Case Report: Familial Gastric Cancer and Chordoma in the Same Family

Gastric cancers are the second most common malignancy in the world and represent a major burden to all societies even though the incidence of disease is decreasing in the industrialized world. The aetiology of the disease is complex and is believed to be primarily due to environmental factors but a small proportion of cases are recognised as being associated with genetic factors. Two inherited forms of stomach cancer have been identified, one which is associated with familial clusterings of stomach cancer and the other being a subgroup of families that belong to hereditary non polyposis colorectal cancer (or Lynch syndrome). In this report we present a small nuclear family which is unusual in that there is a clustering of malignancy which includes stomach cancer, colorectal cancer and chordoma. Genetic analysis failed to reveal any causative mutation in genes associated with HNPCC or in E-cadherin. Together, the clinical picture in this family may indicate that other genetic factors are behind this family's clustering of malignancy

Towards timely diagnosis of symptomatic breast and cervical cancer in South Africa.

The global cancer burden is projected to increase by 50% by 2030 and, disturbingly, most of the increase will occur in LMICs.[1–4] Unique features of cancer in Africa are the disproportionately high burden of cancers in women (56%), the high proportion of infection-related cancers (30% of all cancers) and the late stage at which cancer is diagnosed (e.g. 46% of breast cancer in South Africa (SA) diagnosed at an advanced stage).[3–7] Cancer stage is a measure of cancer growth and spread, with stage at presentation being an important prognostic factor. Earlier stage at presentation, enabling more opportunities for curative treatment and improved outcomes, is thus an important goal in any comprehensive cancer care policy.SAMRC- is this the same, probably no

Evaluation of a Full-Fat Soybean Ration for Channel Catfish Production in Cages

An experimental ration consisting of 50% full-fat soybeans, heated 170°C, was compared to a commercial trout chow in a 120-day feeding trial using two stocks of channel catfish, Ictalurus punctatus Rafinesque. Catfish were reared in 0.9 m³ floating cages, with 200 fish per cage, anchored in a 1.5 hectare farm pond. A Central Arkansas stock significantly outperformed a Southeast Arkansas stock for comparisons of net production and food conversion efficiency (FCE), with 92% greater production and 41% better FCE, respectively. Survival was 90% or greater for all fish. There was no significant difference in dress-out weight between the stocks. However, the catfish fed the trout ration had significantly lower amounts of body fat. The commercial trout chow overall was significantly better for fish production than the full-fat soybean ration. Production with trout chow was 84% greater than with the full-fat soybean ration. Food conversion efficiency was nearly 41% better with the trout ration, while percent body fat was 11% less. There were no differences in percent survival and percent dress-out weight between the rations. The Central Arkansas stock fed the commercial trout ration had the lowest production cost of 0.47¢ per 0.45 kg live weight, while the Southeastern stock had a higher production cost with either feed

Search for young stars among ROSAT All-Sky Survey X-ray sources in and around the R CrA dark cloud

We present the ROSAT All-Sky Survey data in a 126 deg^2 area in and around the CrA star forming region. With low-resolution spectroscopy of unidentified ROSAT sources we could find 19 new pre-main sequence stars, two of which are classical T Tauri stars, the others being weak-lined. The spectral types of these new T Tauri stars range from F7 to M6. The two new classical T Tauri stars are located towards two small cloud-lets outside of the main CrA cloud. They appear to be ~10 Myrs old, by comparing their location in the H-R diagram with isochrones for an assumed distance of 130 pc, the distance of the main CrA dark cloud. The new off-cloud weak-line T Tauri stars may have formed in similar cloud-lets, which have dispersed recently. High-resolution spectra of our new T Tauri stars show that they have significantly more lithium absorption than zero-age main-sequence stars of the same spectral type, so that they are indeed young. From those spectra we also obtained rotational and radial velocities. For some stars we found the proper motion in published catalogs. The direction and velocity of the 3D space motion - south relative to the galatic plane - of the CrA T Tauri stars is consistent with the dark cloud being formed originally by a high-velocity cloud impact onto the galactic plane, which triggered the star formation in CrA. We also present VRIJHK photometry for most of the new T Tauri stars to derive their luminosities, ages, and masses.Comment: A&A Suppl. in pres

