Site amplification estimates in the Garigliano valley, central Italy, based on dense array measurements of ambient noise

A frequency-domain formulation of the Aki (1957, 1965) autocorrelation method has been applied to seismic noise recorded by a 100-m wide circular array deployed on soft Holocene sediments in the Garigliano river valley, where a large amplification of ground motion during earthquakes was experienced (Rovelli et al., 1988). The application of this method to ambient noise recordings demonstrates that microtremors in the valley are dispersive and dominated by surface waves. By assuming that the vertical component reflects Rayleigh wave motion, we obtain a dispersion curve that is interpreted in terms of a layered shear-wave velocity structure. Layer thicknesses are constrained by the stratigraphic information provided by a deep hole drilled in the area, and shear velocities are estimated by means of a trial-and-error approach to achieve a satisfactory fit of the ambient noise dispersion. The best-fit velocity model is used to compute a theoretical transfer function, which is then compared with an average spectral ratio obtained from earthquake weak ground motions recorded at two stations, one in the valley and the other on a limestone reference site. An overall agreement is found between the theoretical curve and the observed spectral ratios. The discrepancies that do exist may be ascribed to the assumption of 1-D inhomogeneity which considerably simplifies the theoretical transfer function. Our results show that the spatial-correlation method can be useful to infer velocity structure down to depths of hundreds of meters, when generalized geological informations are available, and can thus provide useful constraints for theoretical methodologies for the prediction of site response

Ferredoxin-NADP(+) reductase from Plasmodium falciparum undergoes NADP(+)-dependent dimerization and inactivation: functional and crystallographic analysis

The completion of the Plasmodium falciparum genome sequence has recently promoted the search for new antimalarial drugs. More specifically, metabolic pathways of the apicoplast, a key organelle for survival of the parasite, have been recognized as potential targets for the development of specific new antimalarial agents. As most apicomplexan parasites, P. falciparum displays a plant-type ferredoxin-NADP(+) reductase, yielding reduced ferredoxin for essential biosynthetic pathways in the apicoplast. Here we report a molecular, kinetic and ligand binding characterization of the recombinant ferredoxin-NADP(+) reductase from P. falciparum, in the light of current data available for plant ferredoxin-NADP(+) reductases. In parallel with the functional characterization, we describe the crystal structures of P. falciparum ferredoxin-NADP(+) reductase in free form and in complex with 2'-phospho-AMP (at 2.4 and 2.7 A resolution, respectively). The enzyme displays structural properties likely to be unique to plasmodial reductases. In particular, the two crystal structures highlight a covalent dimer, which relies on the oxidation of residue Cys99 in two opposing subunits, and a helix-coil transition that occurs in the NADP-binding domain, triggered by 2'-phospho-AMP binding. Studies in solution show that NADP(+), as well as 2'-phospho-AMP, promotes the formation of the disulfide-stabilized dimer. The isolated dimer is essentially inactive, but full activity is recovered upon disulfide reduction. The occurrence of residues unique to the plasmodial enzyme, and the discovery of specific conformational properties, highlight the NADP-binding domain of P. falciparum ferredoxin-NADP(+) reductase as particularly suited for the rational development of antimalarial compounds

Incidence, Disease Severity, and Follow-Up of Influenza A/A, A/B, and B/B Virus Dual Infections in Children: A Hospital-Based Digital Surveillance Program

Influenza virus (IV) coinfection, i.e., simultaneous infection with IV and other viruses, is a common occurrence in humans. However, little is known about the incidence and clinical impact of coinfection with two different IV subtypes or lineages (“dual infections”). We report the incidence, standardized disease severity, and follow-up of IV dual infections from a hospital-based digital surveillance cohort, comprising 6073 pediatric patients fulfilling pre-defined criteria of influenza-like illness in Berlin, Germany. All patients were tested for IV A/B by PCR, including subtypes/lineages. We assessed all patients at the bedside using the mobile ViVI ScoreApp, providing a validated disease severity score in real-time. IV-positive patients underwent follow-up assessments until resolution of symptoms. Overall, IV dual infections were rare (4/6073 cases; 0.07%, incidence 12/100,000 per year) but showed unusual and/or prolonged clinical presentations with slightly above-average disease severity. We observed viral rebound, serial infection, and B/Yamagata-B/Victoria dual infection. Digital tools, used for instant clinical assessments at the bedside, combined with baseline/follow-up virologic investigation, help identify coinfections in cases of prolonged and/or complicated course of illness. Infection with one IV does not necessarily prevent consecutive or simultaneous (co-/dual) infection, highlighting the importance of multivalent influenza vaccination and enhanced digital clinical and virological surveillance.Peer Reviewe

