Ground Water Monitoring Project for Arkansas, Phase III

This report is composed of two parts. The first part is an interpretation of the pesticide and nitrate data collected in Woodruff County based on samples collected during 1994. Because there is an indication that there were hydrological differences between 1994 and 1995, and because most of the pesticide data is from 1994, this interpretive portion is restricted to 1994 data. Six wells initially sampled in 1994 that contained pesticides had continuing contamination in re-sampling in 1994 and 1995. Part II lists a seventh well in Woodruff County that contained pesticides in February and May of 199

A Gate-To-Gate Life-Cycle Inventory of Solid Hardwood Flooring in the Eastern US

Environmental impacts associated with building materials are under increasing scrutiny in the US. A gate-to-gate life-cycle inventory (LCI) of solid strip and solid plank hardwood flooring production was conducted in the eastern US for the reporting year 2006. Survey responses from hardwood flooring manufacturing facilities in this region accounted for nearly 28% of total US solid hardwood flooring production for that year. This study examined the materials, fuels, and energy required to produce solid hardwood flooring, coproducts, and the emissions to air, land, and water. SimaPro software was used to quantify the environmental impacts associated with the reported materials use and emissions. Impact data were allocated on their mass contribution to all product and coproduct production of 1.0 m3 (oven-dry mass basis) of solid hardwood flooring. Carbon flow and transportation data are provided in addition to the LCI data. Results of this study are useful for creating a cradle-to-gate inventory when linked to LCIs for the hardwood forest resource and the production of solid hardwood lumber in the same region

Post-Den Emergence Behavior of Polar Bears (Ursus maritimus) in Northern Alaska

We observed polar bear (Ursus maritimus) maternity den sites on Alaska’s North Slope in March 2002 and 2003 in an effort to describe bears’ post-den emergence behavior. During 40 sessions spanning 459 h, we observed 8 adults and 14 dependent cubs outside dens for 37.5 h (8.2% of total observation time). There was no significant difference between den emergence dates in 2002 (mean = 15 Mar ± 4.1 d) and 2003 (mean = 21 Mar ± 2.1 d). Following initial den breakout, polar bears remained at their den sites for 1.5 to 14 days (mean = 8.1 ± 5.1 d). The average length of stay in dens between emergent periods was significantly shorter in 2002 (1.79 h) than in 2003 (4.82 h). While outside, adult bears were inactive 49.5% of the time, whereas cubs were inactive 13.4% of the time. We found no significant relationships between den emergence activity and weather. Adult polar bears at den sites subjected to industrial activity exhibited significantly fewer bouts of vigilance than denned bears in undisturbed areas (t = -5.5164, df = 4, p = 0.00). However, the duration of vigilance behaviors at sites near industrial activity was not significantly shorter than at the other sites studied (t = -1.8902, df = 4, p = 0.07). Results for these bears were within the range of findings in other studies of denned polar bears.Nous avons observé des tanières de maternité d’ours polaires (Ursus maritimus) sur le versant nord de l’Alaska aux mois de mars 2002 et 2003 dans le but de décrire le comportement de sortie des ours après leur séjour dans la tanière. Dans le cadre de 40 séances d’observation ayant duré 459 heures, nous avons observé 8 ours adultes et 14 oursons à charge en dehors des tanières pendant 37,5 heures (soit 8,2 % de la durée d’observation totale). Il n’y avait pas de différence importante entre les dates de sortie des tanières en 2002 (moyenne = 15 mars ± 4,1 j) et 2003 (moyenne = 21 mars ± 2,1 j). Après la première sortie de la tanière, les ours polaires restaient à l’emplacement de leur tanière pendant 1,5 à 14 jours (moyenne = 8,1 ± 5.1 j). La longueur moyenne du séjour en tanière entre les périodes de sortie était beaucoup plus courte en 2002 (1,79 h) qu’en 2003 (4,82 h). Une fois sortis, les ours adultes étaient inactifs pendant 49,5 % du temps, tandis que les oursons étaient inactifs pendant 13,4 % du temps. Nous n’avons pas trouvé de lien important entre l’activité une fois sorti de la tanière et le temps qu’il faisait. Les ours polaires adultes à l’emplacement de tanières assujetties à des activités industrielles affichaient beaucoup moins de séquences de vigilance que les ours en tanière des régions tranquilles (t = -5,5164, dl = 4, p = 0,00). Cependant, la durée des comportements de vigilance aux emplacements situés près d’activités industrielles n’était pas beaucoup plus courte qu’aux autres emplacements étudiés (t = - 1,8902, dl = 4, p = 0,07). Les résultats enregistrés pour ces ours tombaient dans l’étendue des constatations découlant d’autres études d’ours polaires en tanière

Arcjet Testing and Thermal Model Development for Multilayer Felt Reusable Surface Insulation

Felt Reusable Surface Insulation was used extensively on leeward external surfaces of the Shuttle Orbiter, where the material is reusable for temperatures up to 670 K. For application on leeward surfaces of the Orion Multi-Purpose Crew Vehicle, where predicted temperatures reach 1620 K, the material functions as a pyrolyzing conformal ablator. An arcjet test series was conducted to assess the performance of multilayer Felt Reusable Surface Insulation at high temperatures, and a thermal-response, pyrolysis, and ablation model was developed. Model predictions compare favorably with the arcjet test dat

