2,994 research outputs found

    Hospitalisations and outpatient visits for undifferentiated fever attributable to scrub typhus in rural south india: retrospective cohort and nested case-control study

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    This dataset contains individual-level information collected as part of a study to estimate the proportion of hospitalisations and outpatient visits for undifferentiated fever that may be attributable to scrub typhus in the South Indian state of Tamil Nadu. We conducted house-to-house screening in 48 villages (42965 people, 11964 households) to identify hospitalised or outpatient cases due to undifferentiated fever during the preceding scrub typhus season. We used scrub typhus IgG to determine past infection. We calculated adjusted odds ratios for the association between IgG positivity and case status. Odds ratios were used to estimate population attributable fractions (PAF) indicating the proportion of hospitalised and outpatient fever cases attributable to scrub typhus. We identified 58 cases of hospitalisation and 236 outpatient treatments. 562 people were enrolled as control group to estimate the background IgG sero-prevalence. IgG prevalence was 20.3% in controls, 26.3% in outpatient cases and 43.1% in hospitalised cases. The PAFs suggested that 29.5% of hospitalisations and 6.1% of outpatient cases may have been due to scrub typhus. In villages with a high IgG prevalence (defined as тЙе15% among controls), the corresponding PAFs were 43.4% for hospitalisations and 5.6% for outpatients. The estimated annual incidence of scrub typhus was 0.8/1000 people (0.3/1000 in low, and 1.3/1000 in high prevalence villages). Evidence for recall error suggested that the true incidences may be about twice as high as these figures. Conclusions: The study suggests scrub typhus as an important cause for febrile hospitalisations in the community. The results confirm the adequacy of empirical treatment for scrub typhus in hospitalised cases with undifferentiated fever. Since scrub typhus may be rare among stable outpatients, the use of empirical treatment remains doubtful in these. Data request button removed at request of data creator on 06 May 2021. Release of data is subject to approval by Institutional Review Board at Christian Medical College, Vellore. Please contact data creator via email to discuss dataset

    Seven trials, seven question marks.

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    An Analytically Solvable Model of Firing Rate Heterogeneity in Balanced State Networks

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    Distributions of neuronal activity within cortical circuits are often found to display highly skewed shapes with many neurons emitting action potentials at low or vanishing rates, while some are active at high rates. Theoretical studies were able to reproduce such distributions, but come with a lack of mathematical tractability, preventing a deeper understanding of the impact of model parameters. In this study, using the Gauss-Rice neuron model, we present a balanced-state cortical circuit model for which the firing rate distribution can be exactly calculated. It offers selfconsistent solutions to recurrent neuronal networks and allows for the combination of multiple neuronal populations, with single or multiple synaptic receptors (e.g. AMPA and NMDA in excitatory populations), paving the way for a deeper understanding of how firing rate distributions are impacted by single neuron or synaptic properties

    A simple microbiological tool to evaluate the effect of environmental health interventions on hand contamination.

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    The effects of interventions such as sanitation or hand hygiene on hand contamination are difficult to evaluate. We explored the ability of a simple microbiological test to: (1) detect recontamination after handwashing; (2) reflect risk factors for microbial contamination and (3) be applicable to large populations. The study was done in rural Andhra Pradesh, India, and Maputo, Mozambique. Participants placed all 10 fingertips on a chromogenic agar that stains Enterococcus spp. and E. coli spp. Outcomes were the number of colonies and the number of fingertips with colonies. In the recontamination study, participants were randomised to handwashing with soap and no handwashing, and tested at 30 min intervals afterwards. In two cross sectional studies, risk factors for hand contamination were explored. Recontamination of hands after washing with soap was fast, with baseline levels reached after 1 h. Child care was associated with higher Enterococcus spp. counts, whereas agricultural activities increased E. coli spp. counts. Food preparation was associated with higher counts for both organisms. In Maputo, counts were not strongly associated with water access, latrine type, education or diarrhoea. The method seems unsuitable for the evaluation of handwashing promotion. It may reflect immediately preceding risk practices but not household-level risk factors

    A novel modulation strategy for integrating digital sub-channels within a PAL/PAL plus signal

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    This paper presents an original methodology which facilitates the modulation of digital signals within the active video portion of a conventional analogue PAL/PALplus television signal. The resultant crosstalk distortion errors which ensue are analysed and a model postulated that enables optimization of a number of important system parameters. It is also shown that applying this model enables a balancing of subjective quality with data-rat

    Women's role in sanitation decision making in rural coastal Odisha, India.

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    BACKGROUND: While women and girls face special risks from lack of access to sanitation facilities, their ability to participate and influence household-level sanitation is not well understood. This paper examines the association between women's decision-making autonomy and latrine construction in rural areas of Odisha, India. METHODS: We conducted a mixed-method study among rural households in Puri district. This included a cross sectional survey among 475 randomly selected households. These were classified as either having a functional latrine, a non-functional latrine or no latrine at all. We also conducted 17 in-depth interviews and 9 focus group discussions among household members of these three categories of households. RESULTS: Decisions on the construction of household level sanitation facilities were made exclusively by the male head in 80% of households; in 11% the decision was made by men who consulted or otherwise involved women. In only 9% of households the decision was made by women. Households where women were more involved in general decision making processes were no more likely to build a latrine, compared to households where they were excluded from decisions. Qualitative research revealed that women's non-involvement in sanitation decision making is attributed to their low socio-economic status and inability to influence the household's financial decisions. Female heads lacked confidence to take decisions independently, and were dependent on their spouse or other male family members for most decisions. The study revealed the existence of power hierarchies and dynamics within households, which constrained female's participation in decision-making processes regarding sanitation. CONCLUSIONS: Though governments and implementers emphasize women's involvement in sanitation programmes, socio-cultural factors and community and household level dynamics often prevent women from participating in sanitation-related decisions. Measures are needed for strengthening sanitation policies and effective implementation of programmes to address gender power relations and familial relationships that influence latrine adoption and use

    Level and change of group-focused enmity in Germany: unconditional and conditional latent growth curve models with four panel waves

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    In this study, we investigate and explain the level and change of six elements of group-focused enmity (GFE; see Zick et al. in J. Soc. Issues 64(2):363-383, 2008) in Germany between 2002 and 2006: racism, xenophobia, anti-Semitism, homophobia, exclusion of homeless people and support for rights of the established. For the data analysis, a representative 4-year panel study of the adult non-immigrant German population collected during the years 2002-2006 is used, and the development of each GFE component is tested by using an unconditional second-order latent growth curve model (LGM) (with full information maximum likelihood, FIML). We find that the level of 5 of the 6 components (racism, xenophobia, anti-Semitism, homophobia, exclusion of homeless people) displays an increase at the beginning of the observed period followed by a decrease. However, the sixth aspect, rights of the established, displays a continuous linear increase over time. The different developmental pattern stands in contrast to Allport's (The nature of prejudice. Perseus Books, Cambridge, 1954) hypothesis for the strong link between the components and their development over time. We try to explain this different developmental pattern by several sociodemographic characteristics. This is performed by using a conditional second-order latent growth curve mode
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