63 research outputs found
Why IT is not being used for financial advisory
Swiss banks have returned to their roots and pay an increasing amount of attention to differentiating themselves from others through good financial advisory services. This has led to a loudly publicized standardization of IT-advisory processes, but not to an increasing use of supporting IT tools. This paper uses interviews with Swiss advisors, sales managers and IT managers, as well as focus groups of users and a survey with users to identify reasons for non-usage. The analysis is based on a framework combining principal-agent theory, IT-business alignment, technology acceptance and information behaviour. We provide evidence that the key problem explanation is the incentive system of the advisors and that poor usability of the software and lack of engagement by sales managers also contribute to the non-usage of most tools
The development and test of a relationship model on system use, job learning, and impact
Swiss banks have returned to their roots and pay an increasing amount of attention to differentiating
themselves from others through good financial advisory services. This has led to a loudly publicized
standardization of IT-advisory processes, but not to an increasing use of supporting IT tools. This paper uses interviews with Swiss advisors, sales managers and IT managers, as well as focus groups of
users and a survey with users to identify reasons for non-usage. The analysis is based on a framework
combining principal-agent theory, IT-business alignment, technology acceptance and information behaviour. We provide evidence that the key problem explanation is the incentive system of the advisors
and that poor usability of the software and lack of engagement by sales managers also contribute to
the non-usage of most tool
Designing for Cost Transparency in Investment Advisory Service Encounters
Investment advisory services of financial service providers (FSPs) exhibit several characteristics that are detrimental to advisory quality. The interaction of advisor and client is strained by a lack of transparency regarding the advisory process (what activities are performed and why) and the information used therein (what information is used for what purpose and with what effect), as well as regarding the precise costs of the service and the recommended products. In prior research, we suggested that process and information transparency issues may be appropriately addressed with collaborative information technology (IT) artifacts. In this paper, we argue that collaborative, transparent artifacts may also be a premise of enabling cost transparency. To this end, we describe a complete research cycle of designing, implementing, and evaluating a shared cost-transparent IT artifact to support client-advisor interaction in investment advisory encounters. Evaluation results suggest the efficacy of our design in improving the clients' perceived cost transparency as well as increase their satisfaction and their willingness to pay for the received investment advice. These findings may also challenge the common belief of FSPs that transparent, fee-based advisory services would neither be accepted by clients nor be economically viable. Practical implications of these findings for designing advisory encounters with supportive IT are discusse
a retrospective study
Introduction Emergency treatment of major sub-/total traumatic amputations
continue to represent a clinical challenge due to high infection rates and
serious handicaps. Effective treatment is based on two columns: surgery and
antimicrobial therapy. Detailed identification of pathogen spectrum and
epidemiology associated with these injuries is of tremendous importance as it
guides the initial empiric antibiotic regimen and prevents adverse septic
effents. Methods In this retrospective study 51 patients with major traumatic
amputations (nâ=â16) and subtotal amputations (nâ=â35) treated from 2001 to
2010 in our trauma center were investigated. All patients received emergency
surgery, debridement with microbiological testing within 6 h after admission
and empircic antimicrobial therapy. Additionally to baseline patient
characteristics, the incidence of positive standardized microbiologic testing
combined with clinical signs of infection, pathogen spectrum, administered
antimicrobial agents and clinical complications were analyzed. Results 70.6%
of the patients (nâ=â36) acquired wound infection. In 39% wounds were
contaminated on day 1, whereas the mean length of duration until first
pathogen detection was 9.1â±â13.4 days after injury. In 37% polymicrobial
colonization and 28% Pseudomonas were responsible for wound infections during
hospitalization. In 45% the empirc antimicrobial therapy focussed on Gram
positive strains did not cover the detected bacteria, according antimicrobial
resistogram. It was significantly more often found in infections associated
with Pseudomonas (p 0.02) or polymicrobial wound infections. Conclusions This
epidemiologic study reveals a pathogen shift from Gram-positive to Gram-
negative strains with high incidence of Pseudomonas and polymicrobial
infections in sub-/total major traumatic amputations. Therefore, empiric
antimicrobial treatment historically focussing on Gram-positive strains must
be adjusted. We recommend the use of Piperacillin/Tazobactam for these
injuries. As soon as possible antimicrobial treatment should be changed from
empiric to goal directed therapy according to the microbiological tests and
resistogram results
Impact of high prevalence of pseudomonas and polymicrobial gram-negative infections in major sub-/total traumatic amputations on empiric antimicrobial therapy: a retrospective study
