Toward an efficient solution for dynamic ad hoc network interoperability

An ad hoc network is formed by an impromptu grouping of network capable nodes. The nodes forming the network have unconstrained mobility, and so provide a dynamic network topology. Current work in this research area has focused on designing routing protocols capable of efficiently forwarding packets in these dynamic network environments. This has led to several designs for ad hoc routing protocols based on various routing algorithms, each suited to specific usage characteristics. This paper will discuss issues relating to routing in ad hoc networks. We will describe an active networking based solution that provides dynamic routing protocol interoperability and enables migration of nodes between ad hoc groups. Our design is motivated by a squad and base scenario which consists of two groups wishing to communicate. These groups have contrasting deployment characteristics and so use different routing protocols

A new mutation in the promoter region of the PAX8 gene causes true congenital hypothyroidism with thyroid hypoplasia in a girl with Down's syndrome

<b>Background:</b> Thyroid dysfunction is common in newborn infants with Down's syndrome (DS), but defects causing classic thyroid dysgenesis (TD) with permanent congenital hypothyroidism (CH) have not been described.<p></p> <b>Objective:</b> We studied a girl with DS and CH who had a mutation in the promoter sequence of the PAX8 gene.<p></p> <b>Results:</b> A female infant was found to have trisomy 21 and CH, with a venous thyrotropin (TSH) of >150 mU/L and a free thyroxine (fT4) of 15.1 pmol/L (day 12). Thyroid peroxidase antibodies and thyroglobulin antibodies were elevated. Scintigraphy showed normal uptake, but ultrasound identified a small gland with heterogenous echotexture and cystic changes. Sequence analysis of the PAX8 gene revealed a new heterozygous maternally inherited mutation (−3C>T) close to the transcription initiation site. Electromobility shift assay studies of the wild type and the mutant PAX8 sequence incubated with nuclear extracts from PCCL3 cells exhibited that the sequence at position −3 is not involved in specific protein binding. However, the mutant PAX8 promoter showed a significantly reduced transcriptional activation of a luciferase reporter gene in vitro tested in HEK, PCCL3, as well as in HeLa cells, indicating that this mutation is very likely to lead to reduced PAX8 expression.<p></p> <b>Conclusions:</b> The persistent CH in this patient with DS is likely to be attributable to the diminished PAX8 expression due to a new heterozygous mutation in the PAX8 promoter sequence. Our case shows that true CH may occur in DS, as in the general population. Furthermore, it is possible that the trisomy 21 itself may have resulted in a more severe phenotypic expression of the PAX8 mutation in the child than the mother

Energy for All: Harnessing the Power of Energy Access for Chronic Poverty Reduction

Policy makers are trying to balance the demands of three broad objectives in the energy sector; energy security to ensure economic stability and growth; reducing energy poverty, by ensuring access to electricity and clean-combusting fuels and equipment for the poor; and managing greenhouse gas emissions from energy. The World Energy Council has called this the "energy trilemma" - of how to achieve an appropriate balance between these sometimes conflicting objectives. Over the past two years, the challenge of providing people living in poverty with access to modern energy has been prominent in policy debates. The UN Secretary General's Sustainable Energy for All initiative is instrumental in highlighting the importance of energy access for poverty reduction. Some developing countries are now drawing-up national strategies for Sustainable Energy for All and over the next few years, attention is likely to continue in the debates about the post-2015 development agenda and during the UN Decade for Sustainable Energy for All (2014-24). However, and despite this policy focus, governments sometimes overlook the needs of chronically poor people when initiating energy for all programmes as they are often the most difficult for energy service providers to reach, and are least able to afford services when they are available. Chronically poor people therefore need to be explicitly considered in measures to deliver energy services. Research and policy evaluation tells us that access to electricity, together with the assets which enable its use in a transformational way, improved cooking technologies, and mechanical power can help people to escape from persistent poverty. There are three broad policy areas which can help achieve this: - expanding electricity coverage and distributing clean-combusting fuels and equipment to populations not yet served; - improving the ability of the poorest people to afford these when they are available; - enhancing the reliability of energy services. This is important if energy is to contribute in a transformational way to escaping poverty. A minimalist approach will not do - energy is needed by poor households for productive uses as well as domestic and community needs. This CPAN Policy Guide provides guidance for developing country policy makers and their advisers when considering the specific measures necessary to ensure that chronically poor people are included in efforts to deliver sustainable energy for all. It is therefore intended for policy and programme designers and implementers in energy agencies, as well as policymakers in ministries of finance and planning, energy, rural development and health alongside those in local government. One message from this guide is that co-ordination and inter-sectoral collaboration is required to ensure that the expansion of energy services contributes to poverty reduction

