Universal Design for Transition: A Conceptual Framework for Blending Academics and Transition Instruction

This theoretical paper comprised the development of a conceptual framework for blending academic and transition content to help members of the special education field meet both the academic and transition needs of students with disabilities, including students with intellectual and developmental disabilities (IDD). The current conceptual framework was used to explain how the components from Universal Design for Learning (UDL) and transition are blended to create the Universal Design for Transition (UDT) framework, which is a guide for implementing and promoting barrier-free transitions. In the current study, the final conceptual framework included multiple components that use the following UDL academic principles: (a) multiple means of representation, (b) multiple means of expression, and (c) multiple means of engagement. The UDL concept of barrier-free learning was combined with the transition-based principles of: (a) multiple life domains, (b) multiple means of assessment, (c) self- determination, and (d) multiple resources and perspectives, to form the UDT conceptual framework. Implications and planning for future research regarding the UDT framework are discussed

Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein.

Developing effective therapeutics for complex diseases such as late-onset, sporadic Alzheimer's disease (SAD) is difficult due to genetic and environmental heterogeneity in the human population and the limitations of existing animal models. Here, we used hiPSC-derived neurons to test a compound that stabilizes the retromer, a highly conserved multiprotein assembly that plays a pivotal role in trafficking molecules through the endosomal network. Using this human-specific system, we have confirmed previous data generated in murine models and show that retromer stabilization has a potentially beneficial effect on amyloid beta generation from human stem cell-derived neurons. We further demonstrate that manipulation of retromer complex levels within neurons affects pathogenic TAU phosphorylation in an amyloid-independent manner. Taken together, our work demonstrates that retromer stabilization is a promising candidate for therapeutic development in AD and highlights the advantages of testing novel compounds in a human-specific, neuronal system

MD vs. NP: A Study on Nurse Practitioner Roles and Responsibilities and their Acceptance in Our Generation

The purpose of this research was to compare the roles of physicians versus nurse practitioners in our community and raise awareness for nurse practitioners amongst our generation. It was hypothesized that there would be no difference in preference among the population to see a nurse practitioner or medical doctor as his/her routine provider. The null hypothesis was supported as evidenced by a p-value of 0.610. Results show that majority of the population understood the definition of a nurse practitioner. However, the surveyed population was unsure of the scope of practice of nurse practitioners. More than 90% of the studied population reported that education on the roles and services of nurse practitioners was desired. Based on the completed research, it was found that individuals have no preference on whether they see a nurse practitioner or a medical doctor for a routine check-up. A follow-up study should be performed

Voltage gated inter-cation selective ion channels from graphene nanopores

With the ability to selectively control ionic flux, biological protein ion channels perform a fundamental role in many physiological processes. For practical applications that require the functionality of a biological ion channel, graphene provides a promising solid-state alternative, due to its atomic thinness and mechanical strength. Here, we demonstrate that nanopores introduced into graphene membranes, as large as 50 nm in diameter, exhibit inter-cation selectivity with a ~20x preference for K+ over divalent cations and can be modulated by an applied gate voltage. Liquid atomic force microscopy of the graphene devices reveals surface nanobubbles near the pore to be responsible for the observed selective behavior. Molecular dynamics simulations indicate that translocation of ions across the pore likely occurs via a thin water layer at the edge of the pore and the nanobubble. Our results demonstrate a significant improvement in the inter-cation selectivity displayed by a solid-state nanopore device and by utilizing the pores in a de-wetted state, offers an approach to fabricating selective graphene membranes that does not rely on the fabrication of sub-nm pores

Eyes Save Lives Water Safety Program for Parents and Caregivers: Program Design and Pilot Evaluation from Southern California

Despite expert consensus and evidence-based preventative strategies against drowning, limited formal study exists on translating recommendations into practical and effective interventions. This paper describes the design of an education-based drowning prevention intervention and reports results from a pilot evaluation of the program’s effect on self-reported water-safe behaviors, attitudes, self-efficacy, and knowledge. Parents and caregivers attending children’s swim lessons in July and August 2018 participated in a brief water-safety education program. A pre-post-test design evaluated Theory of Planned Behavior indicators to assess for changes. We found significant increases in scores related to water safety knowledge, attitudes on maintaining arms reach distance to children in the pool, recognizing a child in distress, and self-efficacy of responding to water emergencies involving a child between pre- and post-program. Swim lessons provided a captive audience receptive to drowning prevention information. Due to minimal costs, the program could easily be replicated and delivered to a variety of parent groups

Effect of ActiGraph\u27s Low Frequency Extension for Estimating Steps and Physical Activity Intensity

