3,310 research outputs found

    Unexpected Challenges in Conducting CPE in Hong Kong 2013

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    Supervising a CPE group one did not select in a cultural setting not one’s own is rich with the challenges of diversity. Seeger discovered that the difference that created the most tension was not cultural but religious

    Answering the Call for Scholarship: The Journal of International Crisis and Risk Communication Research

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    Crisis events have the potential to create broad impacts across a variety of contexts and require multi-disciplinary approaches to understand the causes and consequences. Communication is instrumental to both the understanding and the management of risks and crises and needs to be systematically examined within these contexts. The Journal of International Crisis and Risk Communication Research is designed to be an outlet for multi-disciplinary inquiry of communication phenomena within a wide range of crises and risks using multiple methods and perspectives

    Effect of high-K dielectrics on charge transport in graphene

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    The effect of various dielectrics on charge mobility in single layer graphene is investigated. By calculating the remote optical phonon scattering arising from the polar substrates, and combining it with their effect on Coulombic impurity scattering, a comprehensive picture of the effect of dielectrics on charge transport in graphene emerges. It is found that though high-κ\kappa dielectrics can strongly reduce Coulombic scattering by dielectric screening, scattering from surface phonon modes arising from them wash out this advantage. By comparing the room-temperature transport properties with narrow-bandgap III-V semiconductors, strategies to improve the mobility in single layer graphene are outlined.Comment: 6 pages, 4 Figure

    SNAI transcription factors mediate epithelial--mesenchymal transition in lung fibrosis

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    Background: Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterised by accumulation of activated (myo)fibroblasts and excessive extracellular matrix deposition. The enhanced accumulation of (myo)fibroblasts may be attributed, in part, to the process of transforming growth factor \textgreekb1 (TGF\textgreekb1)-induced epithelial--mesenchymal transition (EMT), the phenotypic switching of epithelial to fibroblast-like cells. Although alveolar epithelial type II (ATII) cells have been shown to undergo EMT, the precise mediators and mechanisms remain to be resolved. The objective of this study is to investigate the role of SNAI transcription factors in the process of EMT and in IPF.Methods: Using quantitative reverse transcription-PCR (RT-PCR), immunofluorescence, immunohistochemistry, western blotting, as well as gain- and loss-of-function studies and functional assays, the role of SNAI1 and SNAI2 in TGF\textgreekb1-induced EMT in ATII cells in vitro was assessed; and the expression of SNAI transcription factors was analysed in experimental and human IPF in vivo.Results: TGF\textgreekb1 treatment increased the expression and nuclear accumulation of SNAI1 and SNAI2, in concert with induction of EMT in ATII cells. SNAI overexpression was sufficient to induce EMT, and small interfering RNA (siRNA)-mediated SNAI depletion attenuated TGF\textgreekb1-induced ATII cell migration and EMT. SNAI expression was elevated in experimental and human IPF and localised to hyperplastic ATII cells in vivo.Conclusions: The results demonstrate that TGF\textgreekb1-induced EMT in ATII cells is essentially controlled by the expression and nuclear translocation of SNAI transcription factors. Increased SNAI1 and SNAI2 expression in experimental and human IPF in vivo suggests that SNAI-mediated EMT may contribute to the fibroblast pool in idiopathic pulmonary fibrosis

    Fast Convergent Algorithms for Expectation Propagation Approximate Bayesian Inference

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    We propose a novel algorithm to solve the expectation propagation relaxation of Bayesian inference for continuous-variable graphical models. In contrast to most previous algorithms, our method is provably convergent. By marrying convergent EP ideas from (Opper&Winther 05) with covariance decoupling techniques (Wipf&Nagarajan 08, Nickisch&Seeger 09), it runs at least an order of magnitude faster than the most commonly used EP solver.Comment: 16 pages, 3 figures, submitted for conference publicatio

    Large Scale Variational Inference and Experimental Design for Sparse Generalized Linear Models

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    Many problems of low-level computer vision and image processing, such as denoising, deconvolution, tomographic reconstruction or super-resolution, can be addressed by maximizing the posterior distribution of a sparse linear model (SLM). We show how higher-order Bayesian decision-making problems, such as optimizing image acquisition in magnetic resonance scanners, can be addressed by querying the SLM posterior covariance, unrelated to the density's mode. We propose a scalable algorithmic framework, with which SLM posteriors over full, high-resolution images can be approximated for the first time, solving a variational optimization problem which is convex iff posterior mode finding is convex. These methods successfully drive the optimization of sampling trajectories for real-world magnetic resonance imaging through Bayesian experimental design, which has not been attempted before. Our methodology provides new insight into similarities and differences between sparse reconstruction and approximate Bayesian inference, and has important implications for compressive sensing of real-world images.Comment: 34 pages, 6 figures, technical report (submitted

    Spillover and Cascading Crises in Public Health and Water Systems: The Orlando Liquid Oxygen Shortage

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    In August 2021, COVID cases spiked in Florida with over 24,000 breakthrough cases per day making Florida the state with the highest increase at the time. Florida saw an increase in hospitalized COVID-19 patients during the last two weeks of August and became the 3rd state in the U.S. to exceed 3 million COVID cases. Not only did this impact public health, but it also created an unforeseen impact on the municipal water system. The surge in COVID cases created a surge in demand for treatment, one in which included liquid oxygen, used for respiratory therapy. Without liquid oxygen, ozone cannot be created and without ozone, the drinking water would be limited, leading to discoloration, a smell like rotten eggs, and questions about safety for consumption. Orlando officials issued an advisory requesting that residents reduced their frivolous water usage for at least two weeks. We use the Orlando case to explore the convergence, cascading and overlapping conditions of crises events. We argue that multiple events, interacting and overlapping will become increasingly common

    Report of the panel on international programs

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    The panel recommends that NASA participate and take an active role in the continuous monitoring of existing regional networks, the realization of high resolution geopotential and topographic missions, the establishment of interconnection of the reference frames as defined by different space techniques, the development and implementation of automation for all ground-to-space observing systems, calibration and validation experiments for measuring techniques and data, the establishment of international space-based networks for real-time transmission of high density space data in standardized formats, tracking and support for non-NASA missions, and the extension of state-of-the art observing and analysis techniques to developing nations
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