Forschung Frankfurt : das Wissenschaftsmagazin. 2014, Nr. 1 ; Wissenschaft im Wandel

This paper describes the results of a pointing task close to the observer. Unlike most research reported in literature, the stimuli were composed of real solid objects in an unambiguous context, free of any cue conflict. Moreover, the stimuli were either within arm-reach or just beyond arm-reach, thus having strong binocular depth cues. Surprisingly, systematic errors up to four times the standard deviation were found. These errors depended mainly on the variations in context and hardly on egocentric distance. In good first approximation, the results were scale invariant. These results are in direct conflict with classic theories about visual space. The stimuli were unambiguous real 3-D equivalents of the computer-generated stimuli we used in a previous experiment. A comparison of the results did not reveal a clear effect of a depth cue conflict between accommodation and disparity

Misreading Black Others in Greco-Roman Antiquity

Responding to studies on prejudice in the Greco-Roman world, E. Gruen argues that Greeks and Romans had more nuanced and complex opinions about foreigners than often recognized. G. observes that the Greek and Romans could discover or invent links with these other societies through cultural appropriations of the past. These connections, G. contends, show that the Greeks and Romans cannot be ‘blanketed’ with xenophobia, ethnocentrism, and “let alone racism” (p. 3). G. argues that the Greeks and Romans were more interested in drawing connections with the other through cultural appropriation. G. contends that this approach reveals a positive outlook which does not reject or degrade the foreign other.Rezension zu: Erich S. Gruen, Rethinking the Other in Antiquity (Princeton 2011)

Clinical guidelines for opioid substitute treatment. Guidance document for OST in the hospital setting.

Submicroscopic genomic copy number changes have been identified only recently as an important cause of mental retardation. We describe the detection of three interstitial, overlapping 17q21.31 microdeletions in a cohort of 1,200 mentally retarded individuals associated with a clearly recognizable clinical phenotype of mental retardation, hypotonia and a characteristic face. The deletions encompass the MAPT and CRHR1 genes and are associated with a common inversion polymorphism

European guidelines for constitutional cytogenomic analysis

With advancing technology and the consequent shift towards an increasing application of molecular genetic techniques (e.g., microarrays, next-generation sequencing) with the potential for higher resolution in specific contexts, as well as the application of combined testing strategies for the diagnosis of chromosomal disorders, it is crucial that cytogenetic/cytogenomic services keep up to date with technology and have documents that provide guidance in this constantly evolving scenario. These new guidelines therefore aim to provide an updated, practical and easily available document that will enable genetic laboratories to operate within acceptable standards and to maintain a quality service

Guidelines for molecular karyotyping in constitutional genetic diagnosis.

Item does not contain fulltextArray-based whole genome investigation or molecular karyotyping enables the genome-wide detection of submicroscopic imbalances. Proof-of-principle experiments have demonstrated that molecular karyotyping outperforms conventional karyotyping with regard to detection of chromosomal imbalances. This article identifies areas for which the technology seems matured and areas that require more investigations. Molecular karyotyping should be part of the genetic diagnostic work-up of patients with developmental disorders. For the implementation of the technique for other constitutional indications and in prenatal diagnosis, more research is appropriate. Also, the article aims to provide best practice guidelines for the application of array comparative genomic hybridisation to ensure both technical and clinical quality criteria that will optimise and standardise results and reports in diagnostic laboratories. In short, both the specificity and the sensitivity of the arrays should be evaluated in every laboratory offering the diagnostic test. Internal and external quality control programmes are urgently needed to evaluate and standardise the test results between laboratories