Signifiers to stand on: on the anticipatory function of the other

In lacanian theory the process of the coming into being of the subject is considered as a continuous and anticipatory process of interaction between the organizational levels of the biological and the social. The latter comprises what Lacan called the symbolic order (“l’Autre” or the Other) that anticipates the coming into being of the subject. It is argued that this anticipatory function of the Other is at stake in Alan Bennett’s play The History Boys (2004). More specifically, by a close reading of Bennett’s text, it is shown how anticipation is implied in the three main themes of the play: 1. in the headmaster’s and Irwin’s vision on education; 2. in Irwin’s view on history; 3. in Hector’s view on the function of poetry

The individual and the collective : sociological influences on Lacan's concept of the relation subject-other

In this conceptual analysis we discuss the sociological influences on Lacan's conceptualization of the relation between the subject and the other. In his writings predating World War II Lacan defines this relation in terms of identification. However, from 1953 onward he defines it in terms of the subject of speech and the Symbolic Other. It is a popular notion to characterize this change in terms of a radical breach, influenced by the reading of Lévi-Strauss. However, through a close reading of both Lacan's early writings and their Durkheimian influences we will demonstrate that what has changed, is Lacan's conceptualization of the relation between the individual and the collective. This change was gradual rather than sudden. Moreover, it can be situated within the theoretical evolution of the contiguous fields of sociology, anthropology and psychoanalysis. Thus we reject the idea of a breach within his own thought and with what came before him. We will establish our point through a summary of how the relation between the individual and the collective was theorized before Lacan. Durkheim conceptualized this relation as dual: the individual and the collective are radically separated. Mauss attempted to unify the field of anthropology through the holistic concept of the total man. In Lévi-Straus's formalization the individual becomes a function within a structured, Symbolic system. Finally, a reading of Lacan's publications concerning the notion of the logic of the collective will testify to his attempts at formulating a notion of the subject that asserts itself against this collective while at the same time retaining its nature of a logical function. This is the conundrum that Lacan will confront time and again throughout his teachings. Lévi-Strauss merely provided him with the methodological tools of structural anthropology that helped him refine the interrogations that he had already begun

Vaccinia-Related Kinase 1 Is Required for the Maintenance of Undifferentiated Spermatogonia in Mouse Male Germ Cells

Vaccinia-related kinase 1 (VRK1) is a crucial protein kinase for mitotic regulation. VRK1 is known to play a role in germ cell development, and its deficiency results in sterility. Here we describe that VRK1 is essential for the maintenance of spermatogonial stem cells. To determine whether VRK1 plays a role in these cells, we assessed the population size of undifferentiated spermatogonia. Flow cytometry analyses showed that the number of undifferentiated spermatogonia was markedly reduced in VRK1-deficient testes. VRK1 was highly expressed in spermatogonial populations, and approximately 66% of undifferentiated spermatogonia that were sorted as an Ep-CAM+/c-kit−/alpha-6-integrin+ population showed a positive signal for VRK1. Undifferentiated stem cells expressing Plzf and Oct4 but not c-kit also expressed VRK1, suggesting that VRK1 is an intrinsic factor for the maintenance of spermatogonial stem cells. Microarray analyses of the global testicular transcriptome and quantitative RT-PCR of VRK1-deficient testes revealed significantly reduced expression levels of undifferentiated spermatogonial marker genes in early postnatal mice. Together, these results suggest that VRK1 is required for the proliferation and differentiation of undifferentiated spermatogonia, which are essential for spermatogenic cell maintenance