Perception of Relative Depth Interval: Systematic Biases in Perceived Depth

Given an estimate of the binocular disparity between a pair of points and an estimate of the viewing distance, or knowledge of eye position, it should be possible to obtain an estimate of their depth separation. Here we show that, when points are arranged in different vertical geometric configurations across two intervals, many observers find this task difficult. Those who can do the task tend to perceive the depth interval in one configuration as very different from depth in the other configuration. We explore two plausible explanations for this effect. The first is the tilt of the empirical vertical horopter: Points perceived along an apparently vertical line correspond to a physical line of points tilted backwards in space. Second, the eyes can rotate in response to a particular stimulus. Without compensation for this rotation, biases in depth perception would result. We measured cyclovergence indirectly, using a standard psychophysical task, while observers viewed our depth configuration. Biases predicted from error due either to cyclovergence or to the tilted vertical horopter were not consistent with the depth configuration results. Our data suggest that, even for the simplest scenes, we do not have ready access to metric depth from binocular disparity.</jats:p

Effects of ß-Lactam Antibiotics and Fluoroquinolones on Human Gut Microbiota in Relation to Clostridium difficile Associated Diarrhea

Clostridium difficile infections are an emerging health problem in the modern hospital environment. Severe alterations of the gut microbiome with loss of resistance to colonization against C. difficile are thought to be the major trigger, but there is no clear concept of how C. difficile infection evolves and which microbiological factors are involved. We sequenced 16S rRNA amplicons generated from DNA and RNA/cDNA of fecal samples from three groups of individuals by FLX technology: (i) healthy controls (no antibiotic therapy); (ii) individuals receiving antibiotic therapy (Ampicillin/Sulbactam, cephalosporins, and fluoroquinolones with subsequent development of C. difficile infection or (iii) individuals receiving antibiotic therapy without C. difficile infection. We compared the effects of the three different antibiotic classes on the intestinal microbiome and the effects of alterations of the gut microbiome on C. difficile infection at the DNA (total microbiota) and rRNA (potentially active) levels. A comparison of antibiotic classes showed significant differences at DNA level, but not at RNA level. Among individuals that developed or did not develop a C. difficile infection under antibiotics we found no significant differences. We identified single species that were up- or down regulated in individuals receiving antibiotics who developed the infection compared to non-infected individuals. We found no significant differences in the global composition of the transcriptionally active gut microbiome associated with C. difficile infections. We suggest that up- and down regulation of specific bacterial species may be involved in colonization resistance against C. difficile providing a potential therapeutic approach through specific manipulation of the intestinal microbiome

The genetic architecture of the human cerebral cortex

INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with human cortical structure at both global and regional levels, we conducted a genome-wide association meta-analysis of brain MRI data from 51,665 individuals across 60 cohorts. We analyzed the surface area and average thickness of the whole cortex and 34 cortical regions with known functional specializations. RESULTS We identified 306 nominally genome-wide significant loci (P < 5 × 10−8) associated with cortical structure in a discovery sample of 33,992 participants of European ancestry. Of the 299 loci for which replication data were available, 241 loci influencing surface area and 14 influencing thickness remained significant after replication, with 199 loci passing multiple testing correction (P < 8.3 × 10−10; 187 influencing surface area and 12 influencing thickness). Common genetic variants explained 34% (SE = 3%) of the variation in total surface area and 26% (SE = 2%) in average thickness; surface area and thickness showed a negative genetic correlation (rG = −0.32, SE = 0.05, P = 6.5 × 10−12), which suggests that genetic influences have opposing effects on surface area and thickness. Bioinformatic analyses showed that total surface area is influenced by genetic variants that alter gene regulatory activity in neural progenitor cells during fetal development. By contrast, average thickness is influenced by active regulatory elements in adult brain samples, which may reflect processes that occur after mid-fetal development, such as myelination, branching, or pruning. When considered together, these results support the radial unit hypothesis that different developmental mechanisms promote surface area expansion and increases in thickness. To identify specific genetic influences on individual cortical regions, we controlled for global measures (total surface area or average thickness) in the regional analyses. After multiple testing correction, we identified 175 loci that influence regional surface area and 10 that influence regional thickness. Loci that affect regional surface area cluster near genes involved in the Wnt signaling pathway, which is known to influence areal identity. We observed significant positive genetic correlations and evidence of bidirectional causation of total surface area with both general cognitive functioning and educational attainment. We found additional positive genetic correlations between total surface area and Parkinson’s disease but did not find evidence of causation. Negative genetic correlations were evident between total surface area and insomnia, attention deficit hyperactivity disorder, depressive symptoms, major depressive disorder, and neuroticism. CONCLUSION This large-scale collaborative work enhances our understanding of the genetic architecture of the human cerebral cortex and its regional patterning. The highly polygenic architecture of the cortex suggests that distinct genes are involved in the development of specific cortical areas. Moreover, we find evidence that brain structure is a key phenotype along the causal pathway that leads from genetic variation to differences in general cognitive function