Effect of Axial Load on the Flexural Properties of an Elastomeric Total Disc Replacement

Study Design. Twelve Cadisc-L devices were subjected to flexion (0°–6°) and extension (0° to -3°) motions at compressive loads between 500 N and 2000 N at a flexural rate between 0.25°/s and 3.0°/s.\ud \ud Objective. To quantify the change in flexural properties of the Cadisc-L (elastomeric device), when subjected to increasing magnitudes of axial load and at different flexural rates.\ud \ud Summary of Background Data. The design of motion preservation devices, used to replace degenerated intervertebral discs, is commonly based on a low-friction, ball-and-socket-articulating joint. Recently, elastomeric implants have been developed that attempt to provide mechanical and motion properties that resemble those of the natural disc more closely.\ud \ud Methods. Twelve Cadisc-L devices (MC-10 mm-9° and MC-10 mm-12° size) were supplied by Ranier Technology Ltd (Cambridge, United Kingdom). The devices were hydrated and tested using a Bose spinal disc-testing machine (Bose Corporation, ElectroForce Systems Group, Eden Prairie, MN) in Ringer's solution at 37°C. A static load of 500 N was applied to a device and it was then subjected to motions of 0° to 6° to 0° (flexion) and 0° to -3° to 0° (extension) at a flexural rate of 0.25°/s, 0.5°/s, 1.0°/s, 1.5°/s, 2.0°/s, and 3.0°/s. Tests were repeated at 1000 N, 1500 N, and 2000 N.\ud \ud Results. Regression analyses showed a significant ($R^2$ > 0.99, $\rho$< 0.05) linear increase in bending moment and flexural stiffness with flexion and extension angles (at 1000 N and higher loads)—a significant ($R^2$> 0.994, $\rho$< 0.05) linear decrease in flexural stiffness in flexion and extension as flexural rate increased.\ud \ud Conclusion. The bending moment of the Cadisc-L increased linearly with flexion and extension angles at 1000 N and higher loads. Flexural stiffness increased with compressive load but decreased with flexural rate.\ud \u

Testing the Evolutionary Sequence of High Mass Protostars with CARMA

We present 1" resolution CARMA observations of the 3mm continuum and 95 GHz methanol masers toward 14 candidate high mass protostellar objects (HMPOs). Dust continuum emission is detected toward seven HMPOs, and methanol masers toward 5 sources. The 3mm continuum sources have diameters < 2x10^4 AU, masses between 21 and 1200 M_sun, and volume densities > 10^8 cm^-3. Most of the 3mm continuum sources are spatially coincident with compact HII regions and/or water masers, and are presumed to be formation sites of massive stars. A strong correlation exists between the presence of 3mm continuum emission, 22 GHz water masers, and 95 GHz methanol masers. However, no 3mm continuum emission is detected toward ultracompact HII regions lacking maser emission. These results are consistent with the hypothesis that 22 GHz water masers and methanol masers are signposts of an early phase in the evolution of an HMPO before an expanding HII region destroys the accretion disk.Comment: accepted to Ap

