria 1987) under the age group of 16-60 years were selected according to the inclusion criteria and were admitted to the IP Unit. Assessment was done by using clinical parameters (objective and subjective) before treatment and after treatment. The results were statistically analyzed using the most appropriate statistical tests. Significant results were noted in all the clinical parameters such as joint pain, joint swelling, tenderness, general functional capacity signifying the effectiveness of Dhanyamla dhara in improving the clinical features and quality of patients life

Inhibitory compound produced by Pseudomonas with effectiveness on Vibrio harveyi

Persistence of the antivibrio property of the potential antagonistic probiotics, Pseudomonas MCCB 102 and 103, at di¡erent temperatures, pH and in organic solvents was studied. The antivibrio compound was extracted, puri¢ed and characterized using thin-layer chromatography, high-pressure liquid chromatography, liquid chromatography-mass spectroscopy, UV^ Vis and nuclear magnetic resonance spectroscopy and identi¢ed as N-methyl-1-hydroxyphenazine, a phenazine antibiotic. The toxicity of the compound was tested in Penaeus monodon haemocyte culture and the IC50 valuewas found to be1.4 _ 0.31mg L_1. The compound was found to be bacteriostatic at 0.5mg L_1. Its stability to varying temperature, pH, organic solvents, prolonged shelf-life and vibriostatic nature point to its suitability for prophylatic aquaculture application

Caste-specific phenotypic plasticity of Asian weaver ants: Revealing the allometric and non-allometric component of female caste system of Oecophylla smaragdina (Hymenoptera: Formicidae) by using geometric morphometrics

In eusocial insects, particularly in ants, caste differentiation is extremely complicated when we rely on traditional taxonomy. In most species, the worker caste does not display any distinct morphological characters neither the caste’s central division according to their morphological size variations. We used a landmark-based geometric morphometric approach to quantify the morphological characteristics of female caste systems (queen, major and minor worker ant) of Oecophylla smaragdina. Our findings suggested that each caste has its unique shape and size. Especially in the worker caste, apart from the size variations, we can use the shape as a prominent tool for distinguishing between them. The O. smaragdina exhibits a triphasic allometry pattern. Studying the allometry and non-allometry components of each caste system revealed a highly complex size and shape relationship in the female caste systems. From the allometric and non-allometric analysis, we concluded that the major worker ants showed a closer relationship with the queen than the minor worker ant. This outcome demonstrated that Asian weaver ant exhibits complex shape variations related to size and is correlated to their functional modular characters. This research sheds new light on caste systems’ taxonomic uncertainties for eusocial hymenopteran groups, especially ants

Adjuvant chemotherapy with or without bevacizumab in patients with resected non-small-cell lung cancer (E1505): an open-label, multicentre, randomised, phase 3 trial.

BackgroundAdjuvant chemotherapy for resected early-stage non-small-cell lung cancer (NSCLC) provides a modest survival benefit. Bevacizumab, a monoclonal antibody directed against VEGF, improves outcomes when added to platinum-based chemotherapy in advanced-stage non-squamous NSCLC. We aimed to evaluate the addition of bevacizumab to adjuvant chemotherapy in early-stage resected NSCLC.MethodsWe did an open-label, randomised, phase 3 trial of adult patients (aged ≥18 years) with an Eastern Cooperative Oncology Group performance status of 0 or 1 and who had completely resected stage IB (≥4 cm) to IIIA (defined by the American Joint Committee on Cancer 6th edition) NSCLC. We enrolled patients from across the US National Clinical Trials Network, including patients from the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network (ECOG-ACRIN) affiliates in Europe and from the Canadian Cancer Trials Group, within 6-12 weeks of surgery. The chemotherapy regimen for each patient was selected before randomisation and administered intravenously; it consisted of four 21-day cycles of cisplatin (75 mg/m2 on day 1 in all regimens) in combination with investigator's choice of vinorelbine (30 mg/m2 on days 1 and 8), docetaxel (75 mg/m2 on day 1), gemcitabine (1200 mg/m2 on days 1 and 8), or pemetrexed (500 mg/m2 on day 1). Patients in the bevacizumab group received bevacizumab 15 mg/kg intravenously every 21 days starting with cycle 1 of chemotherapy and continuing for 1 year. We randomly allocated patients (1:1) to group A (chemotherapy alone) or group B (chemotherapy plus bevacizumab), centrally, using permuted blocks sizes and stratified by chemotherapy regimen, stage of disease, histology, and sex. No one was masked to treatment assignment, except the Data Safety and Monitoring Committee. The primary endpoint was overall survival, analysed by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00324805.FindingsBetween June 1, 2007, and Sept 20, 2013, 1501 patients were enrolled and randomly assigned to the two treatment groups: 749 to group A (chemotherapy alone) and 752 to group B (chemotherapy plus bevacizumab). 383 (26%) of 1458 patients (with complete staging information) had stage IB, 636 (44%) had stage II, and 439 (30%) had stage IIIA disease (stage of disease data were missing for 43 patients). Squamous cell histology was reported for 422 (28%) of 1501 patients. All four cisplatin-based chemotherapy regimens were used: 377 (25%) patients received vinorelbine, 343 (23%) received docetaxel, 283 (19%) received gemcitabine, and 497 (33%) received pemetrexed. At a median follow-up of 50·3 months (IQR 32·9-68·0), the estimated median overall survival in group A has not been reached, and in group B was 85·8 months (95% CI 74·9 to not reached); hazard ratio (group B vs group A) 0·99 (95% CI 0·82-1·19; p=0·90). Grade 3-5 toxicities of note (all attributions) that were reported more frequently in group B (the bevacizumab group) than in group A (chemotherapy alone) were overall worst grade (ie, all grade 3-5 toxicities; 496 [67%] of 738 in group A vs 610 [83%] of 735 in group B), hypertension (60 [8%] vs 219 [30%]), and neutropenia (241 [33%] vs 275 [37%]). The number of deaths on treatment did not differ between the groups (15 deaths in group A vs 19 in group B). Of these deaths, three in group A and ten in group B were considered at least possibly related to treatment.InterpretationAddition of bevacizumab to adjuvant chemotherapy did not improve overall survival for patients with surgically resected early-stage NSCLC. Bevacizumab does not have a role in this setting and should not be considered as an adjuvant therapy for patients with resected early-stage NSCLC.FundingNational Cancer Institute of the National Institutes of Health

Good Environment Management of cage farming using a coupled 3D hydrodynamic particle tracking model - A case study from Pizhala, Cochin, India

Hydrographic conditions such as water level, velocity, adequate water circulation and stratifications have a strong influence on the management of fish cage culture in the estuarine environment. In this study, a 3D hydrodynamic model was used to identify the areas of the mixed and stratified water column and to use this in conjunction with particle tracking models for appropriate site selection for cage culture. A Lagrangian method was used to simulate the instantaneous release of "particles" emulating discharge from fish cages to show the behaviour of waste in terms of water circulation and water exchange. Model simulation at Pizhala cage farm revealed that desirable water exchange is experienced in the monsoon and pre-monsoon period. There have existed strong spring-neap variability in the water level with an average range of 0.7 m with a speed of < 0.12 m/s in pre-monsoon and < 0.24 m/s in monsoon. This consistent flow patterns in the Pizhala region helps in the replenishment of oxygenated water and removal of waste produced beneath the cages, and it is corroborated by the Lagrangian particle transport model experiment coupled with Finite Volume Community Ocean Model (FVCOM) in the study