Measurement of cross sections and leptonic forward-backward asymmetries at the Z pole and determination of electroweak parameters

We report on the measurement of the leptonic and hadronic cross sections and leptonic forward-backward asymmetries at the Z peak with the L3 detector at LEP. The total luminosity of 40.8 pb −1 collected in the years 1990, 1991 and 1992 corresponds to 1.09·10 6 hadronic and 0.98·10 5 leptonic Z decays observed. These data allow us to determine the electroweak parameters. From the cross sections we derive the properties of the Z boson: assuming lepton universality. We obtain an invisible width of Γ inv =496.5±7.9 MeV which, in the Standard Model, corresponds to a number of light neutrino species of N v =2.981±0.050.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47894/1/10052_2005_Article_BF01574160.pd

A microcomputerized interface for computer communication

In this paper an interface device for computer communication is described, based on the use of a programmable microprocessor. The aim of this Micro Front End Processor is to free the main computer from all the communication procedures management, as if some intelligence were added to the transmission line. An outline of the model, the realization of the interlocutor (the entity carrying on the colloquy) is based on, is given, the heart of the device being a software implemented Variable Structure sequential Machine. The boundaries are traced for the device toward the main computer as well as toward the transmission line, and the operation of its main components as the modem handler, the interlocutor module, and the computer handler is described. Hardwired and microprogrammed versus microcomputerized realization tradeoff is examined with respect to cost, performance, and flexibility, and the choosing criteria among the possible architectures and technological features of microcomputers are reviewed. Finally, a block diagram and a functional description of a device, based on Intel 8080 microprocessor, implementing the colloquy for the UNIVAC 1108 under EXEC 8 operating system are presented as well as an estimate of the performance of such a device

An algebraic description of some state-dependent failure mechanisms

Many analogies in the models of failure behaviour of systems suggest to study an abstract basis which could be common to all. In this paper we introduce a possible presentation of the problem from an abstract point of view and discuss its usefulness

Dynamic user profiles and flexible queries in office document retrieval systems

The problem of document management in an Office Information System in view of supporting the decision process by a set of users with different knowledge, capabilities and requirements is considered. User profiles are used to improve the retrieval properties and a control system is outlined to automatically update the utility information used by the searching strategies. user requirements are modeled in Dynamic User Profiles in order to maintain accurate knowledge of the most promising approach to document search, of the interest fields, and of the favourite output format. An example of DUP use is provided adopting a flexible query specification to take advantage of database selection, retrieval via keyword, or full text scanning in a multi-strategy query processing approach. Actual queries are redefined by extracting the aspects suitable for each strateg

Context information for Knowledge reshaping

More and more often, we face the necessity of extracting appropriately reshaped knowledge from an integrated representation of the information space. Be such a global representation a central database, a global view of several ones or an ontological representation of an information domain, we face the need to define personalised views for the knowledge stakeholders: single users, companies or applications. We propose exploiting the information usage context within a methodology for context-aware data design, where the notion of context is formally defined together with its role within the process of view building by information tailoring. This paper presents our context model, called the context dimension tree, which plays a fundamental role in tailoring the information space according to user information needs

Emergent Semantics and Cooperation in Multi-Knowledge Environments: the ESTEEM Architecture

In the present global society, information has to be exchangeable in open and dynamic environments, where interacting peers do not necessarily share a common understanding of the world at hand, and do not have a complete picture of the context where the interaction occurs. In this paper, we present the Esteem approach and the related peer architecture for emergent semantics in dynamic and multi-knowledge environments. In Esteem, semantic communities are built around declared interests in the form of manifesto ontologies, and their autonomous nature is preserved by allowing a shared semantics to naturally emerge from peer interactions