The structure of foreign policy attitudes in transatlantic perspective: comparing the United States, United Kingdom, France and Germany

While public opinion about foreign policy has been studied extensively in the United States, there is less systematic research of foreign policy opinions in other countries. Given that public opinion about international affairs affects who gets elected in democracies and then constrains the foreign policies available to leaders once elected, both comparative politics and international relations scholarship benefit from more systematic investigation of foreign policy attitudes outside the United States. Using new data, this article presents a common set of core constructs structuring both American and European attitudes about foreign policy. Surveys conducted in four countries (the United States, the United Kingdom, France and Germany) provide an expanded set of foreign policy‐related survey items that are analysed using exploratory structural equation modeling (ESEM). Measurement equivalence is specifically tested and a common four‐factor structure that fits the data in all four countries is found. Consequently, valid, direct comparisons of the foreign policy preferences of four world powers are made. In the process, the four‐factor model confirms and expands previous work on the structure of foreign policy attitudes. The article also demonstrates the capability of ESEM in testing the dimensionality and cross‐national equivalence of social science concepts

The COMPLEIK subroutine of the IONORT-ISP system for calculating the non-deviative absorption: A comparison with the ICEPAC formula

The present paper proposes to discuss the ionospheric absorption, assuming a quasi-flat layered ionospheric medium, with small horizontal gradients. A recent complex eikonal model [Settimi et al., 2013b] is applied, useful to calculate the absorption due to the ionospheric D-layer, which can be approximately characterized by a linearized analytical profile of complex refractive index, covering a short range of heights between h1= 50 km and h2= 90 km. Moreover, Settimi et al. [2013c] have already compared the complex eikonal model for the D-layer with the analytical Chapman’s profile of ionospheric electron density; the corresponding absorption coefficient is more accurate than Rawer’s theory [1976] in the range of middle critical frequencies. Finally, in this paper, the simple complex eikonal equations, in quasi-longitudinal (QL) approximation, for calculating the non-deviative absorption coefficient due to the propagation across the D-layer are encoded into a so called COMPLEIK (COMPLex EIKonal) subroutine of the IONORT (IONOspheric Ray-Tracing) program [Azzarone et al., 2012]. The IONORT program, which simulates the three-dimensional (3-D) ray-tracing for high frequencies (HF) waves in the ionosphere, runs on the assimilative ISP (IRI-SIRMUP-P) discrete model over the Mediterranean area [Pezzopane et al., 2011]. As main outcome of the paper, the simple COMPLEIK algorithm is compared to the more elaborate semi-empirical ICEPAC formula [Stewart, undated], which refers to various phenomenological parameters such as the critical frequency of E-layer. COMPLEIK is reliable just like the ICEPAC, with the advantage of being implemented more directly. Indeed, the complex eikonal model depends just on some parameters of the electron density profile, which are numerically calculable, such as the maximum height

Soft tissue regeneration using leukocyte-platelet rich fibrin after exeresis of hyperplastic gingival lesions: Two case reports

Introduction The Leukocyte-PRF (Leukocyte-Platelet Rich Fibrin) belongs to a second generation of platelet concentrates which doesn’t need a biochemical blood manipulation. It is used for tissue healing and regeneration in periodontal and oral-maxillofacial surgery. We report two cases of hyperplastic gingival lesions treated by exeresis and application of PRF membranes in order to improve and accelerate tissue healing. Case Presentation Two patients (one Caucasian female, 78-year-old, and one Caucasian male, 30-year-old) were treated for hyperplastic gingival lesions. They underwent to exeresis of lesions and application of PRF membranes. Tissue healing was clinically evaluated after one, three, seven, fourteen and thirty post-operative days. No recurrences were observed after two years of semiannual follow up. Conclusion We obtained rapid and good healing of soft tissues probably due to the elevated content of leukocytes, platelets and growth factors in the leukocyte-platelet rich fibrin. According to our results we suggest L-PRF employment for wounds covering after exeresis of oral neoformations such as hyperplastic gingival lesions

Peto's paradox and human cancers

Peto's paradox is the lack of the expected trend in cancer incidence as a function of body size and lifespan across species. The leading hypothesis to explain this pattern is natural selection for differential cancer prevention in larger, longer lived species. We evaluate whether a similar effect exists within species, specifically humans. We begin by reanalysing a recently published dataset to separate the effects of stem cell number and replication rate, and show that each has an independent effect on cancer risk. When considering the lifetime number of stem cell divisions in an extended dataset, and removing cases associated with other diseases or carcinogens, we find that lifetime cancer risk per tissue saturates at approximately 0.3-1.3% for the types considered. We further demonstrate that grouping by anatomical site explains most of the remaining variation. Our results indicate that cancer risk depends not only on the number of stem cell divisions but varies enormously (approx. 10 000 times) depending on anatomical site. We conclude that variation in risk of human cancer types is analogous to the paradoxical lack of variation in cancer incidence among animal species and may likewise be understood as a result of evolution by natural selection

