Robustness during Aging—Molecular Biological and Physiological Aspects

Understanding the process of aging is still an important challenge to enable healthy aging and to prevent age-related diseases. Most studies in age research investigate the decline in organ functionality and gene activity with age. The focus on decline can even be considered a paradigm in that field. However, there are certain aspects that remain surprisingly stable and keep the organism robust. Here, we present and discuss various properties of robust behavior during human and animal aging, including physiological and molecular biological features, such as the hematocrit, body temperature, immunity against infectious diseases and others. We examine, in the context of robustness, the different theories of how aging occurs. We regard the role of aging in the light of evolution

Submap Matching for Stereo-Vision Based Indoor/Outdoor SLAM

Autonomous robots operating in semi- or unstructured environments, e.g. during search and rescue missions, require methods for online on-board creation of maps to support path planning and obstacle avoidance. Perception based on stereo cameras is well suited for mixed indoor/outdoor environments. The creation of full 3D maps in GPS-denied areas however is still a challenging task for current robot systems, in particular due to depth errors resulting from stereo reconstruction. State-of-the-art 6D SLAM approaches employ graph-based optimization on the relative transformations between keyframes or local submaps. To achieve loop closures, correct data association is crucial, in particular for sensor input received at different points in time. In order to approach this challenge, we propose a novel method for submap matching. It is based on robust keypoints, which we derive from local obstacle classification. By describing geometrical 3D features, we achieve invariance to changing viewpoints and varying light conditions. We performed experiments in indoor, outdoor and mixed environments. In all three scenarios we achieved a final 3D position error of less than 0.23% of the full trajectory. In addition, we compared our approach with a 3D RBPF SLAM from previous work, achieving an improvement of at least 27% in mean 2D localization accuracy in different scenarios

Efficiency Improvement of a Constant Pressure System using an Intermediate Pressure Line

The paper introduces a new hydraulic system based on a constant pressure system with the aim to increase the efficiency of actuation of hydraulic cylinders in mobile machines. Using a third pressure level located between high pressure and tank pressure called intermediate pressure the system enables additional pressure potentials from high pressure to intermediate pressure and from intermediate pressure to tank pressure. This reduces throttle losses at hydraulic cylinders when driven at low or medium loads. An accumulator connected to the intermediate pressure line is being charged or discharged in function of which pressure potential is currently used. Using the example of a typical duty cycle of a wheel loader the paper describes how the accumulator can be applied in order to reach best efficiency results for the new system and it reveals a theoretical efficiency improvement of 20% compared to a conventional Load Sensing system. Furthermore it proposes an online control strategy using Model Predictive Control with an optimization algorithm created with the Dynamic Programming method

Referral patterns of children with glaucoma and their caretakers in Northern Tanzania.

AIM: To describe the referral patterns of children with primary childhood glaucoma (PCG) or secondary childhood glaucoma (SCG) and their presenting symptoms in Northern Tanzania. METHODS: A retrospective observational study of children 0.48, better eye). Most of the children (60%) and their caretakers presented on their own initiative, while 24% were sent by different general health cadres and 16% by eye care professionals. Buphthalmos was the main symptom mentioned as a trigger for presentation. CONCLUSION: The study shows that most of the children presented late resulting in advanced stages of glaucoma at the time of initiation of treatment. The majority attended the referral eye department on their own initiative with buphthalmos being the most commonly described symptom. Awareness creation among caretakers of children, general health and eye care providers, ideally embedded in general child health promotion activities, is needed to increase and accelerate referrals

Cold Model Investigations of a High Temperature Looping Process in a Dual Circulating Fluidized Bed System

The Calcium Looping process is a promising post-combustion CO2 capture technology. A 200 kWth Dual Circulating Fluidized Bed has been built at IFK, University of Stuttgart. Tests were carried out on a hydrodynamically scaled cold model. Operating parameters have been varied, while the suitability of the 200 kWth design has been prove

The radical induced cell death protein 1 (RCD1) supports transcriptional activation of genes for chloroplast antioxidant enzymes

The rimb1 (redox imbalanced 1) mutation was mapped to the RCD1 locus (radical- induced cell death 1; At1g32230) demonstrating that a major factor involved in redox-regulation genes for chloroplast antioxidant enzymes and protection against photooxidative stress, RIMB1, is identical to the regulator of disease response reactions and cell death, RCD1. Discovering this link let to our investigation of its regulatory mechanism. We show in yeast that RCD1 can physically interact with the transcription factor Rap2.4a which provides redox-sensitivity to nuclear expression of genes for chloroplast antioxidant enzymes. In the rimb1 (rcd1-6) mutant, a single nucleotide exchange results in a truncated RCD1 protein lacking the transcription factor binding site. Protein-protein interaction between full-length RCD1 and Rap2.4a is supported by H2O2, but not sensitive to the antioxidants dithiotreitol and ascorbate. In combination with transcript abundance analysis in Arabidopsis, it is concluded that RCD1 stabilizes the Rap2.4-dependent redox-regulation of the genes encoding chloroplast antioxidant enzymes in a widely redox-independent manner. Over the years, rcd1-mutant alleles have been described to develop symptoms like chlorosis, lesions along the leaf rims and in the mesophyll and (secondary) induction of extra- and intra-plastidic antioxidant defense mechanisms. All these rcd1 mutant characteristics were observed in rcd1-6 to succeed low activation of the chloroplast antioxidant system and glutathione biosynthesis. We conclude that RCD1 protects plant cells from running into reactive oxygen species (ROS)-triggered programs, such as cell death and activation of pathogen-responsive genes (PR genes) and extra-plastidic antioxidant enzymes, by supporting the induction of the chloroplast antioxidant system

Interface-related magnetic and vibrational properties in Fe/MgO heterostructures from nuclear resonant spectroscopy and first-principles calculations

We combine ⁵⁷Fe Mössbauer spectroscopy and ⁵⁷Fe nuclear resonant inelastic x-ray scattering (NRIXS) on nanoscale polycrystalline [bcc−⁵⁷Fe/MgO] multilayers with various Fe-layer thicknesses and layer-resolved density-functional-theory (DFT)-based first-principles calculations of a (001)-oriented [Fe(8 ML)/MgO(8 ML)](001) heterostructure (where ML denotes monolayer) to unravel the interface-related atomic vibrational properties of a multilayer system. Being consistent in theory and experiment, we observe enhanced hyperfine magnetic fields B_(hf) in the multilayers as compared to B_(hf) in bulk bcc Fe; this effect is associated with the Fe/MgO interface layers. NRIXS and DFT both reveal a strong reduction of the longitudinal acoustic phonon peak in combination with an enhancement of the low-energy vibrational density of states (VDOS) suggesting that the presence of interfaces and the associated increase in the layer-resolved magnetic moments results in drastic changes in the Fe-partial VDOS. From the experimental and calculated VDOS, vibrational thermodynamic properties have been determined as a function of Fe thickness and were found to be in excellent agreement