RootJS: Node.js Bindings for ROOT 6

We present rootJS, an interface making it possible to seamlessly integrate ROOT 6 into applications written for Node.js, the JavaScript runtime platform increasingly commonly used to create high-performance Web applications. ROOT features can be called both directly from Node.js code and by JIT-compiling C++ macros. All rootJS methods are invoked asynchronously and support callback functions, allowing non-blocking operation of Node.js applications using them. Last but not least, our bindings have been designed to platform-independent and should therefore work on all systems supporting both ROOT 6 and Node.js. Thanks to rootJS it is now possible to create ROOT-aware Web applications taking full advantage of the high performance and extensive capabilities of Node.js. Examples include platforms for the quality assurance of acquired, reconstructed or simulated data, book-keeping and e-log systems, and even Web browser-based data visualisation and analysis.Comment: 7 pages, 1 figure. To appear in the Proceedings of the 22nd International Conference on Computing in High Energy and Nuclear Physics (CHEP 2016

Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas

Background Piwi-interacting RNAs (piRNAs) are small RNAs of 27–30 nucleotides mapping to transposons or clustering in repeat genomic regions. Preliminary studies suggest an important role in cancerogenesis. This study is the first one investigating their prognostic impact in clear cell renal cell cancer (ccRCC) patients. Methods Three piRNAs (piR-30924, piR-57125, and piR-38756) selected on the basis of initial piRNA microarray analyses were determined using RT-qPCR in non-metastatic (n = 76) and metastatic (n = 30) ccRCC tissue at the time of nephrectomy in comparison to normal renal tissue (n = 77) and tissue from distant ccRCC metastases (n = 13). Primary clinical end points were recurrence-free and overall survival. Results piR-57125 showed lower expression in metastatic than in non-metastatic tumors, whereas the expression of piR-30924 and piR-38756 increased in metastatic tumors. The higher expression of piR-30924 and piR-38756 as well as the lower expression of piR-57125 in metastatic primary tumors were significantly associated with tumor recurrence and overall survival. Multivariate Cox regression analyses revealed both piR-30924 and piR-57125 as independent prognostic predictors. This impact was even more pronounced in non-metastatic patients. Conclusions This study demonstrates that the expression levels of these piRNAs in primary non-metastatic and metastatic ccRCC tissue can serve as potential prognostic biomarkers in combination with clinicopathological factors

Öffentlicher Abschlussbericht von bwFDM-Communities - Wissenschaftliches Datenmanagement an den Universitäten Baden-Württembergs

Im Projekt bwFDM‐Communities wurde Kontakt zu allen wissenschaftlichen Communities aufgebaut, um deren Bedarf an Diensten, Infrastruktur und Unterstützung beim Umgang mit Forschungsdaten an den Universitäten des Landes Baden‐Württemberg zu erfassen. Ziel war es, eine Grundlage für den nachhaltigen Ausbau von Expertise und Know‐How im Forschungsdatenmanagement an allen universitären Rechenzentren, Bibliotheken und anderen Wissenschaftseinrichtungen (z.B. Sonderforschungsbereiche, GESIS, ...) Baden‐Württembergs zu legen, um den wissenschaftlichen Communities langfristig ein Umfeld bieten zu können, in denen sie die neuen Herausforderungen des digitalen Wissenswettbewerbs annehmen können

Die Studierendenbefragung in Deutschland: best3 : Studieren mit einer gesundheitlichen Beeinträchtigung

[no abstract available

Die Studierendenbefragung in Deutschland: 22.Sozialerhebung : Die wirtschaftliche und soziale Lage der Studierenden in Deutschland 2021

[no abstract available

Testing and Assessment in an International Context: Cross- and Multi-cultural Issues

Globalisation, increase of migration flows, and the concurrent worldwide competitiveness impose rethinking of testing and assessment procedures and practices in an international and multicultural context. This chapter reviews the methodological and practical implications for psychological assessment in the field of career guidance. The methodological implications are numerous and several aspects have to be considered, such as cross-cultural equivalence or construct, method, and item bias. Moreover, the construct of culture by itself is difficult to define and difficult to measure. In order to provide non-discriminatory assessment, counsellors should develop their clinical cross-cultural competencies, develop more specific intervention strategies, and respect cultural differences. Several suggestions are given concerning translation and adaptation of psychological instruments, developing culture specific measures, and the use of these instruments. More research in this field should use mixed methods, multi-centric designs, and consider emic and etic psychological variables. A multidisciplinary approach might also allow identifying culture specific and ecological meaningful constructs. Non-discriminatory assessment implies considering the influence and interaction of personal characteristics and environmental factors