Travelling waves in a model of quasi-active dendrites with active spines

Dendrites, the major components of neurons, have many different types of branching structures and are involved in receiving and integrating thousands of synaptic inputs from other neurons. Dendritic spines with excitable channels can be present in large densities on the dendrites of many cells. The recently proposed Spike-Diffuse-Spike (SDS) model that is described by a system of point hot-spots (with an integrate-and-fire process) embedded throughout a passive tree has been shown to provide a reasonable caricature of a dendritic tree with supra-threshold dynamics. Interestingly, real dendrites equipped with voltage-gated ion channels can exhibit not only supra-threshold responses, but also sub-threshold dynamics. This sub-threshold resonant-like oscillatory behaviour has already been shown to be adequately described by a quasi-active membrane. In this paper we introduce a mathematical model of a branched dendritic tree based upon a generalisation of the SDS model where the active spines are assumed to be distributed along a quasi-active dendritic structure. We demonstrate how solitary and periodic travelling wave solutions can be constructed for both continuous and discrete spine distributions. In both cases the speed of such waves is calculated as a function of system parameters. We also illustrate that the model can be naturally generalised to an arbitrary branched dendritic geometry whilst remaining computationally simple. The spatio-temporal patterns of neuronal activity are shown to be significantly influenced by the properties of the quasi-active membrane. Active (sub- and supra-threshold) properties of dendrites are known to vary considerably among cell types and animal species, and this theoretical framework can be used in studying the combined role of complex dendritic morphologies and active conductances in rich neuronal dynamics

A search for J^{PC}=1^{-+} exotic mesons in the pi- pi- pi+ and pi- pi0 pi0 systems

A partial wave analysis (PWA) of the pi-pi-pi+ and pi-pi0pi0 systems produced in the reaction pi- p -> (3pi)-p at 18 GeV/c was carried out using an isobar model assumption. This analysis is based on 3.0M pi-pi0pi0 events and 2.6M pi-pi-pi+ events and shows production of the a2(1320), pi2(1670) and \pi(1800) mesons. An earlier analysis of 250K pi-pi-pi+ events from the same experiment showed possible evidence for a J^{PC}=1^{-+}$ exotic meson with a mass of 1.6 GeV/c^2 decaying into rho pi. In this analysis of a higher statistics sample of the (3pi)- system in two charged modes we find no evidence of an exotic meson.Comment: 4 pages, 5 figures, added comment about the negative reflectivity exotic wave

Cross-cultural effects of color, but not morphological masculinity, on perceived attractiveness of men's faces

This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2012 ElsevierMuch attractiveness research has focused on face shape. The role of masculinity (which for adults is thought to be a relatively stable shape cue to developmental testosterone levels) in male facial attractiveness has been examined, with mixed results. Recent work on the perception of skin color (a more variable cue to current health status) indicates that increased skin redness, yellowness, and lightness enhance apparent health. It has been suggested that stable cues such as masculinity may be less important to attractiveness judgments than short-term, more variable health cues. We examined associations between male facial attractiveness, masculinity, and skin color in African and Caucasian populations. Masculinity was not found to be associated with attractiveness in either ethnic group. However, skin color was found to be an important predictor of attractiveness judgments, particularly for own-ethnicity faces. Our results suggest that more plastic health cues, such as skin color, are more important than developmental cues such as masculinity. Further, unfamiliarity with natural skin color variation in other ethnic groups may limit observers' ability to utilize these color cues

Fast and stable multivariate kernel density estimation by fast sum updating

Kernel density estimation and kernel regression are powerful but computationally expensive techniques: a direct evaluation of kernel density estimates at $M$ evaluation points given $N$ input sample points requires a quadratic $\mathcal{O}(MN)$ operations, which is prohibitive for large scale problems. For this reason, approximate methods such as binning with Fast Fourier Transform or the Fast Gauss Transform have been proposed to speed up kernel density estimation. Among these fast methods, the Fast Sum Updating approach is an attractive alternative, as it is an exact method and its speed is independent of the input sample and the bandwidth. Unfortunately, this method, based on data sorting, has for the most part been limited to the univariate case. In this paper, we revisit the fast sum updating approach and extend it in several ways. Our main contribution is to extend it to the general multivariate case for general input data and rectilinear evaluation grid. Other contributions include its extension to a wider class of kernels, including the triangular, cosine and Silverman kernels, its combination with parsimonious additive multivariate kernels, and its combination with a fast approximate k-nearest-neighbors bandwidth for multivariate datasets. Our numerical tests of multivariate regression and density estimation confirm the speed, accuracy and stability of the method. We hope this paper will renew interest for the fast sum updating approach and help solve large-scale practical density estimation and regression problems.Comment: 38 pages, 29 figure