1,150 research outputs found

    Decline in the U.S. Furniture Industry: A Case Study of the Impacts to the Hardwood Lumber Supply Chain

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    Traditionally, the wood household furniture industry has accounted for a sizeable portion of total hardwood lumber use in the United States. However, for more than a decade, imports have gained an increasing share of the hardwood furniture market, and lumber consumption by this industry has declined dramatically in the last 5 years. We used a case study methodology to investigate the impacts of this decline on the hardwood lumber supply chain. Eleven companies within the hardwood lumber supply chain were chosen as cases: 3 furniture manufacturers, 5 primary producers, and 3 components manufacturers. Seven core questions were asked during each interview and primary producers were asked two additional questions. Questions ranged from the impact of lean manufacturing techniques to the effects "green" certification may have on the industry. Furniture manufacturers appeared to be more optimistic regarding the future of the domestic furniture industry compared to the primary and components manufacturers. Furniture market declines have been quickly replaced by the cabinet and solid wood flooring sectors; however, the supply chain must continue to strategically develop new markets in the event of a housing sector slow down

    Landowner willingness to engage in long-term timber leases in West Virginia, USA

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    As global competition increases for wood-based products, the need for more efficient supply chains becomes increasingly important. In the forest products sector, these supply chains involve individuals and firms ranging from private forestland owners with standing timber to factories producing final finished products. Under the assumption that ‘transparent’ supply chains are beneficial to members within the supply chain, the authors are investigating how this transparency can be increased and what benefits might accrue to private forest owners who are associated with a specific supply chain under a long-term agreement. In recent years, hunting lease agreements between family forest owners and various organized hunt clubs or individuals have become commonplace in the Appalachian mountains of West Virginia. Can long-term timber leases become a new opportunity for landowners, forestry professionals, and wood-based industries? This paper describes a survey of private forestland owners in West Virginia that investigated the perceived concerns, benefits and barriers landowners have with regard to entering long-term timber leases with forestry professionals and timber firms

    Cultural orientations and preference for HRM policies and practices:the case of Oman

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    This study empirically examines the influence of cultural orientations on employee preferences of human resource management (HRM) policies and practices in Oman. Data were collected from 712 employees working in six large Omani organizations. The findings indicate that there is a number of differences among Omani employees regarding value orientations due especially to age, education and work experience. The findings show a strong orientation towards mastery, harmony, thinking and doing, and a weak orientation towards hierarchy, collectivism, subjugation and human nature-as-evil. The results demonstrate a clear link between value orientations and preferences for particular HRM policies and practices. Group-oriented HRM practices are preferred by those who scored high on collectivism and being orientations, and those who scored low on thinking and doing orientations. Hierarchy-oriented HRM practices are preferred by those scoring high on hierarchy, subjugation and human nature-as-bad orientations, and those scoring low on thinking and mastery orientations. Finally, preference for loose and informal HRM practices was positively associated with being, and negatively associated with thinking, doing and harmony orientations. The theoretical and practical implications of these findings are discussed in detail

    Monitoring of activated sludge settling ability through image analysis : validation on full-scale wastewater treatment plants

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    In recent years, a great deal of attention has been focused on the research of activated sludge processes, where the solid–liquid separation phase is frequently considered of critical importance, due to the different problems that severely affect the compaction and the settling of the sludge. Bearing that in mind, in this work, image analysis routines were developed in Matlab environment, allowing the identification and characterization of microbial aggregates and protruding filaments in eight different wastewater treatment plants, for a combined period of 2 years. The monitoring of the activated sludge contents allowed for the detection of bulking events proving that the developed image analysis methodology is adequate for a continuous examination of the morphological changes in microbial aggregates and subsequent estimation of the sludge volume index. In fact, the obtained results proved that the developed image analysis methodology is a feasible method for the continuous monitoring of activated sludge systems and identification of disturbances.Empresa de Águas, Efluentes e ResĂ­duos de Braga, Portugal - EM (AGERE)Fundação para a CiĂȘncia e a Tecnologia (FCT

