Mentoring to Grow Library Leaders

Article discussing mentoring and growing library leaders

ACE Data from the ACE Science Center

The purpose of the ACE Science Center (ASC) is to perform level 1 processing of data from the nine science instruments aboard the Advanced Composition Explorer (ACE) spacecraft and to facilitate access to all ACE data by both the instrument investigators and the space physics community. We describe the ACE data products available from the ASC and the methods by which users may access the data

Incoherent dynamics in neutron-matter interaction

Coherent and incoherent neutron-matter interaction is studied inside a recently introduced approach to subdynamics of a macrosystem. The equation describing the interaction is of the Lindblad type and using the Fermi pseudopotential we show that the commutator term is an optical potential leading to well-known relations in neutron optics. The other terms, usually ignored in optical descriptions and linked to the dynamic structure function of the medium, give an incoherent contribution to the dynamics, which keeps diffuse scattering and attenuation of the coherent beam into account, thus warranting fulfilment of the optical theorem. The relevance of this analysis to experiments in neutron interferometry is briefly discussed.Comment: 15 pages, revtex, no figures, to appear in Phys. Rev.

Room temperature writing of electrically conductive and insulating zones in silicon by nanoindentation

Conventional silicon devices are fabricated in the diamond cubic phase of silicon, so-called Si-I. Other phases of silicon such as Si-XII and Si-III can be formed under pressure applied by nanoindentation and these phases are metastable at room temperature and pressure. We demonstrate in this letter that such phases exhibit different electrical properties to normal (diamond cubic) silicon and exploit this to perform maskless, room temperature, electrical patterning of silicon by writing both conductive and insulating zones directly into silicon substrates by nanoindentation. Such processing opens up a number of potentially new applications without the need for high temperature processing steps.The authors gratefully acknowledge financial support from the Australian Research Council Grant No. DP0879940

Effects of Process Variables and Size Scale on Solidification Microstructure in Laser-Based Solid Freeform Fabrication of Ti-6Al-4V

Mechanical Engineerin

Observer with a constant proper acceleration

Relying on the equivalence principle, a first approach of the general theory of relativity is presented using the spacetime metric of an observer with a constant proper acceleration. Within this non inertial frame, the equation of motion of a freely moving object is studied and the equation of motion of a second accelerated observer with the same proper acceleration is examined. A comparison of the metric of the accelerated observer with the metric due to a gravitational field is also performed.Comment: 5 figure

Nuclear Incompressibility in Asymmetric Systems at Finite Temperature and Entropy

The nuclear incompressibility $\kappa$ is investigated in asymmetric systems in a mean field model. The calculations are done at zero and finite temperatures and include surface, Coulomb and symmetry energy terms for several equations of state. Also considered is the behavior of the incompressibility at constant entropy $kappa_Q$ which is shown to have a very different behavior than the isothermal $kappa$. Namely, $kappa_Q$ decreases with increasing entropy while the isothermal $kappa$ increases with increasing $T$. A duality is found between the adiabatic $kappa_Q$ and the T=0 isothermal $kappa$. Analytic and also simple approximate expressions for $kappa$ are given.Comment: 11 page

Recognition of DNA Termini by the C-Terminal Region of the Ku80 and the DNA-Dependent Protein Kinase Catalytic Subunit

DNA double strand breaks (DSBs) can be generated by endogenous cellular processes or exogenous agents in mammalian cells. These breaks are highly variable with respect to DNA sequence and structure and all are recognized in some context by the DNA-dependent protein kinase (DNA-PK). DNA-PK is a critical component necessary for the recognition and repair of DSBs via non-homologous end joining (NHEJ). Previously studies have shown that DNA-PK responds differentially to variations in DSB structure, but how DNA-PK senses differences in DNA substrate sequence and structure is unknown. Here we explore the enzymatic mechanisms by which DNA-PK is activated by various DNA substrates and provide evidence that the DNA-PK is differentially activated by DNA structural variations as a function of the C-terminal region of Ku80. Discrimination based on terminal DNA sequence variations, on the other hand, is independent of the Ku80 C-terminal interactions and likely results exclusively from DNA-dependent protein kinase catalytic subunit interactions with the DNA. We also show that sequence differences in DNA termini can drastically influence DNA repair through altered DNA-PK activation. These results indicate that even subtle differences in DNA substrates influence DNA-PK activation and ultimately the efficiency of DSB repair

Using state space differential geometry for nonlinear blind source separation

Given a time series of multicomponent measurements of an evolving stimulus, nonlinear blind source separation (BSS) seeks to find a "source" time series, comprised of statistically independent combinations of the measured components. In this paper, we seek a source time series with local velocity cross correlations that vanish everywhere in stimulus state space. However, in an earlier paper the local velocity correlation matrix was shown to constitute a metric on state space. Therefore, nonlinear BSS maps onto a problem of differential geometry: given the metric observed in the measurement coordinate system, find another coordinate system in which the metric is diagonal everywhere. We show how to determine if the observed data are separable in this way, and, if they are, we show how to construct the required transformation to the source coordinate system, which is essentially unique except for an unknown rotation that can be found by applying the methods of linear BSS. Thus, the proposed technique solves nonlinear BSS in many situations or, at least, reduces it to linear BSS, without the use of probabilistic, parametric, or iterative procedures. This paper also describes a generalization of this methodology that performs nonlinear independent subspace separation. In every case, the resulting decomposition of the observed data is an intrinsic property of the stimulus' evolution in the sense that it does not depend on the way the observer chooses to view it (e.g., the choice of the observing machine's sensors). In other words, the decomposition is a property of the evolution of the "real" stimulus that is "out there" broadcasting energy to the observer. The technique is illustrated with analytic and numerical examples.Comment: Contains 14 pages and 3 figures. For related papers, see http://www.geocities.com/dlevin2001/ . New version is identical to original version except for URL in the bylin

MYC is not detected in highly proliferating normal spermatogonia but is coupled with CIP2A in testicular cancers

High MYC expression is linked to proliferative activity in most normal tissues and in cancer. MYC also supports self-renewal and proliferation of many types of tissue progenitor cells. Cancerous inhibitor of PP2A (CIP2A) promotes MYC phosphorylation and activity during intestinal crypt regeneration in vivo and in various cancers. CIP2A also supports male germ cell proliferation in vivo. However, the role of MYC in normal germ cell proliferation and spermatogonial progenitor self-renewal is currently unclear.  Here, we demonstrate that male germ cells are CIP2A-positive but lack detectable levels of MYC protein; whereas MYC is highly expressed in Leydig cells and peritubular myoid cells contributing thereby to the testicular stem cell niche. On the other hand,  MYC was co-expressed with CIP2A in testicular cancers. These results demonstrate that CIP2A and MYC are spatially uncoupled in the regulation of spermatogenesis, but functional relationship between these two human oncoproteins is established during testicular cancer transformation. We propose that further analysis of mechanisms of MYC silencing in spermatogonial progenitors may reveal novel fundamental information relevant to understanding of MYC expression in cancer. </p