Verification of a New NOAA/NSIDC Passive Microwave Sea-Ice Concentration Climate Record

A new satellite-based passive microwave sea-ice concentration product developed for the National Oceanic and Atmospheric Administration (NOAA)Climate Data Record (CDR) programme is evaluated via comparison with other passive microwave-derived estimates. The new product leverages two well-established concentration algorithms, known as the NASA Team and Bootstrap, both developed at and produced by the National Aeronautics and Space Administration (NASA) Goddard Space Flight Center (GSFC). The sea ice estimates compare well with similar GSFC products while also fulfilling all NOAA CDR initial operation capability (IOC) requirements, including (1) self describing file format, (2) ISO 19115-2 compliant collection-level metadata,(3) Climate and Forecast (CF) compliant file-level metadata, (4) grid-cell level metadata (data quality fields), (5) fully automated and reproducible processing and (6) open online access to full documentation with version control, including source code and an algorithm theoretical basic document. The primary limitations of the GSFC products are lack of metadata and use of untracked manual corrections to the output fields. Smaller differences occur from minor variations in processing methods by the National Snow and Ice Data Center (for the CDR fields) and NASA (for the GSFC fields). The CDR concentrations do have some differences from the constituent GSFC concentrations, but trends and variability are not substantially different

Model-Based Estimation of Muscle Forces Exerted During Movements

Estimation of individual muscle forces during human movement can provide insight into neural control and tissue loading and can thus contribute to improved diagnosis and management of both neurological and orthopaedic conditions. Direct measurement of muscle forces is generally not feasible in a clinical setting, and non-invasive methods based on musculoskeletal modeling should therefore be considered. The current state of the art in clinical movement analysis is that resultant joint torques can be reliably estimated from motion data and external forces (inverse dynamic analysis). Static optimization methods to transform joint torques into estimates of individual muscle forces using musculoskeletal models, have been known for several decades. To date however, none of these methods have been successfully translated into clinical practice. The main obstacles are the lack of studies reporting successful validation of muscle force estimates, and the lack of user-friendly and efficient computer software. Recent advances in forward dynamics methods have opened up new opportunities. Forward dynamic optimization can be performed such that solutions are less dependent on measured kinematics and ground reaction forces, and are consistent with additional knowledge, such as the force–length–velocity–activation relationships of the muscles, and with observed electromyography signals during movement. We conclude that clinical applications of current research should be encouraged, supported by further development of computational tools and research into new algorithms for muscle force estimation and their validation

A Deep ROSAT HRI Observation of NGC 1313

We describe a series of observations of NGC 1313 using the ROSAT HRI with a combined exposure time of 183.5 ksec. The observations span an interval between 1992 and 1998; the purpose of observations since 1994 was to monitor the X-ray flux of SN1978K, one of several luminous sources in the galaxy. No diffuse emission is detected in the galaxy to a level of ~1-2x10^37 ergs/s/arcmin^-2. A total of eight sources are detected in the summed image within the D_25 diameter of the galaxy. The luminosities of five of the eight range from \~6x10^37 to ~6x10^38 erg/s; these sources are most likely accreting X-ray binaries, similar to sources obseved in M31 and M33. The remaining three sources all emit above 10^39 erg/s. We present light curves of the five brightest sources. Variability is detected at the 99.9% level from four of these. We identify one of the sources as an NGC 1313 counterpart of a Galactic X-ray source. The light curve, though crudely sampled, most closely resembles that of a Galactic black hole candidate such as GX339-4, but with considerably higher peak X-ray luminosity. An additional seven sources lie outside of the D_25 diameter and are either foreground stars or background AGN.Comment: 18 pages, 9 figures; accepted AJ, scheduled for November 200