Paying for Pensions and Other Public Expenditures: Overtaxing our Children?

This paper argues that although current public pension schemes may shift the major financial burden to future generations, private and public transfers of wealth across generations offset this development. As a result the financing of existing social security and pension arrangements seems to be less problematic than commonly assumed.Policy models that assume there is no linkage between generations except through the state bear little resemblance to empirical reality. An accounting system is therefore needed which highlights the allocation of retirement costs among working and retired population as well as future generations, and includes the public as well as private ledger.Many of the aformentioned features are included in the well-established practice of âGenerational Accountingâ. This paper, however, will integrate private as well as public intergenerational transfers of wealth so as to account not only for the burden, which current generations leave, but also the wealth, which is passed on to future generations.Economics ;

Biological activity of a genetically modified BMP-2 variant with inhibitory activity

<p>Abstract</p> <p>Background</p> <p>Alterations of the binding epitopes of bone morphogenetic protein-2 (BMP-2) lead to a modified interaction with the ectodomains of BMP receptors. In the present study the biological effect of a BMP-2 double mutant with antagonistic activity was evaluated in vivo.</p> <p>Methods</p> <p>Equine-derived collagenous carriers were loaded with recombinant human BMP-2 (rhBMP-2) in a well-known dose to provide an osteoinductive stimulus. The study was performed in a split animal design: carriers only coupled with rhBMP-2 (control) were implanted into prepared cavities of lower limb muscle of rats, specimens coupled with rhBMP-2 as well as BMP-2 double mutant were placed into the opposite limb in the same way. After 28 days the carriers were explanted, measured radiographically and characterized histologically.</p> <p>Results</p> <p>As expected, the BMP-2 loaded implants showed a typical heterotopic bone formation. The specimens coupled with both proteins showed a significant decreased bone formation in a dose dependent manner.</p> <p>Conclusion</p> <p>The antagonistic effect of a specific BMP-2 double mutant could be demonstrated in vivo. The dose dependent influence on heterotopic bone formation by preventing rhBMP-2 induced osteoinduction suggests a competitive receptor antagonism.</p

Understanding Experimental Economics

Experiments have become a well-established methodological tool in economics. e development of experi- mental economics and the diversi cation of experimental methods have equipped economists with new and powerful means of scienti c investigation. eir worth is readily demonstrated in the exciting and promising results they have produced, and will continue to produce. Against the background of this success story, our selective discussion critically highlights four important aspects of experimentation in economics. We concen- trate on the role and importance of material incentives, potentially confounding experimenter demand e ects and strategies to minimise these, the no deception rule as well as the issue of external validity.

GDF-5 can act as a context-dependent BMP-2 antagonist

Background Bone morphogenetic protein (BMP)-2 and growth and differentiation factor (GDF)-5 are two related transforming growth factor (TGF)-β family members with important functions in embryonic development and tissue homeostasis. BMP-2 is best known for its osteoinductive properties whereas GDF-5—as evident from its alternative name, cartilage derived morphogenetic protein 1—plays an important role in the formation of cartilage. In spite of these differences both factors signal by binding to the same subset of BMP receptors, raising the question how these different functionalities are generated. The largest difference in receptor binding is observed in the interaction with the type I receptor BMPR-IA. GDF-5, in contrast to BMP-2, shows preferential binding to the isoform BMPR-IB, which is abrogated by a single amino acid (A57R) substitution. The resulting variant, GDF-5 R57A, represents a “BMP-2 mimic” with respect to BMP receptor binding. In this study we thus wanted to analyze whether the two growth factors can induce distinct signals via an identically composed receptor. Results Unexpectedly and dependent on the cellular context, GDF-5 R57A showed clear differences in its activity compared to BMP-2. In ATDC-5 cells, both ligands induced alkaline phosphatase (ALP) expression with similar potency. But in C2C12 cells, the BMP-2 mimic GDF-5 R57A (and also wild-type GDF-5) clearly antagonized BMP-2-mediated ALP expression, despite signaling in both cell lines occurring solely via BMPR-IA. The BMP-2- antagonizing properties of GDF-5 and GDF-5 R57A could also be observed in vivo when implanting BMP-2 and either one of the two GDF-5 ligands simultaneously at heterotopic sites. Conclusions Although comparison of the crystal structures of the GDF-5 R57A:BMPR-IAEC- and BMP-2:BMPR-IAEC complex revealed small ligand-specific differences, these cannot account for the different signaling characteristics because the complexes seem identical in both differently reacting cell lines. We thus predict an additional component, most likely a not yet identified GDF-5-specific co-receptor, which alters the output of the signaling complexes. Hence the presence or absence of this component then switches GDF-5′s signaling capabilities to act either similar to BMP-2 or as a BMP-2 antagonist. These findings might shed new light on the role of GDF-5, e.g., in cartilage maintenance and/or limb development in that it might act as an inhibitor of signaling events initiated by other BMPs

Application of Copernicus Data for Climate-Relevant Urban Planning Using the Example of Water, Heat, and Vegetation

Specific climate adaptation and resilience measures can be efficiently designed and implemented at regional and local levels. Climate and environmental databases are critical for achieving the sustainable development goals (SDGs) and for efficiently planning and implementing appropriate adaptation measures. Available federated and distributed databases can serve as necessary starting points for municipalities to identify needs, prioritize resources, and allocate investments, taking into account often tight budget constraints. High-quality geospatial, climate, and environmental data are now broadly available and remote sensing data, e.g., Copernicus services, will be critical. There are forward-looking approaches to use these datasets to derive forecasts for optimizing urban planning processes for local governments. On the municipal level, however, the existing data have only been used to a limited extent. There are no adequate tools for urban planning with which remote sensing data can be merged and meaningfully combined with local data and further processed and applied in municipal planning and decision-making. Therefore, our project CoKLIMAx aims at the development of new digital products, advanced urban services, and procedures, such as the development of practical technical tools that capture different remote sensing and in-situ data sets for validation and further processing. CoKLIMAx will be used to develop a scalable toolbox for urban planning to increase climate resilience. Focus areas of the project will be water (e.g., soil sealing, stormwater drainage, retention, and flood protection), urban (micro)climate (e.g., heat islands and air flows), and vegetation (e.g., greening strategy, vegetation monitoring/vitality). To this end, new digital process structures will be embedded in local government to enable better policy decisions for the future