170 Nanometer Nuclear Magnetic Resonance Imaging using Magnetic Resonance Force Microscopy

We demonstrate one-dimensional nuclear magnetic resonance imaging of the semiconductor GaAs with 170 nanometer slice separation and resolve two regions of reduced nuclear spin polarization density separated by only 500 nanometers. This is achieved by force detection of the magnetic resonance, Magnetic Resonance Force Microscopy (MRFM), in combination with optical pumping to increase the nuclear spin polarization. Optical pumping of the GaAs creates spin polarization up to 12 times larger than the thermal nuclear spin polarization at 5 K and 4 T. The experiment is sensitive to sample volumes containing $\sim 4 \times 10^{11}$ $^{71}$Ga$/\sqrt{Hz}$. These results demonstrate the ability of force-detected magnetic resonance to apply magnetic resonance imaging to semiconductor devices and other nanostructures.Comment: Submitted to J of Magnetic Resonanc

Degradation mechanisms and consequences for SOC stocks for the world's largest alpine pastoral ecosystem on the Tibetan Plateau

Approximately 1.5 million km² of the Tibetan Plateau are covered with grasslands. Thereof one third is occupied by the world’s largest pastoral alpine ecosystem (Kobresia pastures). Paleo-records indicate the grazing-induced origin of this ecosystem since more than 8000 years or at least since yak domestication since 4000 years. Long-term moderate grazing by yak and sheep increased belowground C allocation of Kobresia pygmaea, caused the development of dense root-mats and finally lead to an accumulation of soil organic carbon (SOC) and nutrients such as nitrogen (N) and phosphorus (P) in the topsoil. These pastures, however, are increasingly affected by large-scale degradation caused by overgrazing of these highly sensitive ecosystems. Loss of the topsoil threatens several ecosystem functions: i.e. SOC and nutrient storage, biodiversity, provision of grazing-ground and supply of clean water for large parts of SE-Asia. Here, we present a conceptual model and results of degradation processes combining anthropogenic and natural amplifications. To evaluate losses of SOC and nutrients we synthesize field observations and surveys in the highlands and validates this with own analyses in the Kobresia core area. We show that drought- and frost-induced polygonal cracking opens the root-mats, already weakened by overgrazing. This initiates a dying of the Kobresia turf, extends the surface cracks, triggers soil erosion and promotes SOC mineralization and leaching losses. Soil erosion caused further high losses of SOC and nutrients from the topsoil (i.e. 0-10 cm: ~5.1 kg C m-2), whereas SOC loss beneath the surface cracks was primary caused by both, decreasing C-input and SOC mineralization (mineralization-derived SOC loss: ~2.5 kg C m-2). The root biomass decreased with intensity of pasture degradation and lower C input constrains the ecosystem recovery. A negative δ13C shift of SOC reflected intensive decomposition and corresponded to a relative enrichment of 13C depleted lignin components. In sum, degradation triggered high SOC loss (up to 70% of intact soil in 0-30 cm: ~7.6 kg C m-2) from this ecosystem with profound consequences for carbon sequestration, atmospheric CO2, water quality and ecosystem stability

Back-arc extension in the Andaman Sea: Tectonic and magmatic processes imaged by high-precision teleseismic double-difference earthquake relocation

