Ancestry-related assortative mating in Latino populations

Examination of ancestry-informative genetic markers shows that Puerto Rican and Mexican populations have shown strong assortative mating that continues to this day

Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset

<p>Abstract</p> <p>Background</p> <p>When selecting mates, many vertebrate species seek partners with major histocompatibility complex (MHC) genes different from their own, presumably in response to selective pressure against inbreeding and towards MHC diversity. Attempts at replication of these genetic results in human studies, however, have reached conflicting conclusions.</p> <p>Results</p> <p>Using a multi-analytical strategy, we report validated genome-wide relationships between genetic identity and human mate choice in 930 couples of European ancestry. We found significant similarity between spouses in the MHC at class I region in chromosome 6p21, and at the odorant receptor family 13 locus in chromosome 9. Conversely, there was significant dissimilarity in the MHC class II region, near the <it>HLA-DQA1 </it>and -<it>DQB1 </it>genes. We also found that genomic regions with significant similarity between spouses show excessive homozygosity in the general population (assessed in the HapMap CEU dataset). Conversely, loci that were significantly dissimilar among spouses were more likely to show excessive heterozygosity in the general population.</p> <p>Conclusions</p> <p>This study highlights complex patterns of genomic identity among partners in unrelated couples, consistent with a multi-faceted role for genetic factors in mate choice behavior in human populations.</p

Predictors of pathologic outcome of focal FDG uptake in the parotid gland identified on whole-body FDG PET imaging

PURPOSE: To test whether patient's primary malignancy type and presence of FDG-avid cervical lymph node(s) are predictors of pathologic outcome of incidental focal FDG-avid parotid lesions. BASIC PROCEDURES: Retrospective cohort study of pathologically proven incidental cases. MAIN FINDINGS: Focal parotid FDG uptake in the setting of head and neck cancer/melanoma(OR=24.6,p<0.01), lymphoma(OR=7.2,p=0.02), or FDG-avid cervical lymph node(s)(OR=3.6,p=0.07) has a higher odds of representing metastases. No malignant primary parotid tumors were incidentally discovered. PRINCIPAL CONCLUSIONS: In patients with head and neck cancer/melanoma, lymphoma, or FDG-avid cervical lymph node(s) there was a higher odds that focal parotid FDG uptake was a metastasis

Association between Variants of the Leptin Receptor Gene (LEPR) and Overweight: A Systematic Review and an Analysis of the CoLaus Study

BACKGROUND: Three non-synonymous single nucleotide polymorphisms (Q223R, K109R and K656N) of the leptin receptor gene (LEPR) have been tested for association with obesity-related outcomes in multiple studies, showing inconclusive results. We performed a systematic review and meta-analysis on the association of the three LEPR variants with BMI. In addition, we analysed 15 SNPs within the LEPR gene in the CoLaus study, assessing the interaction of the variants with sex. METHODOLOGY/PRINCIPAL FINDINGS: We searched electronic databases, including population-based studies that investigated the association between LEPR variants Q223R, K109R and K656N and obesity- related phenotypes in healthy, unrelated subjects. We furthermore performed meta-analyses of the genotype and allele frequencies in case-control studies. Results were stratified by SNP and by potential effect modifiers. CoLaus data were analysed by logistic and linear regressions and tested for interaction with sex. The meta-analysis of published data did not show an overall association between any of the tested LEPR variants and overweight. However, the choice of a BMI cut-off value to distinguish cases from controls was crucial to explain heterogeneity in Q223R. Differences in allele frequencies across ethnic groups are compatible with natural selection of derived alleles in Q223R and K109R and of the ancient allele in K656N in Asians. In CoLaus, the rs10128072, rs3790438 and rs3790437 variants showed interaction with sex for their association with overweight, waist circumference and fat mass in linear regressions. CONCLUSIONS: Our systematic review and analysis of primary data from the CoLaus study did not show an overall association between LEPR SNPs and overweight. Most studies were underpowered to detect small effect sizes. A potential effect modification by sex, population stratification, as well as the role of natural selection should be addressed in future genetic association studies

The chronopolitics of exile: Hope, heterotemporality and NGO economics along the Thai-Burma border

In this article, we foreground chronopolitics – the politics of time – to examine the ways in which the heterotemporalities of Burmese exiles living in nine “temporary shelters” along the Thai–Burma (Myanmar) border mediate one of the most protracted displacement situations in the world. The imminent repatriation of these Burmese exiles, tens of thousands of whom have been waiting for decades to be resettled to an often elusive third country or to return to a peaceful Burma, has given way to a preeminent “crisis of hope.” The perception that the camps are “out of time” has diverted critical funding streams away from border-related issues and into Burma itself, which has led to a widespread shift in focus for thousands of NGOs in the region. It is within this temporal and spatial context that we argue that the political economy of hope is deeply entangled in the geoeconomics of Burma’s “opening up” to systems of global capital. The forestalled realizations of exiles’ hopes and potential futures are inextricably linked to not only geoeconomic change but also to the shifting foci of NGOs and stakeholders in the region towards liberalization policies and projects in Burma and away from Burma’s exile populations. In this way, along Thai–Burma border, the political economy of hope articulates with chronopolitics in ways that shed new light on the politics and temporalities of refugeedom

Surplus precaritization:supply chain capitalism and the geoeconomics of hope in Myanmar’s borderlands

Abstract The Thai-Myanmar border represents one of the most protracted displacement situations in the world, while the Myanmar-Bangladesh border is now home to nearly one million displaced Rohingya, making it the world’s most populated refugee camp. During the period of “democratic transition,” pre-emptively terminated by the February 2021 military coup, foreign direct investment continued to flow into Myanmar despite ongoing humanitarian crises. Rather than being presented as exacerbating ethnic tension, economic development was frequently deployed as a panacea for conflict in ways that rendered borderland residents increasingly precarious. In this article, we draw on multi-sited ethnographic research carried out between 2014 and 2020 in Myanmar’s borderlands and along the China-Myanmar Economic Corridor to examine how aid donors’ support for displaced ethnic minority populations is supplanted by widespread geoeconomic hope for the ameliorating effects of capitalism. We home in on the role of aid flight, special economic zones, and China’s Belt and Road Initiative to argue that geoeconomic hope surrounding Myanmar’s deepening integration into circuits of global capital obscures processes of surplus precaritization in which populations progressively approach the point at which they become absolutely surplus or beyond reabsorption into labor markets. The article contributes to emerging scholarship on migrant labor exploitation, supply-chain capitalism and the geoeconomics of BRI in Myanmar’s borderlands and beyond