Sewing Constraints and Non-Orientable Open Strings

We extend to non-orientable surfaces previous work on sewing constraints in Conformal Field Theory. A new constraint, related to the real projective plane, is described and is used to illustrate the correspondence with a previous construction of open-string spectra.Comment: phyzzx, 11 pages and 4 figures, ROM2F-93/3

Planar Duality in SU(2)SU(2) WZW Models

We show how to generalize the $SU(2)$ WZW models to allow for open and unoriented sectors. The construction exhibits some novel patterns of Chan-Paton charge assignments and projected spectra that reflect the underlying current algebra.Comment: 13 pages, latex, 1 figure

Immunotherapy in Gynecologic Cancers

During the last years, significant progress in the understanding of signaling pathways of immune cells has revive the field of immune therapy for cancer. In this chapter, we explain the recent immunotherapy-based strategies for the treatment of gynecological cancers including cervical cancer, endometrial cancer, ovarian cancer, and vulvar cancer. This work will mainly focus on emerging clinical data on immune checkpoint inhibitors. But also data on adoptive T cell therapies and vaccines will be presented. It is anticipated that in future biomarker-guided randomized trials will provide better approaches in terms of response and resistance to immune therapy. The use of combination therapy for gynecological cancer might be one possible approach to overcome resistance

A Note on the Green - Schwarz Mechanism in Open - String Theories

An interesting feature of some open superstring models in $D < 10$ is the simultaneous presence, in the spectrum, of gauge fields and of a number of antisymmetric tensor fields. In these cases the Green-Schwarz mechanism can (and does) take a generalized form, resulting from the combined action of all the antisymmetric tensors. These novelties are illustrated referring to some simple rational models in six dimensions, and some of their implications for the low-energy effective field theory are pointed out.Comment: 13 pages, phyzz

Interacting Chiral Gauge Fields in Six Dimensions and Born-Infeld Theory

Dimensional reduction of a self-dual tensor gauge field in 6d gives an Abelian vector gauge field in 5d. We derive the conditions under which an interacting 5d theory of an Abelian vector gauge field is the dimensional reduction of a 6d Lorentz invariant interacting theory of a self-dual tensor. Then we specialize to the particular 6d theory that gives 5d Born-Infeld theory. The field equation and Lagrangian of this 6d theory are formulated with manifest 5d Lorentz invariance, while the remaining Lorentz symmetries are realized nontrivially. A string soliton with finite tension and self-dual charge is constructed.Comment: 22 pages, latex, no figure

Exceptional groups from open strings

We consider type IIB theory compactified on a two-sphere in the presence of mutually nonlocal 7-branes. The BPS states associated with the gauge vectors of exceptional groups are seen to arise from open strings connecting the 7-branes, and multi-pronged open strings capable of ending on more than two 7-branes. These multi-pronged strings are built from open string junctions that arise naturally when strings cross 7-branes. The different string configurations can be multiplied as traditional open strings, and are shown to generate the structure of exceptional groups.Comment: 25 pages, LATEX, 9 figures; minor changes, two references adde

Classical Duality from dimensional reduction of Self Dual 4-form Maxwell Theory in 10 dimensions

By dimensional reduction of a self dual p-form theory on some compact space, we determine the duality generators of the gauge theory in 4 dimensions. In this picture duality is seen as a consequence of the geometry of the compact space. We describe the dimensional reduction of 10-dimensional self dual 4-form Maxwell theory to give a theory in 4-dimensions with scalar, one form and two form fields that all transform non trivially under duality.Comment: 8 pages, tex, no figures, typos corrected, To coincide with published version, references adde

Heterotic and type I strings from twisted supermembranes

As shown by Ho\v{r}ava and Witten, there are gravitational anomalies at the boundaries of $M^{10}\times S^1/Z_2$ of 11 dimensional supergravity. They showed that only 10 dimensional vector multiplets belonging to $E_8$ gauge group can be consistently coupled to this theory. Thus, the dimensional reduction of this theory should be the low energy limit of the $E_8\times E_8$ heterotic string. Here we assume that M-theory is a theory of supermembranes which includes twisted supermembranes. We show that for a target space $M^{10}\times S^1/Z_2$, in the limit in which $S^1/Z_2$ is small, the effective action is the $E_8\times E_8$ heterotic string. We also consider supermembranes on $M^{9}\times S^1\times S^1/Z_2$ and find the dualities expected from 11 dimensional supergravity on this manifold. We show that the requirements for worldsheet anomaly cancellations at the boundaries of the worldvolume action are the same requirements imposed on the Ho\v{r}ava-Witten action.Comment: 17 pages, Late

Symplectic Structures and Self -dual Fields in (4k+2) Dimensions

We discuss symplectic structures for the chiral boson in (1+1) dimensions and the self-dual field in (4k+2) dimensions. Dimensional reduction of the six-dimensional field on a torus is also considered.Comment: 10 pages, plain Tex, new references adde

The Open Descendants of Non-Diagonal SU(2) WZW Models

We extend the construction of open descendants to the $SU(2)$ WZW models with non-diagonal left-right pairing, namely $E_7$ and the $D_{odd}$ series in the $ADE$ classification of Cappelli, Itzykson and Zuber. The structure of the resulting models is determined to a large extent by the ``crosscap constraint'', while their Chan-Paton charge sectors may be embedded in a general fashion into those of the corresponding diagonal models.Comment: 14 pages, latex, 1 figur