645 research outputs found

    Complex, Dynamic Combination of Physical, Chemical and Nutritional Variables Controls Spatio-Temporal Variation of Sandy Beach Community Structure

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    Sandy beach ecological theory states that physical features of the beach control macrobenthic community structure on all but the most dissipative beaches. However, few studies have simultaneously evaluated the relative importance of physical, chemical and biological factors as potential explanatory variables for meso-scale spatio-temporal patterns of intertidal community structure in these systems. Here, we investigate macroinfaunal community structure of a micro-tidal sandy beach that is located on an oligotrophic subtropical coast and is influenced by seasonal estuarine input. We repeatedly sampled biological and environmental variables at a series of beach transects arranged at increasing distances from the estuary mouth. Sampling took place over a period of five months, corresponding with the transition between the dry and wet season. This allowed assessment of biological-physical relationships across chemical and nutritional gradients associated with a range of estuarine inputs. Physical, chemical, and biological response variables, as well as measures of community structure, showed significant spatio-temporal patterns. In general, bivariate relationships between biological and environmental variables were rare and weak. However, multivariate correlation approaches identified a variety of environmental variables (i.e., sampling session, the C:N ratio of particulate organic matter, dissolved inorganic nutrient concentrations, various size fractions of photopigment concentrations, salinity and, to a lesser extent, beach width and sediment kurtosis) that either alone or combined provided significant explanatory power for spatio-temporal patterns of macroinfaunal community structure. Overall, these results showed that the macrobenthic community on Mtunzini Beach was not structured primarily by physical factors, but instead by a complex and dynamic blend of nutritional, chemical and physical drivers. This emphasises the need to recognise ocean-exposed sandy beaches as functional ecosystems in their own right

    Reasons for the migration of church members from one congregation to another

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    This article2 aims to determine the reasons why members of one congregation migrate to another, and to identify factors that play a role in this process. These are determined by the nature and functioning of congregations. This qualitative research involved members of three different congregations that had recently experienced a positive growth in membership numbers. The effects of secularisation and the Enlightenment, and their consequences at various levels, as well as the theories of McDonaldisation and Consumerism were taken into consideration to explain the migration of church members between congregations. The answer is not simple in the sense that two tendencies can be identified: ‘push’ factors that activate the tendency to move out of the previous congregation, and a drawing or ‘pulling’ tendency, representing those factors that attract people. It can be stated that the reasons for migration can, to a large extent, be traced to the nature and functioning of the congregation. In addition, clear tendencies can be identified in terms of ‘push’ and ‘pull’ factors

    Die generasie-interval, van die Suid-Afrikaanse vleismerino

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    The average generation interval of 3,53 years in S.A. Mutton Merino stud flocks in l96ll62 is the result of an average ram-age of 3,57 year sa nd an ewe-agco f 3,49 year s .I n 1971/72 the averagc 'agoef rams and ewesw as 3,86 and 4.13 year sr espec t i vel yw i th an averageg enerat ion interval of ' 4,00 years"T he e>l tendingo f the generat ioni nterval is mainly a resul to f an mcreaseo f 0,64 yearsi n the average age of ewes. The niost important factors leading to thc iatter are a smallcr annual replacement of ewes and the first mating of young ewes at a later age. The generation interval of difierent strata of thc breeding structure could not show a clear relationship between generation interval end the relative imporlanr-e of the flock.Die gemiddelde generasie- intervavia n 3,53 Jaar van S.A. .V leismer inostoetkuddesin l96l /62 is die resul taatv an'n genuddelde ramouderdorn van 3,57 jaar en"n ooioud,;rdonr van -r,49 jaar. In l97 ll72 was die gemiddelde ouderdom van ramme en ooie 3,86 e'n 4,13 jaar onderskeidel ikm et 'n gemiddeldeg cnerasre- intervavla n 4.00 jaar . Dic ver lengingv an die generasie- intervaisl hoofsaakl ikd ie gevolg van 'n toename van 0,64 Jaar rn die gcnriddelde ouderd()m van ooie. Die belangrikste faktore wat hiertoe gelei het is'n kleiner jaarlikse ooiverplasing en die eerstc paring van jong i,roic op 'ir lrrter ouderdom. Diegenerasie-interval van verskillende strata in die teeltstruktuurkon nie 'n duidelike verband tusren senerasie-interval en relatiewe belansrikheid van die kudde aandui nie

    Medical management of myxomatous mitral valve disease : an evidence-based veterinary medicine approach

