Two-State Folding, Folding through Intermediates, and Metastability in a Minimalistic Hydrophobic-Polar Model for Proteins

Within the frame of an effective, coarse-grained hydrophobic-polar protein model, we employ multicanonical Monte Carlo simulations to investigate free-energy landscapes and folding channels of exemplified heteropolymer sequences, which are permutations of each other. Despite the simplicity of the model, the knowledge of the free-energy landscape in dependence of a suitable system order parameter enables us to reveal complex folding characteristics known from real bioproteins and synthetic peptides, such as two-state folding, folding through weakly stable intermediates, and glassy metastability.Comment: 10 pages, 1 figur

Experimental demonstration of continuous variable polarization entanglement

We report the experimental transformation of quadrature entanglement between two optical beams into continuous variable polarization entanglement. We extend the inseparability criterion proposed by Duan, et al. [Duan00] to polarization states and use it to quantify the entanglement between the three Stokes operators of the beams. We propose an extension to this scheme utilizing two quadrature entangled pairs for which all three Stokes operators between a pair of beams are entangled.Comment: 4 pages, 4 figure

Socially Constructing God: Gender, Culture, and a Stratified Trinity

The Problem. Both hierarchicalist and equivalentist evangelicals use Trinitarian relations to argue for their opposing views on gender roles. How can this stalemate be broken if the Bible, the typical evangelical foundation for resolving doctrinal disputes, is used by both sides to argue their contrasting positions? -- Methods and Procedures. I explored the cultural determination of worldview, bringing the fields of sociology, psychology, history, and philosophy to bear on this theological debate and considered whether it may be differing presuppositions and subsequent opposing interpretations that cause the conflicting positions, rather than what the biblical text means. By looking through the eyes of experts in this mix of fields, I gained insight on the development and impact of gender presuppositions in regard to role stratification in the conceptualization of the Trinity. -- Findings. I found that culturally determined presuppositions seem to be at the root of the disagreement. It would seem that the divine is being conceptualized and stratified according to contemporary human society. Until each side of the debate can understand their presuppositions and recognize the extent to which they are creating God in their image, constructive dialogue will be limited and I project that the debate will continue passionately and divisively

Recovery of continuous wave squeezing at low frequencies

We propose and demonstrate a system that produces squeezed vacuum using a pair of optical parametric amplifiers. This scheme allows the production of phase sidebands on the squeezed vacuum which facilitate phase locking in downstream applications. We observe strong, stably locked, continuous wave vacuum squeezing at frequencies as low as 220 kHz. We propose an alternative resonator configuration to overcome low frequency squeezing degradation caused by the optical parametric amplifiers.Comment: 9 pages, 4 figure

Forecast, observation and modelling of a deep stratospheric intrusion event over Europe

A wide range of measurements was carried out in central and southeastern Europe within the framework of the EU-project STACCATO (Influence of Stratosphere-Troposphere Exchange in a Changing Climate on Atmospheric Transport and Oxidation Capacity) with the principle goal to create a comprehensive data set on stratospheric air intrusions into the troposphere along a rather frequently observed pathway over central Europe from the North Sea to the Mediterranean Sea. The measurements were based on predictions by suitable quasi-operational trajectory calculations using ECMWF forecast data. A predicted deep Stratosphere to Troposphere Transport (STT) event, encountered during the STACCATO period on 20-21 June 2001, could be followed by the measurements network almost from its inception. Observations provide evidence that the intrusion affected large parts of central and southeastern Europe. Especially, the ozone lidar observations on 20-21 June 2001 at Garmisch-Partenkirchen, Germany captured the evolution of two marked tongues of high ozone with the first one reaching almost a height of 2 km, thus providing an excellent data set for model intercomparisons and validation. In addition, for the first time to our knowledge concurrent measurements of the cosmogenic radionuclides <sup>10</sup>Be and <sup>7</sup>Be and their ratio <sup>10</sup>Be/<sup>7</sup>Be are presented together as stratospheric tracers in a case study of a stratospheric intrusion. The ozone tracer columns calculated with the FLEXPART model were found to be in good agreement with water vapour satellite images, capturing the evolution of the observed dry streamers of stratospheric origin. Furthermore, the time-height cross section of ozone tracer simulated with FLEXPART over Garmisch-Partenkirchen captures with many details the evolution of the two observed high-ozone filaments measured with the IFU lidar, thus demonstrating the considerable progress in model simulations. Finally, the modelled ozone (operationally available since October 1999) from the ECMWF (European Centre for Medium-Range Weather Forecasts) atmospheric model is shown to be in very good agreement with the observations during this case study, which provides the first successful validation of a chemical tracer that is used operationally in a weather forecast model. This suggests that coupling chemistry and weather forecast models may significantly improve both weather and chemical forecasts in the future

Cryogenic Q-factor measurement of optical substrates for optimization of gravitational wave detectors

Future generations of gravitational wave interferometers are likely to be operated at cryogenic temperatures because one of the sensitivity limiting factors of the present generation is the thermal noise of end mirrors and beam splitters that occurs in the optical substrates as well as in the dielectric coatings. A possible method for minimizing thermal noise is cooling to cryogenic temperatures, maximizing the mechanical quality factor Q, and maximizing the eigenfrequencies of the substrate. We present experimental details of a new cryogenic apparatus that is suitable for the measurement of the temperature-dependent Q-factor of reflective, transmissive as well as nano-structured grating optics down to 5 K. In particular, the SQUID-based and the optical interferometric approaches to the measurement of the amplitude of vibrating test bodies are compared and the method of ring-down recording is described