Magnetic Susceptibility of North American Ordovician Epicontinental Seas: Spatial Variability and Sandbian-Katian Boundary Correlation

Magnetic susceptibility (χ) has gained increased usage as a stratigraphic correlation tool. This project evaluates the utility of a χ correlation tool, including its shortcomings, and attempts its integration with other datasets. The Upper Ordovician of eastern North America represent the stratigraphic interval in which these experiments were conducted. 4566 samples were collected for the purposes of this study, and χ was measured on 3345 of the samples. This project includes three major facets, 1) the spatial variability of χ, 2) correlation of Sandbian-Katian boundary interval strata in eastern North America using χ, and 3) utility of χ for interpreting stratigraphic sequences. 1) Testing the spatial variability of χ was conducted by sampling a single isochronous Upper Ordovician limestone horizon across the lateral extent of the Cincinnati Arch. A small but predictable decrease in χ values with increased distance from the clastic sediment source was documented. These observations match the hypotheses of the Episodic Starvation model of sedimentation on the Cincinnati Arch. Facies changes in proximal positions of the basin, and interbedding of muddy carbonates with shales, result in the deterioration of the χ signature, and correlation becomes increasingly difficult using this method. Based upon this, correlation using χ profiles is most suited for distal portions of basins. 2) Application of the χ technique has been used for correlation of the Sandbian-Katian boundary interval in eastern North America. A series of correlation hypotheses have been proposed but a unique correlation has not been found. Due to a series of unconformities, and biostratigraphic discrepancies it has not been possible to find a datum to hang χ profiles upon. The leading hypothesis is that deepening strata of the Logana-Napanee interval correlates to the lower wackestone unit of the Viola Springs Formation, and upper Womble Shale. 3) In order to incorporate χ datasets into sequence stratigraphic analyses a series of χ samples have been collected across sequence stratigraphic surfaces of know interpretation. Large shifts to lower measured χ values at some sequence boundaries and shifts to higher χ values at most flooding surfaces may be used to aid in sequence stratigraphic interpretation

Tempestites in a Teapot? Condensation-Generated Shell Beds in the Upper Ordovician, Cincinnati Arch, USA.

Skeletal concentrations in mudstones may represent local facies produced by storm winnowing in shallow water, or time-specific deposits related to intervals of diminished sediment supply. Upper Ordovician (Katian) of the Cincinnati region is a mixed siliciclastic-carbonate succession including meter-scale cycles containing a shelly limestone-dominated phase and a mudstone-dominated phase. The “tempestite proximality model” asserts that shell-rich intervals originated by winnowing of mud from undifferentiated fair-weather deposits. Thus shell beds are construed as tempestites, while interbedded mudstones represent either fair-weather or bypassed mud. Meter-scale cycles are attributed to sea-level fluctuation or varying storm intensity. Alternatively, the “episodic starvation model” argues, on the basis of petrographic, taphonomic, and stratigraphic evidence, that, despite widespread evidence for storms or other turbulence events (e.g. tsunamis), winnowing alone could not generate shell beds where none had previously existed. Instead, variations in sediment supply are construed as the principal cause of shelly-mudstone cycles. Shell-rich deposits accrue during periods of siliciclastic sediment starvation and relatively shell-free mud accumulates during periods of sediment influx. Tempestite proximality and episodic starvation models lead to contrasting predictions about proximal-to-distal facies patterns. These are: (i) large versus small volumes of distally-deposited, bypassed mud; (ii) proximal grainstones and distal packstones versus distal grainstones and proximal packstones; and (iii) proximal versus distal amalgamation and condensation of shell beds. In this paper, these predictions are tested by (i) comparing meter-scale cycles from different horizons and depositional environments through the lower Cincinnatian succession (Kope through McMillan Formations representing deep subtidal through intertidal environments), and (ii) correlating intervals and individual meter-scale cycles from the Fairview Formation of the Cincinnati Arch (shallow subtidal) north and west into the Maquoketa Shale (deep subtidal) in subsurface of Ohio and Indiana. Both approaches show patterns consistent with episodic starvation, not winnowing, including: (i) small differences in stratigraphic thickness indicate small volumes of bypassed mud; (ii) discrete distal deep-water grainstones that splay proximally into bundles of thinner shallow-water packstones alternating with shelly muds show that grainstones formed from a lack of, rather than removal of mud; and (iii) distal shell bed amalgamation and condensation (and corresponding proximal splaying) of shell beds shows a proximal source of mud. Thus, winnowing by storms or other turbulence events did not generate shell beds or cycles from undifferentiated sediments despite abundant evidence for storm deposition. High-resolution correlations imply that the shell-bed and mud-bed hemicycles reflect simultaneous basin-wide changes in sedimentary style rather than contemporaneous facies belts that track sea-level. In this sense, shell-rich and mud-rich hemicycles are “non-Waltherian” facies

Upper Ordovician Strata of Southern Ohio-Indiana: Shales, Shell Beds, Storms, Sediment Starvation, and Cycles