The geometry, kinematics, and mode of back-arc extension along the Andaman Sea plate boundary are refined using a new set of significantly improved hypocenters, global centroid moment tensor (CMT) solutions, and high-resolution bathymetry. By applying cross-correlation and double-difference (DD) algorithms to regional and teleseismic waveforms and arrival times from International Seismological Centre and National Earthquake Information Center bulletins (1964–2009), we resolve the fine-scale structure and spatiotemporal behavior of active faults in the Andaman Sea. The new data reveal that back-arc extension is primarily accommodated at the Andaman Back-Arc Spreading Center (ABSC) at ~10°, which hosted three major earthquake swarms in 1984, 2006, and 2009. Short-term spreading rates estimated from extensional moment tensors account for less than 10% of the long-term 3.0–3.8 cm/yr spreading rate, indicating that spreading by intrusion and the formation of new crust make up for the difference. A spatiotemporal analysis of the swarms and Coulomb-stress modeling show that dike intrusions are the primary driver for brittle failure in the ABSC. While spreading direction is close to ridge normal, it is oblique to the adjacent transforms. The resulting component of E-W extension across the transforms is expressed by deep basins on either side of the rift and a change to extensional faulting along the West Andaman fault system after the Mw = 9.2 Sumatra-Andaman earthquake of 2004. A possible skew in slip vectors of earthquakes in the eastern part of the ABSC indicates an en-echelon arrangement of extensional structures, suggesting that the present segment geometry is not in equilibrium with current plate-motion demands, and thus the ridge experiences ongoing re-adjustment

Quantum Heisenberg antiferromagnet on low-dimensional frustrated lattices

Using a lattice-gas description of the low-energy degrees of freedom of the quantum Heisenberg antiferromagnet on the frustrated two-leg ladder and bilayer lattices we examine the magnetization process at low temperatures for these spin models. In both cases the emergent discrete degrees of freedom implicate a close relation of the frustrated quantum Heisenberg antiferromagnet to the classical lattice gas with finite nearest-neighbor repulsion or, equivalently, to the Ising antiferromagnet in a uniform magnetic field. Using this relation we obtain analytical results for thermodynamically large systems in the one-dimensional case. In the two-dimensional case we perform classical Monte Carlo simulations for systems of up to $100 \times 100$ sites.Comment: Submitted to Teoreticheskaya i Matematicheskaya Fizika (special issue dedicated to the 90th anniversary of Professor Sergei Vladimirovich Tyablikov

Accuracy analysis of vertical deflection data observed with the Hannover Digital Zenith Camera System TZK2-D

This paper analyses the accuracy of vertical deflection measurements carried out with the Digital Zenith Camera System TZK2-D, an astrogeodetic state-of-the-art instrumentation developed at the University of Hannover. During 107 nights over a period of 3.5 years, the system was used for repeated vertical deflection observations at a selected station in Hannover. The acquired data set consists of about 27,300 single measurements and covers 276 h of observation time, respectively. For the data collected at an earlier stage of development (2003 to 2004), the accuracy of the nightly mean values has been found to be about 0".10-0".12. Due to applying a refined observation strategy since 2005, the accuracy of the vertical deflection measurements was enhanced into the unprecedented range of 0".05-0".08. Accessing the accuracy level of 0".05 requires usually 1 h of observational data, while the 0".08 accuracy level is attained after 20 min measurement time. In comparison to the analogue era of geodetic astronomy, the accuracy of vertical deflection observations is significantly improved by about one order of magnitude

Understanding the Digital Companions of Our Future Generation

The main protagonist in Kazuo Ishiguro’s latest novel is Klara, an artificial friend whose existential goal is to be children’s companion. Some aspects of this fictional narrative have begun to gradually enter our daily lives. Products reminiscent of Klara are available abundantly on the market: smart toys, adaptive learning applications, and companion robots. Children can relate to these products and perform activities together with them. Preliminary research has shown fundamental differences between existing technologies and these emerging children’s digital companions. However, we still do not know much about their benefits and risks. This paper explores different and even contradicting perspectives on the phenomenon. We present the discussion from four perspectives - temporality, use, trust and ethics, and sociotechnical design - and conclude the paper with an agenda for interdisciplinary IS research. The agenda points to the needs for a psychological, medical, engineering, and temporal research community to understand this emerging sociotechnical phenomenon and design its future for the better