INTRODUCTION: Emergency treatment of major sub-/total traumatic amputations continue to represent a clinical challenge due to high infection rates and serious handicaps. Effective treatment is based on two columns: surgery and antimicrobial therapy. Detailed identification of pathogen spectrum and epidemiology associated with these injuries is of tremendous importance as it guides the initial empiric antibiotic regimen and prevents adverse septic effents. METHODS: In this retrospective study 51 patients with major traumatic amputations (nâ=â16) and subtotal amputations (nâ=â35) treated from 2001 to 2010 in our trauma center were investigated. All patients received emergency surgery, debridement with microbiological testing within 6 h after admission and empircic antimicrobial therapy. Additionally to baseline patient characteristics, the incidence of positive standardized microbiologic testing combined with clinical signs of infection, pathogen spectrum, administered antimicrobial agents and clinical complications were analyzed. RESULTS: 70.6% of the patients (nâ=â36) acquired wound infection. In 39% wounds were contaminated on day 1, whereas the mean length of duration until first pathogen detection was 9.1â±â13.4 days after injury. In 37% polymicrobial colonization and 28% Pseudomonas were responsible for wound infections during hospitalization. In 45% the empirc antimicrobial therapy focussed on Gram positive strains did not cover the detected bacteria, according antimicrobial resistogram. It was significantly more often found in infections associated with Pseudomonas (p 0.02) or polymicrobial wound infections. CONCLUSIONS: This epidemiologic study reveals a pathogen shift from Gram-positive to Gram-negative strains with high incidence of Pseudomonas and polymicrobial infections in sub-/total major traumatic amputations. Therefore, empiric antimicrobial treatment historically focussing on Gram-positive strains must be adjusted. We recommend the use of Piperacillin/Tazobactam for these injuries. As soon as possible antimicrobial treatment should be changed from empiric to goal directed therapy according to the microbiological tests and resistogram results
NewHope on ARM Cortex-M
Recently, Alkim, Ducas, Pöppelmann, and Schwabe proposed a Ring-LWE-based
key exchange protocol called NewHope (Usenix Securitz 2016) and illustrated that
this protocol is very efficient on large Intel processors.
Their paper also claims that the parameter choice enables efficient
implementation on small embedded processors.
In this paper we show that these claims are actually correct
and present NewHope software for the ARM Cortex-M family of
32-bit microcontrollers. More specifically, our software targets
the low-end Cortex-M0 and the high-end Cortex-M4 processor from this family.
Our software starts from the C reference implementation
by the designers of NewHope and then carefully optimizes subroutines in assembly.
In particular, compared to best results known so far,
our NTT implementation achieves a speedup of almost a factor of 2 on the Cortex-M4.
Our Cortex-M0 NTT software slightly outperforms previously best results on the Cortex-M4,
a much more powerful processor.
In total, the server side of the key exchange executes in only
1,476,101 cycles on the M0 and only 834,524 cycles on the M4;
the client side executes in 1,760,837 cycles on the M0 and
982,384 cycles on the M4
The Digital Transformation of PhysicianâPatient Consultations: Identifying Problems and Approaches to Improve Adherence
There is evidence for a correlation between effective physicianâpatient communication in consultations and improved adherence to treatment. Lack of time, limited communication training, growing administrative duties, and low recall of physiciansâ information and recommendations by patients are antagonists to effective physicianâpatient communication. In interviews with physicians, therapists, and patients, we first identify problems of current consultation practices and condense them in a problem scenario. We then use interview results to explore potential solutions, applying modern information technology such as digital medical assistants. Lastly, those potential solutions are condensed in an activity scenario that can be used for further design science research activities
Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas
Background Piwi-interacting RNAs (piRNAs) are small RNAs of 27â30 nucleotides
mapping to transposons or clustering in repeat genomic regions. Preliminary
studies suggest an important role in cancerogenesis. This study is the first
one investigating their prognostic impact in clear cell renal cell cancer
(ccRCC) patients. Methods Three piRNAs (piR-30924, piR-57125, and piR-38756)
selected on the basis of initial piRNA microarray analyses were determined
using RT-qPCR in non-metastatic (nâ=â76) and metastatic (nâ=â30) ccRCC tissue
at the time of nephrectomy in comparison to normal renal tissue (nâ=â77) and
tissue from distant ccRCC metastases (nâ=â13). Primary clinical end points
were recurrence-free and overall survival. Results piR-57125 showed lower
expression in metastatic than in non-metastatic tumors, whereas the expression
of piR-30924 and piR-38756 increased in metastatic tumors. The higher
expression of piR-30924 and piR-38756 as well as the lower expression of
piR-57125 in metastatic primary tumors were significantly associated with
tumor recurrence and overall survival. Multivariate Cox regression analyses
revealed both piR-30924 and piR-57125 as independent prognostic predictors.