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    Myxomatous mitral valve disease (MMVD) is the most common heart disease of dogs. The current management of MMVD in dogs is mostly pharmacological, and the recommendations for treatment are based on a number of veterinary studies. Notwithstanding the current consensus regarding the medical management of MMVD, there remains active debate as to which drugs are the most effective. In order to understand how recommendations are constructed in the pharmacological management of diseases, the veterinarian needs to understand the concept of evidence-based veterinary medicine, and how the findings of these studies can be applied in their own practices. This review summarises the current veterinary literature and explains how the consensus regarding the management of MMVD has been reached. This review highlights the limitations of veterinary studies in order to provide veterinary practitioners with a sense of the difficulty there is in establishing the benefit of one treatment over the other. Veterinarians should therefore apply treatment recommendations based on the best evidence, integrated with a pathomechanistic understanding of the disease process and clinical experience.http://www.jsava.co.zaam201

    Advances in the understanding of the pathogenesis, progression and diagnosis of myxomatous mitral valve disease in dogs

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    A number of key questions remain unanswered in the pathogenesis of myxomatous mitral valve disease (MMVD). As MMVD typically afflicts small-breed dogs, a genetic basis has been implied. In addition, the fact that not all dogs within a risk group develop MMVD is still unexplained. Research into the pathogenesis of MMVD typically falls under three categorical divisions, namely genetic factors, mechanical factors of the valve and systemic factors. Genetic studies have implicated certain loci in the pathogenesis of MMVD. Of particular interest is the insulin-like growth factor (IGF)-1 locus, as IGF-1 is also associated with growth. The mechanical structure and function of the mitral valve have also received much attention in recent years. What has emerged is the notion of a highly complex dynamic structure, which has an uneven distribution of stress and strain according to the flow of blood. Research efforts have also identified a number of systemic factors such as cytokines and signalling pathways that may contribute to the failure of the valve. Serotonin remains an area of interest in this field. Taken together, the amalgamation of research efforts in these three areas will go a long way towards resolving the understanding of this disease. Another area of focus in MMVD has been the development of clinical tests to diagnose the onset of congestive heart failure. To this end, echocardiographic indices and biochemical markers have been investigated. Echocardiographic indices such as left atrial to aortic ratio and the N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) have been identified as specific risk factors to predict progression. Advanced imaging studies such as cardiac magnetic resonance imaging have enabled investigators to determine the earliest remodelling changes that occur in MMVD.http://www.jsava.co.zaam201

    The central role of chloride in the metabolic acid-base changes in canine parvoviral enteritis

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    The acid–base disturbances in canine parvoviral (CPV) enteritis are not well described. In addition, the mechanisms causing these perturbations have not been fully elucidated. The purpose of the present study was to assess acid–base changes in puppies suffering from CPV enteritis, using a modified strong ion model (SIM). The hypothesis of the study was that severe acid–base disturbances would be present and that the SIM would provide insights into pathological mechanisms, which have not been fully appreciated by the Henderson–Hasselbalch model. The study analysed retrospective data, obtained from 42 puppies with confirmed CPV enteritis and 10 healthy control dogs. The CPV-enteritis group had been allocated a clinical score, to allow classification of the data according to clinical severity. The effects of changes in free water, chloride, L-lactate, albumin and phosphate were calculated, using a modification of the base excess algorithm. When the data were summated for each patient, and correlated to each individual component, the most important contributor to the metabolic acid–base changes, according to the SIM, was chloride (P < 0.001). Severely-affected animals tended to demonstrate hypochloraemic alkalosis, whereas mildly-affected puppies had a hyperchloraemic acidosis (P = 0.007). In conclusion, the acid–base disturbances in CPV enteritis are multifactorial and complex, with the SIM providing information in terms of the origin of these changes.http://www.elsevier.com/locate/tvjlhb201

    Cretaceous fossils from the Orapa Diamond Mine

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    Main articleThe Orapa kimberlite pipe, situated in north-central Botswana, is well-known for its rich reserves of diamonds. It is indeed one of the largest and richest diamond mines in the world. The kimberlite magma transporting the diamonds from the upper mantle erupted through a sequence ofKaroo-aged rocks before the deposition ofthe Kalahari Sands. This eruption has been radiometrically dated at early Late Cretaceous (Cenomanian-Coniacian). When volcanism ceased, a succession of epiclastic crater lake sediments was deposited above the kimberlite plug. Analysis of these sediments, which mostly comprise the results of mudflows and debris flows and fmer sediments during quiescenttimes, suggests that most of the sediments within the crater were deposited rapidly as mass flows, and were therefore mobilised soon after the volcanic eruption. Buried within the fine-grained sediments is a unique assemblage of fossils including flowering plants and many whole-bodied insects. The fossils are commonly exquisitely preserved in extremely fine-grained mudstone. Interpretation of the sedimentary facies and fossils is that the mid-Cretaceous climate of central Botswana was temperate, seasonal and wet, and the area surrounding the crater was forested. The fossils represent the recovery of the biota of the area after the violent eruptions of Orapa and other nearby kimberlite fissures and pipes. The fossils have contributed considerably to our understanding of mid-Cretaceous insects and flowering plants and suggest intimate relationships between the two at an early stage in the radiation of flowering plants. It seems that southern Gondwana (including southern Africa) was a centre of diversification for both insects and angiosperms in the mid-Cretaceous.Friends of the Museum, Gaborone; Debswana (Orapa); University of the Witwatersrand; South African Foundation for Research Developmen

