47 research outputs found
Effect of Reducing Atmosphere on the Magnetism of Zn1-xCoxO Nanoparticles
We report the crystal structure and magnetic properties of Zn1-xCoxO
nanoparticles synthesized by heating metal acetates in organic solvent. The
nanoparticles were crystallized in wurtzite ZnO structure after annealing in
air and in a forming gas (Ar95%+H5%). The X-ray diffraction and X-ray
photoemission spectroscopy (XPS) data for different Co content show clear
evidence for the Co+2 ions in tetrahedral symmetry, indicating the substitution
of Co+2 in ZnO lattice. However samples with x=0.08 and higher cobalt content
also indicate the presence of Co metal clusters. Only those samples annealed in
the reducing atmosphere of the forming gas, and that showed the presence of
oxygen vacancies, exhibited ferromagnetism at room temperature. The air
annealed samples remained non-magnetic down to 77K. The essential ingredient in
achieving room temperature ferromagnetism in these Zn1-xCoxO nanoparticles was
found to be the presence of additional carriers generated by the presence of
the oxygen vacancies.Comment: 11 pages, 6 figures, submitted to Nanotechnology IO
Protection Motivation Theory and Contingent Valuation: Perceived Realism, Threat and WTP Estimates for Biodiversity Protection
Estimating the burden and cost of infectious intestinal disease in the Maltese community
The aim of this study was to estimate the burden of infectious intestinal disease (IID) and cost of illness at the community level from a societal aspect. A retrospective, age-stratified cross-sectional telephone study was carried out in Malta in 2004–2005. The number of cases, resources used and cost of resources were computed. The resources involved direct costs (health-care services, stool culture tests, medicines and personal costs) and indirect costs (costs from lost employment by cases and caregivers). This study estimated 0·421 (95% CI 0·092–0·771) separate episodes of IID per person per year in Malta which corresponds to 164 471 (95% CI 35 941–301 205) episodes of IID per year or 450 (95% CI 98–825) episodes of IID each day. The largest proportion of cost is due to provision of health-care services with €10 454 901 [Maltese liri (Lm) 4 558 970] per year; followed by €963 295 (Lm 2 209 393) in lost productivity; €1 286 286 (Lm 561 078) in medicines; €152 335 (Lm 66 452) in stool culture testing and €71 487 (Lm 31 183) in personal costs, giving a total cost of illness of over €16 million (7 million Lm) per year. The burden and cost of IID are high enough to justify efforts to control the illness. Such estimates are important to assess the cost-effectiveness of proposed specific interventions
Regulated control by granulocyte-macrophage colony-stimulating factor AU-rich element during mouse embryogenesis.
In vitro studies have indicated that the granulocyte-macrophage colony-stimulating factor (GM-CSF) gene expression is regulated at the posttranscriptional level by the AU-rich element (ARE) sequence present in its 3' untranslated region (UTR). This study investigated the importance of the ARE in the control of GM-CSF gene expression in vivo. For this purpose, transgenic mice bearing GM-CSF gene constructs containing or lacking the ARE (GM-CSF AU(+) or GM-CSF AU(-), respectively) were generated. Both transgenes were under the transcriptional control of the immediate early promoter of the cytomegalovirus (CMV) to ensure their early, widespread, and constitutive expression. The regulation imposed by the ARE was revealed by comparing transgene expression at day 14 of embryonic development (E14); only the ARE-deleted but not the ARE-containing construct was expressed. Although GM-CSF AU(+) embryos were phenotypically normal, overexpression of GM-CSF in E14 GM-CSF AU(-) embryos led to severe hematopoietic alterations such as abnormal proliferation of granulocytes and macrophages accompanied by an increased number of peroxidase-expressing cells, their putative progenitor cells. These abnormalities compromise development because no viable GM-CSF AU(-) transgenic pups could be obtained. Surprisingly, by E18, significant accumulation of transgene messenger RNA was also observed in GM-CSF AU(+) embryos leading to similar phenotypic abnormalities. Altogether, these observations reveal that GM-CSF ARE is a developmentally controlled regulatory element and highlight the consequences of GM-CSF overexpression on myeloid cell proliferation and differentiation.Comparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tSCOPUS: ar.jinfo:eu-repo/semantics/publishe