The Cincinnatian Series (ca. 450 to 442 Ma) of the Cincinnati Arch features some of the most spectacular Ordovician fossils in the world. The rich faunas of bryozoans, brachiopods, molluscs, echinoderms, and trilobites are preserved as discrete shell-rich limestones, cyclically interbedded with sparsely fossiliferous shales and mudstones that may yield exceptionally preserved trilobites and crinoids. Similar successions of shell beds interbedded with mudstones are common components of Paleozoic successions. In such successions, the genesis of the highly concentrated shell beds is often attributed to storm-winnowing, but is this the whole story? This trip will offer an overview of the classic Cincinnatian Series, with ample opportunity for examining and collecting the rich fossil assemblages throughout much of the succession. Discussions will focus on the origin of interbedded mudstone-limestone cycles. We will emphasize depositional processes, particularly the role of intermittent siliciclastic sediment supply, carbonate (shell) production, and winnowing by storms and other high-energy events in a critical discussion of the storm-winnowing model

Production of Li, Be \& B from Baryon Inhomogeneous Primordial Nucleosynthesis

We investigate the possibility that inhomogeneous nucleosynthesis may eventually be used to explain the abundances of \li6, \be9 and B in population II stars. The present work differs from previous studies in that we have used a more extensive reaction network. It is demonstrated that in the simplest scenario the abundances of the light elements with $A\le7$ constrain the separation of inhomogeneities to sufficiently small scales that the model is indistinguishable from homogeneous nucleosynthesis and that the abundances of \li6, \be9\ and B are then below observations by several orders of magnitude. This conclusion does not depend on the \li7 constraint. We also examine alternative scenarios which involve a post-nucleosynthesis reprocessing of the light elements to reproduce the observed abundances of Li and B, while allowing for a somewhat higher baryon density (still well below the cosmological critical density). Future B/H measurements may be able to exclude even this exotic scenario and further restrict primordial nucleosynthesis to approach the homogeneous model conclusions.Comment: 18 pages; Plain TeX; UMN-TH-1131/9

A Fresh Look at Axions and SN 1987A

We re-examine the very stringent limits on the axion mass based on the strength and duration of the neutrino signal from SN 1987A, in the light of new measurements of the axial-vector coupling strength of nucleons, possible suppression of axion emission due to many-body effects, and additional emission processes involving pions. The suppression of axion emission due to nucleon spin fluctuations induced by many-body effects degrades previous limits by a factor of about 2. Emission processes involving thermal pions can strengthen the limits by a factor of 3-4 within a perturbative treatment that neglects saturation of nucleon spin fluctuations. Inclusion of saturation effects, however, tends to make the limits less dependent on pion abundances. The resulting axion mass limit also depends on the precise couplings of the axion and ranges from 0.5x10**(-3) eV to 6x10**(-3) eV.Comment: 32 latex pages, 13 postscript figures included, uses revtex.sty, submitted to Physical Review

Microbial community assembly and evolution in subseafloor sediment

Bacterial and archaeal communities inhabiting the subsurface seabed live under strong energy limitation and have growth rates that are orders of magnitude slower than laboratory-grown cultures. It is not understood how subsurface microbial communities are assembled and whether populations undergo adaptive evolution or accumulate mutations as a result of impaired DNA repair under such energy-limited conditions. Here we use amplicon sequencing to explore changes of microbial communities during burial and isolation from the surface to the > 5,000-y-old subsurface of marine sediment and identify a small core set of mostly uncultured bacteria and archaea that is present throughout the sediment column. These persisting populations constitute a small fraction of the entire community at the surface but become predominant in the subsurface. We followed patterns of genome diversity with depth in four dominant lineages of the persisting populations by mapping metagenomic sequence reads onto single-cell genomes. Nucleotide sequence diversity was uniformly low and did not change with age and depth of the sediment. Likewise, therewas no detectable change inmutation rates and efficacy of selection. Our results indicate that subsurface microbial communities predominantly assemble by selective survival of taxa able to persist under extreme energy limitation

Tn-Seq reveals hidden complexity in the utilization of host-derived glutathione in \u3cem\u3eFrancisella tularensis\u3c/em\u3e

Host-derived glutathione (GSH) is an essential source of cysteine for the intracellular pathogen Francisella tularensis. In a comprehensive transposon insertion sequencing screen, we identified several F. tularensis genes that play central and previously unappreciated roles in the utilization of GSH during the growth of the bacterium in macrophages. We show that one of these, a gene we named dptA, encodes a proton-dependent oligopeptide transporter that enables growth of the organism on the dipeptide Cys-Gly, a key breakdown product of GSH generated by the enzyme γ-glutamyltranspeptidase (GGT). Although GGT was thought to be the principal enzyme involved in GSH breakdown in F. tularensis, our screen identified a second enzyme, referred to as ChaC, that is also involved in the utilization of exogenous GSH. However, unlike GGT and DptA, we show that the importance of ChaC in supporting intramacrophage growth extends beyond cysteine acquisition. Taken together, our findings provide a compendium of F. tularensis genes required for intracellular growth and identify new players in the metabolism of GSH that could be attractive targets for therapeutic intervention