    γγ Physics

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    This chapter is devoted to QCD and, more generally, Strong Interaction studies in γγ collisions. For our purposes, LEP2 is a continous energy γγ collider with a reach of up to 100 GeV center of mass energy for some observables. At low energy, the main studies concern resonance production and quasi two-body processes which probe the meson and baryon wavefunctions. At high energy, the partonic structure of the photon plays a dominant role and, as for hadronic processes, several tests of perturbative QCD, using many different observables, are possible. A specific feature of γγ collisions is the variability of the mass of the incoming photons which can be used to tune the non-perturbative component of the photon

    The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

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    LKB1 is a master kinase that regulates metabolism and growth through adenosine monophosphate-activated protein kinase (AMPK) and 12 other closely related kinases. Liver-specific ablation of LKB1 causes increased glucose production in hepatocytes in vitro and hyperglycaemia in fasting mice in vivo. Here we report that the salt-inducible kinases (SIK1, 2 and 3), members of the AMPK-related kinase family, play a key role as gluconeogenic suppressors downstream of LKB1 in the liver. The selective SIK inhibitor HG-9-91-01 promotes dephosphorylation of transcriptional co-activators CRTC2/3 resulting in enhanced gluconeogenic gene expression and glucose production in hepatocytes, an effect that is abolished when an HG-9-91-01-insensitive mutant SIK is introduced or LKB1 is ablated. Although SIK2 was proposed as a key regulator of insulin-mediated suppression of gluconeogenesis, we provide genetic evidence that liver-specific ablation of SIK2 alone has no effect on gluconeogenesis and insulin does not modulate SIK2 phosphorylation or activity. Collectively, we demonstrate that the LKB1-SIK pathway functions as a key gluconeogenic gatekeeper in the liver

    Expedited batch processing and analysis of transposon insertions

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    <p>Abstract</p> <p>Background</p> <p>With advances in sequencing technology, greater and greater amounts of eukaryotic genome data are becoming available. Often, large portions of these genomes consist of transposable elements, frequently accounting for 50% or more in vertebrates. Each transposable element family may have thousands or tens of thousands of individual copies within a given genome, and therefore it can take an exorbitant amount of time and effort to process data in a meaningful fashion.</p> <p>Findings</p> <p>In order to combat this problem, we developed a set of bioinformatics techniques and programs to streamline the analysis. This includes a unique Perl script which automates the process of taking BLAST, Repeatmasker and similar data to extract and manipulate the hit sequences from the genome. This script, called Process_hits uses an object-oriented methodology to compile all hit locations from a given file for processing, organize this data into useable categories, and output it in multiple formats.</p> <p>Conclusions</p> <p>The program proved capable of handling large amounts of transposon data in an efficient fashion. It is equipped with a number of useful sub-functions, each of which is contained within its own sub-module to allow for greater expandability and as a foundation for future program design.</p

    Homozygous loss-of-function variants in FILIP1 cause autosomal recessive arthrogryposis multiplex congenita with microcephaly

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    Arthrogryposis multiplex congenita forms a broad group of clinically and etiologically heterogeneous disorders characterized by congenital joint contractures that involve at least two different parts of the body. Neurological and muscular disorders are commonly underlying arthrogryposis. Here, we report five affected individuals from three independent families sharing an overlapping phenotype with congenital contractures affecting shoulder, elbow, hand, hip, knee and foot as well as scoliosis, reduced palmar and plantar skin folds, microcephaly and facial dysmorphism. Using exome sequencing, we identified homozygous truncating variants in FILIP1 in all patients. FILIP1 is a regulator of filamin homeostasis required for the initiation of cortical cell migration in the developing neocortex and essential for the differentiation process of cross-striated muscle cells during myogenesis. In summary, our data indicate that bi-allelic truncating variants in FILIP1 are causative of a novel autosomal recessive disorder and expand the spectrum of genetic factors causative of arthrogryposis multiplex congenita
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