This study examined the effects of the ActiGraph’s (AG) low-frequency extension (LFE) filter on steps and physical activity classification in the free-living environment. Thirty-four African-American women (age, 24.5±5.2 years; BMI, 24.9±4.5 kg/m2) had daily activity measured simultaneously with an AG-GT3X+ accelerometer and a New Lifestyles NL-800 pedometer for seven days. Steps per day (steps/day) and time (minutes/day) spent in sedentary, light, and moderate-to-vigorous physical activity (MVPA) were examined with and without the LFE filter (AG-LFE and AG-N, respectively). The AG-LFE recorded more total steps (13,723±4,983 steps/day) compared to AG-N and NL-800 (6,172±2,838 and 5,817±3,037 steps/day, respectively; p\u3c0.001). Compared to the AG-N, the AG-LFE estimated less time in sedentary behaviors (518.7±92.1 vs. 504.2±105.4 min/day, respectively; p\u3c0.001), and more time in light (247.7±70.4 vs. 279.1±74.7 min/day, respectively; p\u3c0.001) and MVPA (18.9±16.9 vs. 21.5±18.2 min/day, respectively; p\u3c0.001), respectively. These data suggest that steps and physical activity classifications will be affected when using the ActiGraph with and without the LFE filter. Future research should investigate the accuracy of these measures using the LFE filter

Dihydropyrimidine-thiones and clioquinol synergize to target beta-amyloid cellular pathologies through a metal-dependent mechanism

The lack of therapies for neurodegenerative diseases arises from our incomplete understanding of their underlying cellular toxicities and the limited number of predictive model systems. It is critical that we develop approaches to identify novel targets and lead compounds. Here, a phenotypic screen of yeast proteinopathy models identified dihydropyrimidine-thiones (DHPM-thiones) that selectively rescued the toxicity caused by β-amyloid (Aβ), the peptide implicated in Alzheimer’s disease. Rescue of Aβ toxicity by DHPM-thiones occurred through a metal-dependent mechanism of action. The bioactivity was distinct, however, from that of the 8-hydroxyquinoline clioquinol (CQ). These structurally dissimilar compounds strongly synergized at concentrations otherwise not competent to reduce toxicity. Cotreatment ameliorated Aβ toxicity by reducing Aβ levels and restoring functional vesicle trafficking. Notably, these low doses significantly reduced deleterious off-target effects caused by CQ on mitochondria at higher concentrations. Both single and combinatorial treatments also reduced death of neurons expressing Aβ in a nematode, indicating that DHPM-thiones target a conserved protective mechanism. Furthermore, this conserved activity suggests that expression of the Aβ peptide causes similar cellular pathologies from yeast to neurons. Our identification of a new cytoprotective scaffold that requires metal-binding underscores the critical role of metal phenomenology in mediating Aβ toxicity. Additionally, our findings demonstrate the valuable potential of synergistic compounds to enhance on-target activities, while mitigating deleterious off-target effects. The identification and prosecution of synergistic compounds could prove useful for developing AD therapeutics where combination therapies may be required to antagonize diverse pathologies.D.F.T was funded by NRSA Fellowship NIH 5F32NS061419. D.F.T. and S.L. were supported by WIBR funds in support of research on Regenerative Disease, the Picower/JPB Foundation, and the Edward N. and Della L. Thome Foundation. G.A.C. and S.L. were funded by a Howard Hughes Medical Institute (HHMI) Collaborative Innovation Award. L.E.B., R.T., and S.E.S. were funded by NIH GM086180, NIH GM067041, and NIH GM111625. (5F32NS061419 - NRSA Fellowship NIH; WIBR funds in support of research on Regenerative Disease; Picower/JPB Foundation; Edward N. and Della L. Thome Foundation; Howard Hughes Medical Institute (HHMI) Collaborative Innovation Award; GM086180 - NIH; NIH GM067041 - NIH; NIH GM111625 - NIH)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705239/Accepted manuscrip

Associations of Near-Surface Soil Moisture and Annual Plant Community Dynamics

Invasive species have become an increasingly large concern, particularly in already degraded ecosystems, such as sagebrush (Artemisia tridentata)-steppe of the Intermountain West. Much of this ecosystem is already infested with large cheatgrass (Bromus tectorum) stands and is potentially at risk for future invasions depending on biotic and abiotic conditions. In these ecosystems, the existing vegetation, whether native or non-native, may not effectively utilize the soil moisture resources in the upper portion of the soil, termed the growth pool. If the existing vegetation does not effectively utilize moisture in the growth pool, an open resource is left for the establishment of other plants, including invasives. Through a combination of soil moisture modeling and observational studies, we identified three potential invasion pathways, particularly by annual plants, into a cheatgrass-dominated system, all consistent with the fluctuating resource hypothesis, and all resulting from an available water resource in the growth pool. Results suggest these arid and semi-arid systems are likely to be protected from novel invasive species by complete utilization of growth pool soil water resources by any existing vegetation, whether native or non-native. Our results also suggest the same features which make the site more prone to novel annual invaders may also be useful in guiding establishment of desired vegetation during restoration efforts

Comparing Special Education Teachers’ Personality Profile With Their Choice to Teach

Researchers have yet to examine the association of Holland personality profiles as it relates to special education teachers. In response to this need, we report the personality and vocational profiles (Holland Codes) of 134 special education teachers across a special education training program. The purpose of this paper is to summarize findings from the Self-Directed Search measure commonly used to assess the personality of participants in an occupation and suggest implications for participants’ choice in becoming a special education teacher. Our focus was on personality match with vocational choice to include participants’ demographic (e.g., gender, race/ethnicity, and geographical location) profile. Findings from the study reveal that while special educators’ overall personality profile is congruent with the Holland Codes associated with special education teachers, other features may explain participants’ choice to pursue a career as a special education teacher. Implications for teacher preparation programs and K-12 schools training are recommended based on the research findings