This impact was even more pronounced in non-metastatic patients. Conclusions
This study demonstrates that the expression levels of these piRNAs in primary
non-metastatic and metastatic ccRCC tissue can serve as potential prognostic
biomarkers in combination with clinicopathological factors
The effect of air-powder polishing on the fluoride release of bracket adhesives
Fragestellung: In vitro sollte der Einfluss von Pulver-Wasser-StrahlgerÀten
(PWS) auf die Fluoridfreisetzung von BracketadhÀsiven untersucht werden.
Material und Methode: Untersuchte AdhÀsive: Tectosan (fluoridfreie
Kontrollgruppe) [BonaDent], ConTec LC [Dentaurum], Beauty Ortho Bond [SHOFU],
Transbond PLUS Color Change Adhesive [3M Unitek], Light Bond [Reliance
Orthodontic Products], Phase II [Reliance Orthodontic Products], BonaBond plus
LC [BonaDent]. Pro Material wurden 130 Delrin-Ringe [DuPont] (1,5 mm hoch, 7
mm Innen-durchmesser) mit AdhĂ€siv gefĂŒllt und zwischen Polyethylenfolie [MDS]
und Glasscheiben [Becht] unter einer Last von 5 N mit der bluephase 20i
[Ivoclar Vivadent] bei 1200 mW/cmÂČ photopolymerisiert (auĂer Phase II). Die
Polymerisation erfolgte von oben und unten im 90° Winkel durch die jeweilige
Glasplatte (Abstand zum PrĂŒfkörper 5 bis 6 mm). Die Kompositscheiben wurden in
2,5 ml deionisiertem Wasser bei 37 °C in Polypropylen-Röhrchen [Th. Geyer]
gelagert. Die Ober-flÀchenbearbeitung wurde mit zwei unterschiedlichen Pulver-
Wasser-StrahlgerÀten (Prophy-Mate neo [NSK], easyjet pro [mectron])
durchgefĂŒhrt, die mit drei verschiedenen Reinigungspulvern (FLASH pearl/CaCO3
[NSK], prophylaxis powder/NaHC03 [mectron], Clinpro Prophy Powder/Glycin [3M
ESPE]) kombiniert wurden. In AbstÀnden von 28 d ± 4 h wurden die Proben bis
zur 20. Woche entnommen, halbseitig fĂŒr 4 Sekunden mit einem PWS bestrahlt
(Abstand: 3 bis 5 mm, Winkel: 30° bis 60°), (auĂer 10 Referenzproben) und in
ein neues Polypropylen-Röhrchen mit frischem Wasser gegeben. AnschlieĂend
wurde die Fluoridfreisetzung im Eluat mittels ionenselektiver Elektrode (HI
4110 [HANNA Instruments]) bestimmt. Ergebnisse: Die signifikant höchste
Fluoridfreisetzung wurde fĂŒr Transbond PLUS Color Change Adhesive gemessen,
gefolgt von Beauty Ortho Bond. Die statistische Auswertung zwischen der 17.
