Cancer Med

Objective Several studies show that self‐perception of aging (SPA) is a significant predictor of mental and physical health. In this study, we analyze the effect of SPA on mortality in the specific context of geriatric oncology. Methods The sample constituted of 140 individuals aged 65 years and older suffering from a recent nonmetastatic cancer (breast, lung, gynecological, or hematological), followed up to 6 years. We used Cox proportional hazards model to assess the effect of SPA at baseline on mortality. It was adjusted for age, gender, educational and cognitive level, oncological information (the site and kind of cancer), number of comorbidities, and physical and mental health at baseline. Results Patients were aged 73 years at diagnosis and were more often women (85.7%). Individuals with more negative SPA were 3.62 times more likely to die than those with a more positive SPA, with control of gender, age, education and cognitive level, mental and physical health, the category (breast, lung, gynecological, or hematological), and kind (initial or recurrence) of cancer. Conclusions These findings suggest that SPA influence the mortality of older people in the particular context of oncology. Therefore, the need to change our attitudes toward aging and older people implied indirectly by these results is discussed

A wide-area view of the Phoenix dwarf galaxy from VLT/FORS imaging

We present results from a wide-area photometric survey of the Phoenix dwarf galaxy, one of the rare dwarf irregular/ dwarf spheroidal transition type galaxies (dTs) of the Local Group (LG). These objects offer the opportunity to study the existence of possible evolutionary links between the late- and early- type LG dwarf galaxies, since the properties of dTs suggest that they may be dwarf irregulars in the process of transforming into dwarf spheroidals. Using FORS at the VLT we have acquired VI photometry of Phoenix. The data reach a S/N~10 just below the horizontal branch of the system and consist of a mosaic of images that covers an area of 26' x 26' centered on the coordinates of the optical center of the galaxy. Examination of the colour-magnitude diagram and luminosity function revealed the presence of a bump above the red clump, consistent with being a red giant branch bump. The deep photometry combined with the large area covered allows us to put on a secure ground the determination of the overall structural properties of the galaxy and to derive the spatial distribution of stars in different evolutionary phases and age ranges, from 0.1 Gyr to the oldest stars. The best-fitting profile to the overall stellar population is a Sersic profile of Sersic radius R_S = 1.82'+-0.06' and m=0.83+-0.03. We confirm that the spatial distribution of stars is found to become more and more centrally concentrated the younger the stellar population, as reported in previous studies. This is similar to the stellar population gradients found for close-by Milky Way dwarf spheroidal galaxies. We quantify such spatial variations by analyzing the surface number density profiles of stellar populations in different age ranges; [Abridged]Comment: 21 pages; 11 figures. Accepted for publication in MNRA

A systematic review on the use of quantitative imaging to detect cancer therapy adverse effects in normal-appearing brain tissue

Cancer therapy for both central nervous system (CNS) and non-CNS tumors has been previously associated with transient and long-term cognitive deterioration, commonly referred to as ‘chemo fog’. This therapy-related damage to otherwise normal-appearing brain tissue is reported using post-mortem neuropathological analysis. Although the literature on monitoring therapy effects on structural magnetic resonance imaging (MRI) is well established, such macroscopic structural changes appear relatively late and irreversible. Early quantitative MRI biomarkers of therapy-induced damage would potentially permit taking these treatment side effects into account, paving the way towards a more personalized treatment planning. This systematic review (PROSPERO number 224196) provides an overview of quantitative tomographic imaging methods, potentially identifying the adverse side effects of cancer therapy in normal-appearing brain tissue. Seventy studies were obtained from the MEDLINE and Web of Science databases. Studies reporting changes in normal-appearing brain tissue using MRI, PET, or SPECT quantitative biomarkers, related to radio-, chemo-, immuno-, or hormone therapy for any kind of solid, cystic, or liquid tumor were included. The main findings of the reviewed studies were summarized, providing also the risk of bias of each study assessed using a modified QUADAS-2 tool. For each imaging method, this review provides the methodological background, and the benefits and shortcomings of each method from the imaging perspective. Finally, a set of recommendations is proposed to support future research

Identification of a putative quantitative trait nucleotide in guanylate binding protein 5 for host response to PRRS virus infection

