Creating a Linked Data-Friendly Metadata Application Profile for Archival Description

We provide an overview of efforts to apply and extend Schema.org for archives and archival description. The authors see the application of Schema.org and extensions as a low barrier means to publish easily consumable linked data about archival resources, institutions that hold them, and contextual entities such as people and organizations responsible for their creation.Comment: 11 pages, 3 figures; full poster available from http://dcevents.dublincore.org/IntConf/dc-2017/paper/view/50

Evaluation of the Beacon Community Centers Middle School Initiative: Report on the First Year

Evaluates the first year of an initiative to provide structured after-school and summer programs for fifth- through eighth-graders. Examines the centers' adaptation to the new focus, enrollment and participation levels, and implementation of core goals

Stormwater Quality Management in Rhode Island

This study documents the threat that uncontrolled urban stormwater runoff poses to surface water quality and the inadequacy of existing regulations governing land use development in preventing further water quality degradation resulting from urban runoff. The study applies recent research findings from the Nationwide Urban Runoff Program and the experience of other state regulatory programs in evaluating management alternatives and proposing a strategy for Rhode Island. The documented impacts of urban stormwater runoff on water quality, including excesses in criteria for copper, lead, and coliform, and eutrophication, support the need for stormwater quality management. This need is made more evident by a review of existing regulations. Local authority to enact stormwater quality requirements is limited as, the legal basis under the zoning ordinance is uncertain and the subdivision ordinance, while providing adequate legal authority, applies to subdivisions, only. At the state level, no comprehensive policy or guidelines have been adopted under the Freshwater Wetlands (FWW) regulations. The Coastal Resources Management Council (CRMC) has adopted stormwater quality requirements which apply to only certain areas within their jurisdiction. At present, there are no federal regulations governing stormwater runoff. A comprehensive and consistent approach to stormwater quality management requires adoption of uniform applicability and designing criteria, and consistent performance standards. Of the three management alternatives evaluated in this study, the approach entailing the establishment of stormwater quality management requirements as mandatory provisions of the FWW and CRMC programs, as complements to the federally mandated National Pollution Discharge Elimination System program requirements is preferred

Aeroheating Measurements of BOLT Aerodynamic Fairings and Transition Module

The Air Force Office of Scientific Research (AFOSR) has sponsored the Boundary Layer Transition (BOLT) Experiments to investigate hypersonic boundary layer transition on a low-curvature, concave surface with swept leading edges. This paper presents aeroheating measurements on a subscale model of the BOLT Flight Geometry, aerodynamic fairings, and Transition Module (TSM) in the NASA Langley 20-Inch Mach 6 Air Tunnel. The purpose of the test was to investigate and identify any areas of localized heating on the TSM for inclusion in the BOLT Critical Design Review (CDR). Surface heating distributions were measured using global phosphor thermography, and data were obtained for a range of model attitudes and free stream Reynolds numbers. Measurements showed low heating on the fairings and TSM. Additional analysis was completed after the CDR to compare heating on the TSM for the nominal BOLT vehicle reentry angle-of-attack with heating on the TSM for possible reentry angle-of-attack excursions. The results of this analysis were used in conjunction with thermal analyses from Johns Hopkins Applied Physics Lab (JHU/APL) and the Air Force Research Laboratory (AFRL) to assess the need for thermal protection on the flight vehicle TSM

Carman G. Blough: His personality and formative years

The article briefly explores the personality and psychological makeup of Carman G. Blough and discusses some experiences during his formative years that made Blough the person he was

Phosphorylation of androgen receptors at serine 515 is a potential prognostic marker for triple negative breast cancer

1.7 million cases of breast cancer are diagnosed every year with 522,000 deaths. Molecular classifications of breast cancer have resulted in improved treatments. However, treatments for triple negative breast cancer (TNBC) are lacking. Analysis of molecular targets for TNBC is a priority. One potential candidate is androgen receptor (AR) phosphorylation. This study assessed the role of AR phosphorylation at ser81/ser515 and their two upstream effectors, cyclin-dependent kinase 1 (pCDK1) and extracellular-regulated kinase 1/2 (pERK1/2) in 332 ductal breast cancer patients by immunohistochemistry. pERK1/2 combined with AR-515 associated with improved cancer-specific survival (CSS, p = 0.038), decreased size (p = 0.001), invasive grade (p < 0.001), necrosis (p = 0.003), b-lymphocytes (p = 0.020), molecular subtype (p < 0.001) and estrogen receptor (ER)/progesterone receptor (PR)-status (p < 0.001). The cohort was therefore stratified into ER+ve and ER-ve patients. In ER+ve tumours, pERK1/2 combined with AR-515 associated with improved CSS (p = 0.038), smaller size (p = 0.004), invasive grade (p = 0.001), decreased b-lymphocytes (p = 0.013) and increased plasma cells (p = 0.048). In contrast, in TNBC patients, phosphorylation of AR-515 associated with poorer CSS (p = 0.007). pERK1/2 combined with AR-515 associated with decreased inflammation (p = 0.003), increased tumour stroma (p = 0.003) and tumour budding (p = 0.011), with trends towards decrease CSS (p = 0.065) and macrophage levels (p = 0.093). In Conclusions, AR-515 may be an important regulator of inflammation in breast cancer potential via ERK1/2 phosphorylation. AR-515 is a potential prognostic marker and therapeutic target for TNBC