    Extreme hyperthermia tolerance in the world’s most abundant wild bird

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    The thermal tolerances of vertebrates are generally restricted to body temperatures below 45–47 °C, and avian and mammalian critical thermal maxima seldom exceed 46 °C. We investigated thermoregulation at high air temperatures in the red-billed quelea (Quelea quelea), an African passerine bird that occurs in flocks sometimes numbering millions of individuals. Our data reveal this species can increase its body temperature to extremely high levels: queleas exposed to air temperature > 45 °C increased body temperature to 48.0 ± 0.7 °C without any apparent ill-effect, with individual values as high as 49.1 °C. These values exceed known avian lethal limits, with tolerance of body temperature > 48 °C unprecedented among birds and mammals.The DSI-NRF Centre of Excellence at the FitzPatrick Institute and the National Research Foundation of South Africa.http://www.nature.com/srepam2021Zoology and Entomolog

    Comparison of ELISA and HI for detection of antibodies against Wesselsbron disease virus

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    A two-graph Receiver Operating Characteristic analysis was done to determine the optimal cut-off value of an indirect enzyme-linked immunosorbent assay (ELISA) for detection of antibodies to Wesselsbron disease (WSL) virus. When ELISA and haemagglutination-inhibition (HI) results of WSL-positive and WSL-negative control sheep sera were compared, the sensitivity of ELISA was 97,9% and that of HI, 87,5%, while the specificity of ELISA and HI were 95,7% and 100 %, respectively. The ELISA's superior sensitivity was confirmed by the results of the two assays performed on a simulated range of low-positive sera, which showed that the ELISA was able to detect WSL-antibody levels at least ten times lower than those the HI could. The ELISA was also less cross-reactive than the HI to guinea-pig antisera against nine flaviviruses relevant to southern Africa. The combination of the ELISA's ability to test untreated sera in single dilution and its superior sensitivity and lower crossreactivity as compared to that of the traditional HI, makes it the assay of choice for automation and large-scale screening of animals for antibodies to WSL virus.The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat X Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format

    Achieving population-level immunity to rabies in free-roaming dogs in Africa and Asia.

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    Canine rabies can be effectively controlled by vaccination with readily available, high-quality vaccines. These vaccines should provide protection from challenge in healthy dogs, for the claimed period, for duration of immunity, which is often two or three years. It has been suggested that, in free-roaming dog populations where rabies is endemic, vaccine-induced protection may be compromised by immuno-suppression through malnutrition, infection and other stressors. This may reduce the proportion of dogs that seroconvert to the vaccine during vaccination campaigns and the duration of immunity of those dogs that seroconvert. Vaccination coverage may also be limited through insufficient vaccine delivery during vaccination campaigns and the loss of vaccinated individuals from populations through demographic processes. This is the first longitudinal study to evaluate temporal variations in rabies vaccine-induced serological responses, and factors associated with these variations, at the individual level in previously unvaccinated free-roaming dog populations. Individual-level serological and health-based data were collected from three cohorts of dogs in regions where rabies is endemic, one in South Africa and two in Indonesia. We found that the vast majority of dogs seroconverted to the vaccine; however, there was considerable variation in titres, partly attributable to illness and lactation at the time of vaccination. Furthermore, >70% of the dogs were vaccinated through community engagement and door-to-door vaccine delivery, even in Indonesia where the majority of the dogs needed to be caught by net on successive occasions for repeat blood sampling and vaccination. This demonstrates the feasibility of achieving population-level immunity in free-roaming dog populations in rabies-endemic regions. However, attrition of immune individuals through demographic processes and waning immunity necessitates repeat vaccination of populations within at least two years to ensure communities are protected from rabies. These findings support annual mass vaccination campaigns as the most effective means to control canine rabies.This study was funded by the International Fund for Animal Welfare (IFAW) http://www.ifaw.org/united-kingdom and the World Society for the Protection of Animals (WSPA) http://www.wspa.org.uk/, with support from the Charles Slater Fund and Jowett Fund. OR is supported by the Royal Society, and JLNW the Alborada Trust. JLNW, OR and ARF receive support from the Research and Policy for Infectious Disease Dynamics Program of the Science and Technology Directorate, Department of Homeland Security, Fogarty International Centre, National Institute of Health. DLH and ARF are supported by the U.K. Department for the Environment, Food and Rural Affairs project number SEV3500. TJM is supported by Biotechnology and Biological Sciences Research Council grant number BB/I012192/1.This is the final version. It was first published by PLOS in PLOS Neglected Tropical Diseases at http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003160
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