Extracorporeal Circulation During Lung Transplantation Procedures: a Meta-Analysis

Extracorporeal circulation (ECC) is an invaluable tool in lung transplantation (lutx). More than the past years, an increasing number of centers changed their standard for intraoperative ECC from cardiopulmonary bypass (CPB) to extracorporeal membrane oxygenation (ECMO) - with differing results. This meta-analysis reviews the existing evidence. An online literature research on Medline, Embase, and PubMed has been performed. Two persons independently judged the papers using the ACROBAT-NRSI tool of the Cochrane collaboration. Meta-analyses and meta-regressions were used to determine whether veno-arterial ECMO (VA-ECMO) resulted in better outcomes compared with CPB. Six papers - all observational studies without randomization - were included in the analysis. All were considered to have serious bias caused by heparinization as co-intervention. Forest plots showed a beneficial trend of ECMO regarding blood transfusions (packed red blood cells (RBCs) with an average mean difference of -0.46 units 95{\%} CI = -3.72, 2.80, fresh-frozen plasma with an average mean difference of -0.65 units 95{\%} CI = -1.56, 0.25, platelets with an average mean difference of -1.72 units 95{\%} CI = -3.67, 0.23). Duration of ventilator support with an average mean difference of -2.86 days 95{\%} CI = -11.43, 5.71 and intensive care unit (ICU) length of stay with an average mean difference of -4.79 days 95{\%} CI = -8.17, -1.41 were shorter in ECMO patients. Extracorporeal membrane oxygenation treatment tended to be superior regarding 3 month mortality (odds ratio = 0.46, 95{\%} CI = 0.21-1.02) and 1 year mortality (odds ratio = 0.65, 95{\%} CI = 0.37-1.13). However, only the ICU length of stay reached statistical significance. Meta-regression analyses showed that heterogeneity across studies (sex, year of ECMO implementation, and underlying disease) influenced differences. These data indicate a benefit of the intraoperative use of ECMO as compared with CPB during lung transplant procedures regarding short-term outcome (ICU stay). There was no statistically significant effect regarding blood transfusion needs or long-term outcome. The superiority of ECMO in lutx patients remains to be determined in larger multi-center randomized trials

Malignant pleural mesothelioma incidence and survival in the Republic of Ireland 1994-2009.

OBJECTIVE: Malignant pleural mesothelioma (MPM) is a rare malignancy associated with exposure to asbestos. The protracted latent period of MPM means that its incidence has continued to rise across Europe after the introduction of restrictions on asbestos use. In order to obtain a clearer indication of trends in the Republic of Ireland (ROI), incidence and survival were assessed based on all MPM cases reported since the establishment of the National Cancer Registry of Ireland (NCR). METHODS: NCR recorded 337 MPM diagnoses in the ROI during 1994-2009. Survival was assessed for all cases diagnosed with adequate follow-up (n=330). Crude and European age-standardized incidence rates were calculated for all cases and for 4-year periods. A Cox model of observed (all-cause) survival was used to generate hazard ratios for the effect of: gender; age at diagnosis; diagnosis cohort; region of residence; histological type; and tumour stage. Single P-values for the variables indicated were calculated using either a stratified log-rank test or stratified trend test. RESULTS: Over the study period the age-standardized MPM incidence in the ROI rose from 4.98cases per million (cpm) to 7.24cpm. The 1-year survival rate for all MPM cases was 29.6% (CI 24.7-34.6%). Excess mortality risk was associated with age at diagnosis (75-89 yrs vs. 55-64 yrs, HR 1.88, 95% CI 1.35-2.63, P CONCLUSION: MPM incidence and mortality continued to rise in the ROI after the restrictions on asbestos use and the predictors of survival detected in this study are broadly consistent with those identified for other countries

Observation of ultrafast solid-density plasma dynamics using femtosecond X-ray pulses from a free-electron laser

The complex physics of the interaction between short pulse high intensity lasers and solids is so far hardly accessible by experiments. As a result of missing experimental capabilities to probe the complex electron dynamics and competing instabilities, this impedes the development of compact laser-based next generation secondary radiation sources, e.g. for tumor therapy [Bulanov2002,ledingham2007], laboratory-astrophysics [Remington1999,Bulanov2015], and fusion [Tabak2014]. At present, the fundamental plasma dynamics that occur at the nanometer and femtosecond scales during the laser-solid interaction can only be elucidated by simulations. Here we show experimentally that small angle X-ray scattering of femtosecond X-ray free-electron laser pulses facilitates new capabilities for direct in-situ characterization of intense short-pulse laser plasma interaction at solid density that allows simultaneous nanometer spatial and femtosecond temporal resolution, directly verifying numerical simulations of the electron density dynamics during the short pulse high intensity laser irradiation of a solid density target. For laser-driven grating targets, we measure the solid density plasma expansion and observe the generation of a transient grating structure in front of the pre-inscribed grating, due to plasma expansion, which is an hitherto unknown effect. We expect that our results will pave the way for novel time-resolved studies, guiding the development of future laser-driven particle and photon sources from solid targets