und 20. Versuchswoche zeigte, dass durch die OberflÀchenbearbeitung keine
generelle Erhöhung der Fluoridfreisetzung erreicht wurde. Bei verschiedenen
Materialien wurde in AbhÀngigkeit von der gewÀhlten Bearbeitungsvariante eine
Steigerung der Fluoridfreisetzung bewirkt, jedoch wurden damit nicht die
starken Unterschiede in der Fluoridfreisetzung zwischen den untersuchten
Materialien ausgeglichen. AuffÀllig war, dass die Verwendung von
Kalziumkarbonat (FLASH pearl) als Strahlmittel in beiden PWS-GerÀten bei
gleicher GerÀteeinstellung (ohne Wasserzufuhr) eine deutliche Steigerung der
Fluoridfreisetzung gegenĂŒber den unbestrahlten Referenzgruppen und den ĂŒbrigen
Reinigungspulvern (Glycin und Natriumbikarbonat) bewirkte (Ausnahme: Transbond
PLUS Color Change Adhesive). Vergleicht man die Wirkung beider Pulver-Wasser-
StrahlgerÀte hinsichtlich der Verteilung von signifikanten Steigerungen der
Fluoridkonzentrationen gegenĂŒber den unbestrahlten Referenzgruppen, so wurden
bei Betrachtung aller AdhÀsive und Bearbeitungsvarianten mit Prophy-Mate neo
im VerhÀltnis 4:3 mehr signifikante Steigerungen als mit easyjet pro
beobachtet. Schlussfolgerung: Da BracketadhÀsive in der Regel relativ rau
sind, ist es vorteil-haft, dass durch eine PWS-Anwendung die
Fluoridfreisetzung erhöht werden kann.Aim: It was the aim of this study to investigate the effect of air-powder
polishing on the fluoride release of bracket adhesives in vitro. Material and
methods: The following adhesives were investigated: Tectosan (fluoride-free
control group) [BonaDent], ConTec LC [Dentaurum], Beauty Ortho Bond [SHOFU],
Transbond PLUS Color Change Adhesive [3M Unitek], Light Bond [Reliance
Orthodontic Products], Phase II [Reliance Orthodontic Products], BonaBond plus
LC [BonaDent]. For each of these materials, 130 plastic rings made from Delrin
[DuPont] (1.5 mm thick, diameter 7 mm) were filled with adhesive and
photopolymerized (bluephase 20i, 1200 mW/cmÂČ [Ivoclar Vivadent]), (except for
Phase II) between a polyethylene foil [MDS] and a glass plate [Becht] under a
load of 5 N. The Polymerization was carried out at a 90° angle through the
bottom- and the top glass plate (5 to 6 mm thick). The composite discs were
stored in 2.5 ml of deionized water at 37 °C in polypropylene vials [Th.
Geyer]. Surface treatment was carried out with two different air-powder-
polishing devices (APP) (Prophy-Mate neo [NSK], easyjet pro [mectron]), that
were combined with three different cleaning powders (FLASH pearl/CaCO3 [NSK],
prophylaxis powder/NaHC03 [mectron], Clinpro Prophy Powder/glycine [3M ESPE]).
Specimens were taken at intervals of 28 days ± 4 hours up to week 20 from
their vials, were then air-polished on half of their upper and lower surfaces
for 4 seconds (distance: 3-5 mm, angle: 30°-60°), (with the exception of ten
reference specimens) and subsequently transferred into a new polypropylene
vial with fresh deionized water. After that, the fluoride release in the
eluate was determined with a fluoride ion-selective electrode (HI 4110 [HANNA
Instruments]). Results: The significantly highest fluoride release was
measured for Transbond PLUS Color Change Adhesive, followed by Beauty Ortho
Bond. The statistical evaluation between week 17 and 20 showed that no general
increase in the fluoride release was achieved through air-polishing. For
various materials, an increase in the fluoride release was achieved as a
function of the treatment option selected, but this did not compensate for the
big differences in the fluoride release between the materials investigated. It
was noticeable that the use of calcium carbonate (FLASH pearl) as an abrasive
in both APP with the same instrument setting (without water) caused a
significant increase in fluoride release compared with the unexposed reference
groups and the other abrasives (glycine and sodium bicarbonate), (except for
Transbond PLUS Color Change Adhesive). Comparing the effect of both APP in the
allocation of significant increases in the fluoride concentrations compared
