Text-based vs. graphical information formats in sepsis prevention and early detection: A randomized controlled trial on informed choice

Sepsis is associated with 11 million global deaths annually. Although serious consequences of sepsis can generally be avoided with prevention and early detection, research has not yet addressed the efficacy of evidence-based health information formats for different risk groups. This study examines whether two evidence-based health information formats—text based and graphical—differ in how well they foster informed choice and risk and health literacy and in how well they support different sepsis risk groups. Based on a systematic literature review, two one-page educative formats on sepsis prevention and early detection were designed—one text based and one graphical. A sample of 500 German participants was randomly shown one of the two formats; they were then assessed on whether they made informed choices and on their risk and health literacy. For both formats, >70% of participants made informed choices for sepsis prevention and >75% for early detection. Compared with the graphical format, the text-based format was associated with higher degrees of informed choice (p = 0.012, OR = 1.818) and risk and health literacy (p = 0.032, OR = 1.710). Both formats can foster informed choices and risk and health literacy on sepsis prevention and early detection, but the text-based format appears to be more effective

Neuroprotective Effects of Bilobalide are Accompanied by a Reduction of Ischemia-Induced Glutamate Release \u3cem\u3ein vivo\u3c/em\u3e

Neuroprotective properties of bilobalide, a specific constituent of Ginkgo extracts, were tested in a mouse model of stroke. After 24 h of middle cerebral artery occlusion (MCAO), bilobalide reduced infarct areas in the core region (striatum) by 40–50% when given at 10 mg/kg 1 h prior to MCAO. Neuroprotection was also observed at lower doses, or when the drug was given 1 h past stroke induction. Sensorimotor function in mice was improved by bilobalide as shown by corner and chimney tests. When brain metabolism in situ was monitored by microdialysis, MCAO caused a rapid disappearance of extracellular glucose in the striatum which returned to baseline levels after reperfusion. Extracellular levels of glutamate were increased by more than ten-fold in striatal tissue, and by four- to fivefold in hippocampal tissue (penumbra). Bilobalide did not affect glucose levels but strongly attenuated glutamate release in both core and penumbra regions. Bilobalide was equally active when given locally via the microdialysis probe and also reduced ischemia-induced glutamate release in vitro in brain slices. We conclude that bilobalide is a strong neuroprotectant in vivo at doses that can be used therapeutically in humans. The mechanism of action evidently involves reduction of glutamate release, thereby reducing excitotoxicity

Early-career researchers at the 6th European Conference on Permafrost

The 6th European Conference on Permafrost (EUCOP), hosted by the International Permafrost Association (IPA), brought together researchers from all over the world in Puigcerdà, Spain, on 18–22 June 2023. The conference covered relevant aspects of permafrost research, from analysing and modelling the highly dynamic permafrost environment to the assessment of climatic and societal impacts. Approaches and methods were discussed during 3 intensive days of oral presentations and poster sessions, topped with local field trips across the eastern Pyrenees. For the recipients of funding by the German Society for Polar Research (DGP), EUCOP 2023 served as a platform for them to present their research to the international permafrost community, gain insights into current research trends, and establish valuable connections within the field.</p

On the generation of asymmetric warps in disk galaxies

The warps in many spiral galaxies are now known to asymmetric. Recent sensitive observations have revealed that asymmetry of warps may be the norm rather than exception. However there exists no generic mechanism to generate these asymmetries in warps. We have derived the dispersion relation in a compact form for the S-shaped warps(described by the m=1 mode) and the bowl-shaped distribution(described by the m=0 mode) in galactic disk embedded in a dark matter halo. We then performed the numerical modal analysis and used the linear and time-dependent superposition principle to generate asymmetric warps in the disk. On doing the modal analysis we find the frequency of the $m=0$ mode is much larger than that of the $m=1$ mode. The linear and time-dependent superposition of these modes with their unmodulated amplitudes(that is, the coefficients of superposition being unity) results in an asymmetry in warps of ~ 20 - 40 %, whereas a smaller coefficient for the m=0 mode results in a smaller asymmetry. The resulting values agree well with the recent observations. We study the dependence of the asymmetry index on the dark matter halo parameters. This approach can also naturally produce U-shaped warps and L-shaped warps. We show that a rich variety of possible asymmetries in the z-distribution of the spiral galaxies can naturally arise due to a dynamical wave interference between the first two bending modes(i.e. m=0 and m=1) in the disk. This is a simple but general method for generating asymmetric warps that is independent of how the individual modes arise in the disk.Comment: Accepted for publication in A &

Neutral Hydrogen and Optical Observations of Edge-on Galaxies: Hunting for Warps

We present 21-cm HI line and optical R-band observations for a sample of 26 edge-on galaxies. The HI observations were obtained with the Westerbork Synthesis Radio Telescope, and are part of the WHISP database (Westerbork HI Survey of Spiral and Irregular Galaxies). We present HI maps, optical images, and radial HI density profiles. We have also derived the rotation curves and studied the warping and lopsidedness of the HI disks. 20 out of the 26 galaxies of our sample are warped, confirming that warping of the HI disks is a very common phenomenon in disk galaxies. Indeed, we find that all galaxies that have an extended HI disk with respect to the optical are warped. The warping usually starts around the edge of the optical disk. The degree of warping varies considerably from galaxy to galaxy. Furthermore, many warps are asymmetric, as they show up in only one side of the disk or exhibit large differences in amplitude in the approaching and receding sides of the galaxy. These asymmetries are more pronounced in rich environments, which may indicate that tidal interactions are a source of warp asymmetry. A rich environment tends to produce larger warps as well. The presence of lopsidedness seems to be related to the presence of nearby companions.Comment: To appear in Astronomy & Astrophysic