J/Psi Production from Electromagnetic Fragmentation in Z decay

The rate for $Z^{0}\to J/ \psi + \ell^{+}\ell^{-}$ is suprisingly large with about one event for every million $Z^{0}$ decays. The reason for this is that there is a fragmentation contribution that is not suppressed by a factor of $M^{2}_{\psi}/M^{2}_{Z}$. In the fragmentation limit $M_{Z}\to\infty$ with $E_{\psi}/M_{Z}$ fixed, the differential decay rate for $Z^{0}\to J/ \psi + \ell^{+}\ell^{-}$ factors into electromagnetic decay rates and universal fragmentation functions. The fragmentation functions for lepton fragmentation and photon fragmentation into $J/\psi$ are calculated to lowest order in $\alpha$. The fragmentation approximation to the rate is shown to match the full calculation for $E_{\psi}$ greater than about $3 M_{\psi}$.Comment: 16 pages and 8 figure

The role of the emergency department in the management of acute heart failure: an international perspective on education and research

Emergency departments are a major entry point for the initial management of acute heart failure (AHF) patients throughout the world. The initial diagnosis, management and disposition - the decision to admit or discharge - of AHF patients in the emergency department has significant downstream implications. Misdiagnosis, under or overtreatment, or inappropriate admission may place patients at increased risk for adverse events, and add costs to the healthcare system. Despite the critical importance of initial management, data are sparse regarding the impact of early AHF treatment delivered in the emergency department compared to inpatient or chronic heart failure management. Unfortunately, outcomes remain poor, with nearly a third of patients dying or re-hospitalised within 3 months post-discharge. In the absence of robust research evidence, consensus is an important source of guidance for AHF care. Thus, we convened an international group of practising emergency physicians, cardiologists and advanced practice nurses with the following goals to improve outcomes for AHF patients who present to the emergency department or other acute care setting through: (a) a better understanding of the pathophysiology, presentation and management of the initial phase of AHF care; (b) improving initial management by addressing knowledge gaps between best practices and current practice through education and research; and (c) to establish a framework for future emergency department-based international education and research

Leptoproduction of J/psi

We study leptoproduction of $J/\psi$ at large $Q^2$ within the nonrelativistic QCD (NRQCD) factorization formalism. The cross section is dominated by color-octet terms that are of order $\alpha_s$. The color-singlet term, which is of order $\alpha^2_s$, is shown to be a small contribution to the total cross section. We also calculate the tree diagrams for color-octet production at order $\alpha^2_s$ in a region of phase space where there is no leading color-octet contribution. We find that in this regime the color-singlet contribution dominates. We argue that non-perturbative corrections arising from diffractive leptoproduction, higher twist effects, and higher order terms in the NRQCD velocity expansion should be suppressed as $Q^2$ is increased. Therefore, the color-octet matrix elements $$and$$ can be reliably extracted from this process. Finally, we point out that an experimental measurement of the polarization of leptoproduced $J/\psi$ will provide an excellent test of the NRQCD factorization formalism.Comment: 33 pages latex. 10 figures. Uses revtex, epsf, and rotate macros. This paper is also available via the UW phenomenology archives at http://phenom.physics.wisc.edu/pub/preprints

Predictors of multidomain decline in health‐related quality of life after stereotactic body radiation therapy (SBRT) for prostate cancer

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/136687/1/cncr30519_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136687/2/cncr30519.pd

Genome-Wide Analysis of Menin Binding Provides Insights into MEN1 Tumorigenesis

Multiple endocrine neoplasia type I (MEN1) is a familial cancer syndrome characterized primarily by tumors of multiple endocrine glands. The gene for MEN1 encodes a ubiquitously expressed tumor suppressor protein called menin. Menin was recently shown to interact with several components of a trithorax family histone methyltransferase complex including ASH2, Rbbp5, WDR5, and the leukemia proto-oncoprotein MLL. To elucidate menin's role as a tumor suppressor and gain insights into the endocrine-specific tumor phenotype in MEN1, we mapped the genomic binding sites of menin, MLL1, and Rbbp5, to approximately 20,000 promoters in HeLa S3, HepG2, and pancreatic islet cells using the strategy of chromatin-immunoprecipitation coupled with microarray analysis. We found that menin, MLL1, and Rbbp5 localize to the promoters of thousands of human genes but do not always bind together. These data suggest that menin functions as a general regulator of transcription. We also found that factor occupancy generally correlates with high gene expression but that the loss of menin does not result in significant changes in most transcript levels. One exception is the developmentally programmed transcription factor, HLXB9, which is overexpressed in islets in the absence of menin. Our findings expand the realm of menin-targeted genes several hundred-fold beyond that previously described and provide potential insights to the endocrine tumor bias observed in MEN1 patients

