Restoration of Macroscopic Isotropy on (d+1)(d+1)-Simplex Fractal Conductor Networks

Restoration of macroscopic isotropy has been investigated in (d+1)-simplex fractal conductor networks via exact real space renormalization group transformations. Using some theorems of fixed point theory, it has been shown very rigoroursly that the macroscopic conductivity becomes isotropic for large scales and anisotropy vanishes with a scaling exponent which is computed exactly for arbitrary values of d and decimation numbers b=2,3,4 and 5.Comment: 27 Pages, 3 Figure

In-solution Y-chromosome capture-enrichment on ancient DNA libraries.

As most ancient biological samples have low levels of endogenous DNA, it is advantageous to enrich for specific genomic regions prior to sequencing. One approach-in-solution capture-enrichment-retrieves sequences of interest and reduces the fraction of microbial DNA. In this work, we implement a capture-enrichment approach targeting informative regions of the Y chromosome in six human archaeological remains excavated in the Caribbean and dated between 200 and 3000 years BP. We compare the recovery rate of Y-chromosome capture (YCC) alone, whole-genome capture followed by YCC (WGC + YCC) versus non-enriched (pre-capture) libraries. The six samples show different levels of initial endogenous content, with very low (< 0.05%, 4 samples) or low (0.1-1.54%, 2 samples) percentages of sequenced reads mapping to the human genome. We recover 12-9549 times more targeted unique Y-chromosome sequences after capture, where 0.0-6.2% (WGC + YCC) and 0.0-23.5% (YCC) of the sequence reads were on-target, compared to 0.0-0.00003% pre-capture. In samples with endogenous DNA content greater than 0.1%, we found that WGC followed by YCC (WGC + YCC) yields lower enrichment due to the loss of complexity in consecutive capture experiments, whereas in samples with lower endogenous content, the libraries' initial low complexity leads to minor proportions of Y-chromosome reads. Finally, increasing recovery of informative sites enabled us to assign Y-chromosome haplogroups to some of the archeological remains and gain insights about their paternal lineages and origins. We present to our knowledge the first in-solution capture-enrichment method targeting the human Y-chromosome in aDNA sequencing libraries. YCC and WGC + YCC enrichments lead to an increase in the amount of Y-DNA sequences, as compared to libraries not enriched for the Y-chromosome. Our probe design effectively recovers regions of the Y-chromosome bearing phylogenetically informative sites, allowing us to identify paternal lineages with less sequencing than needed for pre-capture libraries. Finally, we recommend considering the endogenous content in the experimental design and avoiding consecutive rounds of capture, as clonality increases considerably with each round

Commercial Aircraft-Cabin Egress: The Current State of Simulation Model Development and the Need for Future Research

There has been increasing interest in developing simulation models capable of analyzing commer cial aircraft-cabin egress under both non-life- threatening and life-threatening scenarios. At issue is the ability to accurately simulate human behavior within non-toxic environments, as well as the debilitating effects that toxic environments (e.g., fire and smoke) have on human-decision making. A set of criteria has been identified by the Federal Aviation Administration for developing simulation models capable of analyzing commer cial aircraft-cabin egress. These criteria are used to (a) compare the capabilities and limitations of four aircraft-evacuation models in existence to day, (b) identify the issues that need to be ad dressed when developing these types of models, and (c) propose a new paradigm for developing aircraft-cabin egress models.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

The UKIDSS Galactic Plane Survey

'The definitive version is available at www.blackwell-synergy.com .' Copyright Blackwell Publishing DOI: 10.1111/j.1365-2966.2008.13924.xThe UKIDSS Galactic Plane Survey (GPS) is one of the five near-infrared Public Legacy Surveys that are being undertaken by the UKIDSS consortium, using the Wide Field Camera on the United Kingdom Infrared TelescopePeer reviewe

A new state in 6He following the 7Li(γ,p)6He reaction

A broad excited state was observed in 6He with energy Ex=5+-1 MeV and width Gamma=3+-1 MeV, following the reaction 7Li(γ,p)6He. The state is consistent with a number of broad resonances predicted by recent cluster model calculations. The well-established reaction mechanism, combined with a simple and transparent analysis procedure confers considerable validity to this observation

Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3 H)-one

© 2015 American Chemical Society. In the face of the clinical challenge posed by resistant bacteria, the present needs for novel classes of antibiotics are genuine. In silico docking and screening, followed by chemical synthesis of a library of quinazolinones, led to the discovery of (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl)quinazolin-4(3H)-one (compound 2) as an antibiotic effective in vivo against methicillin-resistant Staphylococcus aureus (MRSA). This antibiotic impairs cell-wall biosynthesis as documented by functional assays, showing binding of 2 to penicillin-binding protein (PBP) 2a. We document that the antibiotic also inhibits PBP1 of S. aureus, indicating a broad targeting of structurally similar PBPs by this antibiotic. This class of antibiotics holds promise in fighting MRSA infections.Peer Reviewe

Cellular Array Morphology During Directional Solidification

Cellular array morphology has been examined in the shallow cell, deep cell, and cell-to-dendrite transition regime in Pb-2.2 wt pct Sb and Al-4.1 wt pct Cu alloy single-crystal samples that were directionally solidified along [100]. Statistical analysis of the cellular spacing distribution on transverse sections has been carried out using minimum spanning tree (MST), Voronoi polygons, radial distribution factor, and fast Fourier transform (FFT) techniques. The frequency distribution of the number of nearest neighbors and the MST parameters suggest that the arrangement of cells may be visualized as a hexagonal tessellation with superimposed 50 pct random noise. However, the power spectrum of the Fourier transform of the cell centers shows a diffused single-ring pattern that does not agree with the power spectrum from the hexagonal tessellation having a 50 pct superimposed random (uniformly distributed or Gaussian) noise. The radial distribution factor obtained from the cells is similar to that of liquids. An overall steady-state distribution in terms of the mean primary spacing is achieved after directional solidification of about three mushy-zone lengths. However, the process of nearest-neighbor interaction continues throughout directional solidification, as indicated by about 14 pct of the cells undergoing submerging in the shallow cell regime or by an increasing first and second nearest-neighbor ordering along the growth direction for the cells at the cell-to-dendrite transition. The nature of cell distribution in the Al-Cu alloy appears to be the same as that in the Pb-Sb. The ratio between the upper and lower limits of the primary spacing, as defined by the largest and the smallest 10 pct of the population, respectively, is constant: 1.43 +/- 0.11. It does not depend upon the solidification processing conditions

Design and analysis of a 20 MW propulsion power train

The electric ship research program at the University of Texas at Austin focuses on the development of power system technology for future electric ships. The main goal of the on-going research activity is to identify critical, high pay-off technology development needed to enable major improvement, in size and functionality, of navy ships power systems. Initial efforts were directed towards the establishment of a baseline power train which highlights various constraints and provides a basis for later optimization efforts. A 20 MW power train system was chosen for such a baseline, and all components, from fuel to propulsion motor, were considered and their impact on the whole power system assessed. The baseline design consists of a 25 MVA/3600 rpm radial flux permanent magnet generator, a 22 MVA PWM converter, and a 20 MW/150 rpm radial flux permanent magnet motor, along with the amount of fuel sized for an assumed mission profile, and the widely used LM2500 gas turbine. The analysis shows that fuel is by far the dominant component contributing to weight and volume and, consequently, overall efficiency of power train components is the most relevant parameter to reduce weight and volume. The 3600 rpm generator is the smallest component. The 150 rpm motor is the heaviest component, other than fuel, weighing close to 100 tonnes.Center for Electromechanic