with the unexposed reference groups, in view of all adhesives and processing
variants with Prophy-Mate neo were observed more significant increases than
with easyjet pro in ratio of 4 to 3. Conclusion: As bracket adhesives usually
have rather rough surfaces it seems to be a beneficial effect that air-
polishing has the potential to increase the fluoride release under certain
conditions
Experimental investigations for prevention and improvement of surgical therapy of tibia shaft non-unions
Die Inzidenz von Pseudarthrosen nach Frakturen im Bereich des Tibiaschaftes
liegt in AbhÀngigkeit der initialen Traumacharakteristik bei 3-54%. Die
Behandlung von Pseudarthrosen des Tibiaschaftes ist langwierig und stellt
sowohl den behandelnden Chirurgen, als auch den Patienten vor eine
anspruchsvolle Aufgabe. Wir konnten erstmals nachweisen, dass selbst bei
erfolgreich therapierten Patienten mit einer adÀquaten Knochen- und
Weichteilheilung auch im Langzeitverlauf signifikante EinschrÀnkungen
bezĂŒglich des funktionellen Outcomes und der LebensqualitĂ€t bestehen. Vor dem
Hintergrund dieser Aspekte wurden experimentelle AnsÀtze zur Prophylaxe und
Optimierung der Therapie vorgestellt und evaluiert. Als neues Konzept wurde
die lokale Applikation von bioaktiven Substanzen ĂŒber eine Poly(D,L-laktid)
Beschichtung (PDLLA) fĂŒr Implantate eingefĂŒhrt. Dabei fungiert das Implantat
zum einen als mechanischer Stabilisator fĂŒr die Fraktur, bzw. Pseudarthrose,
und zum anderen als âDrugcarrierâ fĂŒr pharmokologische Substanzen, mit der
Potenz den Knochenstoffwechsel positiv zu beeinflussen. Das PDLLA stellt in
seiner Form als Implantatbeschichtung das Bindeglied zwischen dem Implantat
und dem Pharmakon dar. WĂ€hrend in Vorarbeiten die Biodegradierbarkeit und
Freisetzungskinetik von Substanzen aus der Beschichtung bereits dargestellt
wurde, konnte nun auch die BiokompatibilitÀt nachgewiesen werden. Im ersten
Ansatz wurde ĂŒber das Konzept des bioaktiven Implantates ein non-viraler
Gentransfer durchgefĂŒhrt. DafĂŒr wurden Copolymer-geschĂŒtzte, fĂŒr BMP-2
kodierende, DNA-Plasmide in die Implantatbeschichtung eingearbeitet und das
Verfahren in einem etablierten Frakturmodell der Rattentibia hinsichtlich
seiner Sicherheit und EffektivitĂ€t beurteilt. Der Gentransfer fĂŒhrte zu keiner
systemischen Distribution und konnte als sicher eingestuft werden. Es konnte
eine transgene Expression von BMP-2 ĂŒber den gesamten Versuchszeitraum
nachgewiesen werden, wobei der stimulierende Effekt auf die Frakturheilung
moderat war. In der folgenden Aufarbeitung humanen Pseudarthrosengewebes,
inklusive der Konzentrationsbestimmung einzelner Wachstumsfaktoren, war die
BMP-2 Expression unterhalb der Nachweisgrenze. Die Wachstumsfaktoren BMP-7 und
PDGF-AB waren im Vergleich zum Kallusgewebe aus regelhaft geheilten Frakturen
vermindert, wÀhrend gleichzeitig die BMP-Gegenregulatoren Noggin und
Sklerostin im Gewebe nachweisbar waren. Obgleich der Limitationen dieser
Studie ergaben sich hieraus Gedanken hinsichtlich der Sinnhaftigkeit der Gabe
einzelner BMPs zur Prophylaxe und Therapie von Pseudarthrosen im Kontext der
bekannten, engen Regulation und Steuerung durch die Interaktion einer Vielzahl
von molekularen Aktionspartnern. WĂ€hrend die BMPs einen pro-anabolen Effekt
auf den Knochenstoffwechsel haben, sollte im nÀchsten Ansatz die Applikation
von Bisphosphonaten, als anti-katabole Substanzgruppe, auf die Knochenheilung
untersucht werden. Zolendronat ist als Bisphosphonat der dritten Generation
fĂŒr andere Indikationen bereits im breiten klinischen Einsatz. Mit dem
etablierten Frakturmodell der Rattentibia sollte der Einfluss von Zolendronat
in der bekannten PDLLA-Beschichtung auf die Knochenheilung untersucht werden.
Das Ergebnis zeigte eine signifikant beschleunigte Frakturheilung mit erhöhten
Kallusvolumina fĂŒr die Zolendronat-Gruppe im Vergleich zu den Kontrollgruppen
nach 42 Tagen, wÀhrend sich der Effekt nach 84 Tagen tendenziell nivellierte.