Supplemental Information For: Asymmetric Distribution of Lunar Impact Basins Caused by Variations in Target Properties

Maps of crustal thickness derived from NASA's Gravity Recovery and Interior Laboratory (GRAIL) mission revealed more large impact basins on the nearside hemisphere of the Moon than on its farside. The enrichment in heat-producing elements and prolonged volcanic activity on the lunar nearside hemisphere indicate that the temperature of the nearside crust and uppermantle was hotter than that of the farside at the time of basin formation. Using the iSALE-2D hydrocode to model impact basin formation, we found that impacts on the hotter nearside would have formed basins up to two times larger than similar impacts on the cooler farside hemisphere. The size distribution of lunar impact basins is thus not representative of the earliest inner Solar system impact bombardmen

Asymmetric Distribution of Lunar Impact Basins Caused by Variations in Target Properties

Maps of crustal thickness derived from NASA's Gravity Recovery and Interior Laboratory (GRAIL) mission revealed more large impact basins on the nearside hemisphere of the Moon than on its farside. The enrichment in heat-producing elements and prolonged volcanic activity on the lunar nearside hemisphere indicate that the temperature of the nearside crust and upper mantle was hotter than that of the farside at the time of basin formation. Using the iSALE-2D hydrocode to model impact basin formation, we found that impacts on the hotter nearside would have formed basins up to two times larger than similar impacts on the cooler farside hemisphere. The size distribution of lunar impact basins is thus not representative of the earliest inner Solar system impact bombardment

High-throughput, quantitative analyses of genetic interactions in E. coli.

Large-scale genetic interaction studies provide the basis for defining gene function and pathway architecture. Recent advances in the ability to generate double mutants en masse in Saccharomyces cerevisiae have dramatically accelerated the acquisition of genetic interaction information and the biological inferences that follow. Here we describe a method based on F factor-driven conjugation, which allows for high-throughput generation of double mutants in Escherichia coli. This method, termed genetic interaction analysis technology for E. coli (GIANT-coli), permits us to systematically generate and array double-mutant cells on solid media in high-density arrays. We show that colony size provides a robust and quantitative output of cellular fitness and that GIANT-coli can recapitulate known synthetic interactions and identify previously unidentified negative (synthetic sickness or lethality) and positive (suppressive or epistatic) relationships. Finally, we describe a complementary strategy for genome-wide suppressor-mutant identification. Together, these methods permit rapid, large-scale genetic interaction studies in E. coli

Editor's Choice-The role of the emergency department in the management of acute heart failure : An international perspective on education and research

Emergency departments are a major entry point for the initial management of acute heart failure (AHF) patients throughout the world. The initial diagnosis, management and disposition - the decision to admit or discharge - of AHF patients in the emergency department has significant downstream implications. Misdiagnosis, under or overtreatment, or inappropriate admission may place patients at increased risk for adverse events, and add costs to the healthcare system. Despite the critical importance of initial management, data are sparse regarding the impact of early AHF treatment delivered in the emergency department compared to inpatient or chronic heart failure management. Unfortunately, outcomes remain poor, with nearly a third of patients dying or re-hospitalised within 3 months post-discharge. In the absence of robust research evidence, consensus is an important source of guidance for AHF care. Thus, we convened an international group of practising emergency physicians, cardiologists and advanced practice nurses with the following goals to improve outcomes for AHF patients who present to the emergency department or other acute care setting through: (a) a better understanding of the pathophysiology, presentation and management of the initial phase of AHF care; (b) improving initial management by addressing knowledge gaps between best practices and current practice through education and research; and (c) to establish a framework for future emergency department-based international education and research.Peer reviewe

The NN scattering 3S1-3D1 mixing angle at NNLO

The 3S1-3D1 mixing angle for nucleon-nucleon scattering, epsilon_1, is calculated to next-to-next-to-leading order in an effective field theory with perturbative pions. Without pions, the low energy theory fits the observed epsilon_1 well for momenta less than $\sim 50$ MeV. Including pions perturbatively significantly improves the agreement with data for momenta up to $\sim 150$ MeV with one less parameter. Furthermore, for these momenta the accuracy of our calculation is similar to an effective field theory calculation in which the pion is treated non-perturbatively. This gives phenomenological support for a perturbative treatment of pions in low energy two-nucleon processes. We explain why it is necessary to perform spin and isospin traces in d dimensions when regulating divergences with dimensional regularization in higher partial wave amplitudes.Comment: 17 pages, journal versio