The new ionospheric station of Tucumán: first results

An Advanced Ionospheric Sounder, built at the Istituto Nazionale di Geofisica e Vulcanologia, Rome, Italy, was installed at Tucumán, Argentina, particularly interesting for its location, near the southern peak of the ionospheric equatorial anomaly. The aim of this installation is to collect a large number of continuous data useful both to study the dynamics of the equatorial ionospheric plasma and to develop reliable regional ionospheric prediction models. Moreover this ionosonde will contribute to the ionospheric database and real time knowledge of Southern Hemisphere ionospheric conditions for space weather applications. The ionosonde is completely programmable and two PCs support the data acquisition, control, storage and on-line processing. In this work the first results, in terms of ionograms and autoscaled characteristics, are presented and briefly discussed

The effect of national and constituency level expectations on tactical voting in the British general election of 2010

The 2010 elections in the United Kingdom provided voters with numerous and diverse opportunities to reason strategically. The Liberal Democrats (Lib Dems)-traditionally finishing a distant third in terms of seats in Parliament-vied with labour to be the principal competition to the Conservatives, who failed to win a majority of seats, creating a rare case of what the British call a hung parliament. These conditions varied across constituencies at the district level, and we exploit this variation to study the incidence of "tactical" voting. But the national outcome also presented strategic considerations for voters, and the conditions varied to some extent over the course of the campaign, giving voters interviewed at different times different sets of national considerations for tactical voting. This presents us with the opportunity to investigate how both local and national considerations may shape strategic reasoning among voters and relate to each other and to the final choices of voters on Election Day

Importance of a real-time monitoring of the Earth's ionosphere

The ionosphere affects the electromagnetic wave propagation and then its study is important for Earth-Earth, satellite-Earth, and satellite-satellite communication purposes. Diffractive and refractive processes due to irregular electron density structures cause signal fluctuations that can disrupt satellite-ground communications and represent a hazard for navigation systems. The study and the real-time monitoring of the ionosphere are important for Space Weather purposes. The ionospheric vertical sounding is described, together with the automatic scaling of the ionograms.UnpublishedRome2A. Fisica dell'alta atmosferaope

Simulations of organic aerosol with CAMx over the Po Valley during the summer season

A new sensitivity analysis with the Comprehensive Air Quality Model with Extensions (CAMx) using a traditional two-product scheme (SOAP) and the newer Volatility Basis Set (VBS) algorithm for organic aerosol (OA) calculations is presented. The sensitivity simulations include the default versions of the SOAP and VBS schemes, as well as new parametrizations for the VBS scheme to calculate emissions and volatility distributions of semi- and intermediate-volatile organic compounds. The focus of the simulations is the summer season (May to July 2013), in order to quantify the sensitivity of the model in a period with relatively large photochemical activity. In addition to the model sensitivity, we validate the results with ad hoc OA measurements obtained from aerosol mass spectrometers at two monitoring sites. Unlike winter cases previously published, the comparison with experimental data showed limited sensitivity to total OA amount, with an estimated increase in OA concentrations limited to a few tenths of µg m−3, for both the primary and secondary components. We show that the lack of pronounced sensitivity is related to the effect of the new parametrizations on different emissions sectors. Furthermore, the minor sensitivity to the new parametrizations could be related to the greater partitioning of OA towards the gaseous phase in the summer period, thus reducing the organic fraction in the aerosol phase

Generation of pralatrexate resistant T-cell lymphoma lines reveals two patterns of acquired drug resistance that is overcome with epigenetic modifiers

While pralatrexate (PDX) has been successfully developed for the treatment of T-cell lymphoma, the mechanistic basis for its T-cell selectivity and acquired resistance remains elusive. In an effort to potentially identify synergistic combinations that might circumnavigate or delay acquired PDX resistance, we generated resistant cells lines over a broad concentration range. PDX-resistant cell lines H9-12 and H9-200 were developed, each exhibiting an IC50 of 35 and over 1000 nM, respectively. These lines were established in vitro from parental H9 cells. Expression analysis of the proteins known to be important determinants of antifolate pharmacology revealed increase expression of dihydrofolate reductase (DHFR) due to gene amplification, and reduced folate carrier1 downregulation, as the putative mechanisms of resistance in H9-12 and H9-200 cells. Cross resistance was only seen with methotrexate but not with romidepsin, azacitidine (AZA), decitabine, gemcitabine, doxorubicin, or bortezomib. Resistance to PDX was reversed by pretreatment with hypomethylating agents in a concentration-dependent fashion. Comparison of gene expression profiles of parental and resistant cell lines confirmed markedly different patterns of gene expression, and identified the dual specificity phosphatase four (DUSP4) as one of the molecular target of PDX activity. Reduced STAT5 phosphorylation following exposure to PDX was observed in the H9 but not in the H9-12 and H9-200 cells. These data suggest that combination with hypomethylating agents could be potent, and that DUSP4 and STAT5 could represent putative biomarkers of PDX activity