GrundsÀtzlich könnte dieser Ansatz im Rahmen der Akutversorgung zur Prophylaxe
von Tibiaschaftpseudarthrosen beitragen oder im Rahmen der operativen Therapie
von manifesten, atrophen Pseudarthrosen einen sinnvollen Bestandteil
darstellen, um die Knochenheilung positiv zu beeinflussen. Mit der
Fokussierung auf die prophylaktische Anwendung hinsichtlich der Ausbildung von
postoperativen Infektionen bei der primĂ€ren KnochendefektauffĂŒllung bei
atrophen Pseudarthrosen oder zum Schutz des Knochenregenerates bei der
sekundĂ€ren DefektauffĂŒllung bei Infektpseudarthrosen wurde die Kombination des
Knochenersatzmaterials DBM mit verschiedenen Antibiotika zur perioperativen
Anwendung untersucht. Das Mischsystem erwies sich dabei als sicher und
reliabel. Es konnten in vitro solide Freisetzungskinetiken von Tobramycin,
Gentamicin und Vancomycin aus der DBM nachgewiesen werden. Die Antibiotika
zeigten nach Freisetzung ihre biologische AktivitÀt und es konnten in der
Zellkultur mit osteoblastÀren Zellen keine toxischen Nebenwirkungen gefunden
werden. Das Konzept zeigt in vitro groĂes Potential und gerade die
perioperative Anwendung könnte ein eleganter Baustein in der oftmals
individualisierten Therapie von Tibiaschaftpseudarthrosen darstellen.Non-unions after fractures of the tibia shaft show an incidence of 3-54%. The
treatment of tibial shaft non-unions is time consuming and demanding for the
surgeon and the patient. We could demonstrate that even sucessfully treated
patients in terms of an adequate bone and soft tissue consolidation are
suffering from a significant loss of function and reduction in quality of
life. Therefore experimental approaches for prevention and treatment of tibial
non-union have been introduced and evaluated. As a new concept the local
application of bioactive substances with a poly(D,L-laktid) coating (PDLLA)
for orthopaedic implants was introduced. The implant serves as mechanical
stabilisation device and as a âdrug carrierâ for pharmaceutical substances
with the potency to positively influence bone metabolism. In this case the
PDLLA acts as the connector between implant and therapeutic drug. Whereas
previous work already displayed biodegradability and release kinetics from
substances applied via the PDLLA coating, the biocompatibility was now
confirmed. Applying this concept of a bioactive implant a non-viral gene
transfer was performed. Therefore copolymer protected DNA plasmid coding for
BMP-2 were incoporated into the PDLLA coating of osteosynthetic implants. In a
standardized rat fracture model of the tibia this concept was tested for
safety and efficacy. This gene transfer did not lead to a systemic
distribution and was therefore considered to be safe. A transgene expression
of BMP-2 was detected throughout the whole study period, whereas the
stimulating effect on fracture healing was only moderate. In the following
analysis of human non-union tissue the BMP-2 expression was below detection
level. Growth factors BMP-7 and PDGF-AB were diminished in comparison to the
callus of fractures with uneventful healing, whereas the BMP antagonists
Noggin and Sclerostin were detectable in the non-union tissue. Despite some
limitations of this study thoughts about the efficiency of a single BMP
administration in the treatment of non-unions arose, especially in the context
of the tight regulation of multiple molecular mechanisms in bone healing. BMPs
have a pro anabolic effect on the bone metabolism. As a different concept, the
application of bishosphonates, as anti catabolic substances, were investigated
for their role in bone healing. Zolendronate is a third generation
bisphosphonate, which already is established for a variety of clinical
indications. The influence of zolendronate incorporated in the PDLLA coating
was investigated using the same rat fracture model. This led to significantly
higher callus volumes in the zolendronate group compared to the control groups
after 42 days, whereas this effect alleviated after 84 days. Generally this
concept may be beneficial in terms of prevention during the acute treatment of
tibial fractures or might also be an advantageous adjunct for the surgical
therapy of manifest atrophic non-unions. With a focus on prevention against
postoperative infections after primary bone defect filling in atrophic non-
unions or as protection after secondary bone defect filling in the treatment
of infectious non-unions, the combination of demineralized bone matrix with
different antibiotic agents for a perioperative utilization has been
investigated. The mixing procedure was safe and reliable. In vitro, stable
release kinetics of Tobramycin, Gentamicin and Vancomycin from the
demineralized bone matrix were verified. All antibiotic agents showed biologic
activity after their release and no toxic side effects were present. This
concept shows great potential and especially the perioperative application
could be an elegant part of a foremost individualized therapy of tibial non-
unions
- âŠ