Investigating ozone episodes in Portugal: a wavelet-based approach

During the summer season, ozone concentrations regularly exceed the legislation limits in the North of Portugal, namely at Douro Norte monitoring station. The origin of such ozone episodes has been widely reported in several studies although uncertainties regarding its origin still remain. This work intends to investigate how the ozone concentrations measured at the Douro Norte nearest stations, located at west and east directions, are related to those measured at Douro Norte by means of coherence and phase transformations methods. The episodes were selected according to the magnitude of the hourly ozone peaks and the occurrence of exceedances of the threshold value at least in two sites. The results point out that 60 % of the selected episodes highlight significant dependence between Douro Norte station and the other two monitoring sites, with different phase signal and a delay range from 2 to 4 h.The authors wish to thank the financial support of the Comiss˜ao de Coordenac¸ ˜ao e Desenvolvimento Regional do Norte (CCDR-N). Thanks are extended to the Portuguese Foundation for Science and Technology for the financial support through the Project MAPLIA (PTDC/AAG-MAA/4077/2012), and the PhD grant of Carla Gama (SFRH/BD/87468/2012) and the Pos-Doc grant of S. Gouveia (SFRH/-BPD/87037/2012), and CIDMA/UA project PEst- OE/MAT/UI4106/2014 (Centro de Investigac¸ ˜ao e Desenvolvimento em Matem´atica e Aplicac¸ ˜oes, CIDMA/UA, Aveiro, www.cidma.mat. ua.pt), and IEETA/UA project PEst-OE/EEI/-UI0127/2014 (Instituto de Engenharia Electr´onica e Telem´atica de Aveiro, IEETA/UA, Aveiro, www.ieeta.pt).info:eu-repo/semantics/publishedVersio

Interpretando correctamente en salud pública estimaciones puntuales, intervalos de confianza y contrastes de hipótesis

El presente ensayo trata de aclarar algunos conceptos utilizados habitualmente en el campo de investigación de la salud pública, que en numerosas situaciones son interpretados de manera incorrecta. Entre ellos encontramos la estimación puntual, los intervalos de confianza, y los contrastes de hipótesis. Estableciendo un paralelismo entre estos tres conceptos, podemos observar cuáles son sus diferencias más importantes a la hora de ser interpretados, tanto desde el punto de vista del enfoque clásico como desde la óptica bayesiana. El texto completo en inglés de este artículo está disponible en: http://www.insp.mx/salud/index.htm

Non-linear time series: extreme events and integer value problems

This book offers a useful combination of probabilistic and statistical tools for analyzing nonlinear time series. Key features of the book include a study of the extremal behavior of nonlinear time series and a comprehensive list of nonlinear models that address different aspects of nonlinearity. Several inferential methods, including quasi likelihood methods, sequential Markov Chain Monte Carlo Methods and particle filters, are also included so as to provide an overall view of the available tools for parameter estimation for nonlinear models. A chapter on integer time series models based on several thinning operations, which brings together all recent advances made in this area, is also included. Readers should have attended a prior course on linear time series, and a good grasp of simulation-based inferential methods is recommended. This book offers a valuable resource for second-year graduate students and researchers in statistics and other scientific areas who need a basic understanding of nonlinear time series

Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries

Background Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned. Results A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31). Conclusion Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)