Citation: Koltes, J. E., Fritz-Waters, E., Eisley, C. J., Choi, I., Bao, H., Kommadath, A., . . . Reecy, J. M. (2015). Identification of a putative quantitative trait nucleotide in guanylate binding protein 5 for host response to PRRS virus infection. Bmc Genomics, 16, 13. doi:10.1186/s12864-015-1635-9Background: Previously, we identified a major quantitative trait locus (QTL) for host response to Porcine Respiratory and Reproductive Syndrome virus (PRRSV) infection in high linkage disequilibrium (LD) with SNP rs80800372 on Sus scrofa chromosome 4 (SSC4). Results: Within this QTL, guanylate binding protein 5 (GBP5) was differentially expressed (DE) (p < 0.05) in blood from AA versus AB rs80800372 genotyped pigs at 7,11, and 14 days post PRRSV infection. All variants within the GBP5 transcript in LD with rs80800372 exhibited allele specific expression (ASE) in AB individuals (p < 0.0001). A transcript re-assembly revealed three alternatively spliced transcripts for GBP5. An intronic SNP in GBP5, rs340943904, introduces a splice acceptor site that inserts five nucleotides into the transcript. Individuals homozygous for the unfavorable AA genotype predominantly produced this transcript, with a shifted reading frame and early stop codon that truncates the 88 C-terminal amino acids of the protein. RNA-seq analysis confirmed this SNP was associated with differential splicing by QTL genotype (p < 0.0001) and this was validated by quantitative capillary electrophoresis (p < 0.0001). The wild-type transcript was expressed at a higher level in AB versus AA individuals, whereas the five-nucleotide insertion transcript was the dominant form in AA individuals. Splicing and ASE results are consistent with the observed dominant nature of the favorable QTL allele. The rs340943904 SNP was also 100 % concordant with rs80800372 in a validation population that possessed an alternate form of the favorable B QTL haplotype. Conclusions: GBP5 is known to play a role in inflammasome assembly during immune response. However, the role of GBP5 host genetic variation in viral immunity is novel. These findings demonstrate that rs340943904 is a strong candidate causal mutation for the SSC4 QTL that controls variation in host response to PRRSV.Additional Authors: Lunney, J. K.;Liu, P.;Carpenter, S.;Rowland, R. R. R.;Dekkers, J. C. M.;Reecy, J. M

Self-gravitating equilibrium models of dwarf galaxies and the minimum mass for star formation

We construct a series of model galaxies in rotational equilibrium consisting of gas, stars, and a fixed dark matter (DM) halo and study how these equilibrium systems depend on the mass and form of the DM halo, gas temperature, non-thermal and rotation support against gravity, and also on the redshift of galaxy formation. For every model galaxy we find the minimum gas mass M_g^min required to achieve a state in which star formation (SF) is allowed according to contemporary SF criteria. The obtained M_g^min--M_DM relations are compared against the baryon-to-DM mass relation M_b--M_DM inferred from the \LambdaCDM theory and WMAP4 data. Our aim is to construct realistic initial models of dwarf galaxies (DGs), which take into account the gas self-gravity and can be used as a basis to study the dynamical and chemical evolution of DGs. Rotating equilibria are found by solving numerically the steady-state momentum equation for the gas component in the combined gravitational potential of gas, stars, and DM halo using a forward substitution procedure. We find that for a given M_DM the value of M_g^min depends crucially on the gas temperature T_g, gas spin parameter \alpha, degree of non-thermal support \sigma_eff, and somewhat on the redshift for galaxy formation z_gf. Depending on the actual values of T_g, \alpha, \sigma_eff, and z_gf, model galaxies may have M_g^min that are either greater or smaller than M_b. Galaxies with M_DM \ga 10^9 M_sun are usually characterized by M_g^min \la M_b, implying that SF in such objects is a natural outcome as the required gas mass is consistent with what is available according to the \LambdaCDM theory. On the other hand, models with M_DM \la 10^9 M_sun are often characterized by M_g^min >> M_b, implying that they need much more gas than available to achieve a state in which SF is allowed. Abridged.Comment: Accepted for publication in Astronomy & Astrophysic

Financial Satisfaction and (in)formal Sector in a Transition Country

This paper examines the relationship between working in the formal or informal sector and self-reported individual financial satisfaction in a country in transition. It does so by allowing for individual heterogeneity in terms of perceived financial insecurity and tax morale. The empirical analysis uses a dataset for Albania, a country in transition. The method applied is the ‘self-administered questionnaire’, which combines personal contacts with written questionnaire. The results indicate that, for most individuals, working in the informal sector has negative effects on their self reported financial satisfaction. For some individuals, however, this effect is positive. The characteristic defining these two groups of individuals is their attitude towards the perceived financial insecurity related to not paying taxes. These findings have important implications, in particular for transition countries with large informal sectors. Given the involuntary participation in the informal sector in these countries, the majority of individuals working in this sector will remain financially dissatisfied as long as they have no other social safety net

Perspectives for biocatalytic lignin utilization: cleaving 4-O-5 and C??-C?? bonds in dimeric lignin model compounds catalyzed by a promiscuous activity of tyrosinase

Background: In the biorefinery utilizing lignocellulosic biomasses, lignin decomposition to value-added phenolic derivatives is a key issue, and recently biocatalytic delignification is emerging owing to its superior selectivity, low energy consumption, and unparalleled sustainability. However, besides heme-containing peroxidases and laccases, information about lignolytic biocatalysts is still limited till date. Results: Herein, we report a promiscuous activity of tyrosinase which is closely associated with delignification requiring high redox potentials (&gt;1.4 V vs. normal hydrogen electrode [NHE]). The promiscuous activity of tyrosinase not only oxidizes veratryl alcohol, a commonly used nonphenolic substrate for assaying ligninolytic activity, to veratraldehyde but also cleaves the 4-O-5 and C??-C?? bonds in 4-phenoxyphenol and guaiacyl glycerol-??-guaiacyl ether (GGE) that are dimeric lignin model compounds. Cyclic voltammograms additionally verified that the promiscuous activity oxidizes lignin-related high redox potential substrates. Conclusion These results might be applicable for extending the versatility of tyrosinase toward biocatalytic delignification as well as suggesting a new perspective for sustainable lignin utilization. Furthermore, the results provide insight for exploring the previously unknown promiscuous activities of biocatalysts much more diverse than ever thought before, thereby innovatively expanding the applicable area of biocatalysis