Laser Mobile Mapping Standards and Applications in Transportation

This report describes the work that was done to support the development of a chapter for the INDOT Survey Manual on Mobile Mapping. The work includes experiments that were done, data that was collected, analysis that was carried out, and conclusions that were drawn about accuracy of Mobile Terrestrial Laser Scanning (MTLS) systems. The resulting Manual chapter, located in the appendix, defines standards and procedures for preparing, collecting, editing, delivering, exploiting, and archiving electronic mapping data that is created for Indiana Department of Transportation (INDOT). The purpose of the standards and procedures within this manual is to obtain statewide uniformity within the INDOT combined Aerial/Ground Survey process, to establish and maintain MTLS Standards for INDOT and contracted consultants, and allow for all of the project data to be effectively managed from conception to completion. These standards apply to all projects delivered to INDOT by contracted consulting firms, or exchanged internally within INDOT or between state agencies. The standards and procedures are the result of mobile terrestrial laser scanning surveys of two test sites - one urban and one freeway - created for this project. After establishing reference control points on the sites, each site was surveyed by four mobile terrestrial laser scanning vendors. The results from the vendor data over the test sites, in addition to information in published literature, are the basis for the specifications manual. The proposed chapter for the Survey Manual is in Appendix E of this report

RAS mutation status predicts survival and patterns of recurrence in patients undergoing hepatectomy for colorectal liver metastases.

ObjectiveTo determine the impact of RAS mutation status on survival and patterns of recurrence in patients undergoing curative resection of colorectal liver metastases (CLM) after preoperative modern chemotherapy.BackgroundRAS mutation has been reported to be associated with aggressive tumor biology. However, the effect of RAS mutation on survival and patterns of recurrence after resection of CLM remains unclear.MethodsSomatic mutations were analyzed using mass spectroscopy in 193 patients who underwent single-regimen modern chemotherapy before resection of CLM. The relationship between RAS mutation status and survival outcomes was investigated.ResultsDetected somatic mutations included RAS (KRAS/NRAS) in 34 (18%), PIK3CA in 13 (7%), and BRAF in 2 (1%) patients. At a median follow-up of 33 months, 3-year overall survival (OS) rates were 81% in patients with wild-type versus 52.2% in patients with mutant RAS (P = 0.002); 3-year recurrence-free survival (RFS) rates were 33.5% with wild-type versus 13.5% with mutant RAS (P = 0.001). Liver and lung recurrences were observed in 89 and 83 patients, respectively. Patients with RAS mutation had a lower 3-year lung RFS rate (34.6% vs 59.3%, P < 0.001) but not a lower 3-year liver RFS rate (43.8% vs 50.2%, P = 0.181). In multivariate analyses, RAS mutation predicted worse OS [hazard ratio (HR) = 2.3, P = 0.002), overall RFS (HR = 1.9, P = 0.005), and lung RFS (HR = 2.0, P = 0.01), but not liver RFS (P = 0.181).ConclusionsRAS mutation predicts early lung recurrence and worse survival after curative resection of CLM. This information may be used to individualize systemic and local tumor-directed therapies and follow-up strategies

Valsartan for attenuating disease evolution in early sarcomeric hypertrophic cardiomyopathy: the design of the Valsartan for Attenuating Disease Evolution in Early Sarcomeric Hypertrophic Cardiomyopathy (VANISH) trial

Background: Hypertrophic cardiomyopathy (HCM) is often caused by sarcomere gene mutations, resulting in left ventricular hypertrophy (LVH), myocardial fibrosis, and increased risk of sudden cardiac death and heart failure. Studies in mouse models of sarcomeric HCM demonstrated that early treatment with an angiotensin receptor blocker (ARB) reduced development of LVH and fibrosis. In contrast, prior human studies using ARBs for HCM have targeted heterogeneous adult cohorts with well-established disease. The VANISH trial is testing the safety and feasibility of disease-modifying therapy with an ARB in genotyped HCM patients with early disease. Methods: A randomized, placebo-controlled, double-blind clinical trial is being conducted in sarcomere mutation carriers, 8 to 45 years old, with HCM and no/minimal symptoms, or those with early phenotypic manifestations but no LVH. Participants are randomly assigned to receive valsartan 80 to 320 mg daily (depending on age and weight) or placebo. The primary endpoint is a composite of 9 z-scores in domains representing myocardial injury/hemodynamic stress, cardiac morphology, and function. Total z-scores reflecting change from baseline to final visits will be compared between treatment groups. Secondary endpoints will assess the impact of treatment on mutation carriers without LVH, and analyze the influence of age, sex, and genotype. Conclusions: The VANISH trial is testing a new strategy of disease modification for treating sarcomere mutation carriers with early HCM, and those at risk for its development. In addition, further insight into disease mechanisms, response to therapy, and phenotypic evolution will be gained